LOCUS       NM_014772               5765 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cap binding complex dependent translation initiation
            factor (CTIF), transcript variant 1, mRNA.
ACCESSION   NM_014772 XM_375538
VERSION     NM_014772.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5765)
  AUTHORS   Park,Y., Park,J., Hwang,H.J., Kim,L., Jeong,K., Song,H.K.,
            Rufener,S.C., Muhlemann,O. and Kim,Y.K.
  TITLE     Translation mediated by the nuclear cap-binding complex is confined
            to the perinuclear region via a CTIF-DDX19B interaction
  JOURNAL   Nucleic Acids Res 49 (14), 8261-8276 (2021)
   PUBMED   34232997
  REMARK    GeneRIF: Translation mediated by the nuclear cap-binding complex is
            confined to the perinuclear region via a CTIF-DDX19B interaction.
REFERENCE   2  (bases 1 to 5765)
  AUTHORS   Garcia-de-Gracia,F., Gaete-Argel,A., Riquelme-Barrios,S.,
            Pereira-Montecinos,C., Rojas-Araya,B., Aguilera,P.,
            Oyarzun-Arrau,A., Rojas-Fuentes,C., Acevedo,M.L., Chnaiderman,J.,
            Valiente-Echeverria,F., Toro-Ascuy,D. and Soto-Rifo,R.
  TITLE     CBP80/20-dependent translation initiation factor (CTIF) inhibits
            HIV-1 Gag synthesis by targeting the function of the viral protein
            Rev
  JOURNAL   RNA Biol 18 (5), 745-758 (2021)
   PUBMED   33103564
  REMARK    GeneRIF: CBP80/20-dependent translation initiation factor (CTIF)
            inhibits HIV-1 Gag synthesis by targeting the function of the viral
            protein Rev.
REFERENCE   3  (bases 1 to 5765)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5765)
  AUTHORS   Krastev,D.B., Pettitt,S.J., Campbell,J., Song,F., Tanos,B.E.,
            Stoynov,S.S., Ashworth,A. and Lord,C.J.
  TITLE     Coupling bimolecular PARylation biosensors with genetic screens to
            identify PARylation targets
  JOURNAL   Nat Commun 9 (1), 2016 (2018)
   PUBMED   29789535
  REMARK    GeneRIF: CTIF was identified as a novel PARylation target of the
            TNKS2 in the centrosomal region of cells, which plays a role in the
            distribution of the centrosomal satellites.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5765)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 5765)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5765)
  AUTHORS   Anttila,V., Winsvold,B.S., Gormley,P., Kurth,T., Bettella,F.,
            McMahon,G., Kallela,M., Malik,R., de Vries,B., Terwindt,G.,
            Medland,S.E., Todt,U., McArdle,W.L., Quaye,L., Koiranen,M.,
            Ikram,M.A., Lehtimaki,T., Stam,A.H., Ligthart,L., Wedenoja,J.,
            Dunham,I., Neale,B.M., Palta,P., Hamalainen,E., Schurks,M.,
            Rose,L.M., Buring,J.E., Ridker,P.M., Steinberg,S., Stefansson,H.,
            Jakobsson,F., Lawlor,D.A., Evans,D.M., Ring,S.M., Farkkila,M.,
            Artto,V., Kaunisto,M.A., Freilinger,T., Schoenen,J., Frants,R.R.,
            Pelzer,N., Weller,C.M., Zielman,R., Heath,A.C., Madden,P.A.F.,
            Montgomery,G.W., Martin,N.G., Borck,G., Gobel,H., Heinze,A.,
            Heinze-Kuhn,K., Williams,F.M.K., Hartikainen,A.L., Pouta,A., van
            den Ende,J., Uitterlinden,A.G., Hofman,A., Amin,N., Hottenga,J.J.,
            Vink,J.M., Heikkila,K., Alexander,M., Muller-Myhsok,B.,
            Schreiber,S., Meitinger,T., Wichmann,H.E., Aromaa,A.,
            Eriksson,J.G., Traynor,B., Trabzuni,D., Rossin,E., Lage,K.,
            Jacobs,S.B.R., Gibbs,J.R., Birney,E., Kaprio,J., Penninx,B.W.,
            Boomsma,D.I., van Duijn,C., Raitakari,O., Jarvelin,M.R.,
            Zwart,J.A., Cherkas,L., Strachan,D.P., Kubisch,C., Ferrari,M.D.,
            van den Maagdenberg,A.M.J.M., Dichgans,M., Wessman,M., Smith,G.D.,
            Stefansson,K., Daly,M.J., Nyholt,D.R., Chasman,D. and Palotie,A.
