LOCUS       NM_014633               4330 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens CTR9 homolog, Paf1/RNA polymerase II complex component
            (CTR9), transcript variant 1, mRNA.
ACCESSION   NM_014633
VERSION     NM_014633.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4330)
  AUTHORS   Zhao,J., Cato,L.D., Arora,U.P., Bao,E.L., Bryant,S.C., Williams,N.,
            Jia,Y., Goldman,S.R., Nangalia,J., Erb,M.A., Vos,S.M.,
            Armstrong,S.A. and Sankaran,V.G.
  TITLE     Inherited blood cancer predisposition through altered transcription
            elongation
  JOURNAL   Cell 187 (3), 642-658 (2024)
   PUBMED   38218188
  REMARK    GeneRIF: Inherited blood cancer predisposition through altered
            transcription elongation.
REFERENCE   2  (bases 1 to 4330)
  AUTHORS   Chan,N.T., Lee,M.S., Wang,Y., Galipeau,J., Li,W.J. and Xu,W.
  TITLE     CTR9 drives osteochondral lineage differentiation of human
            mesenchymal stem cells via epigenetic regulation of BMP-2 signaling
  JOURNAL   Sci Adv 8 (46), eadc9222 (2022)
   PUBMED   36383652
  REMARK    GeneRIF: CTR9 drives osteochondral lineage differentiation of human
            mesenchymal stem cells via epigenetic regulation of BMP-2
            signaling.
REFERENCE   3  (bases 1 to 4330)
  AUTHORS   Meuwissen,M., Verstraeten,A., Ranza,E., Iwaszkiewicz,J.,
            Bastiaansen,M., Mateiu,L., Nemegeer,M., Meester,J.A.N., Afenjar,A.,
            Amaral,M., Ballhausen,D., Barnett,S., Barth,M., Asselbergh,B.,
            Spaas,K., Heeman,B., Bassetti,J., Blackburn,P., Schaer,M.,
            Blanc,X., Zoete,V., Casas,K., Courtin,T., Doummar,D., Guerry,F.,
            Keren,B., Pappas,J., Rabin,R., Begtrup,A., Shinawi,M., Vulto-van
            Silfhout,A.T., Kleefstra,T., Wagner,M., Ziegler,A., Schaefer,E.,
            Gerard,B., De Bie,C.I., Holwerda,S.J.B., Abbot,M.A.,
            Antonarakis,S.E. and Loeys,B.
  TITLE     Heterozygous variants in CTR9, which encodes a major component of
            the PAF1 complex, are associated with a neurodevelopmental disorder
  JOURNAL   Genet Med 24 (7), 1583-1591 (2022)
   PUBMED   35499524
  REMARK    GeneRIF: Heterozygous variants in CTR9, which encodes a major
            component of the PAF1 complex, are associated with a
            neurodevelopmental disorder.
REFERENCE   4  (bases 1 to 4330)
  AUTHORS   Chan,N.T., Huang,J., Ma,G., Zeng,H., Donahue,K., Wang,Y., Li,L. and
            Xu,W.
  TITLE     The transcriptional elongation factor CTR9 demarcates PRC2-mediated
            H3K27me3 domains by altering PRC2 subtype equilibrium
  JOURNAL   Nucleic Acids Res 50 (4), 1969-1992 (2022)
   PUBMED   35137163
  REMARK    GeneRIF: The transcriptional elongation factor CTR9 demarcates
            PRC2-mediated H3K27me3 domains by altering PRC2 subtype
            equilibrium.
REFERENCE   5  (bases 1 to 4330)
  AUTHORS   Li,Q., Zhang,J., Liu,S., Zhang,F., Zhuang,J. and Chen,Y.
  TITLE     MicroRNA-17-3p is upregulated in psoriasis and regulates
            keratinocyte hyperproliferation and pro-inflammatory cytokine
            secretion by targeting <em>CTR9</em>
  JOURNAL   Eur J Histochem 66 (1), 3275 (2022)
   PUBMED   35016493
  REMARK    GeneRIF: MicroRNA-17-3p is upregulated in psoriasis and regulates
            keratinocyte hyperproliferation and pro-inflammatory cytokine
            secretion by targeting <em>CTR9</em>.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4330)
  AUTHORS   Zhu,B., Zheng,Y., Pham,A.D., Mandal,S.S., Erdjument-Bromage,H.,
            Tempst,P. and Reinberg,D.
