LOCUS       NM_001903               3754 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens catenin alpha 1 (CTNNA1), transcript variant 1, mRNA.
ACCESSION   NM_001903
VERSION     NM_001903.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Rangarajan,E.S., Smith,E.W. and Izard,T.
  TITLE     Distinct inter-domain interactions of dimeric versus monomeric
            alpha-catenin link cell junctions to filaments
  JOURNAL   Commun Biol 6 (1), 276 (2023)
   PUBMED   36928388
  REMARK    GeneRIF: Distinct inter-domain interactions of dimeric versus
            monomeric alpha-catenin link cell junctions to filaments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Coudert,M., Drouet,Y., Delhomelle,H., Svrcek,M., Benusiglio,P.R.,
            Coulet,F., Clark,D.F., Katona,B.W., van Hest,L.P., van der
            Kolk,L.E., Cats,A., van Dieren,J.M., Nehoray,B., Slavin,T.,
            Spier,I., Huneburg,R., Lobo,S., Oliveira,C., Boussemart,L.,
            Masson,L., Chiesa,J., Schwartz,M., Buecher,B., Golmard,L.,
            Bouvier,A.M., Bonadona,V., Stoppa-Lyonnet,D., Lasset,C. and
            Colas,C.
  TITLE     First estimates of diffuse gastric cancer risks for carriers of
            CTNNA1 germline pathogenic variants
  JOURNAL   J Med Genet 59 (12), 1189-1195 (2022)
   PUBMED   36038258
  REMARK    GeneRIF: First estimates of diffuse gastric cancer risks for
            carriers of CTNNA1 germline pathogenic variants.
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Carneiro,F.
  TITLE     Familial and hereditary gastric cancer, an overview
  JOURNAL   Best Pract Res Clin Gastroenterol 58-59, 101800 (2022)
   PUBMED   35988963
  REMARK    GeneRIF: Familial and hereditary gastric cancer, an overview.
            Review article
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Kim,M., Park,J., Bouhaddou,M., Kim,K., Rojc,A., Modak,M.,
            Soucheray,M., McGregor,M.J., O'Leary,P., Wolf,D., Stevenson,E.,
            Foo,T.K., Mitchell,D., Herrington,K.A., Munoz,D.P., Tutuncuoglu,B.,
            Chen,K.H., Zheng,F., Kreisberg,J.F., Diolaiti,M.E., Gordan,J.D.,
            Coppe,J.P., Swaney,D.L., Xia,B., van 't Veer,L., Ashworth,A.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein interaction landscape of breast cancer
  JOURNAL   Science 374 (6563), eabf3066 (2021)
   PUBMED   34591612
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Sacco,P.A., McGranahan,T.M., Wheelock,M.J. and Johnson,K.R.
  TITLE     Identification of plakoglobin domains required for association with
            N-cadherin and alpha-catenin
  JOURNAL   J Biol Chem 270 (34), 20201-20206 (1995)
   PUBMED   7650039
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Aberle,H., Butz,S., Stappert,J., Weissig,H., Kemler,R. and
            Hoschuetzky,H.
  TITLE     Assembly of the cadherin-catenin complex in vitro with recombinant
            proteins
  JOURNAL   J Cell Sci 107 (Pt 12), 3655-3663 (1994)
   PUBMED   7706414
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Barbosa-Matos,R., Cordova,L., Schrader,K. and Oliveira,C.
  TITLE     Diffuse Gastric and Lobular Breast Cancer Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301318
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Herrenknecht,K., Ozawa,M., Eckerskorn,C., Lottspeich,F., Lenter,M.
            and Kemler,R.
  TITLE     The uvomorulin-anchorage protein alpha catenin is a vinculin
            homologue
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9156-9160 (1991)
   PUBMED   1924379
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Nagafuchi,A., Takeichi,M. and Tsukita,S.
  TITLE     The 102 kd cadherin-associated protein: similarity to vinculin and
            posttranscriptional regulation of expression
  JOURNAL   Cell 65 (5), 849-857 (1991)
   PUBMED   1904011
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC369291.1, BC000385.2 and
            AI078507.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001903.4.
