LOCUS       NM_001282597            3932 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens catenin alpha 2 (CTNNA2), transcript variant 3, mRNA.
ACCESSION   NM_001282597 XM_005264153
VERSION     NM_001282597.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3932)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3932)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3932)
  AUTHORS   Song,J., Zhang,P., Liu,M., Xie,M., Gao,Z., Wang,X., Wang,T., Yin,J.
            and Liu,R.
  TITLE     Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer
            Cells Through Targeting CTNNA2
  JOURNAL   DNA Cell Biol 38 (2), 151-161 (2019)
   PUBMED   30526004
  REMARK    GeneRIF: Novel-miR-4885 can bind to 3' untranslated region of
            CTNNA2 to reduce cell adhesion.
REFERENCE   4  (bases 1 to 3932)
  AUTHORS   Schaffer,A.E., Breuss,M.W., Caglayan,A.O., Al-Sanaa,N.,
            Al-Abdulwahed,H.Y., Kaymakcalan,H., Yilmaz,C., Zaki,M.S.,
            Rosti,R.O., Copeland,B., Baek,S.T., Musaev,D., Scott,E.C.,
            Ben-Omran,T., Kariminejad,A., Kayserili,H., Mojahedi,F., Kara,M.,
            Cai,N., Silhavy,J.L., Elsharif,S., Fenercioglu,E., Barshop,B.A.,
            Kara,B., Wang,R., Stanley,V., James,K.N., Nachnani,R., Kalur,A.,
            Megahed,H., Incecik,F., Danda,S., Alanay,Y., Faqeih,E.,
            Melikishvili,G., Mansour,L., Miller,I., Sukhudyan,B., Chelly,J.,
            Dobyns,W.B., Bilguvar,K., Jamra,R.A., Gunel,M. and Gleeson,J.G.
  TITLE     Biallelic loss of human CTNNA2, encoding alphaN-catenin, leads to
            ARP2/3 complex overactivity and disordered cortical neuronal
            migration
  JOURNAL   Nat Genet 50 (8), 1093-1101 (2018)
   PUBMED   30013181
REFERENCE   5  (bases 1 to 3932)
  AUTHORS   Smeland,O.B., Frei,O., Kauppi,K., Hill,W.D., Li,W., Wang,Y.,
            Krull,F., Bettella,F., Eriksen,J.A., Witoelar,A., Davies,G.,
            Fan,C.C., Thompson,W.K., Lam,M., Lencz,T., Chen,C.H., Ueland,T.,
            Jonsson,E.G., Djurovic,S., Deary,I.J., Dale,A.M. and
            Andreassen,O.A.
  CONSRTM   NeuroCHARGE (Cohorts for Heart and Aging Research in Genomic
            Epidemiology) Cognitive Working Group
  TITLE     Identification of Genetic Loci Jointly Influencing Schizophrenia
            Risk and the Cognitive Traits of Verbal-Numerical Reasoning,
            Reaction Time, and General Cognitive Function
  JOURNAL   JAMA Psychiatry 74 (10), 1065-1075 (2017)
   PUBMED   28746715
  REMARK    GeneRIF: Single nucleotide polymorphisms in CTNNA2 show
            associations in Schizophrenia and general cognitive function.
REFERENCE   6  (bases 1 to 3932)
  AUTHORS   Kask,M., Pruunsild,P. and Timmusk,T.
  TITLE     Bidirectional transcription from human LRRTM2/CTNNA1 and
            LRRTM1/CTNNA2 gene loci leads to expression of N-terminally
            truncated CTNNA1 and CTNNA2 isoforms
  JOURNAL   Biochem Biophys Res Commun 411 (1), 56-61 (2011)
   PUBMED   21708131
REFERENCE   7  (bases 1 to 3932)
  AUTHORS   Bogaerts,S., Vanlandschoot,A., van Hengel,J. and van Roy,F.
