LOCUS       NM_001008392            4753 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CTD small phosphatase like (CTDSPL), transcript
            variant 1, mRNA.
ACCESSION   NM_001008392
VERSION     NM_001008392.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4753)
  AUTHORS   Han,J. and Wang,Y.
  TITLE     Hsa-miR-503-5p regulates CTDSPL to accelerate cisplatin resistance
            and angiogenesis of lung adenocarcinoma cells
  JOURNAL   Chem Biol Drug Des 102 (4), 749-762 (2023)
   PUBMED   37341065
  REMARK    GeneRIF: Hsa-miR-503-5p regulates CTDSPL to accelerate cisplatin
            resistance and angiogenesis of lung adenocarcinoma cells.
REFERENCE   2  (bases 1 to 4753)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4753)
  AUTHORS   Krasnov,G.S., Puzanov,G.A., Afanasyeva,M.A., Dashinimaev,E.B.,
            Vishnyakova,K.S., Beniaminov,A.D., Adzhubei,A.A., Kondratieva,T.T.,
            Yegorov,Y.E. and Senchenko,V.N.
  TITLE     Tumor suppressor properties of the small C-terminal domain
            phosphatases in non-small cell lung cancer
  JOURNAL   Biosci Rep 39 (12) (2019)
   PUBMED   31774910
  REMARK    GeneRIF: Tumor suppressor properties of the small C-terminal domain
            phosphatases in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 4753)
  AUTHORS   Sarkar,S., Alam,N., Mandal,S.S., Chatterjee,K., Ghosh,S.,
            Roychoudhury,S. and Panda,C.K.
  TITLE     Differential transmission of the molecular signature of RBSP3,
            LIMD1 and CDC25A in basal/ parabasal versus spinous of normal
            epithelium during head and neck tumorigenesis: A mechanistic study
  JOURNAL   PLoS One 13 (4), e0195937 (2018)
   PUBMED   29672635
  REMARK    GeneRIF: our data also suggests the importance ofLIMD1 and CDC25A
            in conjunction with HPV for use as diagnostic and prognostic
            markers of HNSCC, whereas RBSP3 as a prognostic marker only.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4753)
  AUTHORS   Zhang,L., He,X., Li,F., Pan,H., Huang,X., Wen,X., Zhang,H., Li,B.,
            Ge,S., Xu,X., Jia,R. and Fan,X.
  TITLE     The miR-181 family promotes cell cycle by targeting CTDSPL, a
            phosphatase-like tumor suppressor in uveal melanoma
  JOURNAL   J Exp Clin Cancer Res 37 (1), 15 (2018)
   PUBMED   29382357
  REMARK    GeneRIF: we have presented herein the novel finding that miR-181b
            contributes to cell cycle progression through depressing the
            expression of CTDSPL, which in turn activates the downstream
            effector E2F1 and promotes S-phase entry.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4753)
  AUTHORS   Knockaert,M., Sapkota,G., Alarcon,C., Massague,J. and
            Brivanlou,A.H.
  TITLE     Unique players in the BMP pathway: small C-terminal domain
            phosphatases dephosphorylate Smad1 to attenuate BMP signaling
  JOURNAL   Proc Natl Acad Sci U S A 103 (32), 11940-11945 (2006)
   PUBMED   16882717
REFERENCE   7  (bases 1 to 4753)
  AUTHORS   Kashuba,V.I., Li,J., Wang,F., Senchenko,V.N., Protopopov,A.,
            Malyukova,A., Kutsenko,A.S., Kadyrova,E., Zabarovska,V.I.,
            Muravenko,O.V., Zelenin,A.V., Kisselev,L.L., Kuzmin,I., Minna,J.D.,
            Winberg,G., Ernberg,I., Braga,E., Lerman,M.I., Klein,G. and
            Zabarovsky,E.R.
