LOCUS       NM_004715               3744 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens CTD phosphatase subunit 1 (CTDP1), transcript variant
            1, mRNA.
ACCESSION   NM_004715
VERSION     NM_004715.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3744)
  AUTHORS   Hu,W.F., Krieger,K.L., Lagundzin,D., Li,X., Cheung,R.S.,
            Taniguchi,T., Johnson,K.R., Bessho,T., Monteiro,A.N.A. and
            Woods,N.T.
  TITLE     CTDP1 regulates breast cancer survival and DNA repair through
            BRCT-specific interactions with FANCI
  JOURNAL   Cell Death Discov 5, 105 (2019)
   PUBMED   31240132
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3744)
  AUTHORS   Hu,C.J., Pan,J.B., Song,G., Wen,X.T., Wu,Z.Y., Chen,S., Mo,W.X.,
            Zhang,F.C., Qian,J., Zhu,H. and Li,Y.Z.
  TITLE     Identification of Novel Biomarkers for Behcet Disease Diagnosis
            Using Human Proteome Microarray Approach
  JOURNAL   Mol Cell Proteomics 16 (2), 147-156 (2017)
   PUBMED   27777341
  REMARK    GeneRIF: Study identifies CTDP1 as an autoantigen specific for
            Behcet Disease.
REFERENCE   3  (bases 1 to 3744)
  AUTHORS   Zhong,R., Ge,X., Chu,T., Teng,J., Yan,B., Pei,J., Jiang,L.,
            Zhong,H. and Han,B.
  TITLE     Lentivirus-mediated knockdown of CTDP1 inhibits lung cancer cell
            growth in vitro
  JOURNAL   J Cancer Res Clin Oncol 142 (4), 723-732 (2016)
   PUBMED   26590573
  REMARK    GeneRIF: results demonstrated that CTDP1 was upregulated in human
            lung cancer tissues. In addition, it implied that CTDP1 played an
            important role in cell proliferation and may be a useful
            therapeutic target in human lung cancer.
REFERENCE   4  (bases 1 to 3744)
  AUTHORS   Della Monica,R., Visconti,R., Cervone,N., Serpico,A.F. and
            Grieco,D.
  TITLE     Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55
            activation and mitotic progression
  JOURNAL   Elife 4, e10399 (2015)
   PUBMED   26653855
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3744)
  AUTHORS   Angelicheva,D., Turnev,I., Dye,D., Chandler,D., Thomas,P.K. and
            Kalaydjieva,L.
  TITLE     Congenital cataracts facial dysmorphism neuropathy (CCFDN)
            syndrome: a novel developmental disorder in Gypsies maps to 18qter
  JOURNAL   Eur J Hum Genet 7 (5), 560-566 (1999)
   PUBMED   10439962
REFERENCE   6  (bases 1 to 3744)
  AUTHORS   Cho,H., Kim,T.K., Mancebo,H., Lane,W.S., Flores,O. and Reinberg,D.
  TITLE     A protein phosphatase functions to recycle RNA polymerase II
  JOURNAL   Genes Dev 13 (12), 1540-1552 (1999)
   PUBMED   10385623
REFERENCE   7  (bases 1 to 3744)
  AUTHORS   Marshall,N.F., Dahmus,G.K. and Dahmus,M.E.
  TITLE     Regulation of carboxyl-terminal domain phosphatase by HIV-1 tat
            protein
  JOURNAL   J Biol Chem 273 (48), 31726-31730 (1998)
   PUBMED   9822634
REFERENCE   8  (bases 1 to 3744)
  AUTHORS   Archambault,J., Pan,G., Dahmus,G.K., Cartier,M., Marshall,N.,
            Zhang,S., Dahmus,M.E. and Greenblatt,J.
  TITLE     FCP1, the RAP74-interacting subunit of a human protein phosphatase
            that dephosphorylates the carboxyl-terminal domain of RNA
            polymerase IIO
  JOURNAL   J Biol Chem 273 (42), 27593-27601 (1998)
   PUBMED   9765293
REFERENCE   9  (bases 1 to 3744)
  AUTHORS   Archambault,J., Chambers,R.S., Kobor,M.S., Ho,Y., Cartier,M.,
            Bolotin,D., Andrews,B., Kane,C.M. and Greenblatt,J.
