LOCUS       NM_001904               3661 bp    mRNA    linear   PRI 11-MAR-2025
DEFINITION  Homo sapiens catenin beta 1 (CTNNB1), transcript variant 1, mRNA.
ACCESSION   NM_001904 XM_942045 XM_945648 XM_945650 XM_945651 XM_945652
            XM_945653 XM_945654 XM_945655 XM_945657
VERSION     NM_001904.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3661)
  AUTHORS   Li,Y., Chen,X., Xiong,Y., Xu,X., Xie,C., Min,M., Liang,D., Chen,C.
            and Mao,H.
  TITLE     BRCC36 regulates beta-catenin ubiquitination to alleviate vascular
            calcification in chronic kidney disease
  JOURNAL   J Transl Med 22 (1), 820 (2024)
   PUBMED   39227917
  REMARK    GeneRIF: BRCC36 regulates beta-catenin ubiquitination to alleviate
            vascular calcification in chronic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3661)
  AUTHORS   Garone,G., Innocenti,A., Grasso,M., Mandarino,A., Capuano,A., Della
            Bella,G., Frascarelli,F., Diodato,D., Onesimo,R., Zampino,G.,
            Novelli,A., Digilio,M.C., Bartuli,A., Dentici,M.L., Parisi,P.,
            Galosi,S., Tonduti,D., Bertini,E., Sinibaldi,L. and Specchio,N.
  TITLE     Movement disorder phenotype in CTNNB1-syndrome: A complex but
            recognizable phenomenology
  JOURNAL   Parkinsonism Relat Disord 126, 107057 (2024)
   PUBMED   39067319
  REMARK    GeneRIF: Movement disorder phenotype in CTNNB1-syndrome: A complex
            but recognizable phenomenology.
REFERENCE   3  (bases 1 to 3661)
  AUTHORS   Xu,J., Lou,X., Wang,F., Zhang,W., Xu,X., Ye,Z., Zhuo,Q., Wang,Y.,
            Jing,D., Fan,G., Chen,X., Zhang,Y., Zhou,C., Chen,J., Qin,Y., Yu,X.
            and Ji,S.
  TITLE     MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT Axis
            Promotes Pancreatic Neuroendocrine Tumor Growth and Confers
            Temozolomide Resistance
  JOURNAL   Adv Sci (Weinh) 11 (35), e2308417 (2024)
   PUBMED   39041891
  REMARK    GeneRIF: MEN1 Deficiency-Driven Activation of the beta-Catenin-MGMT
            Axis Promotes Pancreatic Neuroendocrine Tumor Growth and Confers
            Temozolomide Resistance.
REFERENCE   4  (bases 1 to 3661)
  AUTHORS   Zhao,W., Wang,X., Han,L., Zhang,C., Wang,C., Kong,D., Zhang,M.,
            Xu,T., Li,G., Hu,G., Luo,J., Yee,S.W., Yang,J., Stahl,A., Chen,X.
            and Zhang,Y.
  TITLE     SLC13A3 is a major effector downstream of activated beta-catenin in
            liver cancer pathogenesis
  JOURNAL   Nat Commun 15 (1), 7522 (2024)
   PUBMED   39215042
  REMARK    GeneRIF: SLC13A3 is a major effector downstream of activated
            beta-catenin in liver cancer pathogenesis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3661)
  AUTHORS   Bai,Y., Li,R., Hao,J.F., Chen,L.W., Liu,S.T., Zhang,X.L.,
            Lip,G.Y.H., Yang,J.K., Zou,Y.X. and Wang,H.
  TITLE     Accumulated beta-catenin is associated with human atrial fibrosis
            and atrial fibrillation
  JOURNAL   J Transl Med 22 (1), 734 (2024)
   PUBMED   39103891
  REMARK    GeneRIF: Accumulated beta-catenin is associated with human atrial
            fibrosis and atrial fibrillation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3661)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   7  (bases 1 to 3661)
  AUTHORS   Brady-Kalnay,S.M., Rimm,D.L. and Tonks,N.K.
  TITLE     Receptor protein tyrosine phosphatase PTPmu associates with
            cadherins and catenins in vivo
  JOURNAL   J Cell Biol 130 (4), 977-986 (1995)
   PUBMED   7642713
REFERENCE   8  (bases 1 to 3661)
  AUTHORS   Kanai,Y., Ochiai,A., Shibata,T., Oyama,T., Ushijima,S., Akimoto,S.
            and Hirohashi,S.
  TITLE     c-erbB-2 gene product directly associates with beta-catenin and
            plakoglobin
  JOURNAL   Biochem Biophys Res Commun 208 (3), 1067-1072 (1995)
   PUBMED   7702605
REFERENCE   9  (bases 1 to 3661)
  AUTHORS   Aberle,H., Butz,S., Stappert,J., Weissig,H., Kemler,R. and
            Hoschuetzky,H.