  TITLE     RBSP3 (HYA22) is a tumor suppressor gene implicated in major
            epithelial malignancies
  JOURNAL   Proc Natl Acad Sci U S A 101 (14), 4906-4911 (2004)
   PUBMED   15051889
  REMARK    GeneRIF: analysis of RBSP3/HYA22located in the AP20 region, and
            evidence for tumor suppressor function
REFERENCE   8  (bases 1 to 4753)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J Biol Chem 278 (28), 26078-26085 (2003)
   PUBMED   12721286
REFERENCE   9  (bases 1 to 4753)
  AUTHORS   Protopopov,A., Kashuba,V., Zabarovska,V.I., Muravenko,O.V.,
            Lerman,M.I., Klein,G. and Zabarovsky,E.R.
  TITLE     An integrated physical and gene map of the 3.5-Mb chromosome 3p21.3
            (AP20) region implicated in major human epithelial malignancies
  JOURNAL   Cancer Res 63 (2), 404-412 (2003)
   PUBMED   12543795
REFERENCE   10 (bases 1 to 4753)
  AUTHORS   Ishikawa,S., Kai,M., Tamari,M., Takei,Y., Takeuchi,K., Bandou,H.,
            Yamane,Y., Ogawa,M. and Nakamura,Y.
  TITLE     Sequence analysis of a 685-kb genomic region on chromosome
            3p22-p21.3 that is homozygously deleted in a lung carcinoma cell
            line
  JOURNAL   DNA Res 4 (1), 35-43 (1997)
   PUBMED   9179494
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093415.2, AI143812.1, AJ575645.1 and AC105752.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001008392.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ575645.1, BX361022.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273179.10/ ENSP00000273179.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-298               AC093415.2         41043-41340         c
            299-341             AI143812.1         1-43
            342-1301            AJ575645.1         44-1003
            1302-4753           AC105752.2         116545-119996
FEATURES             Location/Qualifiers
     source          1..4753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..4753
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /note="CTD small phosphatase like"
                     /db_xref="GeneID:10217"
                     /db_xref="HGNC:HGNC:16890"
                     /db_xref="MIM:608592"
     exon            1..399
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1151
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1; RB
                     protein serine phosphatase from chromosome 3; CTD small
                     phosphatase-like protein; small CTD phosphatase 3;
                     CTDSP-like; NIF-like protein; NLI-interacting factor 1;
                     small C-terminal domain phosphatase 3; nuclear LIM
                     interactor-interacting factor 1; carboxy-terminal domain
                     RNA polymerase II polypeptide A small phosphatase 3; CTD
                     (carboxy-terminal domain, RNA polymerase II, polypeptide
                     A) small phosphatase-like"
                     /codon_start=1
                     /product="CTD small phosphatase-like protein isoform 1"
                     /protein_id="NP_001008393.1"
                     /db_xref="CCDS:CCDS33734.1"
                     /db_xref="GeneID:10217"
                     /db_xref="HGNC:HGNC:16890"
                     /db_xref="MIM:608592"
                     /translation="MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILS
                     SFFCCFRDYNVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVL
                     DYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQ
                     LFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKV
                     IIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR
                     "
     exon            400..554
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..587
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            588..689
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            690..746
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..839
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1025
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..4753
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4734..4739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /note="hexamer: AATAAA"
     polyA_site      4753
                     /gene="CTDSPL"
                     /gene_synonym="C3orf8; HYA22; PSR1; RBSP3; SCP3"
                     /note="major polyA site"
ORIGIN      
        1 ccttccccct cgcccgcccg ctcccgcttc cagcggcgcc gggcctcccg ctccgcctcc
       61 ccgtgcgcgg ctctcccggg cgcggctccg gggttcatgg tgacgaggcg gcggccgctc
      121 gagcccagcg gcggcggcgg cgggagctgg ggcgcgggcc cgggccgcct ctcccagagc
      181 gcggggccgg gcggcgggcg cgcccaggca gcggctgcga gcgccccccc gcgccgcgcc
      241 cccgcgcccc ccgcgccgcg cccccgcgcg cttggcttgc ggggggccgg gcctgcgggc
      301 ggccgccgcg ccgcgcaccc atggacggcc cggccatcat cacccaggtg accaacccca
      361 aggaggacga gggccggttg ccgggcgcgg gcgagaaagc ctcccagtgc aacgtcagct
      421 taaagaagca gaggagccgc agcatcctta gctccttctt ctgctgcttc cgtgattaca
      481 atgtggaggc ccctccaccc agcagcccca gtgtgcttcc gccactggtg gaggagaatg
      541 gtgggcttca gaagggtgac cagaggcagg tcattcccat accaagtcca ccagctaagt
      601 accttcttcc agaggtgacg gtgcttgact atggaaagaa atgtgtggtc attgatttag
      661 atgaaacatt ggtgcacagt tcgtttaagc ctattagtaa tgctgatttt attgttccgg
      721 ttgaaatcga tggaactata catcaggtgt atgtgctgaa gcggccacat gtggacgagt
      781 tcctccagag gatggggcag ctttttgaat gtgtgctctt tactgccagc ttggccaagt
      841 atgcagaccc tgtggctgac ctcctagacc gctggggtgt gttccgggcc cggctcttca
      901 gagaatcatg tgtttttcat cgtgggaact acgtgaagga cctgagtcgc cttgggcggg
      961 agctgagcaa agtgatcatt gttgacaatt cccctgcctc atacatcttc catcctgaga
     1021 atgcagtgcc tgtgcagtcc tggttcgatg acatgacgga cacggagctg ctggacctca
     1081 tccccttctt tgagggcctg agccgggagg acgacgtgta cagcatgctg cacagactct
     1141 gcaataggta gccctggcct ctgcctgcct cccgcctgtg cactctggaa cctctggcct
     1201 caggggacct gcctgtcctc agctccctgg gagctgaaag tgaggatact ccgtgctcca
     1261 ggccacaggg tgaatgtggc catgcctacc tgttttgttt ttttaagaac agaaacaact
     1321 attttaaaag aactctttta agaaatttca taaagggaca tgcattttac tgggtttgct
     1381 tttcttaaaa cataccaaaa aagaaaaaaa tagaaaaaaa aaaaaaaaaa gcttgatctc
     1441 tatcagactt cctttcaact gtcctcccct ccaagcagac cacctgtccc cttctatccc
     1501 agctcagagc agctgaccca actcagaatc tctttcctac aggatgaagt gccttttgaa
     1561 tgttatttta agccgagagt taatttttct acacaacata tttccagaca tcttttagtc
     1621 ttttattgtc ttagatacta taagaagatg aacatgacaa ttttctagaa cctggtagcg
     1681 tgtgtgtgtg tggcgggggg tgctgaggga ggggagtgag tcacaggagc ctgtccccca
     1741 acaggtgtga ctgctctgac aacctgtggc atgctgcagg gtcaggctcc tgataggagg
     1801 atttcatgac tatgtcattg tctccactca tttttgaccc agtttggaat gtatctgcaa
     1861 ttgtgtggct caacacttta ggaaacaata gattatttta tattattatt tctgatggtg
     1921 acaagtttgt cttgaggtca cattttctcc ttgaaaagtg acatcctgtc acttctgctc
