LOCUS       NM_001332               5888 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens catenin delta 2 (CTNND2), transcript variant 1, mRNA.
ACCESSION   NM_001332
VERSION     NM_001332.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5888)
  AUTHORS   Assendorp,N., Fossati,M., Libe-Philippot,B., Christopoulou,E.,
            Depp,M., Rapone,R., Dingli,F., Loew,D., Vanderhaeghen,P. and
            Charrier,C.
  TITLE     CTNND2 moderates the pace of synaptic maturation and links human
            evolution to synaptic neoteny
  JOURNAL   Cell Rep 43 (10), 114797 (2024)
   PUBMED   39352808
  REMARK    GeneRIF: CTNND2 moderates the pace of synaptic maturation and links
            human evolution to synaptic neoteny.
REFERENCE   2  (bases 1 to 5888)
  AUTHORS   Pauly,M., Krumbiegel,M., Trumpp,S., Braig,S., Rupprecht,T.,
            Kraus,C., Uebe,S., Reis,A. and Vasileiou,G.
  TITLE     Severe manifestation of Rauch-Azzarello syndrome associated with
            biallelic deletion of CTNND2
  JOURNAL   Clin Genet 106 (2), 180-186 (2024)
   PUBMED   38604781
  REMARK    GeneRIF: Severe manifestation of Rauch-Azzarello syndrome
            associated with biallelic deletion of CTNND2.
REFERENCE   3  (bases 1 to 5888)
  AUTHORS   Li,M., Nopparat,J., Aguilar,B.J., Chen,Y.H., Zhang,J., Du,J.,
            Ai,X., Luo,Y., Jiang,Y., Boykin,C. and Lu,Q.
  TITLE     Intratumor delta-catenin heterogeneity driven by genomic
            rearrangement dictates growth factor dependent prostate cancer
            progression
  JOURNAL   Oncogene 39 (22), 4358-4374 (2020)
   PUBMED   32313227
  REMARK    GeneRIF: Intratumor delta-catenin heterogeneity driven by genomic
            rearrangement dictates growth factor dependent prostate cancer
            progression.
REFERENCE   4  (bases 1 to 5888)
  AUTHORS   Miller,D.E., Squire,A. and Bennett,J.T.
  TITLE     A child with autism, behavioral issues, and dysmorphic features
            found to have a tandem duplication within CTNND2 by mate-pair
            sequencing
  JOURNAL   Am J Med Genet A 182 (3), 543-547 (2020)
   PUBMED   31814264
  REMARK    GeneRIF: A child with autism, behavioral issues, and dysmorphic
            features found to have a tandem duplication within CTNND2 by
            mate-pair sequencing.
REFERENCE   5  (bases 1 to 5888)
  AUTHORS   Liang,Y., Feng,Y., Wu,W., Chang,C., Chen,D., Chen,S. and Zhen,G.
  TITLE     microRNA-218-5p plays a protective role in eosinophilic airway
            inflammation via targeting delta-catenin, a novel catenin in asthma
  JOURNAL   Clin Exp Allergy 50 (1), 29-40 (2020)
   PUBMED   31520422
  REMARK    GeneRIF: microRNA-218-5p plays a protective role in eosinophilic
            airway inflammation via targeting delta-catenin, a novel catenin in
            asthma.
REFERENCE   6  (bases 1 to 5888)
  AUTHORS   Lu,Q., Paredes,M., Medina,M., Zhou,J., Cavallo,R., Peifer,M.,
            Orecchio,L. and Kosik,K.S.
  TITLE     delta-catenin, an adhesive junction-associated protein which
            promotes cell scattering
  JOURNAL   J Cell Biol 144 (3), 519-532 (1999)
   PUBMED   9971746
REFERENCE   7  (bases 1 to 5888)
  AUTHORS   Bonne,S., van Hengel,J. and van Roy,F.
  TITLE     Chromosomal mapping of human armadillo genes belonging to the
            p120(ctn)/plakophilin subfamily
  JOURNAL   Genomics 51 (3), 452-454 (1998)
   PUBMED   9721216
REFERENCE   8  (bases 1 to 5888)
  AUTHORS   Paffenholz,R. and Franke,W.W.
  TITLE     Identification and localization of a neurally expressed member of
            the plakoglobin/armadillo multigene family
  JOURNAL   Differentiation 61 (5), 293-304 (1997)
   PUBMED   9342840
REFERENCE   9  (bases 1 to 5888)
  AUTHORS   Zhou,J., Liyanage,U., Medina,M., Ho,C., Simmons,A.D., Lovett,M. and
            Kosik,K.S.