  TITLE     Assembly of the cadherin-catenin complex in vitro with recombinant
            proteins
  JOURNAL   J Cell Sci 107 (Pt 12), 3655-3663 (1994)
   PUBMED   7706414
REFERENCE   10 (bases 1 to 3661)
  AUTHORS   Ho,S.K.L., Tsang,M.H.Y., Lee,M., Cheng,S.S.W., Luk,H.M., Lo,I.F.M.
            and Chung,B.H.Y.
  TITLE     CTNNB1 Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   35593792
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from X87838.1 and AC104307.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001904.3.
            
            Summary: The protein encoded by this gene is part of a complex of
            proteins that constitute adherens junctions (AJs). AJs are
            necessary for the creation and maintenance of epithelial cell
            layers by regulating cell growth and adhesion between cells. The
            encoded protein also anchors the actin cytoskeleton and may be
            responsible for transmitting the contact inhibition signal that
            causes cells to stop dividing once the epithelial sheet is
            complete. Finally, this protein binds to the product of the APC
            gene, which is mutated in adenomatous polyposis of the colon.
            Mutations in this gene are a cause of colorectal cancer (CRC),
            pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058926.1, SRR1660809.110031.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000349496.11/ ENSP00000344456.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2572              X87838.1           1-2572
            2573-3661           AC104307.2         83770-84858
FEATURES             Location/Qualifiers
     source          1..3661
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.1"
     gene            1..3661
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /note="catenin beta 1"
                     /db_xref="GeneID:1499"
                     /db_xref="HGNC:HGNC:2514"
                     /db_xref="MIM:116806"
     exon            1..166
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            167..227
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2560
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /note="isoform 1 is encoded by transcript variant 1;
                     catenin (cadherin-associated protein), beta 1, 88kDa"
                     /codon_start=1
                     /product="catenin beta-1 isoform 1"
                     /protein_id="NP_001895.1"
                     /db_xref="CCDS:CCDS2694.1"
                     /db_xref="GeneID:1499"
                     /db_xref="HGNC:HGNC:2514"
                     /db_xref="MIM:116806"
                     /translation="MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAP
                     SLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPET
                     LDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLL
                     NDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTL
                     HNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLA
                     GGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYE
                     KLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAA
                     TKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRT
                     VLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIK
                     ATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRM
                     EEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQD
                     KEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSL
                     FRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMG
                     GHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL"
     exon            228..455
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            456..709
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            710..948
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1150
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1295
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1399
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1738
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1897
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2017
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2168
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            2169..2290
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2351
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..3661
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3642..3647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /note="hexamer: ATTAAA"
     polyA_site      3661
                     /gene="CTNNB1"
