LOCUS       NM_020248               3006 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens catenin beta interacting protein 1 (CTNNBIP1),
            transcript variant 1, mRNA.
ACCESSION   NM_020248 XM_001128063
VERSION     NM_020248.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3006)
  AUTHORS   Zhang,T., Zhang,Y., Xu,H., Lan,J., Feng,Z., Huang,R., Geng,J.,
            Chi,H. and Bai,X.
  TITLE     LINC00355 Mediates CTNNBIP1 Promoter Methylation and Promotes
            Endoplasmic Reticulum Stress-Induced Podocyte Injury in Diabetic
            Nephropathy
  JOURNAL   Antioxid Redox Signal 39 (4-6), 225-240 (2023)
   PUBMED   36738224
  REMARK    GeneRIF: LINC00355 Mediates CTNNBIP1 Promoter Methylation and
            Promotes Endoplasmic Reticulum Stress-Induced Podocyte Injury in
            Diabetic Nephropathy.
REFERENCE   2  (bases 1 to 3006)
  AUTHORS   Wang,Z., Hu,J., Chen,J., Zhang,J., Li,W., Tian,Y., Liu,H. and
            Yang,X.
  TITLE     ICAT promotes colorectal cancer metastasis via binding to JUP and
            activating the NF-kappaB signaling pathway
  JOURNAL   J Clin Lab Anal 36 (10), e24678 (2022)
   PUBMED   36036768
  REMARK    GeneRIF: ICAT promotes colorectal cancer metastasis via binding to
            JUP and activating the NF-kappaB signaling pathway.
REFERENCE   3  (bases 1 to 3006)
  AUTHORS   Han,H., Zhu,B., Xie,J., Huang,Y., Geng,Y., Chen,K. and Wang,W.
  TITLE     Expression level and prognostic potential of
            beta-catenin-interacting protein in acute myeloid leukemia
  JOURNAL   Medicine (Baltimore) 101 (33), e30022 (2022)
   PUBMED   35984200
  REMARK    GeneRIF: Expression level and prognostic potential of
            beta-catenin-interacting protein in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 3006)
  AUTHORS   Zhang,Z., Jiang,W., Hu,M., Gao,R. and Zhou,X.
  TITLE     MiR-486-3p promotes osteogenic differentiation of BMSC by targeting
            CTNNBIP1 and activating the Wnt/beta-catenin pathway
  JOURNAL   Biochem Biophys Res Commun 566, 59-66 (2021)
   PUBMED   34118593
  REMARK    GeneRIF: MiR-486-3p promotes osteogenic differentiation of BMSC by
            targeting CTNNBIP1 and activating the Wnt/beta-catenin pathway.
REFERENCE   5  (bases 1 to 3006)
  AUTHORS   Hu,J., Wang,Z., Chen,J., Yu,Z., Zhang,J., Li,W., Lin,M., Yang,X.
            and Liu,H.
  TITLE     Overexpression of ICAT Inhibits the Progression of Colorectal
            Cancer by Binding with beta-Catenin in the Cytoplasm
  JOURNAL   Technol Cancer Res Treat 20, 15330338211041253 (2021)
   PUBMED   34569368
  REMARK    GeneRIF: Overexpression of ICAT Inhibits the Progression of
            Colorectal Cancer by Binding with beta-Catenin in the Cytoplasm.
REFERENCE   6  (bases 1 to 3006)
  AUTHORS   Graham,T.A., Clements,W.K., Kimelman,D. and Xu,W.
  TITLE     The crystal structure of the beta-catenin/ICAT complex reveals the
            inhibitory mechanism of ICAT
  JOURNAL   Mol Cell 10 (3), 563-571 (2002)
   PUBMED   12408824
REFERENCE   7  (bases 1 to 3006)
  AUTHORS   Reifenberger,J., Knobbe,C.B., Wolter,M., Blaschke,B., Schulte,K.W.,
            Pietsch,T., Ruzicka,T. and Reifenberger,G.
  TITLE     Molecular genetic analysis of malignant melanomas for aberrations
            of the WNT signaling pathway genes CTNNB1, APC, ICAT and BTRC
  JOURNAL   Int J Cancer 100 (5), 549-556 (2002)
   PUBMED   12124804
  REMARK    GeneRIF: Molecular genetic analysis of malignant melanomas for
            aberrations of the WNT signaling pathway genes CTNNB1, APC, ICAT
            and BTRC.
REFERENCE   8  (bases 1 to 3006)
  AUTHORS   von Koch,C.S., Gulati,M., Aldape,K. and Berger,M.S.