  TITLE     Monoubiquitination of human histone H2B: the factors involved and
            their roles in HOX gene regulation
  JOURNAL   Mol Cell 20 (4), 601-611 (2005)
   PUBMED   16307923
REFERENCE   7  (bases 1 to 4330)
  AUTHORS   Zhu,B., Mandal,S.S., Pham,A.D., Zheng,Y., Erdjument-Bromage,H.,
            Batra,S.K., Tempst,P. and Reinberg,D.
  TITLE     The human PAF complex coordinates transcription with events
            downstream of RNA synthesis
  JOURNAL   Genes Dev 19 (14), 1668-1673 (2005)
   PUBMED   16024656
REFERENCE   8  (bases 1 to 4330)
  AUTHORS   Yart,A., Gstaiger,M., Wirbelauer,C., Pecnik,M., Anastasiou,D.,
            Hess,D. and Krek,W.
  TITLE     The HRPT2 tumor suppressor gene product parafibromin associates
            with human PAF1 and RNA polymerase II
  JOURNAL   Mol Cell Biol 25 (12), 5052-5060 (2005)
   PUBMED   15923622
REFERENCE   9  (bases 1 to 4330)
  AUTHORS   Rozenblatt-Rosen,O., Hughes,C.M., Nannepaga,S.J., Shanmugam,K.S.,
            Copeland,T.D., Guszczynski,T., Resau,J.H. and Meyerson,M.
  TITLE     The parafibromin tumor suppressor protein is part of a human Paf1
            complex
  JOURNAL   Mol Cell Biol 25 (2), 612-620 (2005)
   PUBMED   15632063
REFERENCE   10 (bases 1 to 4330)
  AUTHORS   Malek,S.N., Yang,C.H., Earnshaw,W.C., Kozak,C.A. and Desiderio,S.
  TITLE     p150TSP, a conserved nuclear phosphoprotein that contains multiple
            tetratricopeptide repeats and binds specifically to SH2 domains
  JOURNAL   J Biol Chem 271 (12), 6952-6962 (1996)
   PUBMED   8636124
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP250198.1, D63875.1 and
            BP223102.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014633.4.
            
            Summary: The protein encoded by this gene is a component of the
            PAF1 complex, which associates with RNA polymerase II and functions
            in transcriptional regulation and elongation. This complex also
            plays a role in the modification of histones. [provided by RefSeq,
            Oct 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.39256.1,
                                           SRR1660803.62361.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361367.7/ ENSP00000355013.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BP250198.1         260-340
            82-4324             D63875.1           1-4243
            4325-4330           BP223102.2         582-587
FEATURES             Location/Qualifiers
     source          1..4330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4330
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /note="CTR9 homolog, Paf1/RNA polymerase II complex
                     component"
                     /db_xref="GeneID:9646"
                     /db_xref="HGNC:HGNC:16850"
                     /db_xref="MIM:609366"
     exon            1..212
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..3689
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /note="isoform 1 is encoded by transcript variant 1; SH2
                     domain binding protein 1 (tetratricopeptide repeat
                     containing); TPR-containing, SH2-binding phosphoprotein;
                     RNA polymerase-associated protein CTR9 homolog; Ctr9,
                     Paf1/RNA polymerase II complex component, homolog"
                     /codon_start=1
                     /product="RNA polymerase-associated protein CTR9 homolog
                     isoform 1"
                     /protein_id="NP_055448.1"
                     /db_xref="CCDS:CCDS7805.1"
                     /db_xref="GeneID:9646"
                     /db_xref="HGNC:HGNC:16850"
                     /db_xref="MIM:609366"
                     /translation="MSRGSIEIPLRDTDEVIELDFDQLPEGDEVISILKQEHTQLHIW
                     IALALEYYKQGKTEEFVKLLEAARIDGNLDYRDHEKDQMTCLDTLAAYYVQQARKEKN
                     KDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSP
                     NNIPALLGKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKAR
                     LAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLA
                     NHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQ
                     FASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQE
                     KRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTATRILQEKVQADVP
                     PEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYE
                     AMCEFHEAEKLYKNILREHPNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPD
                     AWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQPTRDREK
                     EKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISD
                     VWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECKQTL
                     LKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLSK
                     VGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKL
                     LKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRGGGGGRRSKKG
                     GEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDD
                     DETENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIAD
                     EGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSD
                     QPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQG
                     SGNESEPEGSNNEASDRGSEHGSDDSD"
     exon            213..311
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            312..551
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            552..669
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            670..759
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            760..908
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1016
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1124
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1361
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1451
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1580
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1764
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1853
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..2039
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2127
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2276
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..2393
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2539
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2540..2611
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2747
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..2894
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2895..3052
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3149
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3150..3262
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..4330
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4308..4313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /note="hexamer: AATAAA"
     polyA_site      4330
                     /gene="CTR9"
                     /gene_synonym="p150; p150TSP; SH2BP1; TSBP"
                     /note="major polyA site"
ORIGIN      
        1 gttgtttaag cggctgacgg gaaggagaag ccagagctcc agcggcgccg cggggcggca
       61 gtcaagacca gagccggagc cgtcactcac ctctggatta gcctgaagcg gagactaccg
      121 gctgcggagc ggcggggcga gacacttgct cgccttttga ccccatcatg tcgcggggct
      181 ccatcgagat tcccctccgg gacactgacg aggtcattga acttgacttc gatcagttac
      241 cggagggaga tgaagttatc agtattctga aacaggaaca cacacaactg cacatatgga
      301 ttgctttggc gctggaatac tacaagcaag gaaaaacaga agagtttgta aaattgttgg
      361 aagcagcacg tatagatggc aatttggact atagagacca tgaaaaagac cagatgactt
      421 gcttggatac attggcagcg tattatgtac aacaggctcg gaaagaaaag aataaggaca
      481 ataaaaagga tcttattaca caggccacct tgttgtatac aatggccgat aaaattatta
      541 tgtatgatca gaaccatttg ttgggaagag cctgcttctg cctacttgag ggtgacaaaa
      601 tggatcaagc tgatgcacag tttcattttg tactcaatca gtctccaaat aatattccag
      661 cccttcttgg taaagcttgc atttccttca acaagaagga ttacagagga gctcttgctt
      721 actataagaa agcattgcgt actaacccag gatgtccagc ggaagttcgt ttaggaatgg
      781 gtcattgctt tgtgaaactt aacaaactgg aaaaagctcg tctggcattc agcagagccc
      841 tggaactcaa ttccaaatgc gtgggagcat tggttggact ggctgttcta gaactcaaca
      901 ataaagaggc tgattccatt aaaaatggtg tccagcttct ttccagagcc tatactattg
      961 atcctagcaa ccctatggta ttgaaccatt tggcaaatca ctttttcttc aaaaaggatt
