LOCUS       NM_001143775            1767 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens CTD nuclear envelope phosphatase 1 (CTDNEP1),
            transcript variant 2, mRNA.
ACCESSION   NM_001143775
VERSION     NM_001143775.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1767)
  AUTHORS   Gao,S., Carrasquillo Rodriguez,J.W., Bahmanyar,S. and Airola,M.V.
  TITLE     Structure and mechanism of the human CTDNEP1-NEP1R1 membrane
            protein phosphatase complex necessary to maintain ER membrane
            morphology
  JOURNAL   Proc Natl Acad Sci U S A 121 (22), e2321167121 (2024)
   PUBMED   38776370
  REMARK    GeneRIF: Structure and mechanism of the human CTDNEP1-NEP1R1
            membrane protein phosphatase complex necessary to maintain ER
            membrane morphology.
REFERENCE   2  (bases 1 to 1767)
  AUTHORS   Luo,Z., Xin,D., Liao,Y., Berry,K., Ogurek,S., Zhang,F., Zhang,L.,
            Zhao,C., Rao,R., Dong,X., Li,H., Yu,J., Lin,Y., Huang,G., Xu,L.,
            Xin,M., Nishinakamura,R., Yu,J., Kool,M., Pfister,S.M.,
            Roussel,M.F., Zhou,W., Weiss,W.A., Andreassen,P. and Lu,Q.R.
  TITLE     Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma
            by triggering MYC amplification and genomic instability
  JOURNAL   Nat Commun 14 (1), 762 (2023)
   PUBMED   36765089
  REMARK    GeneRIF: Loss of phosphatase CTDNEP1 potentiates aggressive
            medulloblastoma by triggering MYC amplification and genomic
            instability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1767)
  AUTHORS   Penfield,L., Shankar,R., Szentgyorgyi,E., Laffitte,A., Mauro,M.S.,
            Audhya,A., Muller-Reichert,T. and Bahmanyar,S.
  TITLE     Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear
            envelope closure
  JOURNAL   J Cell Biol 219 (5) (2020)
   PUBMED   32271860
  REMARK    GeneRIF: Regulated lipid synthesis and LEM2/CHMP7 jointly control
            nuclear envelope closure.
REFERENCE   4  (bases 1 to 1767)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1767)
  AUTHORS   Naderi,M., Pazouki,A., Arefian,E., Hashemi,S.M.,
            Jamshidi-Adegani,F., Gholamalamdari,O., Soudi,S., Azadmanesh,K.,
            Mirab Samiee,S., Merat,S., Gholami Fesharaki,M., Mondanizadeh,M.,
            Vasei,M. and Soleimani,M.
  TITLE     Two Triacylglycerol Pathway Genes, CTDNEP1 and LPIN1, are
            Down-Regulated by hsa-miR-122-5p in Hepatocytes
  JOURNAL   Arch Iran Med 20 (3), 165-171 (2017)
   PUBMED   28287811
  REMARK    GeneRIF: CTDNEP1 is upregulated in non-alcoholic fatty liver
            disease. Up-regulation of miR-122 can trigger the compensatory
            response of LPIN1 and CTDNEP1 in hepatosteatosis.
REFERENCE   6  (bases 1 to 1767)
  AUTHORS   Wu,R., Garland,M., Dunaway-Mariano,D. and Allen,K.N.
  TITLE     Homo sapiens dullard protein phosphatase shows a preference for the
            insulin-dependent phosphorylation site of lipin1
  JOURNAL   Biochemistry 50 (15), 3045-3047 (2011)
   PUBMED   21413788
  REMARK    GeneRIF: dullard shows specificity for the peptide corresponding to
            the insulin-dependent phosphorylation site (Ser106) of lipin
REFERENCE   7  (bases 1 to 1767)
  AUTHORS   Kim,Y., Gentry,M.S., Harris,T.E., Wiley,S.E., Lawrence,J.C. Jr. and
            Dixon,J.E.
  TITLE     A conserved phosphatase cascade that regulates nuclear membrane
            biogenesis
  JOURNAL   Proc Natl Acad Sci U S A 104 (16), 6596-6601 (2007)
   PUBMED   17420445
  REMARK    GeneRIF: Dullard participates in a unique phosphatase cascade
            regulating nuclear membrane biogenesis, a cascade that is conserved
            from yeast to mammals.
REFERENCE   8  (bases 1 to 1767)
  AUTHORS   Zhang,Y., Kim,Y., Genoud,N., Gao,J., Kelly,J.W., Pfaff,S.L.,
            Gill,G.N., Dixon,J.E. and Noel,J.P.
  TITLE     Determinants for dephosphorylation of the RNA polymerase II
            C-terminal domain by Scp1
  JOURNAL   Mol Cell 24 (5), 759-770 (2006)
   PUBMED   17157258
REFERENCE   9  (bases 1 to 1767)
  AUTHORS   Satow,R., Kurisaki,A., Chan,T.C., Hamazaki,T.S. and Asashima,M.
  TITLE     Dullard promotes degradation and dephosphorylation of BMP receptors
            and is required for neural induction
  JOURNAL   Dev Cell 11 (6), 763-774 (2006)
   PUBMED   17141153
REFERENCE   10 (bases 1 to 1767)
  AUTHORS   Satow,R., Chan,T.C. and Asashima,M.
