LOCUS       NM_016396               6433 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CTD small phosphatase like 2 (CTDSPL2), mRNA.
ACCESSION   NM_016396
VERSION     NM_016396.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6433)
  AUTHORS   Klerk,D.H., Kooi,E.M., Bos,A.F., Hulscher,J.B.,
            Verkaik-Schakel,R.N. and Plosch,T.
  TITLE     Hypermethylation of CTDSPL2 prior to necrotizing enterocolitis
            onset
  JOURNAL   Epigenomics 15 (8), 479-486 (2023)
   PUBMED   37309586
  REMARK    GeneRIF: Hypermethylation of CTDSPL2 prior to necrotizing
            enterocolitis onset.
REFERENCE   2  (bases 1 to 6433)
  AUTHORS   Xiao,Y., Chen,Y., Peng,A. and Dong,J.
  TITLE     The phosphatase CTDSPL2 is phosphorylated in mitosis and a target
            for restraining tumor growth and motility in pancreatic cancer
  JOURNAL   Cancer Lett 526, 53-65 (2022)
   PUBMED   34813892
  REMARK    GeneRIF: The phosphatase CTDSPL2 is phosphorylated in mitosis and a
            target for restraining tumor growth and motility in pancreatic
            cancer.
REFERENCE   3  (bases 1 to 6433)
  AUTHORS   Polyanskaya,S.A., Moreno,R.Y., Lu,B., Feng,R., Yao,Y., Irani,S.,
            Klingbeil,O., Yang,Z., Wei,Y., Demerdash,O.E., Benjamin,L.A.,
            Weiss,M.J., Zhang,Y.J. and Vakoc,C.R.
  TITLE     SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling
            dependency in acute myeloid leukemia
  JOURNAL   Cell Rep 38 (2), 110233 (2022)
   PUBMED   35021089
  REMARK    GeneRIF: SCP4-STK35/PDIK1L complex is a dual phospho-catalytic
            signaling dependency in acute myeloid leukemia.
REFERENCE   4  (bases 1 to 6433)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 6433)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 6433)
  AUTHORS   Liu,X., Yu,R., Sun,L., Garibotto,G., Lin,X., Wang,Y., Thomas,S.S.,
            Li,R. and Hu,Z.
  TITLE     The nuclear phosphatase SCP4 regulates FoxO transcription factors
            during muscle wasting in chronic kidney disease
  JOURNAL   Kidney Int 92 (2), 336-348 (2017)
   PUBMED   28506762
  REMARK    GeneRIF: expression significantly increased in skeletal muscle of
            chronic kidney disease patients
REFERENCE   7  (bases 1 to 6433)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   8  (bases 1 to 6433)
  AUTHORS   Wani,S., Sugita,A., Ohkuma,Y. and Hirose,Y.
  TITLE     Human SCP4 is a chromatin-associated CTD phosphatase and exhibits
            the dynamic translocation during erythroid differentiation
  JOURNAL   J Biochem 160 (2), 111-120 (2016)
   PUBMED   26920047
  REMARK    GeneRIF: SCP4 is a unique chromatin-associated, Ser5-preferential
            CTD phosphatase that preferentially distributes to
            transcriptionally silenced gene regions and may participate in gene
            regulation during erythroid differentiation.
REFERENCE   9  (bases 1 to 6433)
  AUTHORS   Kang,N., Koo,J., Wang,S., Hur,S.J. and Bahk,Y.Y.
  TITLE     A systematic study of nuclear interactome of C-terminal domain
            small phosphatase-like 2 using inducible expression system and
            shotgun proteomics
  JOURNAL   BMB Rep 49 (6), 319-324 (2016)
   PUBMED   26674342
  REMARK    GeneRIF: proteomic screening was conducted to identify binding
            partners of CTDSPL2 in nuclear extract through immunoprecipitation
            of CTDSPL2 with its associated.
REFERENCE   10 (bases 1 to 6433)
  AUTHORS   Ma,Y.N., Zhang,X., Yu,H.C. and Zhang,J.W.
  TITLE     CTD small phosphatase like 2 (CTDSPL2) can increase epsilon- and
            gamma-globin gene expression in K562 cells and CD34+ cells derived
            from umbilical cord blood
  JOURNAL   BMC Cell Biol 11, 75 (2010)
   PUBMED   20932329
  REMARK    GeneRIF: increases epsilon- and gamma-globin gene expression during
            erythroid differentiation
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF161478.1, BC035744.1 and AC009996.7.