  CONSRTM   North American Brain Expression Consortium; UK Brain Expression
            Consortium
  TITLE     Genome-wide meta-analysis identifies new susceptibility loci for
            migraine
  JOURNAL   Nat Genet 45 (8), 912-917 (2013)
   PUBMED   23793025
REFERENCE   8  (bases 1 to 5765)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   9  (bases 1 to 5765)
  AUTHORS   Choe,J., Cho,H., Chi,S.G. and Kim,Y.K.
  TITLE     Ago2/miRISC-mediated inhibition of CBP80/20-dependent translation
            and thereby abrogation of nonsense-mediated mRNA decay require the
            cap-associating activity of Ago2
  JOURNAL   FEBS Lett 585 (17), 2682-2687 (2011)
   PUBMED   21840310
  REMARK    GeneRIF: Study reveals that Ago2, but not Ago2F2V2, inhibits the
            binding of CBP80/20 to cap structure.
REFERENCE   10 (bases 1 to 5765)
  AUTHORS   Kim,K.M., Cho,H., Choi,K., Kim,J., Kim,B.W., Ko,Y.G., Jang,S.K. and
            Kim,Y.K.
  TITLE     A new MIF4G domain-containing protein, CTIF, directs nuclear
            cap-binding protein CBP80/20-dependent translation
  JOURNAL   Genes Dev 23 (17), 2033-2045 (2009)
   PUBMED   19648179
  REMARK    GeneRIF: a new MIF4G domain-containing protein, CTIF that interacts
            directly with CBP80 and is part of the CBP80/20-dependent
            translation initiation complex [CBP80/20-dependent translation
            initiation factor, CTIF]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC048380.12, AB007887.1, AK095970.1, BC042146.1 and BU688371.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014772.2.
            
            Summary: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20
            (NCBP2; MIM 605133) translation initiation complex that binds
            cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20
            complex is involved in a simultaneous editing and translation step
            that recognizes premature termination codons (PTCs) in mRNAs and
            directs PTC-containing mRNAs toward nonsense-mediated decay (NMD).
            On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with
            cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM
            600495), and steady-state translation of the mRNAs resumes in the
            cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM,
            Dec 2009].
