LOCUS       NM_001085458            6670 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens catenin delta 1 (CTNND1), transcript variant 1, mRNA.
ACCESSION   NM_001085458
VERSION     NM_001085458.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6670)
  AUTHORS   Herrera-Pariente,C., Bonjoch,L., Munoz,J., Fernandez,G., Soares de
            Lima,Y., Mahmood,R., Cuatrecasas,M., Ocana,T., Lopez-Prades,S.,
            Llargues-Sistac,G., Dominguez-Rovira,X., Llach,J., Luzko,I.,
            Diaz-Gay,M., Lazaro,C., Brunet,J., Castillo-Manzano,C.,
            Garcia-Gonzalez,M.A., Lanas,A., Carrillo,M., Hernandez San Gil,R.,
            Quintero,E., Sala,N., Llort,G., Aguilera,L., Carot,L.,
            Diez-Redondo,P., Jover,R., Ramon Y Cajal,T., Cubiella,J.,
            Castells,A., Balaguer,F., Bujanda,L., Castellvi-Bel,S. and
            Moreira,L.
  TITLE     CTNND1 is involved in germline predisposition to early-onset
            gastric cancer by affecting cell-to-cell interactions
  JOURNAL   Gastric Cancer 27 (4), 747-759 (2024)
   PUBMED   38796558
  REMARK    GeneRIF: CTNND1 is involved in germline predisposition to
            early-onset gastric cancer by affecting cell-to-cell interactions.
REFERENCE   2  (bases 1 to 6670)
  AUTHORS   Fridianto,K.T. and Aye,Y.
  TITLE     Tag, you're it: G-ICAT identifies p120-cysteine glutathionylation
            triggering E-cadherin destabilization
  JOURNAL   Cell Chem Biol 30 (12), 1501-1504 (2023)
   PUBMED   38134879
  REMARK    GeneRIF: Tag, you're it: G-ICAT identifies p120-cysteine
            glutathionylation triggering E-cadherin destabilization.
REFERENCE   3  (bases 1 to 6670)
  AUTHORS   Kanoh,T., Lu,J., Mizoguchi,T. and Itoh,M.
  TITLE     The E3 ubiquitin ligase MIB1 suppresses breast cancer cell
            migration through regulating CTNND1 protein level
  JOURNAL   Biochem Biophys Res Commun 667, 73-80 (2023)
   PUBMED   37209565
  REMARK    GeneRIF: The E3 ubiquitin ligase MIB1 suppresses breast cancer cell
            migration through regulating CTNND1 protein level.
REFERENCE   4  (bases 1 to 6670)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6670)
  AUTHORS   Li,X.L., Feng,Q.M., Yang,H.N., Ruan,J.W., Kang,Y.F., Yu,Z.E.,
            Liu,J.X., Chen,A.N., Cui,Y.H., Liu,Z. and Lu,X.
  TITLE     p120 regulates E-cadherin expression in nasal epithelial cells in
            chronic rhinosinusitis
  JOURNAL   Rhinology 60 (4), 270-281 (2022)
   PUBMED   35934314
  REMARK    GeneRIF: p120 regulates E-cadherin expression in nasal epithelial
            cells in chronic rhinosinusitis.
REFERENCE   6  (bases 1 to 6670)
  AUTHORS   Reynolds,A.B., Daniel,J.M., Mo,Y.Y., Wu,J. and Zhang,Z.
  TITLE     The novel catenin p120cas binds classical cadherins and induces an
            unusual morphological phenotype in NIH3T3 fibroblasts
  JOURNAL   Exp Cell Res 225 (2), 328-337 (1996)
   PUBMED   8660921
REFERENCE   7  (bases 1 to 6670)
  AUTHORS   Reynolds,A.B., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Shapiro,D.N., Wu,J. and Daniel,J.M.
  TITLE     The gene encoding p120cas, a novel catenin, localizes on human
            chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)
  JOURNAL   Genomics 31 (1), 127-129 (1996)
   PUBMED   8808291
REFERENCE   8  (bases 1 to 6670)
  AUTHORS   Daniel,J.M. and Reynolds,A.B.
