LOCUS       NM_005730               4785 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CTD small phosphatase 2 (CTDSP2), mRNA.
ACCESSION   NM_005730
VERSION     NM_005730.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4785)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4785)
  AUTHORS   Krasnov,G.S., Puzanov,G.A., Afanasyeva,M.A., Dashinimaev,E.B.,
            Vishnyakova,K.S., Beniaminov,A.D., Adzhubei,A.A., Kondratieva,T.T.,
            Yegorov,Y.E. and Senchenko,V.N.
  TITLE     Tumor suppressor properties of the small C-terminal domain
            phosphatases in non-small cell lung cancer
  JOURNAL   Biosci Rep 39 (12) (2019)
   PUBMED   31774910
  REMARK    GeneRIF: Tumor suppressor properties of the small C-terminal domain
            phosphatases in non-small cell lung cancer.
REFERENCE   4  (bases 1 to 4785)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4785)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 4785)
  AUTHORS   Thompson,J., Lepikhova,T., Teixido-Travesa,N., Whitehead,M.A.,
            Palvimo,J.J. and Janne,O.A.
  TITLE     Small carboxyl-terminal domain phosphatase 2 attenuates
            androgen-dependent transcription
  JOURNAL   EMBO J 25 (12), 2757-2767 (2006)
   PUBMED   16724108
  REMARK    GeneRIF: These results suggest that SCP2 is involved in promoter
            clearance during steroid-activated transcription.
REFERENCE   7  (bases 1 to 4785)
  AUTHORS   Yeo,M., Lin,P.S., Dahmus,M.E. and Gill,G.N.
  TITLE     A novel RNA polymerase II C-terminal domain phosphatase that
            preferentially dephosphorylates serine 5
  JOURNAL   J Biol Chem 278 (28), 26078-26085 (2003)
   PUBMED   12721286
REFERENCE   8  (bases 1 to 4785)
  AUTHORS   Su,Y.A., Lee,M.M., Hutter,C.M. and Meltzer,P.S.
  TITLE     Characterization of a highly conserved gene (OS4) amplified with
            CDK4 in human sarcomas
  JOURNAL   Oncogene 15 (11), 1289-1294 (1997)
   PUBMED   9315096
REFERENCE   9  (bases 1 to 4785)
  AUTHORS   Beutler,E., Gelbart,T., West,C., Kuhl,W. and Lee,P.
  TITLE     A strategy for cloning the hereditary hemochromatosis gene
  JOURNAL   Blood Cells Mol Dis 21 (3), 207-216 (1995)
   PUBMED   8673473
REFERENCE   10 (bases 1 to 4785)
  AUTHORS   Su,Y.A., Trent,J.M., Guan,X.Y. and Meltzer,P.S.
  TITLE     Direct isolation of genes encoded within a homogeneously staining
            region by chromosome microdissection
  JOURNAL   Proc Natl Acad Sci U S A 91 (19), 9121-9125 (1994)
   PUBMED   8090779
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN313995.1, BC018922.2 and AC121759.9.
            
            On Nov 22, 2018 this sequence version replaced NM_005730.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF000152.1, AK226076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398073.7/ ENSP00000381148.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CN313995.1         161-193
            34-2786             BC018922.2         1-2753
            2787-2790           AC121759.9         8000-8003
            2791-4785           BC018922.2         2758-4752
FEATURES             Location/Qualifiers
     source          1..4785
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q14.1"
     gene            1..4785
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /note="CTD small phosphatase 2"
                     /db_xref="GeneID:10106"
                     /db_xref="HGNC:HGNC:17077"
                     /db_xref="MIM:608711"
     exon            1..358
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             295..1110
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /EC_number="3.1.3.16"
                     /note="conserved gene amplified in osteosarcoma; nuclear
                     LIM interactor-interacting factor 2; small CTD phosphatase
                     2; NLI-interacting factor 2; protein OS-4; small
                     C-terminal domain phosphatase 2; CTD (carboxy-terminal
