LOCUS       NM_003798               2454 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens catenin alpha like 1 (CTNNAL1), transcript variant 1,
            mRNA.
ACCESSION   NM_003798
VERSION     NM_003798.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Wu,D., Zhu,J., Yang,F., Li,R., Liu,L., Liu,D., Liu,C., Qu,X.,
            Liu,H., Ji,M., Qin,X., Hua,L. and Xiang,Y.
  TITLE     CTNNAL1 deficiency suppresses CFTR expression in HDM-induced asthma
            mouse model through ROCK1-CAL signaling pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (10), 1618-1629 (2023)
   PUBMED   37715489
  REMARK    GeneRIF: CTNNAL1 deficiency suppresses CFTR expression in
            HDM-induced asthma mouse model through ROCK1-CAL signaling pathway.
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Tung,C.H., Huang,M.F., Liang,C.H., Wu,Y.Y., Wu,J.E., Hsu,C.L.,
            Chen,Y.L. and Hong,T.M.
  TITLE     alpha-Catulin promotes cancer stemness by antagonizing
            WWP1-mediated KLF5 degradation in lung cancer
  JOURNAL   Theranostics 12 (3), 1173-1186 (2022)
   PUBMED   35154481
  REMARK    GeneRIF: alpha-Catulin promotes cancer stemness by antagonizing
            WWP1-mediated KLF5 degradation in lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2454)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2454)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2454)
  AUTHORS   Wang,Y., Jiang,Q., Cai,H., Xu,Z., Wu,W., Gu,B., Li,L. and Cai,W.
  TITLE     Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant
            interaction networks, contribute to the risk of Hirschsprung
            disease
  JOURNAL   Aging (Albany NY) 12 (5), 4379-4393 (2020)
   PUBMED   32139661
  REMARK    GeneRIF: Genetic variants in RET, ARHGEF3 and CTNNAL1, and relevant
            interaction networks, contribute to the risk of Hirschsprung
            disease.
REFERENCE   6  (bases 1 to 2454)
  AUTHORS   Surpili,M.J., Delben,T.M. and Kobarg,J.
  TITLE     Identification of proteins that interact with the central
            coiled-coil region of the human protein kinase NEK1
  JOURNAL   Biochemistry 42 (51), 15369-15376 (2003)
   PUBMED   14690447
REFERENCE   7  (bases 1 to 2454)
  AUTHORS   Shieh,Y.S., Chang,L.C., Chiu,K.C., Wu,C.W. and Lee,H.S.
  TITLE     Cadherin and catenin expression in mucoepidermoid carcinoma:
            correlation with histopathologic grade, clinical stage, and patient
            outcome
  JOURNAL   J Oral Pathol Med 32 (5), 297-304 (2003)
   PUBMED   12694354
  REMARK    GeneRIF: Abnormal expression of alpha-catenin was seen in
            mucoepidermoid carcinoma.
REFERENCE   8  (bases 1 to 2454)
  AUTHORS   Park,B., Nguyen,N.T., Dutt,P., Merdek,K.D., Bashar,M.,
            Sterpetti,P., Tosolini,A., Testa,J.R. and Toksoz,D.
  TITLE     Association of Lbc Rho guanine nucleotide exchange factor with
            alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports
            serum response factor activation
  JOURNAL   J Biol Chem 277 (47), 45361-45370 (2002)
   PUBMED   12270917
  REMARK    GeneRIF: Results show that alpha-catulin co-expression leads to
            increased Lbc-induced serum response factor activation and may
            modulate Rho pathway signaling in vivo by providing a scaffold for
            the Lbc Rho guanine nucleotide exchange factor.
REFERENCE   9  (bases 1 to 2454)
  AUTHORS   Janssens,B., Staes,K. and van Roy,F.
  TITLE     Human alpha-catulin, a novel alpha-catenin-like molecule with
            conserved genomic structure, but deviating alternative splicing
  JOURNAL   Biochim Biophys Acta 1447 (2-3), 341-347 (1999)
   PUBMED   10542337
REFERENCE   10 (bases 1 to 2454)
  AUTHORS   Zhang,J.S., Nelson,M., Wang,L., Liu,W., Qian,C.P., Shridhar,V.,
            Urrutia,R. and Smith,D.I.
