LOCUS       NM_025099               7039 bp    mRNA    linear   PRI 04-OCT-2024
DEFINITION  Homo sapiens CST telomere replication complex component 1 (CTC1),
            transcript variant 1, mRNA.
ACCESSION   NM_025099 XM_496182
VERSION     NM_025099.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7039)
  AUTHORS   Takai,H., Aria,V., Borges,P., Yeeles,J.T.P. and de Lange,T.
  TITLE     CST-polymerase alpha-primase solves a second telomere
            end-replication problem
  JOURNAL   Nature 627 (8004), 664-670 (2024)
   PUBMED   38418884
  REMARK    GeneRIF: CST-polymerase alpha-primase solves a second telomere
            end-replication problem.
REFERENCE   2  (bases 1 to 7039)
  AUTHORS   Liu,L., Luo,H., Sheng,Y., Kang,X., Peng,H., Luo,H. and Fan,L.L.
  TITLE     A novel mutation of CTC1 leads to telomere shortening in a chinese
            family with interstitial lung disease
  JOURNAL   Hereditas 160 (1), 37 (2023)
   PUBMED   37978541
  REMARK    GeneRIF: A novel mutation of CTC1 leads to telomere shortening in a
            chinese family with interstitial lung disease.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7039)
  AUTHORS   Wang,H., Ma,T., Zhang,X., Chen,W., Lan,Y., Kuang,G., Hsu,S.J.,
            He,Z., Chen,Y., Stewart,J., Bhattacharjee,A., Luo,Z., Price,C. and
            Feng,X.
  TITLE     CTC1 OB-B interaction with TPP1 terminates telomerase and prevents
            telomere overextension
  JOURNAL   Nucleic Acids Res 51 (10), 4914-4928 (2023)
   PUBMED   37021555
  REMARK    GeneRIF: CTC1 OB-B interaction with TPP1 terminates telomerase and
            prevents telomere overextension.
REFERENCE   4  (bases 1 to 7039)
  AUTHORS   Zaug,A.J., Goodrich,K.J., Song,J.J., Sullivan,A.E. and Cech,T.R.
  TITLE     Reconstitution of a telomeric replicon organized by CST
  JOURNAL   Nature 608 (7924), 819-825 (2022)
   PUBMED   35831508
  REMARK    GeneRIF: Reconstitution of a telomeric replicon organized by CST.
REFERENCE   5  (bases 1 to 7039)
  AUTHORS   Polvi,A., Linnankivi,T., Kivela,T., Herva,R., Keating,J.P.,
            Makitie,O., Pareyson,D., Vainionpaa,L., Lahtinen,J., Hovatta,I.,
            Pihko,H. and Lehesjoki,A.E.
  TITLE     Mutations in CTC1, encoding the CTS telomere maintenance complex
            component 1, cause cerebroretinal microangiopathy with
            calcifications and cysts
  JOURNAL   Am J Hum Genet 90 (3), 540-549 (2012)
   PUBMED   22387016
  REMARK    GeneRIF: Observed four recessively inherited compound heterozygous
            mutations in CTC1, which encodes the CTS telomere maintenance
            complex component 1.
REFERENCE   6  (bases 1 to 7039)
  AUTHORS   Anderson,B.H., Kasher,P.R., Mayer,J., Szynkiewicz,M.,
            Jenkinson,E.M., Bhaskar,S.S., Urquhart,J.E., Daly,S.B.,
            Dickerson,J.E., O'Sullivan,J., Leibundgut,E.O., Muter,J.,
            Abdel-Salem,G.M., Babul-Hirji,R., Baxter,P., Berger,A., Bonafe,L.,
            Brunstom-Hernandez,J.E., Buckard,J.A., Chitayat,D., Chong,W.K.,
            Cordelli,D.M., Ferreira,P., Fluss,J., Forrest,E.H., Franzoni,E.,
            Garone,C., Hammans,S.R., Houge,G., Hughes,I., Jacquemont,S.,
            Jeannet,P.Y., Jefferson,R.J., Kumar,R., Kutschke,G., Lundberg,S.,
            Lourenco,C.M., Mehta,R., Naidu,S., Nischal,K.K., Nunes,L.,
            Ounap,K., Philippart,M., Prabhakar,P., Risen,S.R., Schiffmann,R.,
            Soh,C., Stephenson,J.B., Stewart,H., Stone,J., Tolmie,J.L., van der
            Knaap,M.S., Vieira,J.P., Vilain,C.N., Wakeling,E.L., Wermenbol,V.,
            Whitney,A., Lovell,S.C., Meyer,S., Livingston,J.H.,
            Baerlocher,G.M., Black,G.C., Rice,G.I. and Crow,Y.J.
  TITLE     Mutations in CTC1, encoding conserved telomere maintenance
            component 1, cause Coats plus
  JOURNAL   Nat Genet 44 (3), 338-342 (2012)
   PUBMED   22267198
  REMARK    GeneRIF: Mutations in CTC1, encoding conserved telomere maintenance
            component 1, cause Coats plus.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7039)
  AUTHORS   Surovtseva,Y.V., Churikov,D., Boltz,K.A., Song,X., Lamb,J.C.,
            Warrington,R., Leehy,K., Heacock,M., Price,C.M. and Shippen,D.E.
