LOCUS       NM_001906                870 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chymotrypsinogen B1 (CTRB1), transcript variant 1,
            mRNA.
ACCESSION   NM_001906 XM_001717935
VERSION     NM_001906.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Seltsam,K., Pentner,C., Weigl,F., Sutedjo,S., Zimmer,C., Beer,S.,
            Bugert,P., Ewers,M., Ruffert,C., Michl,P., Laumen,H., Witt,H. and
            Rosendahl,J.
  TITLE     Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis
  JOURNAL   Pancreatology 20 (8), 1598-1603 (2020)
   PUBMED   33036922
  REMARK    GeneRIF: Sequencing of the complex CTRB1-CTRB2 locus in chronic
            pancreatitis.
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Rosendahl,J., Kirsten,H., Hegyi,E., Kovacs,P., Weiss,F.U.,
            Laumen,H., Lichtner,P., Ruffert,C., Chen,J.M., Masson,E., Beer,S.,
            Zimmer,C., Seltsam,K., Algul,H., Buhler,F., Bruno,M.J., Bugert,P.,
            Burkhardt,R., Cavestro,G.M., Cichoz-Lach,H., Farre,A., Frank,J.,
            Gambaro,G., Gimpfl,S., Grallert,H., Griesmann,H., Grutzmann,R.,
            Hellerbrand,C., Hegyi,P., Hollenbach,M., Iordache,S., Jurkowska,G.,
            Keim,V., Kiefer,F., Krug,S., Landt,O., Leo,M.D., Lerch,M.M.,
            Levy,P., Loffler,M., Lohr,M., Ludwig,M., Macek,M., Malats,N.,
            Malecka-Panas,E., Malerba,G., Mann,K., Mayerle,J., Mohr,S., Te
            Morsche,R.H.M., Motyka,M., Mueller,S., Muller,T., Nothen,M.M.,
            Pedrazzoli,S., Pereira,S.P., Peters,A., Pfutzer,R., Real,F.X.,
            Rebours,V., Ridinger,M., Rietschel,M., Rosmann,E., Saftoiu,A.,
            Schneider,A., Schulz,H.U., Soranzo,N., Soyka,M., Simon,P.,
            Skipworth,J., Stickel,F., Strauch,K., Stumvoll,M., Testoni,P.A.,
            Tonjes,A., Werner,L., Werner,J., Wodarz,N., Ziegler,M.,
            Masamune,A., Mossner,J., Ferec,C., Michl,P., P H Drenth,J.,
            Witt,H., Scholz,M. and Sahin-Toth,M.
  CONSRTM   all members of the PanEuropean Working group on ACP
  TITLE     Genome-wide association study identifies inversion in the
            CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic
            chronic pancreatitis
  JOURNAL   Gut 67 (10), 1855-1863 (2018)
   PUBMED   28754779
  REMARK    GeneRIF: An inversion in the CTRB1-CTRB2 locus modifies risk for
            Alcoholic and Non-alcoholic Chronic Pancreatitis indicating that
            common pathomechanisms are involved in these inflammatory
            disorders.
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Tang,X.Y., Zou,W.B., Masson,E., Hu,L.H., Ferec,C., Chen,J.M.,
            Li,Z.S. and Liao,Z.
  TITLE     The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in
            European populations does not contribute to disease risk variation
            in the Chinese population due to near allele fixation
  JOURNAL   Gut 67 (7), 1368-1369 (2018)
   PUBMED   28951524
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Chen,L.Z., Harris,P.C., Apostolou,S., Baker,E., Holman,K.,
            Lane,S.A., Nancarrow,J.K., Whitmore,S.A., Stallings,R.L.,
            Hildebrand,C.E. et al.
  TITLE     A refined physical map of the long arm of human chromosome 16
  JOURNAL   Genomics 10 (2), 308-312 (1991)
   PUBMED   2071140
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Natt,E., Magenis,R.E., Zimmer,J., Mansouri,A. and Scherer,G.
  TITLE     Regional assignment of the human loci for uvomorulin (UVO) and
            chymotrypsinogen B (CTRB) with the help of two overlapping
            deletions on the long arm of chromosome 16
  JOURNAL   Cytogenet Cell Genet 50 (2-3), 145-148 (1989)
   PUBMED   2789125
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Potempa,J., Shieh,B.H. and Travis,J.
  TITLE     Alpha-2-antiplasmin: a serpin with two separate but overlapping
            reactive sites
  JOURNAL   Science 241 (4866), 699-700 (1988)
   PUBMED   2456616
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Vercaigne-Marko,D., Carrere,J., Ducourouble,M.P., Davril,M.,
            Laine,A., Amouric,M., Figarella,C. and Hayem,A.
