LOCUS       NM_001911                914 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens cathepsin G (CTSG), mRNA.
ACCESSION   NM_001911
VERSION     NM_001911.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Hu,L., Zheng,C., Kong,Y., Luo,Z., Huang,F., Zhu,Z., Li,Q. and
            Liang,M.
  TITLE     Cathepsin G promotes arteriovenous fistula maturation by positively
            regulating the MMP2/MMP9 pathway
  JOURNAL   Ren Fail 46 (1), 2316269 (2024)
   PUBMED   38362707
  REMARK    GeneRIF: Cathepsin G promotes arteriovenous fistula maturation by
            positively regulating the MMP2/MMP9 pathway.
REFERENCE   2  (bases 1 to 914)
  AUTHORS   Schuhmann,F., Bordallo,H.N. and Pezeshkian,W.
  TITLE     Physics-Based Protein Networks Might Recover Effectful Mutations
            horizontal line a Case Study on Cathepsin G
  JOURNAL   J Phys Chem B 128 (41), 10043-10050 (2024)
   PUBMED   39357873
  REMARK    GeneRIF: Physics-Based Protein Networks Might Recover Effectful
            Mutations horizontal line a Case Study on Cathepsin G.
REFERENCE   3  (bases 1 to 914)
  AUTHORS   Douka,A., Gintoni,I., Derka,S., Vairaktari,G., Vassiliou,S. and
            Yapijakis,C.
  TITLE     Investigation of Genetic Association Between a High Activity
            Variant of Cathepsin G and Risk for Basal Cell Carcinoma
  JOURNAL   Anticancer Res 44 (5), 2091-2094 (2024)
   PUBMED   38677729
  REMARK    GeneRIF: Investigation of Genetic Association Between a High
            Activity Variant of Cathepsin G and Risk for Basal Cell Carcinoma.
REFERENCE   4  (bases 1 to 914)
  AUTHORS   Chan,S., Wang,X., Wang,Z., Du,Y., Zuo,X., Chen,J., Sun,R.,
            Zhang,Q., Lin,L., Yang,Y., Yu,Z., Zhao,H., Zhang,H. and Chen,W.
  TITLE     CTSG Suppresses Colorectal Cancer Progression through Negative
            Regulation of Akt/mTOR/Bcl2 Signaling Pathway
  JOURNAL   Int J Biol Sci 19 (7), 2220-2233 (2023)
   PUBMED   37151875
  REMARK    GeneRIF: CTSG Suppresses Colorectal Cancer Progression through
            Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 914)
  AUTHORS   Tanigawa,K., Kiriya,M., Hayashi,Y., Shinden,Y., Kijima,Y.,
            Natsugoe,S., Sumimoto,T., Morimoto-Kamata,R., Yui,S., Hama,K.,
            Yokoyama,K., Nakamura,Y., Suzuki,K., Nojiri,H., Inoue,K. and
            Karasawa,K.
  TITLE     Cathepsin G-induced malignant progression of MCF-7 cells involves
            suppression of PAF signaling through induced expression of PAFAH1B2
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1867 (8), 159164 (2022)
   PUBMED   35462067
  REMARK    GeneRIF: Cathepsin G-induced malignant progression of MCF-7 cells
            involves suppression of PAF signaling through induced expression of
            PAFAH1B2.
REFERENCE   6  (bases 1 to 914)
  AUTHORS   Sasaki,T. and Ueno-Matsuda,E.
  TITLE     Immunocytochemical localization of cathepsins B and G in
            odontoclasts of human deciduous teeth
  JOURNAL   J Dent Res 71 (12), 1881-1884 (1992)
   PUBMED   1452887
REFERENCE   7  (bases 1 to 914)
  AUTHORS   Cohen,A.B., Stevens,M.D., Miller,E.J., Atkinson,M.A. and
            Mullenbach,G.
  TITLE     Generation of the neutrophil-activating peptide-2 by cathepsin G
            and cathepsin G-treated human platelets
  JOURNAL   Am J Physiol 263 (2 Pt 1), L249-L256 (1992)
   PUBMED   1387511
REFERENCE   8  (bases 1 to 914)
  AUTHORS   Maison,C.M., Villiers,C.L. and Colomb,M.G.
  TITLE     Proteolysis of C3 on U937 cell plasma membranes. Purification of
            cathepsin G
  JOURNAL   J Immunol 147 (3), 921-926 (1991)
   PUBMED   1861080
REFERENCE   9  (bases 1 to 914)
  AUTHORS   Brandt,E., Van Damme,J. and Flad,H.D.
  TITLE     Neutrophils can generate their activator neutrophil-activating
            peptide 2 by proteolytic cleavage of platelet-derived connective
            tissue-activating peptide III
  JOURNAL   Cytokine 3 (4), 311-321 (1991)
   PUBMED   1873479
REFERENCE   10 (bases 1 to 914)
  AUTHORS   Bangalore,N., Travis,J., Onunka,V.C., Pohl,J. and Shafer,W.M.