  TITLE     Nuclear translocation of alphaN-catenin by the novel zinc finger
            transcriptional repressor ZASC1
  JOURNAL   Exp Cell Res 311 (1), 1-13 (2005)
   PUBMED   16182284
REFERENCE   8  (bases 1 to 3932)
  AUTHORS   Krauss,R.S., Cole,F., Gaio,U., Takaesu,G., Zhang,W. and Kang,J.S.
  TITLE     Close encounters: regulation of vertebrate skeletal myogenesis by
            cell-cell contact
  JOURNAL   J Cell Sci 118 (Pt 11), 2355-2362 (2005)
   PUBMED   15923648
  REMARK    Review article
REFERENCE   9  (bases 1 to 3932)
  AUTHORS   Claverie,J.M., Hardelin,J.P., Legouis,R., Levilliers,J.,
            Bougueleret,L., Mattei,M.G. and Petit,C.
  TITLE     Characterization and chromosomal assignment of a human cDNA
            encoding a protein related to the murine 102-kDa
            cadherin-associated protein (alpha-catenin)
  JOURNAL   Genomics 15 (1), 13-20 (1993)
   PUBMED   8432524
REFERENCE   10 (bases 1 to 3932)
  AUTHORS   Hirano,S., Kimoto,N., Shimoyama,Y., Hirohashi,S. and Takeichi,M.
  TITLE     Identification of a neural alpha-catenin as a key regulator of
            cadherin function and multicellular organization
  JOURNAL   Cell 70 (2), 293-301 (1992)
   PUBMED   1638632
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010975.9, AC096573.1, AC096753.5, AC011746.6, FJ695201.1,
            AC104780.4, AC011741.9 and AC008067.3.
            
            On Apr 6, 2020 this sequence version replaced NM_001282597.2.
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2805875.1,
                                           SRR1660809.103074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402739.9/ ENSP00000384638.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC010975.9         38147-38303
            158-264             AC096573.1         7399-7505
            265-460             AC096753.5         5247-5442
            461-627             AC011746.6         16258-16424
            628-747             AC011746.6         28061-28180
            748-1014            AC011746.6         32321-32587
            1015-1218           FJ695201.1         34-237
            1219-1299           AC104780.4         31930-32010
            1300-1452           AC104780.4         58168-58320
            1453-1545           AC011741.9         109200-109292
            1546-1702           AC011741.9         110125-110281
            1703-1903           AC011741.9         119911-120111
            1904-2055           AC011741.9         138381-138532
            2056-2169           AC008067.3         4706-4819
            2170-2351           AC008067.3         12304-12485
            2352-2457           AC008067.3         27074-27179
            2458-2592           AC008067.3         31184-31318
            2593-2736           AC008067.3         42085-42228
            2737-3932           AC008067.3         70585-71780
FEATURES             Location/Qualifiers
     source          1..3932
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p12"
     gene            1..3932
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /note="catenin alpha 2"
                     /db_xref="GeneID:1496"
                     /db_xref="HGNC:HGNC:2510"
                     /db_xref="MIM:114025"
     exon            1..157
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            158..264
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3024
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cancer/testis antigen 114; alpha-N-catenin;
                     cadherin-associated protein, related;
                     alpha-catenin-related protein; catenin
                     (cadherin-associated protein), alpha 2"
                     /codon_start=1
                     /product="catenin alpha-2 isoform 3"
                     /protein_id="NP_001269526.1"
                     /db_xref="CCDS:CCDS62944.1"