                     /gene_synonym="armadillo; CTNNB; EVR7; MRD19; NEDSDV"
                     /note="major polyA site"
ORIGIN      
        1 aagcctctcg gtctgtggca gcagcgttgg cccggccccg ggagcggaga gcgaggggag
       61 gcggagacgg aggaaggtct gaggagcagc ttcagtcccc gccgagccgc caccgcaggt
      121 cgaggacggt cggactcccg cggcgggagg agcctgttcc cctgagggta tttgaagtat
      181 accatacaac tgttttgaaa atccagcgtg gacaatggct actcaagctg atttgatgga
      241 gttggacatg gccatggaac cagacagaaa agcggctgtt agtcactggc agcaacagtc
      301 ttacctggac tctggaatcc attctggtgc cactaccaca gctccttctc tgagtggtaa
      361 aggcaatcct gaggaagagg atgtggatac ctcccaagtc ctgtatgagt gggaacaggg
      421 attttctcag tccttcactc aagaacaagt agctgatatt gatggacagt atgcaatgac
      481 tcgagctcag agggtacgag ctgctatgtt ccctgagaca ttagatgagg gcatgcagat
      541 cccatctaca cagtttgatg ctgctcatcc cactaatgtc cagcgtttgg ctgaaccatc
      601 acagatgctg aaacatgcag ttgtaaactt gattaactat caagatgatg cagaacttgc
      661 cacacgtgca atccctgaac tgacaaaact gctaaatgac gaggaccagg tggtggttaa
      721 taaggctgca gttatggtcc atcagctttc taaaaaggaa gcttccagac acgctatcat
      781 gcgttctcct cagatggtgt ctgctattgt acgtaccatg cagaatacaa atgatgtaga
      841 aacagctcgt tgtaccgctg ggaccttgca taacctttcc catcatcgtg agggcttact
      901 ggccatcttt aagtctggag gcattcctgc cctggtgaaa atgcttggtt caccagtgga
      961 ttctgtgttg ttttatgcca ttacaactct ccacaacctt ttattacatc aagaaggagc
     1021 taaaatggca gtgcgtttag ctggtgggct gcagaaaatg gttgccttgc tcaacaaaac
     1081 aaatgttaaa ttcttggcta ttacgacaga ctgccttcaa attttagctt atggcaacca
     1141 agaaagcaag ctcatcatac tggctagtgg tggaccccaa gctttagtaa atataatgag
     1201 gacctatact tacgaaaaac tactgtggac cacaagcaga gtgctgaagg tgctatctgt
     1261 ctgctctagt aataagccgg ctattgtaga agctggtgga atgcaagctt taggacttca
     1321 cctgacagat ccaagtcaac gtcttgttca gaactgtctt tggactctca ggaatctttc
     1381 agatgctgca actaaacagg aagggatgga aggtctcctt gggactcttg ttcagcttct
     1441 gggttcagat gatataaatg tggtcacctg tgcagctgga attctttcta acctcacttg
     1501 caataattat aagaacaaga tgatggtctg ccaagtgggt ggtatagagg ctcttgtgcg
     1561 tactgtcctt cgggctggtg acagggaaga catcactgag cctgccatct gtgctcttcg
     1621 tcatctgacc agccgacacc aagaagcaga gatggcccag aatgcagttc gccttcacta
     1681 tggactacca gttgtggtta agctcttaca cccaccatcc cactggcctc tgataaaggc
     1741 tactgttgga ttgattcgaa atcttgccct ttgtcccgca aatcatgcac ctttgcgtga
     1801 gcagggtgcc attccacgac tagttcagtt gcttgttcgt gcacatcagg atacccagcg
     1861 ccgtacgtcc atgggtggga cacagcagca atttgtggag ggggtccgca tggaagaaat
     1921 agttgaaggt tgtaccggag cccttcacat cctagctcgg gatgttcaca accgaattgt
     1981 tatcagagga ctaaatacca ttccattgtt tgtgcagctg ctttattctc ccattgaaaa
     2041 catccaaaga gtagctgcag gggtcctctg tgaacttgct caggacaagg aagctgcaga
     2101 agctattgaa gctgagggag ccacagctcc tctgacagag ttacttcact ctaggaatga
     2161 aggtgtggcg acatatgcag ctgctgtttt gttccgaatg tctgaggaca agccacaaga
     2221 ttacaagaaa cggctttcag ttgagctgac cagctctctc ttcagaacag agccaatggc
     2281 ttggaatgag actgctgatc ttggacttga tattggtgcc cagggagaac cccttggata
     2341 tcgccaggat gatcctagct atcgttcttt tcactctggt ggatatggcc aggatgcctt
     2401 gggtatggac cccatgatgg aacatgagat gggtggccac caccctggtg ctgactatcc
     2461 agttgatggg ctgccagatc tggggcatgc ccaggacctc atggatgggc tgcctccagg
     2521 tgacagcaat cagctggcct ggtttgatac tgacctgtaa atcatccttt aggtaagaag
     2581 ttttaaaaag ccagtttggg taaaatactt ttactctgcc tacagaactt cagaaagact
     2641 tggttggtag ggtgggagtg gtttaggcta tttgtaaatc tgccacaaaa acaggtatat
     2701 actttgaaag gagatgtctt ggaacattgg aatgttctca gatttctggt tgttatgtga
     2761 tcatgtgtgg aagttattaa ctttaatgtt ttttgccaca gcttttgcaa cttaatactc
     2821 aaatgagtaa catttgctgt tttaaacatt aatagcagcc tttctctctt tatacagctg
     2881 tattgtctga acttgcattg tgattggcct gtagagttgc tgagagggct cgaggggtgg
     2941 gctggtatct cagaaagtgc ctgacacact aaccaagctg agtttcctat gggaacaatt
     3001 gaagtaaact ttttgttctg gtcctttttg gtcgaggagt aacaatacaa atggattttg
     3061 ggagtgactc aagaagtgaa gaatgcacaa gaatggatca caagatggaa tttatcaaac
     3121 cctagccttg cttgttaaat tttttttttt ttttttttaa gaatatctgt aatggtactg
     3181 actttgcttg ctttgaagta gctctttttt tttttttttt tttttttttg cagtaactgt
     3241 tttttaagtc tctcgtagtg ttaagttata gtgaatactg ctacagcaat ttctaatttt
     3301 taagaattga gtaatggtgt agaacactaa ttcataatca ctctaattaa ttgtaatctg
     3361 aataaagtgt aacaattgtg tagccttttt gtataaaata gacaaataga aaatggtcca
     3421 attagtttcc tttttaatat gcttaaaata agcaggtgga tctatttcat gtttttgatc
     3481 aaaaactatt tgggatatgt atgggtaggg taaatcagta agaggtgtta tttggaacct
     3541 tgttttggac agtttaccag ttgcctttta tcccaaagtt gttgtaacct gctgtgatac
     3601 gatgcttcaa gagaaaatgc ggttataaaa aatggttcag aattaaactt ttaattcatt
     3661 c
//