  TITLE     The tyrosine kinase substrate p120cas binds directly to E-cadherin
            but not to the adenomatous polyposis coli protein or alpha-catenin
  JOURNAL   Mol Cell Biol 15 (9), 4819-4824 (1995)
   PUBMED   7651399
REFERENCE   9  (bases 1 to 6670)
  AUTHORS   Shibamoto,S., Hayakawa,M., Takeuchi,K., Hori,T., Miyazawa,K.,
            Kitamura,N., Johnson,K.R., Wheelock,M.J., Matsuyoshi,N.,
            Takeichi,M. et al.
  TITLE     Association of p120, a tyrosine kinase substrate, with
            E-cadherin/catenin complexes
  JOURNAL   J Cell Biol 128 (5), 949-957 (1995)
   PUBMED   7876318
REFERENCE   10 (bases 1 to 6670)
  AUTHORS   Hulsken,J., Birchmeier,W. and Behrens,J.
  TITLE     E-cadherin and APC compete for the interaction with beta-catenin
            and the cytoskeleton
  JOURNAL   J Cell Biol 127 (6 Pt 2), 2061-2069 (1994)
   PUBMED   7806582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001931.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001085458.1.
            
            Summary: This gene encodes a member of the Armadillo protein
            family, which function in adhesion between cells and signal
            transduction. Multiple translation initiation codons and
            alternative splicing result in many different isoforms being
            translated. Not all of the full-length natures of the described
            transcript variants have been determined. Read-through
            transcription also exists between this gene and the neighboring
            upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
            [provided by RefSeq, Dec 2010].
            
            Transcript Variant: This variant (1) is the longest variant and it
            encodes the longest protein (isoform 1ABC). This variant has also
            been called hp120ctn-1ABC.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF062341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399050.10/ ENSP00000382004.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AP001931.5         41859-42176
            319-437             AP001931.5         69094-69212
            438-726             AP001931.5         71442-71730
            727-798             AP001931.5         74067-74138
            799-951             AP001931.5         75634-75786
            952-1487            AP001931.5         76514-77049
            1488-1951           AP001931.5         81790-82253
            1952-2135           AP001931.5         83678-83861
            2136-2253           AP001931.5         84720-84837
            2254-2407           AP001931.5         85939-86092
            2408-2425           AP001931.5         86518-86535
            2426-2494           AP001931.5         86972-87040
            2495-2622           AP001931.5         88222-88349
            2623-2773           AP001931.5         88447-88597
            2774-2966           AP001931.5         89331-89523
            2967-3081           AP001931.5         90166-90280
            3082-3169           AP001931.5         91456-91543
            3170-3232           AP001931.5         94368-94430
            3233-3339           AP001931.5         95451-95557
            3340-3426           AP001931.5         95972-96058
            3427-6670           AP001931.5         96354-99597
FEATURES             Location/Qualifiers
     source          1..6670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..6670
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="catenin delta 1"
                     /db_xref="GeneID:1500"
                     /db_xref="HGNC:HGNC:2515"
                     /db_xref="MIM:601045"
     exon            1..318
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            319..437
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            438..726
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..3438
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="isoform 1ABC is encoded by transcript variant 1;