  TITLE     Familial medulloblastoma: case report of one family and review of
            the literature
  JOURNAL   Neurosurgery 51 (1), 227-33 (2002)
   PUBMED   12182422
  REMARK    GeneRIF: presentation of medulloblastoma in two siblings (one of
            each sex) and their great-uncle; immunostaining for gene products
            in medulloblastoma differed in the two siblings for beta-catenin
            and was similar with staining for gli.
            Review article
REFERENCE   9  (bases 1 to 3006)
  AUTHORS   Ashihara,K., Saito,T., Mizumoto,H., Adachi,K., Tanaka,R.,
            Nishimura,M., Ito,E. and Kudo,R.
  TITLE     Loss of gamma-Catenin expression in squamous differentiation in
            endometrial carcinomas
  JOURNAL   Int J Gynecol Pathol 21 (3), 246-254 (2002)
   PUBMED   12068170
  REMARK    GeneRIF: stimulation of beta-catenin and suppression of
            gamma-catenin expression, occur within endometrial carcinomas with
            squamous differentiation
REFERENCE   10 (bases 1 to 3006)
  AUTHORS   Tago,K., Nakamura,T., Nishita,M., Hyodo,J., Nagai,S., Murata,Y.,
            Adachi,S., Ohwada,S., Morishita,Y., Shibuya,H. and Akiyama,T.
  TITLE     Inhibition of Wnt signaling by ICAT, a novel
            beta-catenin-interacting protein
  JOURNAL   Genes Dev 14 (14), 1741-1749 (2000)
   PUBMED   10898789
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357140.33, CB995652.1 and
            BI226022.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_020248.2.
            
            Summary: The protein encoded by this gene binds CTNNB1 and prevents
            interaction between CTNNB1 and TCF family members. The encoded
            protein is a negative regulator of the Wnt signaling pathway. Two
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB021262.1, ERR279858.1749.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377263.6/ ENSP00000366474.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL357140.33        115126-115136       c
            12-175              CB995652.1         28-191
            176-505             BI226022.1         118-447
            506-3006            AL357140.33        53143-55643         c
FEATURES             Location/Qualifiers
     source          1..3006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..3006
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /note="catenin beta interacting protein 1"
                     /db_xref="GeneID:56998"
                     /db_xref="HGNC:HGNC:16913"
                     /db_xref="MIM:607758"
     exon            1..175
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     exon            176..209
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     exon            210..294
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     exon            295..414
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..564
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /note="beta-catenin-interacting protein ICAT; inhibitor of
                     beta-catenin and Tcf-4"
                     /codon_start=1
                     /product="beta-catenin-interacting protein 1"
                     /protein_id="NP_064633.1"
                     /db_xref="CCDS:CCDS106.1"
                     /db_xref="GeneID:56998"
                     /db_xref="HGNC:HGNC:16913"
                     /db_xref="MIM:607758"
                     /translation="MNREGAPGKSPEEMYIQQKVRVLLMLRKMGSNLTASEEEFLRTY
                     AGVVNSQLSQLPPHSIDQGAEDVVMAFSRSETEDRRQ"
     exon            415..505
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     exon            506..3006
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /note="hexamer: ATTACA"
     polyA_site      1173
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /note="major polyA site"
     regulatory      2986..2991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
                     /note="hexamer: AATAAA"