  TITLE     Molecular cloning and characterization of dullard: a novel gene
            required for neural development
  JOURNAL   Biochem Biophys Res Commun 295 (1), 85-91 (2002)
   PUBMED   12083771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC003688.1, BC009295.2 and AC120057.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001143775.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.376103.1,
                                           SRR1163658.437385.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574322.6/ ENSP00000460683.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC003688.1         54073-54130         c
            59-520              AC003688.1         53611-54072         c
            521-1519            BC009295.2         529-1527
            1520-1767           AC120057.9         197737-197984       c
FEATURES             Location/Qualifiers
     source          1..1767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1767
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /note="CTD nuclear envelope phosphatase 1"
                     /db_xref="GeneID:23399"
                     /db_xref="HGNC:HGNC:19085"
                     /db_xref="MIM:610684"
     exon            1..540
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     CDS             439..1173
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /EC_number="3.1.3.16"
                     /note="serine/threonine-protein phosphatase dullard;
                     dullard homolog; C-terminal domain nuclear envelope
                     phosphatase 1"
                     /codon_start=1
                     /product="CTD nuclear envelope phosphatase 1"
                     /protein_id="NP_001137247.1"
                     /db_xref="CCDS:CCDS11093.1"
                     /db_xref="GeneID:23399"
                     /db_xref="HGNC:HGNC:19085"
                     /db_xref="MIM:610684"
                     /translation="MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYD
                     ILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKH
                     PVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQH
                     CTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLL
                     PMLDALRFTADVRSVLSRNLHQHRLW"
     exon            541..607
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            608..726
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            727..798
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            799..915
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1027
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1112
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1767
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1748..1753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /note="hexamer: ATTATA"
     polyA_site      1767
                     /gene="CTDNEP1"
                     /gene_synonym="DULLARD; HSA011916; NET56"
                     /note="major polyA site"
ORIGIN      
        1 agccccctag cgcgcctgcg cagcgggcca ctctctgctt tccccccctc cccttccctt
       61 ttcccttcct cccttttccc tagccccctc ccccactgcc ccctccccca attatccttc
      121 cccttccctc caggtctcgg aggaccccat cctagcccta cctgtctcgg cccgcaacct
      181 ccccgaagcc gtcggtgcca ctcccagccc atgtgggccc ccgcgggctg cccacgcctg
      241 tcccccagct ccccgttccg ctgggcttta ccctcgccag gggtggcttt ctgagccgcc
      301 cgctccgtgc ccctctctgc agcctctcct gccactcggg gcccccgttc cccctcccgg
      361 cggcgggggg ctgcccccgg ggggctggcg gagctgggcc gcgggggccc cggggccggc
      421 ggtgccgggg tcatcgggat gatgcggacg cagtgtctgc tggggctgcg cacgttcgtg
      481 gccttcgccg ccaagctctg gagcttcttc atttaccttc tgcggaggca gatccgcacg
      541 gtaattcagt accaaactgt tcgatatgat atcctcccct tatctcctgt gtcccggaat
      601 cggctagccc aggtgaagag gaagatcctg gtgctggatc tggatgagac acttattcac
      661 tcccaccatg atggggtcct gaggcccaca gtccggcctg gtacgcctcc tgacttcatc
      721 ctcaaggtgg taatagacaa acatcctgtc cggttttttg tacataagag gccccatgtg
      781 gatttcttcc tggaagtggt gagccagtgg tacgagctgg tggtgtttac agcaagcatg
      841 gagatctatg gctctgctgt ggcagataaa ctggacaata gcagaagcat tcttaagagg
      901 agatattaca gacagcactg cactttggag ttgggcagct acatcaagga cctctctgtg
      961 gtccacagtg acctctccag cattgtgatc ctggataact ccccaggggc ttacaggagc
     1021 catccagaca atgccatccc catcaaatcc tggttcagtg accccagcga cacagccctt
     1081 ctcaacctgc tcccaatgct ggatgccctc aggttcaccg ctgatgttcg ttccgtgctg
     1141 agccgaaacc ttcaccaaca tcggctctgg tgacagctgc tccccctcca cctgagttgg
     1201 ggtggggggg aaagggaggg cgagcccttg ggatgccgtc tgatgccctg tccaatgtga
     1261 ggactgcctg ggcagggtct gcccctccca cccctctctg ccctgggagc cctacactcc
     1321 acttggagtc tggatggaca catgggccag gggctctgaa gcagcctcac tcttaacttc
     1381 gtgttcacac tccatggaaa ccccagactg ggacacaggc ggaagcctag gagagccgaa
     1441 tcagtgtttg tgaagaggca ggactggcca gagtgacaga catacggtga tccaggaggc
     1501 tcaaagagaa gccaagtcag ctttgttgtg atttgatttt ttttaaaaaa ctcttgtaca
     1561 aaactgatct aattcttcac tcctgctcca agggctgggc tgtgggtggg atactgggat
     1621 tttgggccac tggattttcc ctaaatttgt ccccccttta ctctccctct atttttctct
     1681 ccttagactc cctcagacct gtaaccagct ttgtgtcttt tttccttttc tctcttttaa
     1741 accatgcatt ataactttga aaccaaa
//