                     /db_xref="GeneID:1496"
                     /db_xref="HGNC:HGNC:2510"
                     /db_xref="MIM:114025"
                     /translation="MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNK
                     GPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGET
                     MRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEAL
                     EAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNAT
                     MLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIGEL
                     AAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAE
                     CNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSF
                     LETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRM
                     AATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDD
                     FLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVY
                     TEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIR
                     KAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAK
                     IAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSD
                     VINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAE
                     VQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDS
                     SMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKK
                     PLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF"
     exon            265..460
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            461..627
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            628..747
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            748..1014
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1218
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1299
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1452
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1545
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1702
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1903
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2055
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2169
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2351
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2457
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2592
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2593..2736
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..3932
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3912..3917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /note="hexamer: AATAAA"
     polyA_site      3932
                     /gene="CTNNA2"
                     /gene_synonym="CAP-R; CAPR; CDCBM9; CT114; CTNR"
                     /note="major polyA site"
ORIGIN      
        1 agagcaggcg gcaccgcacc tcggccagag gcggctgcag cagctgctgc ccttgtccct
       61 gccgccgcct ctccagtccc ttctgtgatt accactccag ctgctgggaa cgggcgagaa
      121 agaggaggag gcgagaaact cccaccgacc cacagaggga gcatgacttc ggcaacttca
      181 cctatcattc tgaaatggga ccccaaaagt ttggaaatcc ggacgctaac agtggaaagg
      241 ctgttggagc cacttgttac acaggtgact acacttgtca acacaagcaa caaaggccca
      301 tctggtaaaa agaaagggag gtcaaagaaa gcccatgtac tagctgcctc tgtagagcaa
      361 gccactcaga atttcctgga aaagggtgaa cagatcgcta aggagagtca agatctcaaa
      421 gaagagttgg tggctgctgt agaggatgtg cgcaaacaag gtgagacgat gcggatcgcc
      481 tcctccgagt ttgcagatga cccttgctcg tcggtaaagc gcggcaccat ggtacgggcg
      541 gcaagggctt tgctctccgc ggtgacacgc ttactcatcc tggcggacat ggcagatgtc
      601 atgagacttt tatcccatct gaaaattgtg gaagaggccc tggaagctgt caaaaatgct
      661 acaaatgagc aagaccttgc aaaccgtttt aaagagtttg ggaaagagat ggtgaaactt
      721 aactatgtag cagcaagaag acaacaggag ctgaaggatc ctcactgtcg ggatgagatg
      781 gcagccgccc gaggggctct gaagaagaat gccacaatgc tgtacacggc ctctcaagca
