LOCUS       NM_001330               1644 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens cardiotrophin 1 (CTF1), transcript variant 1, mRNA.
ACCESSION   NM_001330
VERSION     NM_001330.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1644)
  AUTHORS   Kale,I. and Dizdar,M.
  TITLE     Investigation of maternal serum cardiotrophin-1 concentrations in
            pregnant women with preeclampsia; a prospective case-control study
  JOURNAL   J Matern Fetal Neonatal Med 36 (2), 2229931 (2023)
   PUBMED   37369375
  REMARK    GeneRIF: Investigation of maternal serum cardiotrophin-1
            concentrations in pregnant women with preeclampsia; a prospective
            case-control study.
REFERENCE   2  (bases 1 to 1644)
  AUTHORS   Fiedorczuk,P., Olszewska,E., Rogalska,J. and Brzoska,M.M.
  TITLE     Osteoprotegerin, Chitinase 3-like Protein 1, and Cardiotrophin-1 as
            Potential Biomarkers of Obstructive Sleep Apnea in Adults-A
            Case-Control Study
  JOURNAL   Int J Mol Sci 24 (3), 2607 (2023)
   PUBMED   36768925
  REMARK    GeneRIF: Osteoprotegerin, Chitinase 3-like Protein 1, and
            Cardiotrophin-1 as Potential Biomarkers of Obstructive Sleep Apnea
            in Adults-A Case-Control Study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1644)
  AUTHORS   Akkoc,Y., Dalci,K., Karakas,H.E., Erbil-Bilir,S., Yalav,O.,
            Sakman,G., Celik,F., Arikan,S., Zeybek,U., Ergin,M., Akkiz,H.,
            Dilege,E., Dengjel,J., Dogan-Ekici,A.I. and Gozuacik,D.
  TITLE     Tumor-derived CTF1 (cardiotrophin 1) is a critical mediator of
            stroma-assisted and autophagy-dependent breast cancer cell
            migration, invasion and metastasis
  JOURNAL   Autophagy 19 (1), 306-323 (2023)
   PUBMED   35722965
  REMARK    GeneRIF: Tumor-derived CTF1 (cardiotrophin 1) is a critical
            mediator of stroma-assisted and autophagy-dependent breast cancer
            cell migration, invasion and metastasis.
REFERENCE   4  (bases 1 to 1644)
  AUTHORS   Ping,Y., Wang,X., Dai,Y., Wang,D., Liu,W., Yu,P. and Tao,Z.
  TITLE     A quantitative detection of Cardiotrophin-1 in chronic heart
            failure by chemiluminescence immunoassay
  JOURNAL   J Clin Lab Anal 35 (4), e23570 (2021)
   PUBMED   33713510
  REMARK    GeneRIF: A quantitative detection of Cardiotrophin-1 in chronic
            heart failure by chemiluminescence immunoassay.
REFERENCE   5  (bases 1 to 1644)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1644)
  AUTHORS   Erdmann,J., Hassfeld,S., Kallisch,H., Fleck,E. and
            Regitz-Zagrose,V.
  TITLE     Genetic variants in the promoter (g983G>T) and coding region (A92T)
            of the human cardiotrophin-1 gene (CTF1) in patients with dilated
            cardiomyopathy
  JOURNAL   Hum Mutat 16 (5), 448 (2000)
   PUBMED   11058912
REFERENCE   7  (bases 1 to 1644)
  AUTHORS   Pennica,D., Arce,V., Swanson,T.A., Vejsada,R., Pollock,R.A.,
            Armanini,M., Dudley,K., Phillips,H.S., Rosenthal,A., Kato,A.C. and
            Henderson,C.E.
  TITLE     Cardiotrophin-1, a cytokine present in embryonic muscle, supports
            long-term survival of spinal motoneurons
  JOURNAL   Neuron 17 (1), 63-74 (1996)
   PUBMED   8755479
REFERENCE   8  (bases 1 to 1644)
  AUTHORS   Pennica,D., Swanson,T.A., Shaw,K.J., Kuang,W.J., Gray,C.L.,
            Beatty,B.G. and Wood,W.I.
  TITLE     Human cardiotrophin-1: protein and gene structure, biological and
            binding activities, and chromosomal localization
  JOURNAL   Cytokine 8 (3), 183-189 (1996)
   PUBMED   8833032
REFERENCE   9  (bases 1 to 1644)
  AUTHORS   Pennica,D., Shaw,K.J., Swanson,T.A., Moore,M.W., Shelton,D.L.,
            Zioncheck,K.A., Rosenthal,A., Taga,T., Paoni,N.F. and Wood,W.I.
  TITLE     Cardiotrophin-1. Biological activities and binding to the leukemia
            inhibitory factor receptor/gp130 signaling complex
  JOURNAL   J Biol Chem 270 (18), 10915-10922 (1995)
   PUBMED   7738033
REFERENCE   10 (bases 1 to 1644)
  AUTHORS   Pennica,D., King,K.L., Shaw,K.J., Luis,E., Rullamas,J., Luoh,S.M.,
            Darbonne,W.C., Knutzon,D.S., Yen,R., Chien,K.R. et al.
