LOCUS       NM_001907               1165 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chymotrypsin like (CTRL), mRNA.
ACCESSION   NM_001907
VERSION     NM_001907.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Deng,X., Zhou,P., Wei,X., Uhlman,M., Lin,Y., Lin,X., Wu,S.,
            Diao,P., Xie,H., Liu,J., Xie,K. and Tang,P.
  TITLE     Plasma proteasomal chymotrypsin-like activity correlates with
            prostate cancer progression
  JOURNAL   Tumour Biol 36 (6), 4115-4121 (2015)
   PUBMED   25578495
  REMARK    GeneRIF: We found CT-like activity to be an independent predictor
            of high-risk PCa, and as such, it may be a good candidate as a
            biomarker for high-risk PCa detection and stratification.
REFERENCE   3  (bases 1 to 1165)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Reseland,J.E., Larsen,F., Solheim,J., Eriksen,J.A., Hanssen,L.E.
            and Prydz,H.
  TITLE     A novel human chymotrypsin-like digestive enzyme
  JOURNAL   J Biol Chem 272 (12), 8099-8104 (1997)
   PUBMED   9065485
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Larsen,F., Solheim,J., Kristensen,T., Kolsto,A.B. and Prydz,H.
  TITLE     A tight cluster of five unrelated human genes on chromosome 16q22.1
  JOURNAL   Hum Mol Genet 2 (10), 1589-1595 (1993)
   PUBMED   8268911
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X71877.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001907.2.
            
            Summary: This gene encodes a serine-type endopeptidase with
            chymotrypsin- and elastase-2-like activities. The gene encoding
            this zymogen is expressed specifically in the pancreas and likely
            functions as a digestive enzyme. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: X71877.1, BC039716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151405, SAMEA2153347
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574481.6/ ENSP00000458537.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1165              X71877.1           1-1165
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1165
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /note="chymotrypsin like"
                     /db_xref="GeneID:1506"
                     /db_xref="HGNC:HGNC:2524"
                     /db_xref="MIM:118888"
     exon            1..62
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..805
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /EC_number="3.4.21.-"
                     /note="chymotrypsin-like protease CTRL-1"
                     /codon_start=1
                     /product="chymotrypsin-like protease CTRL-1 precursor"
                     /protein_id="NP_001898.1"
                     /db_xref="CCDS:CCDS10852.1"
                     /db_xref="GeneID:1506"
                     /db_xref="HGNC:HGNC:2524"
                     /db_xref="MIM:118888"
                     /translation="MLLLSLTLSLVLLGSSWGCGIPAIKPALSFSQRIVNGENAVLGS
                     WPWQVSLQDSSGFHFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDRSSNAEPLQVL
                     SVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCLASSNEALTEGLTCVTTGW
                     GRLSGVGNVTPAHLQQVALPLVTVNQCRQYWGSSITDSMICAGGAGASSCQGDSGGPL
                     VCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTWINQVIAYN"
     exon            63..166
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            167..246
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            247..328
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..509
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..643
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..1165
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1108..1113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /note="hexamer: AATACA"
     polyA_site      1135
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /note="major polyA site"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="CTRL"
                     /gene_synonym="CTRL1"
                     /note="major polyA site"
ORIGIN      
        1 atctgccacg atgttgctgc tcagcctgac cctaagcctg gttctcctcg gctcctcctg
       61 gggctgcggc attcctgcca tcaaaccggc actgagcttc agccagagga ttgtcaacgg
      121 ggagaatgca gtgttgggct cctggccctg gcaggtgtcc ctgcaggaca gcagcggctt
      181 ccacttctgc ggtggttctc tcatcagcca gtcctgggtg gtcactgctg cccactgcaa
      241 tgtcagccct ggccgccatt ttgttgtcct gggcgagtat gaccgatcat caaacgcaga
      301 gcccttgcag gttctgtccg tctctcgggc cattacacac cctagctgga actctaccac
      361 catgaacaat gacgtgacgc tgctgaagct cgcctcgcca gcccagtaca caacacgcat
      421 ctcgccagtt tgcctggcat cctcaaacga ggctctgact gaaggcctca cgtgtgtcac
      481 caccggctgg ggtcgcctca gtggcgtggg caatgtgaca ccagcacatc tgcagcaggt
      541 ggctttgccc ctggtcactg tgaatcagtg ccggcagtac tggggctcaa gtatcactga
      601 ctccatgatc tgtgcaggtg gcgcaggtgc ctcctcgtgc cagggtgact ccggaggccc
      661 tcttgtctgc cagaagggaa acacatgggt gcttattggt attgtctcct ggggcaccaa
      721 aaactgcaat gtgcgcgcac ctgctgtgta tactcgagtt agcaagttca gcacctggat
      781 caaccaggtc atagcctaca actgagctca ccacaggccc tccccagctc aacccattaa
      841 agacccaggc cctgtcccat catgcattca tgtctgtctt cctggctcag gagaaagaag
      901 aggctgttga gggtccgact ccctacttgg acttctggca cagaaggggc tgagtgactc
      961 cttgagtagc agtggctctt cctagagtag ccatgccgag gccggggccc ccacccctcc
     1021 tccagggcaa ccccttggtc ctacagcaag aagccagaac tgttggaatg aatggcagcc
     1081 ctccctggag aggcagcctg tttactgaat acagaggata cgtttacaaa ctgaatacgc
     1141 ataataaata actgcacatt ctcca
//