  TITLE     An essential component of a C-terminal domain phosphatase that
            interacts with transcription factor IIF in Saccharomyces cerevisiae
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14300-14305 (1997)
   PUBMED   9405607
REFERENCE   10 (bases 1 to 3744)
  AUTHORS   Kalaydjieva,L. and Chamova,T.
  TITLE     CTDP1-Related Congenital Cataracts, Facial Dysmorphism, and
            Neuropathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC047999.1, DR001939.1,
            BC052576.1 and BM512113.1.
            
            On Nov 22, 2019 this sequence version replaced NM_004715.4.
            
            Summary: This gene encodes a protein which interacts with the
            carboxy-terminus of the RAP74 subunit of transcription initiation
            factor TFIIF, and functions as a phosphatase that processively
            dephosphorylates the C-terminus of POLR2A (a subunit of RNA
            polymerase II), making it available for initiation of gene
            expression. Mutations in this gene are associated with congenital
            cataracts, facial dysmorphism and neuropathy syndrome (CCFDN).
            Alternatively spliced transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Feb 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes the longest isoform (1, also known as
            FCP1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047999.1, AF154115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613122.5/ ENSP00000484525.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-325               BC047999.1         3-327
            326-456             DR001939.1         316-446
            457-1122            BC047999.1         459-1124
            1123-2961           BC052576.1         717-2555
            2962-3116           BM512113.1         44-198
            3117-3744           BC052576.1         2711-3338
FEATURES             Location/Qualifiers
     source          1..3744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..3744
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /note="CTD phosphatase subunit 1"
                     /db_xref="GeneID:9150"
                     /db_xref="HGNC:HGNC:2498"
                     /db_xref="MIM:604927"
     exon            1..459
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..3031
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /EC_number="3.1.3.16"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor IIF-associating CTD phosphatase 1;
                     TFIIF-associating CTD phosphatase 1; serine phosphatase
                     FCP1a; CTD of POLR2A, phosphatase of, subunit 1; RNA
                     polymerase II subunit A C-terminal domain phosphatase; CTD
                     (carboxy-terminal domain, RNA polymerase II, polypeptide
                     A) phosphatase, subunit 1"
                     /codon_start=1
                     /product="RNA polymerase II subunit A C-terminal domain
                     phosphatase isoform 1"
                     /protein_id="NP_004706.3"
                     /db_xref="CCDS:CCDS12017.1"
                     /db_xref="GeneID:9150"
                     /db_xref="HGNC:HGNC:2498"
                     /db_xref="MIM:604927"
                     /translation="MEVPAAGRVPAEGAPTAAVAEVRCPGPAPLRLLEWRVAAGAAVR
                     IGSVLAVFEAAASAQSSGASQSRVASGGCVRPARPERRLRSERAGVVRELCAQPGQVV
                     APGAVLVRLEGCSHPVVMKGLCAECGQDLTQLQSKNGKQQVPLSTATVSMVHSVPELM