            
            On Nov 23, 2018 this sequence version replaced NM_016396.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.13585.1,
                                           SRR1660803.252795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260327.9/ ENSP00000260327.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-266               AF161478.1         2-267
            267-1655            BC035744.1         224-1612
            1656-1658           AF161478.1         1654-1656
            1659-4627           AC009996.7         10090-13058
            4628-6433           AC009996.7         13059-14864
FEATURES             Location/Qualifiers
     source          1..6433
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.3-q21.1"
     gene            1..6433
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="CTD small phosphatase like 2"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
     exon            1..144
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            145..354
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1569
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /EC_number="3.1.3.-"
                     /note="CTDSP-like 2; CTD (carboxy-terminal domain, RNA
                     polymerase II, polypeptide A) small phosphatase like 2"
                     /codon_start=1
                     /product="CTD small phosphatase-like protein 2"
                     /protein_id="NP_057480.2"
                     /db_xref="CCDS:CCDS10110.1"
                     /db_xref="GeneID:51496"
                     /db_xref="HGNC:HGNC:26936"
                     /db_xref="MIM:618739"
                     /translation="MRLRTRKASQQSNQIQTQRTARAKRKYSEVDDSLPSGGEKPSKN
                     ETGLLSSIKKFIKGSTPKEERENPSKRSRIERDIDNNLITSTPRAGEKPNKQISRVRR
                     KSQVNGEAGSYEMTNQHVKQNGKLEDNPSSGSPPRTTLLGTIFSPVFNFFSPANKNGT
                     SGSDSPGQAVEAEEIVKQLDMEQVDEITTSTTTSTNGAAYSNQAVQVRPSLNNGLEEA
                     EETVNRDIPPLTAPVTPDSGYSSAHAEATYEEDWEVFDPYYFIKHVPPLTEEQLNRKP
                     ALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFRE
                     FLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNI
                     LGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELNEDVR
                     PHIRDRFRLHDLLPPD"
     exon            355..493
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            494..643
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            644..859
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            860..938
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1050
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1137
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1200
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1280
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1407
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1503
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..6433
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3550..3555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="hexamer: AATAAA"
     polyA_site      3575
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="major polyA site"
     regulatory      4593..4598
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="hexamer: TATAAA"
     polyA_site      4615
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="major polyA site"
     regulatory      6413..6418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="hexamer: AATAAA"
     polyA_site      6433
                     /gene="CTDSPL2"
                     /gene_synonym="HSPC058; HSPC129; SCP4"
                     /note="major polyA site"
ORIGIN      
        1 gcagcaggtc ggtaggcggg aaatggcgac tggctgaagg agctggttct gttgctgctg
       61 cggggtaagc gggaaagaca ccacacattg cgcagtcggg accatcgccg gagcctgagg
      121 acacttctct gtcgtcacag ttagttttac atgtggcacc cataaaagat gaggctgaga