     1981 tcacactact gccatacatt tgtgtttttt gttgttattg tttgggtaga gcagttacaa
     2041 gaaaccctaa aacccttgga tataaaagaa atctgtttat tgatttttaa atctttcctt
     2101 tccaaaagct ggatacacat ggagctgttt gggaattttc cttgctgcta ccgcgctgcc
     2161 accaaatgga attgaccagc ggctgttaca ctgttctttg ccactgtgcc tatgctcaga
     2221 atatgctcac tgctaagcta caaactcgga cagggtcaga aacagaggtg tcccatccca
     2281 ttgcagcctc caccacctgt aaccccttcc tggcattggc cactgaaggg tacaaaggca
     2341 aaaggaccac agcaccactt aggtgtagca tggattttaa actgcagtca gtatcagatc
     2401 ctgtttgata aataagctga ctgttctctc ttgagaacct gtggcctcaa ccagccacca
     2461 agctgatgtg gcccaagtcc atctcttggt cttctccttt gaagcacagc ctatttctga
     2521 gccaagggtt ggggaagcct gtctagatgt gggactcatt gccccaaacc agggagagga
     2581 agagctccca cagggagagc ccaggctctc tttgcagcct ttcccagttt ggtgtttaag
     2641 cagtgccatg ttccttgttt gacaacaaga cagtctgtaa agtattgctc ttaaaaacaa
     2701 ttaaaaagaa ccctttcata ttggcaccat tgccttagtc ctctgtgggt tggtcttcag
     2761 ccagcattct ggtgggagtg actggcatta acaagactgg aaatcggggg tcaaagtaaa
     2821 atatctttgt tttgctttca ttcacaaagt aatgaagcca gctgccaatt acatcctccc
     2881 aacagcactt tggtctgtgg actgctgtgt gaatattcag aagggaagta agtattcagg
     2941 gggtaaacag gtctcccagc attctgagtg ttccaaacca gtaatccaca tgccaattca
     3001 aatagaacag ccccttgcta gatattacca cagataatga cagttacatg gtagaactgc
     3061 ccatgccaca aatatttatt tggaaaagta gtcattaaat gaacccactg ccttaaatgt
     3121 cttgaatgtt gcagtcaagt gtctgtcatg tgttgatatc cacacagaat taggccctaa
     3181 tgagagcctt agaccctcaa ccatgccccc ttcgttggca tcacagggcc ttatttggaa
     3241 gagcgggcaa agaggatgga aatcataaaa tatttcatgg gaatcgaacc tagggatagt
     3301 gctccacttc tgacgatgga gtgaagacac ttggcagact tgagccagac acttcaccta
     3361 gtagttcctg aaactgtgag caccactgca ctaagccagt gcggagctgt tagggacggg
     3421 cccagctcct gcaccacgga cacagaatgt ctggagaggg ccagcaggcc ctctgagggt
     3481 tctggaatct gtgcacctta tttgaccaca ctccaaaatt ctgtttttat tttaaccctt
     3541 gaatctgctt tatgtacata atcaaaatat ctatatctat atctatatct atatctatat
     3601 atttttaatc atctacatgt aaatgaagca atagaattct aacataaggc caagaaatga
     3661 gacgaatgtt tggggtttat gttttttaag gtaaatacgg gtattgtttt taattattac
     3721 catgtattaa attgtgggct ttgaaaccta atgaaacctg ttagccactt ctctgtgcca
     3781 tatacttccc atgttaccaa aataccccca actctttagc caaaagagaa ccctgacctc
     3841 ctgagtttcc atgctccttt ctgtaccagg tttaaatgta gtcttctgga gaagtatttt
     3901 tgacattgag ctctgggaca ggacaccttg ggtttgtgga ctgcagccca ctatgatgtt
     3961 attacttctc tggccaggcc tccagtggaa gtgcacaggc actcccaatg ttgttaatgc
     4021 tctgtcttcc atttgttctg gaatcctacg tgttggtctg tggttccatg cattagctgt
     4081 ttgtaaataa tgcatttgca tactgaaaaa ggaatgccac ctgccacagt tgatggtgag
     4141 gaagctcctt tgacgtggtg caattttgat gagatgtctc tggggacacg aggatgccct
     4201 aatgatgctg acttgtcatg gttgcagcat ttgaactttt ggtgttaaaa aaaaaaacct
     4261 gtaagtctgt aacctggcaa cattttacaa ccctgtattt ttaaagatgg ctttctaata
     4321 aaaaatccag aaccacacag ccctatggtc aaacaatcct acgtttgtgc ctctgctttt
     4381 aaaggtgctg tgctggacag ttggcatgcc agggttcgag aagagtgaat ggcttgacgt
     4441 acttgcagtt aactgtgcaa aattggctgg ctgcctctgt tcctactgta ctgtaacttt
     4501 gatcatgtct gttcctgttc cattctccca ggagcttctc tgcagactga cacaccctcc
     4561 cccaccccgg gtagtggaga tgctggtgtc tgggtagtca tggatttctg ctggacattt
     4621 gaatgtgata aacaatccag cattacttag gaaatgctac atgcggaatg tgcacgtttc
     4681 caggggcgag tattgtcaat caaaaggttt gcaatgattt ccttcctgcc aaaaataaac
     4741 atgtgaaact gca
//