                     VSSEQAEQLGREDQQRLHRNRKLVLMVDLDQTLIHTTEQHCQQMSNKGIFHFQLGRGE
                     PMLHTRLRPHCKDFLEKIAKLYELHVFTFGSRLYAHTIAGFLDPEKKLFSHRILSRDE
                     CIDPFSKTGNLRNLFPCGDSMVCIIDDREDVWKFAPNLITVKKYVYFQGTGDMNAPPG
                     SRESQTRKKVNHSRGTEVSEPSPPVRDPEGVTQAPGVEPSNGLEKPARELNGSEAATP
                     RDSPRPGKPDERDIWPPAQAPTSSQELAGAPEPQGSCAQGGRVAPGQRPAQGATGTDL
                     DFDLSSDSESSSESEGTKSSSSASDGESEGKRGRQKPKAAPEGAGALAQGSSLEPGRP
                     AAPSLPGEAEPGAHAPDKEPELGGQEEGERDGLCGLGNGCADRKEAETESQNSELSGV
                     TAGESLDQSMEEEEEEDTDEDDHLIYLEEILVRVHTDYYAKYDRYLNKEIEEAPDIRK
                     IVPELKSKVLADVAIIFSGLHPTNFPIEKTREHYHATALGAKILTRLVLSPDAPDRAT
                     HLIAARAGTEKVLQAQECGHLHVVNPDWLWSCLERWDKVEEQLFPLRDDHTKAQRENS
                     PAAFPDREGVPPTALFHPMPVLPKAQPGPEVRIYDSNTGKLIRTGARGPPAPSSSLPI
                     RQEPSSFRAVPPPQPQMFGEELPDAQDGEQPGPSRRKRQPSMSETMPLYTLCKEDLES
                     MDKEVDDILGEGSDDSDSEKRRPEEQEEEPQPRKPGTRRERTLGAPASSERSAAGGRG
                     PRGHKRKLNEEDAASESSRESSNEDEGSSSEADEMAKALEAELNDLM"
     exon            460..543
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            544..637
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..766
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            767..917
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1008
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1175
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..2213
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2214..2355
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2562
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2725
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..2892
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2893..3744
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3725..3730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /note="hexamer: AATAAA"
     polyA_site      3744
                     /gene="CTDP1"
                     /gene_synonym="CCFDN; FCP1"
                     /note="major polyA site"
ORIGIN      
        1 aagtcggcgc gggctaggcg acgggtggaa gccggtaccg agaggaacta cagcgtcgcc
       61 gcctgggttg tgtcgccgcg gtaggcgctg cgctctgagc gcagcgcagg ccccgtaccg
      121 accgcccgcc cgccctctgt ccgcgatgga ggtgccggcc gcgggtcgcg ttcctgccga
      181 gggcgccccg acggcggctg tggccgaggt gcgctgcccg gggcccgcgc cgctgcgcct
      241 gctggagtgg agggtggcgg cgggcgcggc cgtgcgcatc ggctcggtgc tggccgtgtt
      301 cgaggccgcc gcctccgcgc agtcctccgg ggcctctcag tcccgtgtag cctccggggg
      361 ctgcgtgcgc cccgcgcggc cggaacgcag gctgaggtcg gagcgcgcgg gcgtggtgcg
      421 ggagctgtgc gcgcagccgg gccaggtggt cgccccagga gcggttctgg tgaggttgga
      481 aggatgcagc cacccggttg tcatgaaagg cctgtgtgct gaatgtggcc aagacctcac
      541 ccagttgcag agtaagaacg ggaagcagca ggtgccgctg tccacggcga ccgtgtccat
      601 ggtgcacagc gtgccggagt tgatggtgag ctccgagcaa gctgaacagc tgggaagaga
      661 agaccagcag cgactgcacc gaaaccggaa gctggtgctc atggtggact tggaccagac
      721 gttgattcac acaaccgagc agcactgtca gcagatgtcg aataaaggca tctttcactt
      781 ccagctgggc cggggtgagc ccatgctgca cacgcgcctg cgtccacact gcaaggactt
      841 cctggagaag atcgccaagc tgtacgagct gcacgtcttc accttcggca gccggctgta
      901 cgcacacacc atcgcaggct ttttagaccc cgagaagaag cttttttctc accgaatatt
      961 atcaagggat gaatgtattg acccattttc taaaacggga aaccttagaa atctctttcc