            
            Transcript Variant: This variant (1) represents the more
            predominant transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007887.1, SRR7346977.2419178.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256413.8/ ENSP00000256413.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC048380.12        145655-145679       c
            26-1191             AB007887.1         1-1166
            1192-2044           AK095970.1         900-1752
            2045-2864           AB007887.1         2020-2839
            2865-4065           BC042146.1         2771-3971
            4066-5741           AB007887.1         4041-5716
            5742-5765           BU688371.1         9-32                c
FEATURES             Location/Qualifiers
     source          1..5765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..5765
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /note="cap binding complex dependent translation
                     initiation factor"
                     /db_xref="GeneID:9811"
                     /db_xref="HGNC:HGNC:23925"
                     /db_xref="MIM:613178"
     exon            1..282
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            283..490
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..2107
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CBP80/20-dependent translation initiation factor"
                     /codon_start=1
                     /product="CBP80/20-dependent translation initiation factor
                     isoform 1"
                     /protein_id="NP_055587.1"
                     /db_xref="CCDS:CCDS11935.1"
                     /db_xref="GeneID:9811"
                     /db_xref="HGNC:HGNC:23925"
                     /db_xref="MIM:613178"
                     /translation="MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADK
                     TEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDNSLDMLGTDIWAA
                     NTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLND
                     IEKVLPAWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAK
                     HNRDHQKSYQGGSAPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGAHRNAKETMT
                     IENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERI
                     GERPKITLLQSSKDRLRRRLKEKDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVDTK
                     LTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRS
                     LLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLR
                     ELLQSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSL
                     LLEVIELHANSWNPLTPPITQYYNRTIQKLTA"
     exon            491..562
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            563..636
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            637..741
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            742..817
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            818..894
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1381
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1681
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1837
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1891
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..5765
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5740..5745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /note="hexamer: AATAAA"
     polyA_site      5747
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /note="major polyA site"
     polyA_site      5765
                     /gene="CTIF"
                     /gene_synonym="Gm672; KIAA0427"