  TITLE     Presenilin 1 interaction in the brain with a novel member of the
            Armadillo family
  JOURNAL   Neuroreport 8 (8), 2085-2090 (1997)
   PUBMED   9223106
REFERENCE   10 (bases 1 to 5888)
  AUTHORS   Simmons,A.D., Overhauser,J. and Lovett,M.
  TITLE     Isolation of cDNAs from the Cri-du-chat critical region by direct
            screening of a chromosome 5-specific cDNA library
  JOURNAL   Genome Res 7 (2), 118-127 (1997)
   PUBMED   9049630
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC127460.2, DC341093.1,
            AB013805.1, U52351.1, U96136.1 and AC010626.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001332.3.
            
            Summary: This gene encodes an adhesive junction associated protein
            of the armadillo/beta-catenin superfamily and is implicated in
            brain and eye development and cancer formation. The protein encoded
            by this gene promotes the disruption of E-cadherin based adherens
            junction to favor cell spreading upon stimulation by hepatocyte
            growth factor. This gene is overexpressed in prostate
            adenocarcinomas and is associated with decreased expression of
            tumor suppressor E-cadherin in this tissue. This gene resides in a
            region of the short arm of chromosome 5 that is deleted in Cri du
            Chat syndrome. Alternative splicing results in multiple transcript
            variants encoding different isoforms. [provided by RefSeq, Dec
            2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U96136.1, AB013805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304623.13/ ENSP00000307134.8
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-403               AC127460.2         36825-37227
            404-551             DC341093.1         1-148
            552-4525            AB013805.1         105-4078
            4526-4941           U52351.1           2888-3303
            4942-5460           U96136.1           4350-4868
            5461-5615           U52351.1           3824-3978
            5616-5884           U96136.1           5030-5298
            5885-5888           AC010626.6         154035-154038       c
FEATURES             Location/Qualifiers
     source          1..5888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p15.2"
     gene            1..5888
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="catenin delta 2"
                     /db_xref="GeneID:1501"
                     /db_xref="HGNC:HGNC:2516"
                     /db_xref="MIM:604275"
     exon            1..630
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             594..4271
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     catenin (cadherin-associated protein), delta 2 (neural
                     plakophilin-related arm-repeat protein); T-cell
                     delta-catenin; neurojungin"
                     /codon_start=1
                     /product="catenin delta-2 isoform 1"
                     /protein_id="NP_001323.1"
                     /db_xref="CCDS:CCDS3881.1"
                     /db_xref="GeneID:1501"
                     /db_xref="HGNC:HGNC:2516"
                     /db_xref="MIM:604275"
                     /translation="MFARKPPGAAPLGAMPVPDQPSSASEKTSSLSPGLNTSNGDGSE
                     TETTSAILASVKEQELQFERLTRELEAERQIVASQLERCKLGSETGSMSSMSSAEEQF
                     QWQSQDGQKDIEDELTTGLELVDSCIRSLQESGILDPQDYSTGERPSLLSQSALQLNS
                     KPEGSFQYPASYHSNQTLALGETTPSQLPARGTQARATGQSFSQGTTSRAGHLAGPEP