     1021 atagtaaagt ccagcatctg gccctccatg cattccataa tacagaagtg gaagctatgc
     1081 aagcagagag ctgctatcag ctagctagat cattccatgt tcaggaagat tatgaccaag
     1141 cttttcagta ctattatcaa gccacacagt ttgcctcatc ctcttttgtg ctcccatttt
     1201 ttggtttggg acaaatgtat atttatcgag gtgacaaaga aaatgcatct cagtgctttg
     1261 agaaggtttt gaaagcttat cctaataatt acgaaactat gaaaattctc ggctctctct
     1321 atgctgcctc agaagatcaa gaaaaacgag atattgccaa gggccatttg aagaaggtca
     1381 cagaacagta tcccgatgat gttgaagctt ggattgaatt ggcacaaatc ttagaacaga
     1441 ctgatataca gggtgccctt tcagcctatg gaacagcaac acgaatcctt caggagaaag
     1501 tgcaggccga tgttcctcca gagattctca ataatgtggg tgccctccat tttagacttg
     1561 gaaacctagg ggaggctaag aaatattttt tggcgtcatt ggaccgtgca aaagcagaag
     1621 cggaacacga tgagcattac tataacgcca tttccgttac cacgtcatat aatctcgcca
     1681 ggctatatga ggcgatgtgt gaattccatg aagcagaaaa actgtataaa aacatcttac
     1741 gcgaacatcc taattatgtt gactgctatt tgcgcctagg agccatggct agagataagg
     1801 gaaactttta tgaggcttca gattggttta aggaagctct tcagattaat caggatcatc
     1861 cagatgcttg gtctttgatt ggcaatcttc atttggcaaa acaagaatgg ggtcctgggc
     1921 agaagaagtt tgagaggata ttaaaacagc catccacaca gagtgatacc tattctatgc
     1981 tagcccttgg caacgtgtgg ctccaaactt tacatcagcc cacccgagat cgagaaaagg
     2041 aaaagcgtca tcaagatcgt gctctggcca tctacaaaca agtactcaga aatgatgcaa
     2101 agaatctgta tgctgccaat ggcataggag ctgttttggc ccacaaagga tattttcgtg
     2161 aagctcgtga tgtatttgcc caagtaagag aagcaacagc agatattagt gatgtgtggc
     2221 tgaacttagc acacatctat gtggagcaaa agcagtacat cagcgccgtt cagatgtatg
     2281 aaaactgcct ccgaaagttc tataagcacc aaaacactga agttgtactc tatttggccc
     2341 gggccctctt caagtgtggc aagttacagg aatgcaaaca gactttgctg aaggctagac
     2401 atgtggcacc cagtgataca gttcttatgt ttaatgtggc cttggtcctg caaagattag
     2461 ctacctctgt cctgaaagat gaaaaaagta atctgaagga agtacttaat gctgtgaaag
     2521 aactggagct tgcacataga tacttcagtt atttgagtaa agtgggagat aaaatgagat
     2581 ttgatttggc ccttgctgct acagaagcca ggcagtgttc tgacttactg agccaggccc
     2641 agtaccatgt ggcccgggca cgcaaacaag atgaagaaga gcgggagctg cgggccaagc
     2701 aagagcaaga aaaggagctg ttaaggcaga aacttcttaa agaacaggaa gagaaacgtc
     2761 tcagagaaaa ggaagagcaa aagaaacttt tggaacagcg ggcccagtat gtggagaaga
     2821 ccaaaaatat tcttatgttt actggtgaga ctgaagcaac aaaagagaag aaaagaggtg
     2881 gtggtggtgg acggcgttct aagaagggag gagagtttga tgaatttgtc aatgatgaca
     2941 ctgatgatga cctacctata tccaaaaaga agaagagaag aaagggtagt ggcagtgaac
     3001 aagaaggtga agatgaggag ggtggtgaga gaaagaagaa aaagaggaga agacatccaa
     3061 agggagaaga aggatctgat gatgatgaaa cagaaaatgg ccccaaacca aaaaaacgac
     3121 gtccaccaaa agcagagaag aaaaaggctc ccaagccaga acgtctgcct ccatcaatga
     3181 agggaaaaat aaaatccaaa gccataattt catcaagtga tgactcttcg gatgaggata
     3241 aacttaaaat tgctgatgaa ggacatccca ggaacagcaa cagcaacagt gactcagacg
     3301 aggacgaaca acgaaagaaa tgtgcctcat cagagagtga ttccgatgag aaccagaaca
     3361 agtctggcag cgaggccggc agtccccgga ggccacgaag acagcggtca gatcaggact
     3421 cagacagtga ccagccatcc agaaagagaa ggccctccgg ttctgagcag tctgacaatg
     3481 aatctgtgca gtcagggaga agccactcag gagtttctga gaacgactct cgcccagctt
     3541 ctccaagtgc cgaatcagat cacgaatcgg agagaggatc tgataatgag ggttctggcc
     3601 aaggctctgg aaatgaatcg gaaccagagg gatccaacaa tgaggcctca gatagaggct
     3661 cagaacatgg gtcagatgat agtgactagg ttttatttca tcaataagct tcatctctgg
     3721 aggaaacttt tttaatatat gaaagctgtg ataaaaatgt ttcagatgtt tagtcaattg
     3781 tgaaattttt cttaaggcaa ttttcttttc tatcagtttg tatattacta agccccaaga
     3841 gacatttcct gtgctagagt ccaatatttg agtctctcgt gcaaatgaga ctattctttg
     3901 tggtacaatt ccacctatca tatgtgaaaa ctgcagtaaa aataaaccca gatgctaaat
     3961 cattcctaca aaggtttgac tgaaactgtg gcagatgtct catcttcttt atatgttaag
     4021 cagcatactc ttctgatttt tattgcaatc ttttaccaag tggtgcacaa acttggtatt
     4081 gatgtcttta ttccattttg agtttagatt gagaatattt ttattttctg aaggcagaga
     4141 tatctactgt ataattgcac caaagtacat ttgaaaggaa ggttttcaat agtgtaatac
     4201 tgcagcgatg tagataaaat cacaaatgta taatgtgtta ggttgaataa ggtgtggaaa
     4261 atgcttttct gttagtagaa tgcaaaaacc tacctaagcc acataataat aaaattcttt
     4321 taccaacttt
//
