LOCUS       NM_138455               1240 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens collagen triple helix repeat containing 1 (CTHRC1),
            transcript variant 1, mRNA.
ACCESSION   NM_138455
VERSION     NM_138455.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1240)
  AUTHORS   Liu,Y., Chen,X., Xu,Y., Yang,T., Wang,H., Wang,Z., Hu,Z., Chen,L.,
            Zhang,Z. and Wu,Y.
  TITLE     CTHRC1 promotes colorectal cancer progression by recruiting
            tumor-associated macrophages via up-regulation of CCL15
  JOURNAL   J Mol Med (Berl) 102 (1), 81-94 (2024)
   PUBMED   37987774
  REMARK    GeneRIF: CTHRC1 promotes colorectal cancer progression by
            recruiting tumor-associated macrophages via up-regulation of CCL15.
REFERENCE   2  (bases 1 to 1240)
  AUTHORS   Toomey,B.H., Mitrovic,S.A., Lindner-Liaw,M., Leon Vazquez,R.G.,
            Kacer,D., Ryzhov,S., Prudovsky,I. and Lindner,V.
  TITLE     Activated CTHRC1 promotes glycolysis in endothelial cells:
            Implications for metabolism and angiogenesis
  JOURNAL   Vascul Pharmacol 153, 107246 (2023)
   PUBMED   38040222
  REMARK    GeneRIF: Activated CTHRC1 promotes glycolysis in endothelial cells:
            Implications for metabolism and angiogenesis.
REFERENCE   3  (bases 1 to 1240)
  AUTHORS   Li,G., Li,X., Li,Z., Luo,X., Jing,L., Guo,D., Guan,K., Yuan,F. and
            Pan,B.
  TITLE     Sox2ot /miR-9 /Cthrc1 Promote Proliferation and Migration of
            Schwann Cells Following Nerve Injury
  JOURNAL   Neuroscience 519, 47-59 (2023)
   PUBMED   36924985
  REMARK    GeneRIF: Sox2ot /miR-9 /Cthrc1 Promote Proliferation and Migration
            of Schwann Cells Following Nerve Injury.
REFERENCE   4  (bases 1 to 1240)
  AUTHORS   Baiken,Y., Markhametova,Z., Ashimova,A., Zhulamanova,A.,
            Nogaibayeva,A., Kozina,L., Matkarimov,B., Aituov,B., Gaipov,A. and
            Myngbay,A.
  TITLE     Elevated Levels of Plasma Collagen Triple Helix Repeat Containing 1
            (CTHRC1) Are Strongly Associated with eGFR and Albuminuria in
            Chronic Kidney Disease
  JOURNAL   Medicina (Kaunas) 59 (4), 651 (2023)
   PUBMED   37109608
  REMARK    GeneRIF: Elevated Levels of Plasma Collagen Triple Helix Repeat
            Containing 1 (CTHRC1) Are Strongly Associated with eGFR and
            Albuminuria in Chronic Kidney Disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1240)
  AUTHORS   Liu,K., Li,X., Yang,Z. and Zhang,R.
  TITLE     Activation of CTHRC1 by HOXB9 Promotes Angiogenesis through Fatty
            Acid Metabolism in Lung Adenocarcinoma
  JOURNAL   Rev Invest Clin 75 (2), 63-75 (2022)
   PUBMED   37205792
  REMARK    GeneRIF: Activation of CTHRC1 by HOXB9 Promotes Angiogenesis
            through Fatty Acid Metabolism in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 1240)
  AUTHORS   Wang,P., Wang,Y.C., Chen,X.Y., Shen,Z.Y., Cao,H., Zhang,Y.J.,
            Yu,J., Zhu,J.D., Lu,Y.Y. and Fang,J.Y.
  TITLE     CTHRC1 is upregulated by promoter demethylation and transforming
            growth factor-beta1 and may be associated with metastasis in human
            gastric cancer
  JOURNAL   Cancer Sci 103 (7), 1327-1333 (2012)
   PUBMED   22590977
  REMARK    GeneRIF: Data indicate that the upregulated expression of collagen
            triple helix repeat containing 1 (CTHRC1) in gastric carcinogenesis
            contributes to tumor cell invasion and metastasis.
REFERENCE   7  (bases 1 to 1240)
  AUTHORS   Orloff,M., Peterson,C., He,X., Ganapathi,S., Heald,B., Yang,Y.R.,
            Bebek,G., Romigh,T., Song,J.H., Wu,W., David,S., Cheng,Y.,
            Meltzer,S.J. and Eng,C.
  TITLE     Germline mutations in MSR1, ASCC1, and CTHRC1 in patients with
            Barrett esophagus and esophageal adenocarcinoma
  JOURNAL   JAMA 306 (4), 410-419 (2011)
   PUBMED   21791690
  REMARK    GeneRIF: Three major genes, MSR1, ASCC1, and CTHRC1 were associated
            with Barrett esophagus/esophageal adenocarcinoma
REFERENCE   8  (bases 1 to 1240)
  AUTHORS   Leclair,R.J., Wang,Q., Benson,M.A., Prudovsky,I. and Lindner,V.
  TITLE     Intracellular localization of Cthrc1 characterizes differentiated
            smooth muscle
  JOURNAL   Arterioscler Thromb Vasc Biol 28 (7), 1332-1338 (2008)
   PUBMED   18467647
  REMARK    GeneRIF: Intracellular localization of Cthrc1 characterizes
            differentiated smooth muscle.
REFERENCE   9  (bases 1 to 1240)
  AUTHORS   Tang,L., Dai,D.L., Su,M., Martinka,M., Li,G. and Zhou,Y.