  TITLE     'In vivo' and 'in vitro' inhibition of human pancreatic
            chymotrypsin A by serum inhibitors
  JOURNAL   Biol Chem Hoppe Seyler 368 (1), 37-45 (1987)
   PUBMED   2435303
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Geuze,J.J., Slot,J.W. and Tokuyasu,K.T.
  TITLE     Immunocytochemical localization of amylase and chymotrypsinogen in
            the exocrine pancreatic cell with special attention to the Golgi
            complex
  JOURNAL   J Cell Biol 82 (3), 697-707 (1979)
   PUBMED   511932
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX497259.1, M24400.1 and
            AW338596.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001906.5.
            
            Summary: This gene encodes a member of the serine protease family
            of enzymes and forms a principal precursor of the pancreatic
            proteolytic enzymes. The encoded preproprotein is synthesized in
            the acinar cells of the pancreas and secreted into the small
            intestine where it undergoes proteolytic activation to generate a
            functional enzyme. This CTRB1 gene is located head-to-head with the
            related CTRB2 gene. Some human populations have an alternate
            haplotype which inverts a 16.6 Kb region containing portions of
            intron 1, exon 1, and the upstream sequence of the CTRB1 and CTRB2
            genes. In this inversion haplotype exon 1 and flanking sequence is
            swapped in CTRB1 and CTRB2. This inversion is associated with
            differential gene expression and increased risk for chronic
            pancreatitis. The GRCh38 assembly represents the minor allele for
            SNP rs8048956 of the CTRB1 gene. SNP rs8048956 in intron 1 of the
            CTRB2 gene is diagnostic for this inversion. This CTRB1 gene
            encodes distinct isoforms, some or all of which may undergo similar
            processing to generate the mature protein. [provided by RefSeq, Jan
            2021].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138526.334431.1,
                                           DRR138526.11435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361017.9/ ENSP00000354294.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                BX497259.1         3-74
            73-650              M24400.1           69-646
            651-870             AW338596.1         2-221               c
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.1"
     gene            1..870
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /note="chymotrypsinogen B1"
                     /db_xref="GeneID:1504"
                     /db_xref="HGNC:HGNC:2521"
                     /db_xref="MIM:118890"
     exon            1..72
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..812
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /EC_number="3.4.21.1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; chymotrypsinogen B"
                     /codon_start=1
                     /product="chymotrypsinogen B isoform 1 precursor"
                     /protein_id="NP_001897.4"
                     /db_xref="CCDS:CCDS32490.1"
                     /db_xref="GeneID:1504"
                     /db_xref="HGNC:HGNC:2521"
                     /db_xref="MIM:118890"
                     /translation="MASLWLLSCFSLVGAAFGCGVPAIHPVLSGLSRIVNGEDAVPGS
                     WPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQGSDEENIQVLK
                     IAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSADDDFPAGTLCATTGWG
                     KTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGASGVSSCMGDSGGPLV
                     CQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKILAAN"
     exon            73..176
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     exon            177..256
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     exon            257..335
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     exon            336..516
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     exon            517..650
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     exon            651..870
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      852..857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /note="hexamer: AGTAAA"
     polyA_site      870
                     /gene="CTRB1"
                     /gene_synonym="CTRB"
                     /note="major polyA site"
ORIGIN      
        1 acaccttctg aggcagcggc atggcttccc tctggctcct ctcctgcttc tcccttgtgg
       61 gggccgcctt tggctgcggg gtccccgcca tccaccctgt gctcagcggc ctgtccagga
      121 tcgtgaatgg ggaggacgcc gtccccggct cctggccctg gcaggtgtcc ctgcaggaca
      181 aaaccggctt ccacttctgc gggggctccc tcatcagcga ggactgggtg gtcaccgctg
      241 cccactgcgg ggtcaggacc tccgacgtgg tcgtggctgg ggagtttgac cagggctctg
      301 acgaggagaa catccaggtc ctgaagatcg ccaaggtctt caagaacccc aagttcagca
      361 ttctgaccgt gaacaatgac atcaccctgc tgaagctggc cacacctgcc cgcttctccc
      421 agacagtgtc cgccgtgtgc ctgcccagcg ccgacgacga cttccccgcg gggacactgt
      481 gtgccaccac aggctggggc aagaccaagt acaacgccaa caagacccct gacaagctgc
      541 agcaggcagc cctgcccctc ctgtccaatg ccgaatgcaa gaagtcctgg ggcaggagga
      601 tcaccgacgt gatgatctgt gccggggcca gtggcgtctc ctcctgcatg ggcgactctg
      661 gcggccccct ggtctgccaa aaggatggag cctggaccct ggtgggcatt gtgtcctggg
      721 gcagcgacac ctgctccacc tccagccctg gcgtgtacgc ccgtgtcacc aagctcatac
      781 cttgggtgca gaagatcctg gctgccaact gagcccgcgg ctccctccga ccctgctccc
      841 cacagagcct cagtaaaccc atggaacaca
//