                     APPPPPPPREPFAPSLGSAFHLPDAPPAAAAAALYYSSSTLPAPPRGGSPLAAPQGGS
                     PTKLQRGGSAPEGATYAAPRGSSPKQSPSRLAKSYSTSSPINIVVSSAGLSPIRVTSP
                     PTVQSTISSSPIHQLSSTIGTYATLSPTKRLVHASEQYSKHSQELYATATLQRPGSLA
                     AGSRASYSSQHGHLGPELRALQSPEHHIDPIYEDRVYQKPPMRSLSQSQGDPLPPAHT
                     GTYRTSTAPSSPGVDSVPLQRTGSQHGPQNAAAATFQRASYAAGPASNYADPYRQLQY
                     CPSVESPYSKSGPALPPEGTLARSPSIDSIQKDPREFGWRDPELPEVIQMLQHQFPSV
                     QSNAAAYLQHLCFGDNKIKAEIRRQGGIQLLVDLLDHRMTEVHRSACGALRNLVYGKA
                     NDDNKIALKNCGGIPALVRLLRKTTDLEIRELVTGVLWNLSSCDALKMPIIQDALAVL
                     TNAVIIPHSGWENSPLQDDRKIQLHSSQVLRNATGCLRNVSSAGEEARRRMRECDGLT
                     DALLYVIQSALGSSEIDSKTVENCVCILRNLSYRLAAETSQGQHMGTDELDGLLCGEA
                     NGKDAESSGCWGKKKKKKKSQDQWDGVGPLPDCAEPPKGIQMLWHPSIVKPYLTLLSE
                     CSNPDTLEGAAGALQNLAAGSWKWSVYIRAAVRKEKGLPILVELLRIDNDRVVCAVAT
                     ALRNMALDVRNKELIGKYAMRDLVHRLPGGNNSNNTASKAMSDDTVTAVCCTLHEVIT
                     KNMENAKALRDAGGIEKLVGISKSKGDKHSPKVVKAASQVLNSMWQYRDLRSLYKKDG
                     WSQYHFVASSSTIERDRQRPYSSSRTPSISPVRVSPNNRSASAPASPREMISLKERKT
                     DYECTGSNATYHGAKGEHTSRKDAMTAQNTGISTLYRNSYGAPAEDIKHNQVSAQPVP
                     QEPSRKDYETYQPFQNSTRNYDESFFEDQVHHRPPASEYTMHLGLKSTGNYVDFYSAA
                     RPYSELNYETSHYPASPDSWV"
     exon            631..767
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            768..880
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            881..915
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1032
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1205
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1770
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1965
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2221
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2354
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2568
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2752
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2753..2870
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2871..3056
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3057..3230
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3381
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3382..3592
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3593..3677
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3804
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3936
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3937..4010
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..5888
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4794
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="major polyA site"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="hexamer: AATAAA"
     polyA_site      5193
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="major polyA site"
     regulatory      5863..5868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="hexamer: AATAAA"
     polyA_site      5888
                     /gene="CTNND2"
                     /gene_synonym="GT24; NPRAP"
                     /note="major polyA site"
ORIGIN      
        1 gcacccgggg ccggtttcgg cggcggggcg gacgctccct cactagccgg gcgcccgggc
       61 cggccgccga ggtttaggtg gaggctgagg ctgccgcgcg ccgcgggagg agcctcgccc
      121 tcggcggctg aggcggcggc ggcacaggtg gcgcgggccg cgcgcggggc gcagctcggg
      181 agcgctcggc gccgggcgcc gcggcggccc caggctcgcg cccgcggcga cagccggctg