     1021 ttgtggagac tcaatggttt gcattattga tgatcgagaa gatgtctgga agtttgcccc
     1081 caatctgata actgtgaaga aatatgtata cttccagggc acgggtgata tgaatgcgcc
     1141 ccctgggtcc cgagaatctc agacgagaaa gaaagtaaat cattctcgag gcactgaggt
     1201 ctcagagcca tctccgcccg tgagagaccc tgagggggta acgcaggccc ctggagtgga
     1261 gcccagcaat ggcctggaga agcctgcacg ggagctgaac ggcagcgagg ccgccacccc
     1321 gcgggactca ccccgccccg ggaagccaga cgagagggac atctggcccc ctgcccaggc
     1381 ccccaccagc agccaagagc tggcaggcgc tcctgagccc cagggatcct gtgcgcaggg
     1441 tggccgggtg gcaccgggac agcggcctgc ccagggtgcc acgggcactg acctggactt
     1501 tgacttatcc agcgacagcg agagcagcag tgagtccgag ggcacgaagt cctcctcctc
     1561 cgcctctgat ggcgaaagcg aggggaaaag aggccggcag aagccgaagg ctgccccaga
     1621 gggagccggg gcgctggcac agggcagttc cctggagccg gggcggcctg cagcaccgag
     1681 tctccccgga gaggccgagc ctggcgcgca tgccccggac aaggagcctg agctgggtgg
     1741 gcaggaggag ggcgagcggg atggcctctg cggcctgggc aacggctgtg ccgacaggaa
     1801 ggaggcggag accgagtcac agaacagcga gctgtcgggg gtcactgcgg gtgagtccct
     1861 ggaccagagc atggaggagg aggaggagga ggacacggat gaggatgacc acctcatcta
     1921 cctggaggag atcctggtcc gtgtacacac tgactactat gccaagtatg accgctacct
     1981 caacaaggag atcgaggagg cgccggacat ccgcaagatc gtgccggagc tcaagagcaa
     2041 ggtgctggca gacgtggcca taattttcag tgggctacac ccgacaaact tcccgataga
     2101 gaagacgcgg gagcattacc acgccacggc gctgggagcg aagatcctca ctcggctggt
     2161 gctgagcccc gacgcccctg acagggccac gcacctgatc gccgcgcgag ctggcacaga
     2221 gaaggtgctg caggcacagg agtgcggaca cctgcacgtg gtcaaccctg actggctgtg
     2281 gagctgcctg gagcgctggg acaaggtgga ggagcagctc ttcccgctca gggacgatca
     2341 caccaaggca cagagggaga acagccctgc ggcctttccc gaccgggagg gtgtgccccc
     2401 caccgccttg ttccacccga tgccggttct tcccaaggcc cagcctggcc ccgaggttcg
     2461 gatctacgac tccaacacgg ggaagctcat caggacgggc gcccgggggc ccccagcacc
     2521 ctccagctcc ctacccatcc gccaggagcc ctcttccttc agagcggttc cgccacccca
     2581 gccgcagatg tttggtgaag agctgcctga cgctcaggac ggagagcagc ctggcccttc
     2641 tagaagaaag cgacagccca gtatgtctga gacaatgccg ctgtacactc tttgtaagga
     2701 ggatttagag agtatggaca aagaggtgga cgacatcctt ggagaaggca gcgacgacag
     2761 cgacagcgag aagaggaggc ctgaggagca ggaggaggag ccccagcccc ggaagccagg
     2821 gacccgcagg gagcggacgc tcggggcacc tgcgtccagc gagaggagcg cggcaggggg
     2881 ccgggggccc agaggccaca agaggaagct gaatgaagag gacgccgcca gcgagtccag
     2941 cagggagtcc agcaacgagg atgagggcag cagctccgag gccgacgaga tggccaaggc
     3001 gctggaggcg gagctcaacg acctcatgtg agcgcgggca gcgggcaggg actgaagcct
     3061 gaccgacctc cagcagcact cggacgtccc cggaccagcc ctcagtctcg gtccacgctg
     3121 ctttcttccc aaaggacatg tatatttgca gagctccaca tacagaaaca cattattttg
     3181 cagaaatagg tgtttttaag aagttttact acaggaatgt ctacttttgt aagtgacagg
     3241 tgttaaaggc ccaggtgtgc tgtgccaaag agctcagcag aggctcacgt ggcccaggct
     3301 ggtgcgcccg ctgtctcggt aaggggcggg ttggtgtgtt ttccccttgt gtaccagagc
     3361 acattcctta ggggacggct ttgggggtcc cacgagacat ggactaggag tttaagcagg
     3421 acagtgtgcg tgcacgagct ccgagcccag cacagacatg cctggaaccc ccgccgcctg
     3481 ctgctccctc ctagggaacc catttccggg gaacgccgtg actgtcgggc agcctggagc
     3541 ttcctgcagc ctcctacgca gggtccacgc cacgtggcct gggctgccat cctgccgtcc
     3601 tcccactggc atcctggcaa gggggcgttg cttttcctgg gcggcctttt atgtcttgga
     3661 gacacctgat gtaaagtttc tgtaaatcta tttcatatct gacccaccaa acagatttct
     3721 ctttaataaa aatccttttt gtaa
//