      181 acacggaaag cttctcagca gtcaaatcaa atccaaacac aacgcactgc cagagcaaag
      241 aggaaatatt cagaggttga tgatagcctg ccttcaggag gagaaaaacc atcgaagaat
      301 gaaaccggct tgttgtcttc aattaaaaaa tttattaaag gaagcacacc taaggaagag
      361 agagaaaatc cttcaaaacg gagtagaatt gaacgtgata tagataacaa tttgatcacg
      421 tcaacaccaa gagcaggaga aaaacctaac aaacagatat ctcgagtaag acggaaaagt
      481 caagtaaatg gagaagctgg tagttatgaa atgacaaatc aacatgtaaa acaaaatgga
      541 aaattagaag ataatccttc ctctggcagt cctccaagga ctactttgtt ggggaccata
      601 ttttcacctg tcttcaactt tttttcacca gcaaataaaa atggaacgtc aggatcagat
      661 tctccaggac aggctgtgga agctgaagaa atagtaaaac aacttgatat ggaacaggtg
      721 gatgagatca ctaccagtac tactacatca actaatggag cagcttactc aaatcaagca
      781 gttcaagtga gaccatcact aaacaatggt ttagaagaag cagaagaaac agttaatcgt
      841 gatatcccac cccttacagc accagtaact ccagatagtg gttattcatc agcccacgcg
      901 gaggccacct atgaagaaga ctgggaagta tttgacccct attatttcat caaacatgtc
      961 ccgccactga cagaagaaca actaaatagg aaacctgctc ttccgttgaa aacaagaagc
     1021 acaccggaat tctccctagt tttagacttg gatgaaacac tagtgcattg tagtctaaat
     1081 gagctagaag atgcagcact tacttttcca gtccttttcc aagatgtcat ttatcaggtt
     1141 tatgtgagat taagaccatt tttcagggaa ttcctggaac gaatgtctca gatgtatgag
     1201 atcattcttt ttactgcttc taagaaggtg tatgcagaca agttactgaa catactagac
     1261 cctaaaaagc aactggtcag gcaccggctt ttccgtgaac attgtgtttg tgtacaagga
     1321 aactatataa aggacttaaa tattcttgga agagatcttt caaaaactat aataattgac
     1381 aactcaccac aagcctttgc atatcagctt tctaatggaa tccctataga aagttggttt
     1441 atggataaaa atgacaatga actcctaaaa ttgattccat tcctggagaa gcttgtagaa
     1501 ctgaatgaag atgttcgacc acacatcaga gacagatttc gcttgcatga tttgctgccc
     1561 ccagattaag tacaaagact tgtcaaatca ctgaaggggg agagaatgca ggaccctttt
     1621 ggactaagac aaaaacattg ccattactgt tgaaattttg catttttgta ccccgtcttg
     1681 cttttcttat ctttggtgcc caataataat taagggttac agaaagagac tttatctatc
     1741 tcagatcgaa tacatatagt aggtaggcta aaacagaaga gtctttagaa ctagtgcaac
     1801 tccagtgaaa ttttttatgt acaggacatc tgcagtttat aaagaattct gtttctgcca
     1861 ccagcagttt gacctgtagt cacacaggat tttatgataa taacagagat gaaaatggac
     1921 ttttattttc tctctgtttg gtgctctaag tgggtttgta gccacttttc tgttacttta
     1981 tgattctcat ttcaacagga atggccagta aaagttgttt tatttttcct gttaaggttt
     2041 ataacctttt tacatttttg acctgtatta gattagaatt tcattatgca ttccttttag
     2101 ttgaggcgct tcatagtttt ctggagatag tcaattttta gttttttatt atacatttga
     2161 atggccgttt tcctgctttg tctgcctgca cattgtatat ttgtttaaaa atattctcta
     2221 cttttagtct atgtaagttt catttagaaa gacatgcatt tatattttgt ttctgtaata
     2281 ttctactgta ggtgaaatct tttcaaaaat caagagactg ggtagataag aatatatgaa
     2341 tgactaatat acaaaagatt taaaccattg tgatggcgta tattctcaaa tggtaatatc
     2401 ttgcaatggc acacagattt aatggataaa ggtatacctc agacttcact gtgctcacaa
     2461 atctttgagg agaaagtttg gtcacctgtt tggcttgatt tagttactgc tgcctttggt
     2521 tttctccagg aatgaagtat tcagcacagt gactcagtat ttttagttat tttgcatggg
     2581 ctggtagtac ctctgttatg ctctcagtta caatcaattt aaaactgtat aacagtcttg
     2641 gtacctaaca gtagctatgc ataatcctgt ggcacagtac actcccaagc caccaatgca
     2701 gttaatatgc tctcatagtg gtttttctat gctatatgaa aatagtcttc aagccttggt
     2761 tctctaatgc agctaccaca agaggttgat atttttatag tggcgtgtaa tctccttttc
     2821 gggaggcttt ttatggaagg tagaatttgt aaaagttcgt atgctttgcc tctcaactgc
     2881 attaacatgc cacaggctca gactgttttt gtgtaaagga tgtcaaagaa cggcactttt
     2941 tctaaagaga agtttgatat tttgtatgct tgttaagaaa gtacagtatt ggaaattaaa
     3001 ggtggacaac tgataattga ggagtatgtc aattaatttt ttatgtatat tacctgttta
     3061 cttgtacaac ttactgtaca aattacatgc agcttcattt tcaaatgaat ccttaaaata
     3121 aggaaatctt tttaggaaaa catttaattt ttgtattttt gattttaaag gcatgagtta
     3181 tgtcaatttt cagtgtatta atgaagattt taacttttca tcaggttgag tgttttctta
     3241 ctatattatc tgttgtgtat gtagttagca tattgtgtca ctgaactgtt taaaaatcta