  TITLE     Expression cloning of cardiotrophin 1, a cytokine that induces
            cardiac myocyte hypertrophy
  JOURNAL   Proc Natl Acad Sci U S A 92 (4), 1142-1146 (1995)
   PUBMED   7862649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135048.2.
            
            On Feb 26, 2020 this sequence version replaced NM_001330.4.
            
            Summary: The protein encoded by this gene is a secreted cytokine
            that induces cardiac myocyte hypertrophy in vitro. It has been
            shown to bind and activate the ILST/gp130 receoptor. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049822.1, U43030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000279804.3/ ENSP00000279804.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC135048.2         110062-110116       c
            56-174              AC135048.2         107197-107315       c
            175-1644            AC135048.2         103183-104652       c
FEATURES             Location/Qualifiers
     source          1..1644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1644
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /note="cardiotrophin 1"
                     /db_xref="GeneID:1489"
                     /db_xref="HGNC:HGNC:2499"
                     /db_xref="MIM:600435"
     exon            1..55
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..636
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cardiophin 1"
                     /codon_start=1
                     /product="cardiotrophin-1 isoform 1"
                     /protein_id="NP_001321.1"
                     /db_xref="CCDS:CCDS10694.1"
                     /db_xref="GeneID:1489"
                     /db_xref="HGNC:HGNC:2499"
                     /db_xref="MIM:600435"
                     /translation="MSRREGSLEDPQTDSSVSLLPHLEAKIRQTHSLAHLLTKYAEQL
                     LQEYVQLQGDPFGLPSFSPPRLPVAGLSAPAPSHAGLPVHERLRLDAAALAALPPLLD
                     AVCRRQAELNPRAPRLLRRLEDAARQARALGAAVEALLAALGAANRGPRAEPPAATAS
                     AASATGVFPAKVLGLRVCGLYREWLSRTEGDLGQLLPGGSA"
     exon            56..174
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /inference="alignment:Splign:2.1.0"
     exon            175..1644
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /note="hexamer: AATAAA"
     polyA_site      1644
                     /gene="CTF1"
                     /gene_synonym="CT-1; CT1"
                     /note="major polyA site"
ORIGIN      
        1 gaagggagcc gggatcagcc aggggccagc atgagccgga gggagggaag tctggaagac
       61 ccccagactg attcctcagt ctcacttctt ccccacttgg aggccaagat ccgtcagaca
      121 cacagccttg cgcacctcct caccaaatac gctgagcagc tgctccagga atatgtgcag
      181 ctccagggag accccttcgg gctgcccagc ttctcgccgc cgcggctgcc ggtggccggc
      241 ctgagcgccc cggctccgag ccacgcgggg ctgccagtgc acgagcggct gcggctggac
      301 gcggcggcgc tggccgcgct gcccccgctg ctggacgcag tgtgtcgccg ccaggccgag
      361 ctgaacccgc gcgcgccgcg cctgctgcgc cgcctggagg acgcggcgcg ccaggcccgg
      421 gccctgggcg ccgccgtgga ggccttgctg gccgcgctgg gcgccgccaa ccgcgggccc
      481 cgggccgagc cccccgccgc caccgcctca gccgcctccg ccaccggggt cttccccgcc
      541 aaggtgctgg ggctccgcgt ttgcggcctc taccgcgagt ggctgagccg caccgagggc
      601 gacctgggcc agctgctgcc cgggggctcg gcctgagcgc cgcggggcag ctcgccccgc
      661 ctcctcccgc tgggttccgt ctctccttcc gcttctttgt ctttctctgc cgctgtcggt
      721 gtctgtctgt ctgctcttag ctgtctccat tgcctcggcc ttctttgctt tttgtggggg
      781 agaggggagg ggacgggcag ggtctctgtc gcccaggctg gggtgcagtg gcgcgatccc
      841 agcactgcag cctcaacctc ctgggctcaa gccatccttc cgcctcagct tccccagcag
      901 ctgggactac aggcacgcgc caccacagcc ggctaatttt ttatttaatt ttttgtagag
      961 acgaggtttc gccatgttgc ccaggctggt cttgaactcc ggggctcaag cgatcctccc
     1021 gcttcagcct ccctaagtgc tgggattgca ggcgtgagcc actttcccag cctctctttg
     1081 ctttgcctgc cccgttctct taactcttgg accctcctcg tctgcatggt aactccgtct
     1141 gagtctacca ttttcttgct ctccctcctt ccttgggcct gcctcagttc cctttggcct
     1201 ccccctttac ccagctcttg gggtgtctct gttttttcca tccccacttc ctgccttctc
     1261 gtggccctgt gtgagcacat gtgtacatct cagccttatc tcaaggaggt gacaccttct
     1321 ctccttgtcc ccatctggct gtctctctgt gcttccctgg ccaggggcgt gcctgctggt
     1381 cctatggggg gaaggctact ctgcatctca gccaccttcc tcaggctcac tccacctaca
     1441 tccccagtct gccacacccc atccctttgg gcctcagccc tgtccctttg atgtcctcct
     1501 ttccttcagc ccctctgccc tgtccctgca cacctccact gcctcccagc agatctgtgg
     1561 agacaaaaca agcaacacct taaaagagtt ttatttctga aaataaatta attttttgta
     1621 aataaaatgt ttaaaaataa aaaa
//