                     /note="major polyA site"
ORIGIN      
        1 actctcctac attctctttc cctgtgtcag atcagggatc attttttttc cttcctctac
       61 tccctccccc ctacccgccc ctccctccct gtttcccttc cctccctccc tcccctctct
      121 gctgggtctg tgcgctgggg cgcccgatcc cctccgcagc tgggacgctc cgaactcgag
      181 gcaggagtcg gctctccgga gcctcgtccc tcccttcccc ttccctgccc ccttccccca
      241 cccccgactc gggcttggcg cggcggccag aggaaccccg agtcccggcc caggcccctg
      301 agctggaggg atggaaaact cctctgcagc atcagcctcc tcggaggcag ggagcagccg
      361 ctcccaggag atcgaggagc tggagcgctt catcgacagc tacgtgctgg agtaccaggt
      421 gcaggggctg ctggctgaca agacggaggg tgatggcgag agcgagagga cccagtccca
      481 catctcccag tggacagcgg actgcagcga accgctggac agcagctgtt ccttctcccg
      541 agggcgagcc cccccacagc agaatggcag caaagacaac tctctggaca tgctgggcac
      601 ggacatctgg gcggccaaca ccttcgattc cttcagtggt gccacctggg acctgcagcc
      661 ggaaaagctg gacttcaccc agttccaccg caaagtccga cacacgccca agcagcccct
      721 gccacacatc gaccgcgaag ggtgtggcaa agggaagctg gaagatgggg atggcatcaa
      781 cctgaatgac atcgagaagg tccttccagc ctggcagggc taccacccga tgccccatga
      841 agtggagatc gcacacacca agaagctgtt ccgcaggagg agaaatgatc gaaggcggca
      901 gcagagacct ccggggggca acaagcccca acagcatggt gaccaccagc caggcagtgc
      961 caaacacaac agggaccacc agaaatccta ccaggggggc tcagcacccc acccctcagg
     1021 gaggcccact caccatggct acagccagaa ccggcgctgg caccatggca acatgaagca
     1081 cccaccaggc gacaaggggg aggcaggcgc acaccgcaat gccaaagaga ccatgaccat
     1141 cgagaaccca aaactggagg acactgcagg ggacaccggg cacagcagcc ttgaggcccc
     1201 ccgcagccct gacaccctgg ccccggtggc ttctgagcgg ctgcccccac agcagtcagg
     1261 ggggccagag gttgagacaa aacgtaaaga cagtattctt cccgagcgca tcggggagcg
     1321 gcccaaaatt accctgctcc agtcttccaa agacagactg cggcgaaggc taaaggaaaa
     1381 ggatgaagtg gccgtggaga cgaccactcc ccagcagaac aagatggaca agctgatcga
     1441 gatcctgaac agcatgcgga acaacagcag cgacgtggac accaagctca ccaccttcat
     1501 ggaggaggcc cagaactcca ccaactccga ggagatgctg ggcgagatcg tgcgcacaat
     1561 ctaccagaag gctgtgtccg accgcagctt cgccttcacc gctgccaagc tctgcgacaa
     1621 gatggcgctc tttatggtgg aggggaccaa gttccggagc ctgctcctca acatgctgca
     1681 gaaggacttc acggtgcgcg aggagctgca gcagcaggac gtggagcgct ggctgggctt
     1741 catcaccttc ctgtgcgagg tcttcggcac catgcgcagc agcacaggcg agcccttccg
     1801 tgtgctcgtg tgccccatct acacctgcct cagggagctc ttgcaatctc aggatgtgaa
     1861 ggaagatgct gtcctttgct gctctatgga gctgcagagt acaggccggc tgctggagga
     1921 acagctgcct gagatgatga cagagctcct ggccagcgca cgggacaaga tgctgtgccc
     1981 ctcggagtcc atgctgaccc ggtcgctgct cctagaggtc atcgagctcc acgctaacag
     2041 ctggaaccct ctgacgcccc ccatcacgca gtactacaac agaaccatcc agaaactgac
     2101 agcctgacag ccagggggcc tggcaggcgg cccacgggca gctggggccc tggtgcacag
     2161 ggccagatgg acaggcggga ggacaggggt ggccctggcg ggagaaagaa atggggagga
     2221 gggcaggcag agtcggtggc cagtctggag ccagacgggg aagggagcaa atccctgaga
     2281 ggagtgcccc cgcacaagcc ccccagcccg agcatgcaag ctcacaccaa taagggaagc
     2341 atgtttcttt ttcctggtgg ccctggccct ccccttcctc actcccgcct ctcccctccc
     2401 catcagaccc atcccccacg gagctttgtg tgagggatct catcgctgtg actcctcgga
     2461 gaccttggca gcctcgcacg ccggggcacc gcttgggtca gaaaggacct cggaaggctg
     2521 aaaaagtggg tcggagacgg gctcgcattg ttcccgcatg ctgtcagccg cagtcgccaa
     2581 ctggcagcag gcgacgtgta gcagatgtcc gggaggacaa aggcaggcac ggtccccacc
     2641 agccgcccgt aattgacggc ctttgtcagc catggcagag ctgacgctcc acctcccacc
     2701 tccaagtcct cctcactgca gcccccacag cctcaggcct agggggtcag gcgcagcggg
     2761 ggagatggag tttgcagttc cacttgcact cttttgttta ttgtgtttta tttttcaaaa
     2821 gtcggttgct ttgaagtctc tttggccaat gaaaatgccc gtgatgtgat cacacagtca