                     p120 catenin; cadherin-associated Src substrate; catenin
                     (cadherin-associated protein), delta 1"
                     /codon_start=1
                     /product="catenin delta-1 isoform 1ABC"
                     /protein_id="NP_001078927.1"
                     /db_xref="CCDS:CCDS44604.1"
                     /db_xref="GeneID:1500"
                     /db_xref="HGNC:HGNC:2515"
                     /db_xref="MIM:601045"
                     /translation="MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERV
                     RVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHSHLLYSTIPRM
                     QEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGP
                     DGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYE
                     DGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFH
                     PEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPSDQY
                     YWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQH
                     LCYRNDKVKTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNC
                     DGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGW
                     EREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEI
                     GQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKG
                     KDEWFSRGKKPIEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILE
                     ASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLTNEHERVVKAASGALRNLAVD
                     ARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRE
                     TQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNA
                     SRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHN
                     RTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQVSYPSMQKI"
     exon            727..798
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            799..951
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1487
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1951
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2135
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2253
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2254..2407
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2425
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2426..2494
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2622
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2773
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2966
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3081
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3169
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3232
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3233..3339
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3426
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..6670
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5556..5561
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="hexamer: AATAAA"
     polyA_site      5577
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="major polyA site"
     regulatory      6286..6291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="hexamer: ATTAAA"
     polyA_site      6310
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
     regulatory      6652..6657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
                     /note="hexamer: AATAAA"
     polyA_site      6670
                     /gene="CTNND1"
                     /gene_synonym="BCDS2; CAS; CTNND; p120; p120(CAS);
                     p120(CTN); P120CAS; P120CTN"
ORIGIN      
        1 agatcagttt gtcaccaccc aggctccctt gcctttggct gggtgcaact tccattttag
       61 gtgttggatc tgagggggaa aaaaaagaga gagggagaga gagagaaaga agagcaggaa
      121 agatcccgaa aggaggaaga ggtggcgaaa aatcaactgc cctgctggat ttgtctttct
      181 cagcaccttg gcgaagcctt gggtttcttt cttaaaggac tgatttttag aactccacat
      241 ttgaggtgtg tggcttttga agaaaatgta tgtactgacg ggaaaaggag gataagcaag