  TITLE     Aberrant expression of collagen triple helix repeat containing 1 in
            human solid cancers
  JOURNAL   Clin Cancer Res 12 (12), 3716-3722 (2006)
   PUBMED   16778098
  REMARK    GeneRIF: Aberrant expression of CTHRC1 is widely present in human
            solid cancers and seems to be associated with cancer tissue
            invasion and metastasis.
REFERENCE   10 (bases 1 to 1240)
  AUTHORS   Pyagay,P., Heroult,M., Wang,Q., Lehnert,W., Belden,J., Liaw,L.,
            Friesel,R.E. and Lindner,V.
  TITLE     Collagen triple helix repeat containing 1, a novel secreted protein
            in injured and diseased arteries, inhibits collagen expression and
            promotes cell migration
  JOURNAL   Circ Res 96 (2), 261-268 (2005)
   PUBMED   15618538
  REMARK    GeneRIF: CTHRC1 is transiently expressed in the arterial wall in
            response to injury where it may contribute to vascular remodeling
            by limiting collagen matrix deposition and promoting cell
            migration.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021025.1, BI763295.1 and
            AI743774.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_138455.3.
            
            Summary: This locus encodes a protein that may play a role in the
            cellular response to arterial injury through involvement in
            vascular remodeling. Mutations at this locus have been associated
            with Barrett esophagus and esophageal adenocarcinoma. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014245.2, BC021025.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330295.10/ ENSP00000330523.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-766               BC021025.1         24-789
            767-1054            BI763295.1         424-711
            1055-1240           AI743774.1         20-205              c
FEATURES             Location/Qualifiers
     source          1..1240
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.3"
     gene            1..1240
                     /gene="CTHRC1"
                     /note="collagen triple helix repeat containing 1"
                     /db_xref="GeneID:115908"
                     /db_xref="HGNC:HGNC:18831"
                     /db_xref="MIM:610635"
     exon            1..269
                     /gene="CTHRC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..851
                     /gene="CTHRC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; collagen triple helix repeat-containing protein
                     1"
                     /codon_start=1
                     /product="collagen triple helix repeat-containing protein
                     1 isoform 1 precursor"
                     /protein_id="NP_612464.1"
                     /db_xref="CCDS:CCDS6299.1"
                     /db_xref="GeneID:115908"
                     /db_xref="HGNC:HGNC:18831"
                     /db_xref="MIM:610635"
                     /translation="MRPQGPAASPQRLRGLLLLLLLQLPAPSSASEIPKGKQKAQLRQ
                     REVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESW
                     TPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFT
                     FNGAECSGPLPIEAIIYLDQGSPEMNSTINIHRTSSVEGLCEGIGAGLVDVAIWVGTC
                     SDYPKGDASTGWNSVSRIIIEELPK"
     exon            270..491
                     /gene="CTHRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..708
                     /gene="CTHRC1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..1240
                     /gene="CTHRC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      847..852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTHRC1"
                     /note="hexamer: AATAAA"
     polyA_site      866
                     /gene="CTHRC1"
     regulatory      1220..1225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTHRC1"
                     /note="hexamer: AATAAA"
     polyA_site      1240
                     /gene="CTHRC1"
                     /note="major polyA site"
ORIGIN      
        1 gaaaggcgca ttgatgcagc ctgcggcggc ctcggagcgc ggcggagcca gacgctgacc
       61 acgttcctct cctcggtctc ctccgcctcc agctccgcgc tgcccggcag ccgggagcca
      121 tgcgacccca gggccccgcc gcctccccgc agcggctccg cggcctcctg ctgctcctgc
      181 tgctgcagct gcccgcgccg tcgagcgcct ctgagatccc caaggggaag caaaaggcgc
      241 agctccggca gagggaggtg gtggacctgt ataatggaat gtgcttacaa gggccagcag
      301 gagtgcctgg tcgagacggg agccctgggg ccaatggcat tccgggtaca cctgggatcc
      361 caggtcggga tggattcaaa ggagaaaagg gggaatgtct gagggaaagc tttgaggagt
      421 cctggacacc caactacaag cagtgttcat ggagttcatt gaattatggc atagatcttg
      481 ggaaaattgc ggagtgtaca tttacaaaga tgcgttcaaa tagtgctcta agagttttgt
      541 tcagtggctc acttcggcta aaatgcagaa atgcatgctg tcagcgttgg tatttcacat
      601 tcaatggagc tgaatgttca ggacctcttc ccattgaagc tataatttat ttggaccaag
      661 gaagccctga aatgaattca acaattaata ttcatcgcac ttcttctgtg gaaggacttt
      721 gtgaaggaat tggtgctgga ttagtggatg ttgctatctg ggttggtact tgttcagatt
      781 acccaaaagg agatgcttct actggatgga attcagtttc tcgcatcatt attgaagaac
      841 taccaaaata aatgctttaa ttttcatttg ctacctcttt ttttattatg ccttggaatg
      901 gttcacttaa atgacatttt aaataagttt atgtatacat ctgaatgaaa agcaaagcta
      961 aatatgttta cagaccaaag tgtgatttca cactgttttt aaatctagca ttattcattt
     1021 tgcttcaatc aaaagtggtt tcaatatttt ttttagttgg ttagaatact ttcttcatag
     1081 tcacattctc tcaacctata atttggaata ttgttgtggt cttttgtttt ttctcttagt
     1141 atagcatttt taaaaaaata taaaagctac caatctttgt acaatttgta aatgttaaga
     1201 atttttttta tatctgttaa ataaaaatta tttccaacaa
//