      841 tttctccgcc acccagatgt cgccgctacg agagccaacc gagattatgt gttcaaacaa
      901 gtccaggagg ccatcgccgg catctccaat gctgctcaag ctacctcgcc cactgacgaa
      961 gccaagggcc acacgggcat cggcgagctg gctgcggctc ttaatgagtt tgacaataag
     1021 attatcctgg accccatgac gttcagcgag gccaggttcc ggccgtccct ggaggagagg
     1081 ctggagagca tcatcagcgg cgcagcgctg atggccgact cctcctgcac gcgagacgac
     1141 cggcgcgaga ggatcgtggc ggagtgcaac gccgtgcggc aggcgctcca ggacctgctc
     1201 agcgagtaca tgaataatac tggaaggaaa gaaaaaggag atcctctcaa cattgcgatt
     1261 gataagatga ctaagaaaac aagagatcta aggagacagc ttcggaaagc agtgatggat
     1321 cacatatctg actctttcct ggaaaccaat gttcctttgc tagttctcat tgaggctgca
     1381 aagagcggaa atgaaaagga agtgaaagaa tatgcccaag ttttccgtga gcatgccaac
     1441 aaactggtag aggttgccaa tttggcctgt tccatctcca acaatgaaga aggggtgaaa
     1501 ttagttcgga tggcagccac ccagattgac agcctgtgtc cccaggtcat caatgccgct
     1561 ctgacactgg ctgcccggcc acagagcaaa gttgctcagg ataacatgga cgtcttcaaa
     1621 gaccagtggg agaagcaggt ccgagtgttg acagaggccg tggatgacat cacctcagtg
     1681 gatgacttcc tctctgtctc agaaaatcac atcttggagg atgtgaacaa gtgtgtgata
     1741 gccctccaag agggcgatgt ggacactctg gaccggactg caggggccat caggggccgg
     1801 gcagctcgag tcatacacat catcaatgct gagatggaga actatgaagc tggggtttat
     1861 actgagaagg tgttggaagc tacaaaattg ctttctgaaa cagtgatgcc acgcttcgct
     1921 gaacaagtag aggttgccat tgaagccctg agtgccaacg ttcctcaacc gtttgaggag
     1981 aatgagttca tcgatgcctc tcgcctggtg tatgatggcg ttcgggacat cagaaaggct
     2041 gtgctgatga tcaggacccc agaagaacta gaggatgatt ctgactttga gcaggaagat
     2101 tatgatgtgc gtagcaggac aagtgttcag actgaggatg accagctcat tgcagggcag
     2161 agcgcacggg ccatcatggc gcaactaccg caggaggaga aggcaaaaat agctgagcag
     2221 gtggagatat tccatcaaga gaaaagcaag ctggatgcag aagtggccaa atgggacgac
     2281 agcggcaatg atatcattgt actggccaag cagatgtgta tgatcatgat ggaaatgaca
     2341 gacttcacaa gaggcaaagg cccattgaaa aatacatctg atgtcattaa tgctgccaag
     2401 aaaattgccg aagcaggttc tcgaatggac aaattagctc gtgctgtggc tgatcagtgt
     2461 cctgattcag catgtaagca ggatttatta gcctaccttc aacgaattgc cttgtattgc
     2521 catcagctta atatctgcag caaggtgaag gcagaagtgc agaatctggg aggagagctc
     2581 attgtgtcag ggacaggagt tcagagcact ttcactacct tttatgaggt agattgtgat
     2641 gtcatagatg ggggcagggc tagtcaactt tctacccacc tcccaacctg tgctgaggga
     2701 gctccgatcg ggagtggaag cagtgattcc tccatgctgg acagtgccac atcgcttatc
     2761 caggcagcta aaaacctgat gaatgctgtt gtcctcacgg tgaaagcatc ctatgtggcc
     2821 tcaaccaaat accagaaggt ctatgggaca gcagctgtca actcacctgt tgtgtcttgg
     2881 aagatgaagg ctccagagaa gaagcccctt gtgaagagag aaaagcctga agaattccag
     2941 acacgagttc gacgaggttc tcagaagaaa cacatttcgc ctgtacaggc tttaagtgaa
     3001 ttcaaagcaa tggattcctt ctaggacgat aggttttaac aagaaagctt tttctttctt
     3061 ttctttcttt ctttttcttt ttaattccat ttttgtatgc atacctgcca gctcgtatgc
     3121 ctctggcatg gggaaattaa gggaacagtg tctgtttgca tgtaagatga gatgagatca
     3181 atactactga tccatctgta gcctgggaag gagacaggac attcctgtac taaggtggca
     3241 cagagctgtc ctttgcaaca ttctcataaa attgggcaca gagttcgcat tggcgcaata
     3301 tttatgggag tgggagggat ggggaaaata aacttaactc tacaaaagca aactctaatg
     3361 catgcaagaa tcattaggtt ggcaggtata tgcataagtg aaaaatctgg aagtgtaatg
     3421 gtagaacata aaacttgtat tgcttctgtt tcagtgcaaa aatgtactag ccaatacgct
     3481 taagtgtgtg gcccatgaat tgaacaattt aaccttgaag tctatatccg tgatattatg
     3541 tcgattttta actgagggga aattaactag tccagcctaa aatgcttctt ttaatctgca
     3601 ttctgtttcc tcttctagtt gtgccattac tagtgatcat gtttttttcc cccctttaat
     3661 gaaaacaata aacatctatt tgagacaatt aaaatccttc tgggggcact ggaagcacaa
     3721 tacggtgacc aatcttgctt tcattttttt ttctttttaa tttgaaccat gattttgcta
     3781 gaaatagaag gcccagtggt ggaatattag agggaaggaa actgacaacg tgtgaaagtt
     3841 agaggcaaat acataggtgt agcttggagt gctggtatct aatataccat tgtattcact
     3901 aactaactca aaataaacac atttaatctt ga
//