     3301 gcatgtagag caagcctgtt ttgtggaaaa tccttattca ttaaaaaaat aatcatggca
     3361 gattttctgc aaaaaaaaaa caaaagcatt tgcaattcag aatactgatt tttttaattt
     3421 tatttaaaga aaggtatttt gcttgcagga aaaaaatact acagattcat tttaatgaga
     3481 atctttgaaa tgtatttatc tttagggcat ctgggcatct ttatgctgtt tgtcttctgt
     3541 ctttcttgaa ataaaatgta catacgttac ctttacatat gctcttgctc aaaattgtga
     3601 acctagttac atttctccct gctcccttcc tttttatgct caaacagcga aacccaaaac
     3661 ttaaaagatc tgaactttca gcatgcattc tgattgctga aagatttcct gatttagtgc
     3721 attctcaaaa gggctttccc ataatctaaa gggaaatgta agcacctata ctcttgtgcc
     3781 tgtgggcact tcaataataa aaaccaactt tttaaactaa tcatctttta tcaatgataa
     3841 agttgttttc agtcccacac taggagagtt cctttaagtc agctgatcaa gcataagata
     3901 cttccgtaaa gaaataaact aagaaaattt tttatggctt gagaaaattc cttgaggcca
     3961 aattaatata tttttctttg ttattttatt tgagtcattt taaatttgtt aatacaaaat
     4021 ttaagataat ttacagagac aatttatcca gcttccttct accttaatac aatgttttgt
     4081 cttcccatta tcctctcttt tctttatctg ttggtagatg taaaaaactt ccatttagtt
     4141 aatcggaggt gtgtattttt taaattgaaa tgtgcccagc cccttcagct cacacaggaa
     4201 acatgaactc ttaaaaaact gactagtaaa tgcaggagag gtggatacct gatgagacac
     4261 agcgaaagtg acctgtatac acattacaac tctggagtac atattaaagt cgtgctattt
     4321 ccagtggtaa atgtctgact tttaagacat tcttttaaat atttgtatca ttgttaggat
     4381 gttttaatca gttgtttttt aattccatgt aatatatgta gccctcatca gatttatatc
     4441 accatatttc tccttgtgtc ctaagagaat tgatgacaat tcgtaaccat aaattgtttt
     4501 atattagcta gtatgtatat ttatttttac ccaatggctt tatctgtttc ccaaaatttg
     4561 tttgggattt gttgaaagca ttgtgtaact tctataaacg gctattttct tgtaactgtc
     4621 agtgaaatga atgtgtacat tgttttcttg tatttctctg ggttgttttt tgtttttttt
     4681 tccaagggtt aacatagaat gtttttttta aaaaattatc tttggccaat gactttttca
     4741 tctagatctt actttcattc aaccttctaa agaagttcgt ttctcattgt tttgttctgt
     4801 caacttgcct gaaaaacaga gacttcatct catcaatgaa gaaagcattt cattattcct
     4861 acagatcttt cctgcgagca cagaattctt cataaggacc agatctcttc catgtctgtg
     4921 tcaatcacat aaagctaaaa tgtaaaggac attgaagcct ttatttaatt gtactaatat
     4981 gatggtgtta tatactacat cattagctag ttaaggtttt ctgacctgac ttctctttgt
     5041 cttcctaggt atttatttgt tatcttttaa tcttgtgtat ctaaattaac ttagttaata
     5101 gttacccacc gaataactat gccaagcaac tagtaaagaa tgtttatttt atttcccctt
     5161 ataggggaag agtggactgg gaacaaaaat gtatgggcca aaaggcctta gggttgtcat
     5221 tcattgactt tcttattcct ctcatgagct ataattgagt atagtatttt tttagtgctg
     5281 atgtcattac ttctcatgtc ttcccctgag ttgaaagcct acgacaaaca tgtataaaat
     5341 acatttaaga attttcagaa tatgaaccac aaaactcagt atcttatatt taaatgctac
     5401 ttaagttatt attggaatcc aagtctcact aactagggta catttttata aaatgtttct
     5461 ctgtatcttg aattgaaatt acttgcccag aggcaagagt tctggggata taacatgatt
     5521 tgagatcttt tttaaaaaag ggtggggcgg cgggggagag agcgacaagt ttatactagt
     5581 ttatgctttt gatattagta ttttaagata catcagttga tcccgaaacc tgaccattag
     5641 aattactctg aggagctttt aaaatagatt cctggagcct acccctggaa aattgtctcg
     5701 ctggatctcg agaggggcct gagagttctg gctttttttt tttgtttggt tggttttgtt
     5761 ttgttttgtt ttgttttttc tttaaagctc tcctggtgat tctaatagcc agtattgggt
     5821 aatcaatgtt ttagctaaat gtgacactgg tttgagagta ggcaacaaaa ttaaagttca
     5881 ccagacatct ctttgtggta gagttttttt ttttttaaac tgggaccaga tttcacagag
     5941 cttattcaag atacatggag gaataataaa gaagattaag gctactgctc attatcattt
     6001 ttgtctttca tattttttaa gggtttgcat ttctaggact tggaatagtt gaccatatac
     6061 atagctaaag gacatgtccc tgaatgagac cattatatat attatctgta aaatatttca
     6121 ctattttttt attttataaa tctttgtaga aataagcaat gaaatactac tttcatcttt
     6181 tgaaatggga tttttcaagg cagtgtcctt ttggcattaa ggtagggggg agttaatatt
     6241 ctctctgcct tgtttccacg tgaatcaata ttaaagtcat ggacatttta aaatctcaat
     6301 ttaatttctt cttatttact atgcagtata gccgtgaaca agtaatgtag atttagtttt
     6361 ctcatcttca aatgccctga tcaccctacc tcacagggtt gttgtgggga taaataaaac
     6421 ttttatggaa gca
//