            
            Summary: This gene encodes a member of the catenin family of
            proteins that play an important role in cell adhesion process by
            connecting cadherins located on the plasma membrane to the actin
            filaments inside the cell. The encoded mechanosensing protein
            contains three vinculin homology domains and undergoes
            conformational changes in response to cytoskeletal tension,
            resulting in the reconfiguration of cadherin-actin filament
            connections. Certain mutations in this gene cause butterfly-shaped
            pigment dystrophy. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.183070.1,
                                           SRR1803614.52802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302763.12/ ENSP00000304669.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                DC369291.1         30-52
            24-3432             BC000385.2         1-3409
            3433-3754           AI078507.1         9-330               c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..3754
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="catenin alpha 1"
                     /db_xref="GeneID:1495"
                     /db_xref="HGNC:HGNC:2509"
                     /db_xref="MIM:116805"
     exon            1..86
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            87..193
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..2809
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alpha-E-catenin; renal carcinoma antigen NY-REN-13;
                     catenin (cadherin-associated protein), alpha 1, 102kDa;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="catenin alpha-1 isoform 1"
                     /protein_id="NP_001894.2"
                     /db_xref="CCDS:CCDS34243.1"
                     /db_xref="GeneID:1495"
                     /db_xref="HGNC:HGNC:2509"
                     /db_xref="MIM:116805"
                     /translation="MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNS
                     KGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGD
                     LMKAAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDG
                     ILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGHRDQMAAARGILQKNV
                     PILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDASQHQGGGGG
                     ELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIV
                     AECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSD
                     SFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLV
                     RMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSI
                     DDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPG
                     VYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRD
                     IRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKA
                     KIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTS
                     DVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKA
                     EVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPA
                     VSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI"
     exon            194..389
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..556
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            557..676
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..946
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1150
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1231
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1384
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1477
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1634
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1835
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1987
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2098
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2280
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2386
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2387..2521
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..3754
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3410..3415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="hexamer: AATAAA"
     polyA_site      3432
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="major polyA site"
     regulatory      3728..3733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="hexamer: AATAAA"
     polyA_site      3754
                     /gene="CTNNA1"
                     /gene_synonym="CAP102; MDBS2; MDPT2"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctag ccggactgga gggagacaaa gcagcgcccg tctgcttcgg gcctctggaa