      301 tcgaattttt gtcttacgct ctctccttcc tgcttcctcc ttgctgtggt ggctgggatg
      361 cttcttccat gattttttga atctagactg ggctgttctc tgtgttaaac caatcagttg
      421 cgaccttctc ttaacagtgt gaagtgaggg ggtctctctc cctccttctc cttcctctgt
      481 gattcacctt cctttttacc ctgccctgcg gcggctccgc cccttacctt catggacgac
      541 tcagaggtgg agtcgaccgc cagcatcttg gcctctgtga aggaacaaga ggcccagttt
      601 gagaagctga cccgggcgct ggaggaggaa cggcgccacg tctcggcgca gctggaacgc
      661 gtccgggtct caccacaaga tgccaaccca ctcatggcca acggcacact cacccgccgg
      721 catcagaacg gccggtttgt gggcgatgct gaccttgaaa gacagaaatt ttcagatttg
      781 aaactcaacg gaccccagga tcacagtcac cttctatata gcaccatccc caggatgcag
      841 gagccggggc agattgtgga gacctacacg gaggaggatc ctgagggagc catgtctgta
      901 gtctctgtgg agacctcaga tgatgggacc actcggcgca cagagaccac ggtcaagaaa
      961 gtagtgaaga ctgtgacaac acggacagta cagccagtcg ctatgggacc agacgggttg
     1021 cctgtggatg cttcatcagt ttctaacaac tatatccaga ctttgggtcg tgatttccgc
     1081 aagaatggca atgggggacc tggtccctat gtggggcaag ctggcactgc tacccttcct
     1141 aggaacttcc actaccctcc tgatggttat agtcgccact atgaagatgg ttatccaggt
     1201 ggcagtgata actatggcag tctgtcccgg gtgacccgca ttgaggagcg gtataggccc
     1261 agcatggaag gctaccgggc acctagtaga caggatgtgt atgggcccca accccaggtt
     1321 cgggtaggtg ggagcagcgt ggatctgcat cgctttcatc cagagcctta tgggctagag
     1381 gatgaccagc gtagtatggg ctatgatgac ctggattatg gtatgatgtc tgattatggc
     1441 actgcccgtc ggactgggac accctctgac cctcgtcggc gcctcaggag ctatgaagac
     1501 atgattggtg aggaggtgcc atcggatcaa tactactggg ctcctttggc ccagcatgag
     1561 cgaggaagtt tagcaagctt ggatagcctg cgcaaaggag ggcctccacc tcctaattgg
     1621 agacagccag agctgccaga ggtgatcgcc atgcttggat tccgcttgga tgctgtcaag
     1681 tccaatgcag ctgcatacct gcaacactta tgctaccgca atgacaaggt gaagactgac
     1741 gtgcggaagc tcaagggcat cccagtactg gtgggattgt tagaccatcc caaaaaggaa
     1801 gtgcaccttg gagcctgtgg agctctcaag aatatctctt ttggacgtga ccaggataac
     1861 aagattgcca taaaaaactg tgatggtgtg cctgcccttg tgcgattgct tcgaaaggct
     1921 cgtgatatgg accttactga agttattacc ggaaccctgt ggaatctttc atcccatgac
     1981 tcaatcaaaa tggagattgt ggaccatgca ctgcatgcct tgacagatga agtgatcatt
     2041 cctcattctg gttgggagcg ggaacctaat gaagactgta agccacgcca cattgagtgg
     2101 gaatcggtgc tcaccaacac agctggctgc cttaggaatg taagctcaga gaggagtgaa
     2161 gctcgccgga aacttcggga atgtgatggt ttagttgatg ccctcatttt cattgttcag
     2221 gctgagattg ggcagaagga ttcagacagc aagcttgtag agaactgtgt ttgccttctt
     2281 cggaacttat catatcaagt tcaccgggag atcccacagg cagagcgtta ccaagaggca
     2341 gctcccaatg ttgccaacaa tactgggcca catgctgcca gttgctttgg ggccaagaag
     2401 ggcaaagatg agtggttctc cagagggaaa aaacctatag aggatccagc aaacgataca
     2461 gtggatttcc ctaaaagaac gagtccagct cgaggctatg agctcttatt tcagccagag
     2521 gtggttcgga tatacatctc acttcttaag gagagcaaga ctcctgccat cctagaagcc
     2581 tcagctggag ctatccagaa cttgtgtgct gggcgctgga cgtatggtcg atacatccgc
     2641 tctgctctgc gtcaagagaa ggctctttct gccatagctg acctcctgac taatgaacat
     2701 gaacgggtgg tgaaagctgc atctggagca ctgagaaacc tggctgtgga tgctcgcaac
     2761 aaagaattaa ttggtaaaca tgctattcct aacttggtaa agaatctgcc aggaggacag
     2821 cagaactcct cttggaattt ctctgaggac actgtcatct ctattttgaa cactatcaac
     2881 gaggttatcg ctgagaactt ggaggctgcc aaaaagcttc gagagacaca gggtattgag
     2941 aagctggtgt tgatcaacaa atcagggaac cgctcagaaa aagaagttcg agcagcagca
     3001 cttgtattac agacaatctg gggatataag gaactgcgga agccactgga aaaagaagga
     3061 tggaagaaat cagactttca ggtgaatcta aacaatgctt cccgaagcca gagcagtcat
     3121 tcatatgatg atagtactct ccctctcatt gaccggaacc aaaaatcaga taagaaacct
     3181 gatcgggaag aaattcagat gagcaatatg ggatcaaaca caaaatcact agataacaac
     3241 tattccacac caaatgagag aggagaccac aatagaacac tggatcgatc gggggatcta
     3301 ggcgacatgg agccattgaa gggaacaaca cccttgatgc aggacgaggg gcaggaatct
     3361 ctggaggaag agttggatgt gttggttttg gatgatgagg ggggccaagt gtcttacccc
     3421 tccatgcaga agatttagca ccactatctc cgttccatct gggcttatat gtacttttat