                     domain, RNA polymerase II, polypeptide A) small
                     phosphatase 2"
                     /codon_start=1
                     /product="carboxy-terminal domain RNA polymerase II
                     polypeptide A small phosphatase 2"
                     /protein_id="NP_005721.3"
                     /db_xref="CCDS:CCDS41801.1"
                     /db_xref="GeneID:10106"
                     /db_xref="HGNC:HGNC:17077"
                     /db_xref="MIM:608711"
                     /translation="MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCC
                     FRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRI
                     CVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECV
                     LFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDN
                     SPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP"
     exon            359..507
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            508..546
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            547..648
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..705
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..798
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            799..984
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     exon            985..4785
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1910
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
     regulatory      4753..4758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /note="hexamer: AATAAA"
     polyA_site      4785
                     /gene="CTDSP2"
                     /gene_synonym="OS4; PSR2; SCP2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgtttt cgctccggat tctccatgtt ggacccaaac tgaggagccc ggagctgccg
       61 ctgggggatc ggggccgggg gcacccgggg gagccgctgc ccgggccgcc cgccctttgt
      121 acaggccgcc tcccttcccg gtccggggag gaaacgagag gggggatgtg aacagctgtg
      181 gaagtcggag tctcgggagc cggagcgggc ccccgcccag gccccccagc ccagcccagc
      241 ccgcgcgccc gcccgtcctc ccgcccagcc agcccgggcc cgcgggattg ttagatggaa
      301 cacggctcca tcatcaccca ggcgcggagg gaagacgccc tggtgctcac caagcaaggc
      361 ctggtctcca agtcctctcc taagaagcct cgtggacgta acatcttcaa ggcccttttc
      421 tgctgttttc gcgcccagca tgttggccag tcaagttcct ccactgagct cgctgcgtat
      481 aaggaggaag caaacaccat tgctaagtcg gatctgctcc agtgtctcca gtaccagttc
      541 taccagatcc cagggacctg cctgctccca gaggtgacag aggaagatca aggaaggatc
      601 tgtgtggtca ttgacctcga tgaaaccctt gtgcatagct cctttaagcc aatcaacaat
      661 gctgacttca tagtgcctat agagattgag gggaccactc accaggtgta tgtgctcaag
      721 aggccttatg tggatgagtt cctgagacgc atgggggaac tctttgaatg tgttctcttc
      781 actgccagcc tggccaagta tgccgaccct gtgacagacc tgctggaccg gtgtggggtg
      841 ttccgggccc gcctattccg tgagtcttgc gtgttccacc agggctgcta cgtcaaggac
      901 ctcagccgcc tggggaggga cctgagaaag accctcatcc tggacaactc gcctgcttct
      961 tacatattcc accccgagaa tgcagtgcct gtgcagtcct ggtttgatga catggcagac
     1021 actgagttgc tgaacctgat cccaatcttt gaggagctga gcggagcaga ggacgtctac
     1081 accagccttg ggcagctgcg ggccccttag cctgccctgc ttccaagcga cggccatccc
     1141 agtaggggac tttcccacac tgtgccttta cgatcagcgt gacagagtag aagctggagt
     1201 gcctcaccac acggcccgga aacagcggga agtaactgga aagagcttta ggacagctta
     1261 gatgccgagt gggcgaatgc cagaccaatg atacccagag ctacctgccg ccaacttgtt
     1321 gagatgtgtg tttgactgtg agagagtgtg tgtttgtgtg tgtgttttgc catgaactgt
     1381 ggccccagtg tatagtgttt cagtggggga gaagctgaaa gaccaagact cttcccaagt
     1441 tagcttgtct cctctcctgt caccctaaga gccactgagt tgtgtaggga tgaagactat
     1501 tgaagactcc attgccaaac catggccttt cctcagtgtt gtaaggccta tgccaaggat
     1561 aaaggaaggg tatgcctttg ggtactccag gcacacacct ttctgaaatc cttctccagc
     1621 cagctgctgc agacaaaaga tcacatttct gggaagatga gaacttgttt ccagaccagc