     2881 gcactgttga ggacccccgg attagtggga gatcaaaccc agctcccctc tagaagaagg
     2941 attcgagcca cagacagctt gccagtagcc aattagggta attggaaact tctgccccgg
     3001 cggggggtcc ccgctggaat cctgtgttcc tcgccactgg cttccagcgc ctctgttttc
     3061 tcaaagggct gatactgtca ccactgggac caagttaaac ctggtcctgg ccccaggggc
     3121 cttgtggcaa acagggcaca gaacgagact ggcaaattaa aaccaaaatt ctagatggtg
     3181 tcttgcgctc cacacgcagg tcttactggg gaaaaggatg ggagtggggg ctccccagga
     3241 ctcgatttta gctaatgcgc tgtgtcactg ccccagctcg gacgtagaag cccagccctc
     3301 cgtgagctct tgggaaaggg gtgaattcac tgggtcatgg aagggacagt caggtgacca
     3361 gcggggtcgc cagatgaagc ttcccagccg ggaaacaaga cggggtttct tggcaggccc
     3421 tggtcctggg gagcaggccc tgttgttggc tggagaggaa ggtgtggggt ggaacaggtg
     3481 tccacatagc tccatctctg ggggctggag cacacacttt gatgagcccc cccggaaatg
     3541 atgtcagagc ctagccgctt ccttatttgc tcttttattg aggccgggca ggccctgggt
     3601 cactttggag gcccctcttg gtccacactg gactggccgg gaggtgatgg gcggggaagg
     3661 ttctcgtgat tgattgattc tgagtctgag agtggcgagt ggggagaggc ttccccagtt
     3721 ctctccagct ttccctgcag ctgcaacctg ccctctggtc ccaggtgtgg agcctttgcc
     3781 tgtctctaaa aagagcctgt tggcgacaag gtgtaggggg cacaagttta cctgaaacag
     3841 gtcagtggtc tctcccaaga agcgcacgcc acctctggtc cctggccctg aaccctgcct
     3901 tcttcctccc tccacggttt cttcccagac tttctcaagc tcctcctcac tgcccttcct
     3961 ccccagccca gcctgggaac acagatgccc cgcgggtagg aggcctcgag ggaggagccg
     4021 ggctgatgcg gggctgctca gggcaggccc cagggcgagc ttgccatcgt ggccaggcag
     4081 cctccacctg tgcttcagtg gcccctgccc ccctgaagca tgtggggttt gtccgctagg
     4141 aggaggcaag gcccccgaag agaggagaga cctgggagtg ggagctcagg tcagggagga
     4201 ggcaggggag tggggtctcc cagacccaac ggtgagctca gagcaagctt cacgcaggac
     4261 gctccgaaac actgtgtgga gggggctgtg ttgtgggcac cttggggcct gattctcctt
     4321 cctccgaacg ggctccttga tggcctggcc acaggggcag ctccccattg gctgttagga
     4381 ccagagtgtg aagaagaagt gaaatataaa tatgtataca tatataaata tatttttaat
     4441 tacatgtcgt gtcacggtgg ctccagacat actgtttgcc tagtttattc cactgcttga
     4501 aagcgcttcc tagccaatct gaacaacaac actttaagct gtttttctaa atgcaggttg
     4561 ctgctccttt ttcagatatg gaaggaaaac gttaagacta tttttttttt aaagaaacaa
     4621 cagtcaagcc taaaatttga gaccccgagg cagcttcccg agggagactg ctcagacagg
     4681 aactgcagga cagaagtgga tgccccacag accctggccc cctccccaag tccatcccct
     4741 ctctgtggca tgaggaaggc cgcgtccgag ttgacctctg aatgtatgtg atgagaggca
     4801 gagctggata ttgcatttct aaggcttgca ttgctttccc ctcgcccgcg gttcttggcg
     4861 catggaagag gcggtccagc catctgatgt tgatcctgtc tcagtctccc cactgcctgt
     4921 caggatgagt tagtcattgt ttttctccga ggcggcctgc ttgccacagc cctgctcccc
     4981 aaggcctggt ggctttgccg aagctctggg accgcagccc cagcgaggcc cccaacctca
     5041 cccagacgag gccaggagcc ccgccaccct ccacgggatg tgcaccctca gaccccattc
     5101 tctctgttcg tccttccttg accagtctgt aaaccttcac tgtttgggga tcgtcctgtc
     5161 catccatgta aatgtaaatg ttggccgagt cggtatttat tctgattgat ttttatttta
     5221 ttctattatt ttctccgagg gatgagggtg gggggtgtgg gaagggtacc acagatcagg
     5281 ccggggcagc tgtaggggcg ggggcccaga cagccaggcc gccaccagag cagccccatg
     5341 gggtgcccca gacgcgggcc tccaagaagc caagtcccag tctgttttct ggcatcagac
     5401 accggcccgt gttccttgtc agacagacag actctcaggc ctgcctgggg agtcgtgtcc
     5461 ctcagctgca gggcactgtg ttgggaaacc attggctggg cctttgagga cacagatcag
     5521 aagaaagaaa gacaactttc ctctgcgcgg aacactcaca cggaagggct ggccgcctcc
     5581 ctgagccggc tgggagtgga cgacaggacc tacctcccca gagcaagggc ctggggcttc
     5641 ccgccaaagc tgccgcggaa ccccgctagt gcgaccaccc tccctccgtc ggtatgtcct
     5701 gctttccagc tgaacccaaa ctacaagtgg gtttaaaaaa ataaacacca ccaccaaaaa
     5761 caaaa
//