  TITLE     Identification of the primary antimicrobial domains in human
            neutrophil cathepsin G
  JOURNAL   J Biol Chem 265 (23), 13584-13588 (1990)
   PUBMED   2116408
  REMARK    GeneRIF: Cathepsin G is an antimicrobial protein with bacteriocidal
            activity against S. aureus and N. gonorrhoeae.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL136018.4.
            
            On Nov 26, 2018 this sequence version replaced NM_001911.2.
            
            Summary: The protein encoded by this gene, a member of the
            peptidase S1 protein family, is found in azurophil granules of
            neutrophilic polymorphonuclear leukocytes. The encoded protease has
            a specificity similar to that of chymotrypsin C, and may
            participate in the killing and digestion of engulfed pathogens, and
            in connective tissue remodeling at sites of inflammation. In
            addition, the encoded protein is antimicrobial, with bacteriocidal
            activity against S. aureus and N. gonorrhoeae. Transcript variants
            utilizing alternative polyadenylation signals exist for this gene.
            [provided by RefSeq, Sep 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014460.1, BI833632.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match                 :: ENST00000216336.3/
                                                  ENSP00000216336.2
            Protein has antimicrobial activity :: PMID: 2116408
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL136018.4         19523-19604         c
            83-230              AL136018.4         18619-18766         c
            231-366             AL136018.4         18029-18164         c
            367-621             AL136018.4         17599-17853         c
            622-914             AL136018.4         16872-17164         c
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..914
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /note="cathepsin G"
                     /db_xref="GeneID:1511"
                     /db_xref="HGNC:HGNC:2532"
                     /db_xref="MIM:116830"
     exon            1..82
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..795
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /EC_number="3.4.21.20"
                     /codon_start=1
                     /product="cathepsin G preproprotein"
                     /protein_id="NP_001902.1"
                     /db_xref="CCDS:CCDS9631.1"
                     /db_xref="GeneID:1511"
                     /db_xref="HGNC:HGNC:2532"
                     /db_xref="MIM:116830"
                     /translation="MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPA
                     GQSRCGGFLVREDFVLTAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQ
                     RTIQNDIMLLQLSRRVRRNRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLR
                     EVQLRVQRDRQCLRIFGSYDPRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYG
                     KSSGVPPEVFTRVSSFLPWIRTTMRSFKLLDQMETPL"
     exon            83..230
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /inference="alignment:Splign:2.1.0"
     exon            231..366
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /inference="alignment:Splign:2.1.0"
     exon            367..621
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /inference="alignment:Splign:2.1.0"
     exon            622..914
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      849..854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /note="hexamer: AATAAA"
     polyA_site      878
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /note="major polyA site"
     regulatory      893..898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
                     /note="hexamer: ATTAAA"
     polyA_site      914
                     /gene="CTSG"
                     /gene_synonym="CATG; CG"
ORIGIN      
        1 aactgactgg gcagcctttc aggaaagatg cagccactcc tgcttctgct ggcctttctc
       61 ctacccactg gggctgaggc aggggagatc atcggaggcc gggagagcag gccccactcc
      121 cgcccctaca tggcgtatct tcagatccag agtccagcag gtcagagcag atgtggaggg
      181 ttcctggtgc gagaagactt tgtgctgaca gcagctcatt gctggggaag caatataaat
      241 gtcaccctgg gcgcccacaa tatccagaga cgggaaaaca cccagcaaca catcactgcg
      301 cgcagagcca tccgccaccc tcaatataat cagcggacca tccagaatga catcatgtta
      361 ttgcagctga gcagaagagt cagacggaat cgaaacgtga acccagtggc tctgcctaga
      421 gcccaggagg gactgagacc cgggacgctg tgcactgtgg ccggctgggg cagggtcagc
      481 atgaggaggg gaacagatac actccgagag gtgcagctga gagtgcagag ggataggcag
      541 tgcctccgca tcttcggttc ctacgacccc cgaaggcaga tttgtgtggg ggaccggcgg
      601 gaacggaagg ctgccttcaa gggggattcc ggaggccccc tgctgtgtaa caatgtggcc
      661 cacggcatcg tctcctatgg aaagtcgtca ggggttcctc cagaagtctt caccagggtc
      721 tcaagtttcc tgccctggat aaggacaaca atgagaagct tcaaactgct ggatcagatg
      781 gagacccccc tgtgactgac tcttcttctc ggggacacag gccagctcca cagtgttgcc
      841 agagccttaa taaacgtcca cagagtataa ataaccaatt cctcatttgt tcattaaacg
      901 tcattcagta ctta
//