      241 agcggagctg cgggcgcggc ggctgctctc tcagcccggc cggctggcgg cggcgcccgg
      301 agccccgagg agcccgcagg agcccgtgga gcccgcggag ccgggcaggg ggcgctgcgc
      361 tcgccgagct cggaggggcc gccgggccgg gcgctgcgca ctcgcgtcgg gagccgcctc
      421 tcgcccgcgg cgctcgcccc tgccgcccgc cagcatccct tgtcccgcgg ccgcgctcag
      481 acaacaaaag cggaagatgc tgcagttggg caaggtcagg accttgccct gaagccgggc
      541 ggcgccgcgc acgcctcttc ccggactgag gagctgtcgc cggcggaggg tgcatgtttg
      601 cgaggaagcc gccgggcgcc gcgcctttgg gagctatgcc tgttccagac cagccttcat
      661 cagcctcaga gaagacgagt tccctgagcc ccggcttaaa cacctccaac ggggatggct
      721 ctgaaacaga aaccacctct gccatcctcg cctcagtcaa agaacaggaa ttacagtttg
      781 aaaggctgac ccgagagctg gaggctgaac ggcagatcgt agccagccag ctggagcgat
      841 gcaagctcgg atccgagact ggcagcatga gcagcatgag ttcagcagaa gagcagtttc
      901 agtggcagtc acaagatggt caaaaagata tcgaagatga gcttacaaca ggtctcgagc
      961 tggtggactc ctgtattagg tcactacagg aatcaggaat acttgaccca caggattatt
     1021 ctacaggtga aaggcccagc ctgctctccc agagtgcact tcagctcaat tccaaacctg
     1081 aagggtcttt ccagtatccg gccagctacc atagcaacca gaccctggcc ctgggggaaa
     1141 ccaccccttc acagctcccg gcccgaggca cacaagcccg agctacgggc cagagcttca
     1201 gccagggcac gaccagccgc gccggccacc tggcggggcc cgagcccgcg ccgccgccgc
     1261 cgccgccgcc gcgggagccg ttcgcgccca gcctgggcag cgccttccac ctgcccgacg
     1321 cgccgcccgc cgccgccgcc gccgcgctct actactccag ctccacgctg cccgcgccgc
     1381 cgcgcggggg ctccccgctg gccgcgcccc agggcggttc gcccaccaag ctgcagcgcg
     1441 gcggctcggc ccccgagggc gccacctacg ccgcgccgcg cggctcctcg cccaagcagt
     1501 cgcccagccg cctggccaag tcctacagca ccagctcgcc catcaacatc gtcgtgtcct
     1561 cggccggcct gtccccgatc cgcgtgacct cgccccccac cgtgcagtcc accatctcct
     1621 cctcgcccat ccaccagctg agctccacca tcggcacgta cgccaccctg tcgcccacca
     1681 agcgcctggt ccacgcgtcc gagcagtaca gcaagcactc gcaggagctg tatgccacgg
     1741 ccaccctcca gaggccgggc agcctggcag ctggttcccg agcctcatac agcagccagc
     1801 atgggcacct gggcccagag ttgcgggccc tgcagtcccc agaacaccac atagatccca
     1861 tctatgaaga ccgcgtctat cagaagcccc ctatgaggag tctcagccag agccaggggg
     1921 accctctgcc gccagcacac accggcacct accgcacgag cacagcccca tcttcccctg
     1981 gtgtcgactc cgtccccttg cagcgcacag gcagccagca cggcccacag aatgccgccg
     2041 cggccacctt ccagagggcc agctatgccg ccggcccagc ctccaattac gcggacccct
     2101 accgacagct gcagtattgt ccctctgttg agtctccata cagcaaatcc ggccctgctc
     2161 tcccgcctga aggcaccttg gccaggtccc cgtccattga tagcattcag aaagatccca
     2221 gagaatttgg atggagagac ccggaactgc cggaagtgat tcagatgttg cagcaccagt
     2281 ttccctcggt ccagtctaac gcggcagcct acttgcaaca cctctgtttt ggagacaaca
     2341 aaattaaagc cgagataagg agacaaggag gcatccagct cctggtggac ctgttggatc
     2401 atcggatgac cgaagtccac cgtagtgcct gtggagctct gagaaacctg gtgtatggga
     2461 aggccaacga tgataacaaa attgccctga aaaactgtgg tggcatccca gcactggtga
     2521 ggttactccg caagacgact gacctggaga tccgggagct ggtcacagga gtcctttgga
     2581 acctctcctc atgcgatgca ctcaaaatgc caatcatcca ggatgcccta gcagtactga
     2641 ccaacgcggt gattatcccc cactcaggct gggaaaattc gcctcttcag gatgatcgga
     2701 aaatacagct gcattcatca caggtgctgc gtaacgccac cgggtgccta aggaatgtta
     2761 gttcggccgg agaggaggcc cgcagaagga tgagagagtg tgatgggctt acggatgcct
     2821 tgctgtacgt gatccagtct gcgctgggga gcagtgagat cgatagcaag accgttgaaa
     2881 actgtgtgtg cattttaagg aacctctcgt accggctggc ggcagaaacg tctcagggac
     2941 agcacatggg cacggacgag ctggacgggc tactctgtgg cgaggccaat ggcaaggatg
     3001 ctgagagctc tgggtgctgg ggcaagaaga agaagaaaaa gaaatcccaa gatcagtggg