       61 tttagcgctc gcccagctag ccgcagaaat gactgctgtc catgcaggca acataaactt
      121 caagtgggat cctaaaagtc tagagatcag gactctggca gttgagagac tgttggagcc
      181 tcttgttaca caggttacaa cccttgtaaa caccaatagt aaagggccct ctaataagaa
      241 gagaggtcgt tctaagaagg cccatgtttt ggctgcatct gttgaacaag caactgagaa
      301 tttcttggag aagggggata aaattgcgaa ggagagccag tttctcaagg aggagcttgt
      361 ggctgctgta gaagatgttc gaaaacaagg tgatttgatg aaggctgctg caggagagtt
      421 cgcagatgat ccctgctctt ctgtgaagcg aggcaacatg gttcgggcag ctcgagcttt
      481 gctctctgct gttacccggt tgctgatttt ggctgacatg gcagatgtct acaaattact
      541 tgttcagctg aaagttgtgg aagatggtat cttgaagttg aggaatgctg gcaatgaaca
      601 agacttagga atccagtata aagccctaaa acctgaagtg gataagctga acattatggc
      661 agccaaaaga caacaggaat tgaaagatgt tggccatcgt gatcagatgg ctgcagctag
      721 aggaatcctg cagaagaacg ttccgatcct ctatactgca tcccaggcat gcctacagca
      781 ccctgatgtc gcagcctata aggccaacag ggacctgata tacaagcagc tgcagcaggc
      841 ggtcacaggc atttccaatg cagcccaggc cactgcctca gacgatgcct cacagcacca
      901 gggtggagga ggaggagaac tggcatatgc actcaataac tttgacaaac aaatcattgt
      961 ggaccccttg agcttcagcg aggagcgctt taggccttcc ctggaggagc gtctggaaag
     1021 catcattagt ggggctgcct tgatggccga ctcgtcctgc acgcgtgatg accgtcgtga
     1081 gcgaattgtg gcagagtgta atgctgtccg ccaggccctg caggacctgc tttcggagta
     1141 catgggcaat gctggacgta aagaaagaag tgatgcactc aattctgcaa tagataaaat
     1201 gaccaagaag accagggact tgcgtagaca gctccgcaaa gctgtcatgg accacgtttc
     1261 agattctttc ctggaaacca atgttccact tttggtattg attgaagctg caaagaatgg
     1321 aaatgagaaa gaagttaagg agtatgccca agttttccgt gaacatgcca acaaattgat
     1381 tgaggttgcc aacttggcct gttccatctc aaataatgaa gaaggtgtaa agcttgttcg
     1441 aatgtctgca agccagttag aagccctctg tcctcaggtt attaatgctg cactggcttt
     1501 agcagcaaaa ccacagagta aactggccca agagaacatg gatcttttta aagaacaatg
     1561 ggaaaaacaa gtccgtgttc tcacagatgc tgtcgatgac attacttcca ttgatgactt
     1621 cttggctgtc tcagagaatc acattttgga agatgtgaac aaatgtgtca ttgctctcca
     1681 agagaaggat gtggatggcc tggaccgcac agctggtgca attcgaggcc gggcagcccg
     1741 ggtcattcac gtagtcacct cagagatgga caactatgag ccaggagtct acacagagaa
     1801 ggttctggaa gccactaagc tgctctccaa cacagtcatg ccacgtttta ctgagcaagt
     1861 agaagcagcc gtggaagccc tcagctcgga ccctgcccag cccatggatg agaatgagtt
     1921 tatcgatgct tcccgcctgg tatatgatgg catccgggac atcaggaaag cagtgctgat
     1981 gataaggacc cctgaggagt tggatgactc tgactttgag acagaagatt ttgatgtcag
     2041 aagcaggacg agcgtccaga cagaagacga tcagctgata gctggccaga gtgcccgggc
     2101 gatcatggct cagcttcccc aggagcaaaa agcgaagatt gcggaacagg tggccagctt
     2161 ccaggaagaa aagagcaagc tggatgctga agtgtccaaa tgggacgaca gtggcaatga
     2221 catcattgtg ctggccaagc agatgtgcat gattatgatg gagatgacag actttacccg
     2281 aggtaaagga ccactcaaaa atacatcgga tgtcatcagt gctgccaaga aaattgctga
     2341 ggcaggatcc aggatggaca agcttggccg caccattgca gaccattgcc ccgactcggc
     2401 ttgcaagcag gacctgctgg cctacctgca acgcatcgcc ctctactgcc accagctgaa
     2461 catctgcagc aaggtcaagg ccgaggtgca gaatctcggc ggggagcttg ttgtctctgg
     2521 ggtggacagc gccatgtccc tgatccaggc agccaagaac ttgatgaatg ctgtggtgca
     2581 gacagtgaag gcatcctacg tcgcctctac caaataccaa aagtcacagg gtatggcttc
     2641 cctcaacctt cctgctgtgt catggaagat gaaggcacca gagaaaaagc cattggtgaa
     2701 gagagagaaa caggatgaga cacagaccaa gattaaacgg gcatctcaga agaagcacgt
     2761 gaacccggtg caggccctca gcgagttcaa agctatggac agcatctaag tctgcccagg
     2821 ccggccgccc ccacccctcg gggctcctga atatcagtca ctgttcgtca ctcaaatgaa
     2881 tttgctaaat acaacactga tactagattc cacagggaaa tgggcagact gaaccagtcc
     2941 aggtggtgaa ttttccaaga acatagttta agttgattaa aaatgctttt agaatgcagg
     3001 agcctacttc tagctgtatt ttttgtatgc ttaaataaaa ataaaaattc ataaccaaag
     3061 agaatcccac attagcttgt tagtaatgct ctgaccaagc cgagatgccc attctcttag
     3121 tgatggcggc gttagggttt gagagaaggg aatttggctc aacttcagtt gagagggtgc
     3181 agtccagaca gcttgactgc ttttaaatga ccaaagatga cctgtggtaa gcaacctggg
     3241 catcttagga agcagtccct ggagaaggca tgttcccaga aaggtctctg gagggacaaa
     3301 ctcactcagt aaaacataat gtatcatgaa gaaaactgat tctctatgac atgaaatgaa
     3361 aattttaatg cattgttata attactaatg tacgctgctg caggacatta ataaagttgc
     3421 ttttttaggc tacagtgtct cgatgccata atcagaacac actttttttc ctctttctcc
     3481 cagcttcaaa tgcaaattca tcattgggct cacttctaat aactgcagtg tttcccgcct
     3541 tgggcttgca gcagaaaaac ctgacaacat agtgtttgct aaggcagtaa tttagacttt
     3601 accttatttg tgattactgt agtgattgat tgattgatta ctattaacta caaggtataa
     3661 tttactatca ccttatttaa attttatgaa ttaatttgaa tgttttttac actaactaac
     3721 ttttcccaat aaagtccact atgaaaccac gaca
//