     1681 atccagtggc catcaggtct tgtggcccaa aggctatgct tgcctccggc tgagtgcctg
     1741 ggataggcct tttctatgtc tccccaaggc tggggtgctg agcctgcctt cctcaccacc
     1801 tagccatagt ctcaaacctg tggggaagga ggttttctcc ctgcccggga agaggacaga
     1861 taactgattt ccgttctttt gactgtgttt taaaattctc tttctaaaca cagagtgttg
     1921 ggcctggttt gtttctgaca aagttacagt cctgggcctg taatgaatgt cggcggcgct
     1981 ggggttgcag ggaaaagaca aatcctcaaa gcgtggacgt gtgtccccat ggcttgtgga
     2041 tcagctaagc tcgggatcat ttccataagt ctgcttttca gggattctct gctggtgctg
     2101 gtgcaaggac ttctgttcca aaggctggga aaaactaagc tgtcccagcc cctcccattt
     2161 cttgggcagg gctcttttcc tgttgtgtct tcccccaggg cctgtcctgt accgagctct
     2221 gtctgttcca gccttcatcc ttcctggctg ttgcttttcc tcttaagggc ctcagaactc
     2281 ttgctcttcc tgggctgagg gggaatgagt gttcttgcca tttgccagcc taatgcgcat
     2341 gctttctgcc tctggtaaca ggagtgagtg agcccctcag acctgcactc tgggtgtctc
     2401 ctgctttcaa aggttcttaa tagtgaatgc tttaaaatta aagtcatcac gaaatggaag
     2461 ttttcccagg gtggaaaata agaggaagtg ctgctgtaat tgggagcaca aggggcctcc
     2521 caaaaaggag ccccacctca gcatcactgc cttaatcgtg gcctccctgg ggtgggtggg
     2581 gttctctcct ccctccctcc ctcctcctgg ggtgggaggg cgctcctgtt cccatctctg
     2641 tgttccctgg aggcaggtat cacaaagcat ttgtgaattg ctttaggtgc agggacacca
     2701 cccactcagg actcttcccc atcatccctt ccattgccac accctagatc cagcctcagg
     2761 aactaacaag ttttgagaaa agcaggtagt agagcagcag cttcgtgctc tcagcggtgg
     2821 ctggctggca tttttctcta gcgttgtggt gccaccttcc cttcttgtcc caaggttata
     2881 aggccttgtc tttctctttg gaatcataaa gtggaacaga gtccccagaa ctcatgtggc
     2941 catttccgcc agcatcactc cccggtgcct atggggtccc ggtgtaccta aagggagaag
     3001 gaccccatgt gctagccaga aatatactgt ctcttgaagg aaagcaggag ctcagactct
     3061 tagagccagc tgtggcttcg gacccaaggc ctgacctagg ctgctatcct aatattgcag
     3121 gaggggcctc tcttccaagc cccaccctaa gggttagccc ttggccaaat cttttgccgt
     3181 ctaggcccag ccaggctttt ctgactaaat aagcaataag aggctctaag ctgactgagt
     3241 tgcaaggacc ctttccgccc tcccttggat ctccatgttt ttccagatgg cggaagagca
     3301 tgtgccaccc cctttcctaa cagacttgtc caagtgcttg gcgtgggacc catgaccaaa
     3361 gcccaggatg gcttggtggg agtgtccctg ctgcatctgc atgaagcccc tgctttttag
     3421 gcctcactcc catcagaacc ctgcctgccc acctgcaact cccccccaac aatgccattc
     3481 ccacttgccc cagagaagct actcggccaa acctagccag ggtctgttct tgtggaccag
     3541 agccagccta gtcattattt gctgtcgggt ttccagtttc accgtgtgtt agggtgaggg
     3601 atgattgtaa aatttgctcc tcaaaggaat caggccagac tcaattttgg agggcaagac
     3661 agggaggagg ccgcttcatc ccagactctc ttctagggct tcccaccatc agcccctccc
     3721 acttgagact ggtctttggg aggcaatagg ccaccatgcc tggtcagcac caattcaagc
     3781 catgccagga atctgcctac ctgccaggtt cagttctttt aaggtgcctc ttcagggaca
     3841 cagtgtgtct ctctgattgg gcttctaaat caaaagcctg atgttcgtgt ccctctcata
     3901 gggggagctt tggacacagg accagtttgg aaaagggtca ggtaagggtt tccactctgc
     3961 acattgtaga gggaacactc tgtaggccca tgggtccctt actagagagg ttgagtgaat
     4021 ttgccttcag ttaacatggg accttctgtt tagcttcctc ttgcttccca aagattttaa
     4081 gcattttgta aatgtataaa ctcacctctg gtaacagtgg cccagacgct gctttgtgct
     4141 aaaagcatgg gaaatgtaaa ggcagtcttt ctctgggaaa tggatgctat tctattctgc
     4201 tgcccctacc tgttcctgag gcctcattta gaaagaaaat cccctcagaa ggctgtctgg
     4261 cacccagtgt cctagccagg ccaagtatat gagaaaggta agtccatttt ccccttcagg
     4321 tcctcagtgg attacttaac cactgctgtc cctcggtccc tttttcctaa acgggtttag
     4381 ttctgtcttt tttctccttt tttctaaatg ctggtaaata tttacattca gccagggaag
     4441 aggaggccag aggtcgggcc agctgcccca ttcttttaac gttgtagggc ctgcccatgg
     4501 agcggaccct cctctttggg cctcgtgagc ttttttgctt atcatgttcc atttcgtgcc
     4561 gctttccccc ttcaagatgc catttggagg gtaggggatc tgcttcccac tgtgactggg
     4621 ctatgggatt ctgactacct tgcttacaga ttcatggttt gataaatttg ttgtattcaa
     4681 aaacttgaaa tgcaggacgc cattaagtgt ctgtttatat ttttggaata tttgtattac
     4741 ttacaattaa ttaataaaag tgggtttaaa aaacctttcc aggaa
//