     3061 atggagtagg acctcttcca gactgtgctg aaccaccaaa agggatccag atgctgtggc
     3121 acccatcaat agtcaaaccc tacctcacac tgctctctga gtgctcaaat ccagacacgc
     3181 tggaaggggc ggcaggcgcc ctgcagaact tggctgcagg gagctggaag tggtcagtat
     3241 atatccgagc cgctgtccga aaagagaaag gcctgcccat cctcgtggag ctgctccgaa
     3301 tagacaatga ccgtgtggtg tgcgcggtgg ccactgcgct gcggaacatg gccttggacg
     3361 tcagaaataa ggagctcatc ggcaaatacg ccatgcgaga cctagtccac aggcttccag
     3421 gagggaacaa cagcaacaac actgcaagca aggccatgtc ggatgacaca gtgacagctg
     3481 tctgctgcac actgcacgaa gtgattacca agaacatgga gaacgccaag gccttacggg
     3541 atgccggtgg catcgagaag ttggtcggca tctccaaaag caaaggagat aaacactctc
     3601 caaaagtggt caaggctgca tctcaggtcc tcaacagcat gtggcagtac cgagatctga
     3661 ggagtctcta caaaaaggat ggatggtcac aataccactt tgtagcctcg tcttcaacca
     3721 tcgagaggga ccggcaaagg ccctactcct cctcccgcac gccctccatc tcccctgtgc
     3781 gcgtgtctcc caacaaccgc tcagcaagtg ccccagcttc acctcgggaa atgatcagcc
     3841 tcaaagaaag gaaaacagac tacgagtgca ccggcagcaa cgccacctac cacggagcta
     3901 aaggcgaaca cacttccagg aaagatgcca tgacagctca aaacactgga atttcaactt
     3961 tgtataggaa ttcttatggt gcgcccgctg aagacatcaa acacaaccag gtttcagcac
     4021 agccagtccc acaggagccc agcagaaaag attacgagac ctaccagcca tttcagaatt
     4081 ccacaagaaa ttacgatgag tccttcttcg aggaccaggt ccaccatcgc cctcccgcca
     4141 gcgagtacac catgcacctg ggtctcaagt ccaccggcaa ctacgttgac ttctactcag
     4201 ctgcccgtcc ctacagtgaa ctgaactatg aaacgagcca ctacccggcc tcccccgact
     4261 cctgggtgtg aggagcaggg cacaggcgct ccgggaacag tgcatgtgca tgcataccac
     4321 aagacatttc tttctgtttt gtttttttct cctgcaaatt tagtttgtta aagcctgttc
     4381 cataggaagg ctgtgataac cagtaaggaa atattaagag ctattttaga aagctaaatg
     4441 aatcgcaagt taacttggaa atcagtagaa agctaaagtg atcctaaata tgacagtggg
     4501 cagcaccttt ctagcgtgag ctgtagagta acgagaagtg ctttatactg aacgtggttg
     4561 atgggaggag agacgaggca ttcgggccgg tggggcgtaa gggttatcgt taagcacaag
     4621 acacagaata gtttacacac tgtgtggggg acggcttctc acgctttgtt tactctcttc
     4681 atccgttgtg actctaggct tcaggttgca ttggggttcc tctgtacagc aagatgtttc
     4741 ttgccttttg ttaatgcatt gttgtaaagt atttgatgta cattacagat taaagaagaa
     4801 aagcgcgttg tgtatattac accaatgccg ccgtgtttcc tcatctatgg ttctaaatat
     4861 tgcttcaatt tcaaactttt gaaagatgta tggatttcca gtttttcttt actttctccc
     4921 agtatgtttt aacaaaaaaa aaaaaaagca ggaaaaaagg aatatttagc agtattgttc
     4981 gttctgatat gtgaatttgt ttgtgacaac taaacaaggc attcagcagt ttctgacaat
     5041 taacatacat cattccacac tccttgtcaa caaagtgctt tttcactgcc taaaatttta
     5101 gatgtagata tttgaaatag attttttcat ttataccagt tttctttatg atgatacagt
     5161 gttaaaagaa aataaattac aattgatctg tcatccatat ttgctaagaa tgtctatttc
     5221 caagaaccta tatcttacaa aatacacatt cttgcttgtg tgtctgtgtg tgtgggtgta
     5281 tgtatgtcca cgtactagaa aaattacctg tgtgagattt tattttgaca gaagctattt
     5341 catttgctgt tcatcttgta caaactttgt ttttggtttt ttagtataaa tgtacatcag
     5401 tttgttcctt ttgtactgta tctattcttc tgaccatcta gtgactcagg atattaggcc
     5461 agttgaagtg gagttatagg attttcacac attcacgcat acttggatat caaccctctc
     5521 tacaggtccg tttccttaca cattttatcc cctcagaaca cgataaacca tggccaattc
     5581 agtttcactt tggggccaat tacttgaagt atccacagaa aatgtaaact gctcgcctta
     5641 ttcccccaaa ctttttgttc atgtggcagg gagcagtaca caactatgga atagattatt
     5701 aaaactgaac ttgaagctaa cgttagaata gtggttaaca gagctaagaa ataaggctaa
     5761 ccatcgaaaa gaacatgggc cgcgggtaaa ctagctttgc tctttagatg caagtggctg
     5821 aggccaatag gtgcctagta aatgttaact gttcttggaa aaaataaaaa catcagtaac
     5881 aaaagaaa
//