  TITLE     Identification and chromosomal localization of CTNNAL1, a novel
            protein homologous to alpha-catenin
  JOURNAL   Genomics 54 (1), 149-154 (1998)
   PUBMED   9806841
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK022926.1 and AF030233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003798.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK022926.1, AK223230.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325551.9/ ENSP00000320434.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               AK022926.1         1-825
            826-2454            AF030233.1         813-2441
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..2454
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /note="catenin alpha like 1"
                     /db_xref="GeneID:8727"
                     /db_xref="HGNC:HGNC:2512"
                     /db_xref="MIM:604785"
     exon            1..198
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..2262
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /note="isoform a is encoded by transcript variant 1;
                     alpha-catulin; alpha2-catulin; catenin alpha-like protein
                     1; alpha-catenin-related protein; catenin
                     (cadherin-associated protein), alpha-like 1"
                     /codon_start=1
                     /product="alpha-catulin isoform a"
                     /protein_id="NP_003789.1"
                     /db_xref="CCDS:CCDS6775.1"
                     /db_xref="GeneID:8727"
                     /db_xref="HGNC:HGNC:2512"
                     /db_xref="MIM:604785"
                     /translation="MAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPL
                     VSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINI
                     ACIEAKQAGETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLAD
                     RVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDE
                     KKKAKMAAARAVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIV
                     TDCKPNGETDISSISIFTGIKEFKMNIEALRENLYFQSKENLSVTLEVILERMEDFTD
                     SAYTSHEHRERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNE
                     LKKELHSTATQLAADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVET
                     CRLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAW
                     ESQISDMSTLLREINDVFEGRRGEKYGYLSLPKPMKNNANLKSLKPDKPDSEEQAKIA
                     KLGLKLGLLTSDADCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQDLI
                     HQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQLQTVTKTSLQNKV
                     FLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQMENNGWVSVTNKDTMDSKT"
     exon            199..388
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            389..576
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            577..696
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            697..786
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            787..957
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1158
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1245
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1404
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1497
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1648
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1686
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1737
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1892
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1941
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..1998
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2112
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2196
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     exon            2197..2454
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2432..2437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /note="hexamer: AATAAA"
     polyA_site      2454
                     /gene="CTNNAL1"
                     /gene_synonym="ACRP; alpha-CATU; CLLP"
                     /note="major polyA site"
ORIGIN      
        1 gactggcggc aggctcgccg cggcgcggag tcccggctgc gggatagacc gagggccatg
       61 gccgcctctc ccggacccgc cggcgttggc ggcgccggag cagtctacgg ctccggctct
      121 tcgggcttcg ccctcgactc gggactggag atcaaaactc gctcggtgga gcagacgcta
      181 ctcccgctgg tttctcagat caccacgctt attaatcata aagataatac caaaaagtct
      241 gataaaactc tgcaagcaat tcagcgtgta ggacaagctg tcaacttggc agttggaaga
      301 tttgttaaag taggagaagc tatagccaat gaaaactggg atttgaaaga agaaataaat
      361 attgcttgta ttgaagctaa acaagcagga gaaacaattg cagcacttac agacataacc
      421 aacttgaacc atctggaatc tgatgggcag atcacaattt ttacagacaa aacaggagtg
      481 ataaaggctg caagattact tctttcttca gtgacaaaag tgttgttgct ggcagaccga
      541 gtagtcatta aacagataat aacatcaaga aataaggttc tcgcaactat ggaaagacta
      601 gagaaagtga atagctttca agagtttgtc caaatattca gtcaatttgg aaatgaaatg
      661 gtggagtttg cacatctgag tggagataga caaaatgatt tgaaagatga aaagaaaaag
      721 gcaaaaatgg cagcagctag ggcagttctt gaaaagtgta caatgatgct tctcacagct
      781 tcaaagacat gtctgaggca tcctaactgc gaatcagccc ataaaaacaa agaaggagta
      841 tttgaccgta tgaaagtggc attggataag gtcattgaaa ttgtgactga ctgtaaaccg
      901 aatggagaga ctgacatttc atctatcagt atttttactg gaattaagga attcaagatg
      961 aatattgaag ctcttcggga gaatctttat tttcagtcca aagagaacct ttctgtgaca
     1021 ttggaagtca tcttggagcg tatggaggac tttactgatt ctgcctacac cagccatgag
     1081 cacagagaac gcatcttgga actgtcaact caggcgagaa tggaactgca gcagttaatt
     1141 tctgtgtgga ttcaagctca aagcaagaaa acaaaaagca tcgctgaaga actggaactc
     1201 agtattttga aaatcagtca cagtcttaat gaacttaaga aagaacttca tagtacagcg
     1261 acacagctgg cagcagatct attaaaatac catgctgatc atgtggttct aaaagcatta
     1321 aaacttactg gagtagaagg aaatttagaa gctttggctg aatatgcctg taaactctct
     1381 gaacagaaag agcagcttgt tgagacctgt cgattgttac gacacatatc tgggacagaa
     1441 cctctggaaa taacctgtat acatgcagag gagacatttc aggtgactgg ccaacagata
     1501 atttctgctg ctgaaacatt gacattgcat ccatctagta aaattgctaa agaaaaccta
     1561 gatgtatttt gtgaagcttg ggaatcccaa attagtgaca tgtcaacact gctgagagaa
     1621 atcaatgacg tgtttgaagg aagacgagga gagaagtatg gctacctttc acttccaaag
     1681 ccaatgaaga ataatgcaaa cctgaaatca ttaaagccag acaagcctga ctctgaggag
     1741 caagccaaga tagcaaagct tggacttaag ctgggtttgc tcacctctga cgctgactgc
     1801 gaaattgaga agtgggaaga tcaggagaat gagattgttc aatatggacg gaacatgtcc
     1861 agtatggcct attctctgta tttatttact agaggagagg ggccactgaa aacttcccag
     1921 gatttaattc atcaactaga ggtttttgct gcagagggtt taaagcttac ttccagtgtt
     1981 caagcttttt caaaacagct gaaagacgat gacaagctta tgcttctcct ggaaataaac
     2041 aagctaattc ctctatgcca ccagctccag acagtaacta agacttcttt gcagaataaa
     2101 gtatttctaa aggttgacaa gtgtattacg aagacaagat ccatgatggc tctcttagtc
     2161 caacttcttt cactttgtta taaactgctg aagaagcttc agatggaaaa taacggatgg
     2221 gtctcagtta caaataagga cactatggat agtaaaactt gagaagcttt tggggtcaga
     2281 tctctggaac atcatgtgat gaagctgaca tttttaaaaa tcaaatgatc ctttatcttt
     2341 tcagaaattc atcaatttta taaagaaaac aatattgaaa ttttgctcta ttttctgatc
     2401 atgaaactga ttgtaaagct ttttgacaac taataaatgt cttggtaatt gcta
//