     3481 tttttggtgg tgaaattgac tgatgatttt cctttttctt cgctggacta ttgtgccaac
     3541 tgccaggctg cctcctgccc ttacagccct aagtggctgc cttctttcca tcaactccca
     3601 acttcttcct gtgaagttta attgtctcaa cgcctccccc tcccccattc cctccatttt
     3661 tctcccaaga aacctgactc aattatttgc atattttgag aaactgctgc agattagttc
     3721 tttttgccag ttttccctgg aactcctggc cttttgtgga ggggagggat ggagagaata
     3781 ggaatcttca ctagaagccg tgggaagaat tggaagttac atgctgtata tgcaatgtcc
     3841 agcagtctga taaactgacg attcttaatc aagatttttt tcctgatggg gaagggactt
     3901 ttattttctt ttagagaggg gaaagtgtga gctcttccct tattcctaat ggctattttt
     3961 gaagcaaaga aggccagcaa cattggcaca tgccacctgg caaaggaccc ttgagtaagt
     4021 gaaggtctcc taaaactggg attaagaaac cttgctctcc tcatctccaa ggcagggacc
     4081 atcaagaacc tacagactcc atctcttctg caagcctcat gccaaccctg ggctattgct
     4141 gctgcccctt aaacacaggc tgtccttaac ccacctctcc tgccctgtga tatgtctgct
     4201 gagttggcct ggccatttcc aagaggctgt agaaagggga gaatgtcaag gaagactttt
     4261 ggtagagaag gagcagaaag atgtgttttt gggaagaaga agacctctag gaggagctag
     4321 taggaatgta catgaagcaa ttagtctgaa actggcttcc ccactccccc gtttctcctt
     4381 ttcctatcct tataggcctg tcccttgcct ctgccctgga ttggttggca aactaaagga
     4441 cttgatgtac ataactcctg tcccttttcc cttacaaggt ggggattgcc cctggctttg
     4501 cctcttcttt gtgcctttgg cctggggtgc atctcctccc gcccttccat gtgcctttct
     4561 ttgcctctgc agtctcattt ctcataattt tgcaaattat attttgttgc tttcttacct
     4621 actattggcc ctaaatagca gaaagaagag aagtgaccga gagaacctca gattcttcat
     4681 tgaggattgg tatagccatg atttcagtca tagcaagctt ttgctcaaca gcatatgggt
     4741 gggattttgc aaaaatccta ttctgatgaa tctcaaagta aggctggtaa gagaagtgag
     4801 tggtgtgact cttactcctt aggtgcccag aatttaccat catctctgaa ggagttacag
     4861 ggaagtggtc tccccaattc tcccctccct ccagtattgc cccctctcac tttagcatat
     4921 attaattagc aggttgggct agagaaatca gctgctatgc gggttgatta ttattattat
     4981 ttctaatcct tttccttatt tgccttctac tccccttaat ctaatctaaa agctctgttc
     5041 catgcaactg gagttcctta tccctctctt ccccttccct tatatattga ggctatgggg
     5101 taggagaaaa gtgcacaacc caccaccccc tttactcgtg cattaaaatt tcttatttac
     5161 ccttttcccc cttcccattt cttcccactt tcatctacct tttctggcaa aaaggagcct
     5221 tttgctctct gtgaccctaa gagcacactg cacagggaaa attgccccat ccagacctgg
     5281 ctccactctt gatctctctt gtcctcttct gctcttttcc tggtgctctt ttttctcggt
     5341 ggggtgtggg taatagaaca gccgtgggct tttggggacc tttaactttt ttttctctct
     5401 tttgtttata aaaaacacta aacattcaat tccagagaac caaaaatccc accttcccac
     5461 cgaacactac taaggggctt gtgttctgct ccataccttt tctcttttct ttctgtcttg
     5521 ttaatgcttt taaaaacaaa tgagtttttt atataaataa agtttttaaa gtgtgtatgt
     5581 ggggggtctg tgtcatttct tcacttcaag ctgttatttc ttccctgctt tgcatctttg
     5641 ttacttcctt atgtatcagt gtcctttcca gagcaaccag aaggaggtta taccaggatt
     5701 tattttgagc tcagccccaa ctctttatca agcaacattc ttgttaacta tatgtgaaac
     5761 attttttctt ctgaagattc ttaaaaattg aatgtggctg aagttgaaca tgggagctta
     5821 ttgctaattt agagatagga aactgaagca taaagaatta atgacttact ttaattactg
     5881 gaattcttct gcaacatttg acaaaactaa ccttgaataa ggcccactgt aatacgtagc
     5941 tctcttaaat ataacactta ggactagaag attagaaact accaatccca actacgtaat
     6001 aggaaaatgt aggatcaaaa ggcccatgta tataagtact gaccactggg ccataatgtt
     6061 gcttctcagg ctatatgcag tcctttagtc agaagtcaat aggcctattt attaatattt
     6121 tacagaccat attacctgga ttaccaggga ctatctttgc tgcagagatc aagggttaag
     6181 atctatggga agatacttat ttttctgagg tccttatgtc ctgtcatata attaaagact
     6241 caagagaatt tatgtgaaat gctttctgta tgcccaaatc tttagattaa aattatatag
     6301 ctgctcctga tgatggtcct gtcttgtttt attgaactag gacttgggta tgaaaacttt
     6361 catgggctag tgagaccagg aaatcaacta gcttttaaag cttgatttgt gtctaacaat
     6421 tgtagtgtta gattagaggt tgaagtacaa agccaaaaag ctattaagag tttactttcc
     6481 aaagagtttt gatagccctg cttgagatga tttttatcta aatagaaaag cctggctgct
     6541 tgtcagcaac actttatttc cctgttatgt tcttatcctt tggcattgag ctagatacaa
     6601 accctactct tctctcttcc ttctggattg gtccatttgt ttatctcatt caataaatat
     6661 ttgccaagca
//