     polyA_site      3006
                     /gene="CTNNBIP1"
                     /gene_synonym="ICAT"
ORIGIN      
        1 ctccccaccg cggtgactct cggagcggga ggcggaggct gaggcggccg ctcctgctgc
       61 tgctactgcc gccgccgcag cggctgctcg ggctgagcac gccccggaac aggccgccgc
      121 gcgctgcgcg ccggacccgc tgcccctgcc ggcccggccg ggtcgggcgg cccagggacc
      181 gacagacttg acaacggtga cagcactggg gcggcacctt cctacttctg cccagccaca
      241 gccctcccct cacagttgag cacctgtttg cctgaagtta atttccagaa gcaggagtcc
      301 ccagagccag gcagggggat gaaccgcgag ggagctcccg ggaagagtcc ggaggagatg
      361 tacattcagc agaaggtccg agtgctgctc atgctgcgga agatgggatc aaacctgaca
      421 gccagcgagg aggagttcct gcgcacctat gcaggggtgg tcaacagcca gctcagccag
      481 ctgcctccgc actccatcga ccagggtgca gaggacgtgg tgatggcgtt ttccaggtcg
      541 gagacggaag accggaggca gtagctgcaa agcccttgga acaccctgga tgctgttgag
      601 ggccaagaga tctgtgtggc tcctgggccg gctgagtggc agcagccccc cttgccccac
      661 ctcccccttc ccctacccaa ccctgccctg ccccacccca cctcacagct actcagtggg
      721 gctggcatca agggagacac cagtggtgcg tttataattg gcttaaaggg atggacttgt
      781 gattggctgc aggaagaaac ttttttattt tttaaatctt gaccaacaga aaccttttat
      841 ttttatttct gactcttatt ttttaaaaaa tttgcgcctc ggtatctggc ttccctggaa
      901 gctctccgag ctctggtgct ttagttaggt cattttttta gaaatgtgaa gaggtctgat
      961 tggctgctta aactggaaag gatctgtgat tggctggtta atgggaaacg gtttttttct
     1021 ttggctgcag gtgttctgct gatatcaaca gcttccctat tttgaatgca gaaaacaggg
     1081 tctgggacat tagtcgttat atttgacttg aaaagaaaga aaccaagtgc gctttgcaat
     1141 atttattaca caaagaactt gctgctgcct tcacatttgg ggtttgtgtt tgattggctt
     1201 tcgatgcgtg tgtttggttt cccattggtt cacctgtgac tcctgttgcc atggattcac
     1261 ccccctctgc tgccggctct gggcctgagg gtccacctgg agagtacatt tgctttaatg
     1321 agtgcacctg cctccaccag caaggggacc ccgagaaccc tgagcagggt ccacagctgg
     1381 aaagttgggc ccctgaggag ctttgtgtcg tcttgaacga gcagcccagg gcctagaggt
     1441 aaccgttagg cgggatttat gtgcactgcc tgcatgagct ggcaaccagc cagcgtccct
     1501 tggtgagaaa gggattgctg aggcaccgtc caggccccac cggccaggcc gcgcccagca
     1561 gaggcgtact acccagctct gtcctcttgg ccatccttct gtgtaccact tcctgaggcc
     1621 tcattttggg ggtcatcttg gaaaggggag gagcttctcc cagtgtgaga ccccaaagac
     1681 tctggaggtc atctggcgga ggtctctggg agcccagaac ccacataaaa gccccagctt
     1741 ggctcacaag gcccaggaga cctccagcta aacaccaacc cctgacctac cccagccagg
     1801 ctcctacctg tctgctgcca gcacagtagg tcccggccag ctctggagtt ctctcatcgg
     1861 aggcccatgc cctccactcc actgcctttg gaagggtctc tctccaggtc agcctggaag
     1921 ggacagtatc gtttgtttat gaaatgccac tgggacagct ggctgggcct tcaccaagca
     1981 agtcccttca gactggccct taagccaaac tcaggcccag aattgcagtt cagaatggca
     2041 gtcctggagg cagggggtga ggggcaggtc tagtgttcct gcaccaaacc taagtccttc
     2101 cacctgccac ccccttccct gggagggagg tggtcctcct atctccctgg ctcactggca
     2161 ggtgtgggat ctggggagag cggctggaga aagatgcagt cctcaggaag ggggccgcca
     2221 ccctccccta tgctggtaga tgctgaggcc cctaggtgcc cagggccagt gggaccctct
     2281 cagaaccaaa tctttcccct ttctcggggc ttggggctcg ggccgtaggg gctcctgagt
     2341 gtcatgaagt gcacaggagc caaatgaccg agccctggag agccccatgg tgggtaggtg
     2401 gttcgtgctg tgctctggca ccatcagcct gttccagaag gaggattcga gcatcaggct
     2461 aagaccctgt gtcctccacc atgcactcac ccctagccct ggttagctga cagtcagctg
     2521 tggggaacac agctacaacc ctaccctggc agggacctga gagcatctca ggaggggcag
     2581 cgcatgtgtg catgtgctgt gtgagtgagc acacccgtgt gcacactcat acacatgtgc
     2641 acacacacgc actctccccg ctcaggggcc tggaggtctg gctgagcccc tggggaaagg
     2701 tgagttcttt catctccctc ctccaggtcg gagtgcctgg agtcaggtgt cgaggccaca
     2761 ttgctggctg ccccctcttt gtagctccta taaagggccc acacctggtg gatacctggt
     2821 tgagtgtgtg gtctctgccc cagcctgtcc ttgtcacgat cacaggcctt gcttttgtaa
     2881 caatgatgac cccggcctgt ctcatcttct gaagaggaaa agtcaaagtg ttgctgtggc
     2941 tccatatttc aactaaaaat atatctgttg gagaaagaaa ttaacaataa agaattttca
     3001 taggtt
//