  TITLE     Conserved telomere maintenance component 1 interacts with STN1 and
            maintains chromosome ends in higher eukaryotes
  JOURNAL   Mol Cell 36 (2), 207-218 (2009)
   PUBMED   19854131
  REMARK    GeneRIF: CTC1 participates in telomere maintenance in diverse
            species and that a CST-like complex is required for telomere
            integrity in multicellular organisms.
REFERENCE   8  (bases 1 to 7039)
  AUTHORS   Miyake,Y., Nakamura,M., Nabetani,A., Shimamura,S., Tamura,M.,
            Yonehara,S., Saito,M. and Ishikawa,F.
  TITLE     RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded
            DNA and protects telomeres independently of the Pot1 pathway
  JOURNAL   Mol Cell 36 (2), 193-206 (2009)
   PUBMED   19854130
  REMARK    GeneRIF: Ctc1-Stn1-Ten1 is a replication protein A (RPA)-like
            complex that is not directly involved in conventional DNA
            replication at forks but plays a role in DNA metabolism frequently
            required by telomeres.
REFERENCE   9  (bases 1 to 7039)
  AUTHORS   Casteel,D.E., Zhuang,S., Zeng,Y., Perrino,F.W., Boss,G.R.,
            Goulian,M. and Pilz,R.B.
  TITLE     A DNA polymerase-{alpha}{middle dot}primase cofactor with homology
            to replication protein A-32 regulates DNA replication in mammalian
            cells
  JOURNAL   J Biol Chem 284 (9), 5807-5818 (2009)
   PUBMED   19119139
REFERENCE   10 (bases 1 to 7039)
  AUTHORS   Savage,S.A. and Niewisch,M.R.
  TITLE     Dyskeratosis Congenita and Related Telomere Biology Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301779
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC135178.13 and KF456245.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2018 this sequence version replaced NM_025099.5.
            
            Summary: This gene encodes a component of the CST complex. This
            complex plays an essential role in protecting telomeres from
            degradation. This protein also forms a heterodimer with the CST
            complex subunit STN1 to form the enzyme alpha accessory factor.
            This enzyme regulates DNA replication. Mutations in this gene are
            the cause of cerebroretinal microangiopathy with calcifications and
            cysts. Alternate splicing results in both coding and non-coding
            variants. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091077.1, BC111783.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000651323.1/ ENSP00000498499.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC135178.13        136527-136579
            54-217              AC135178.13        141435-141598
            218-274             AC135178.13        145954-146010
            275-455             KF456245.1         199-379             c
            456-504             KF456245.1         1-49                c
            505-667             AC135178.13        146390-146552
            668-812             AC135178.13        147064-147208
            813-1097            AC135178.13        148241-148525
            1098-1226           AC135178.13        148624-148752
            1227-1459           AC135178.13        149298-149530
            1460-1637           AC135178.13        149657-149834
            1638-1838           AC135178.13        149928-150128
            1839-1965           AC135178.13        151551-151677
            1966-2080           AC135178.13        152108-152222
            2081-2405           AC135178.13        152356-152680
            2406-2495           AC135178.13        152768-152857
            2496-2689           AC135178.13        153114-153307
            2690-2778           AC135178.13        153932-154020
            2779-2953           AC135178.13        154115-154289
            2954-3031           AC135178.13        154615-154692
            3032-3176           AC135178.13        155137-155281
            3177-3241           AC135178.13        155377-155441
            3242-3407           AC135178.13        155691-155856
            3408-3534           AC135178.13        155954-156080
            3535-7039           AC135178.13        156264-159768
FEATURES             Location/Qualifiers
     source          1..7039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..7039
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="CST telomere replication complex component 1"
                     /db_xref="GeneID:80169"
                     /db_xref="HGNC:HGNC:26169"
                     /db_xref="MIM:613129"
     exon            1..53
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..3674
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="isoform 1 is encoded by transcript variant 1; CST
                     complex subunit CTC1; alpha accessory factor 132;
                     conserved telomere capping protein 1; HBV
                     DNAPTP1-transactivated protein B; CTS telomere maintenance
                     complex component 1; CST telomere maintenance complex
                     component 1"
                     /codon_start=1
                     /product="CST complex subunit CTC1 isoform 1"
                     /protein_id="NP_079375.3"
                     /db_xref="CCDS:CCDS42259.1"
                     /db_xref="GeneID:80169"
                     /db_xref="HGNC:HGNC:26169"
                     /db_xref="MIM:613129"
                     /translation="MAAGRAQVPSSEQAWLEDAQVFIQKTLCPAVKEPNVQLTPLVID
                     CVKTVWLSQGRNQGSTLPLSYSFVSVQDLKTHQRLPCCSHLSWSSSAYQAWAQEAGPN
                     GNPLPREQLLLLGTLTDLSADLEQECRNGSLYVRDNTGVLSCELIDLDLSWLGHLFLF
                     PRWSYLPPARWNSSGEGHLELWDAPVPVFPLTISPGPVTPIPVLYPESASCLLRLRNK
                     LRGVQRNLAGSLVRLSALVKSKQKAYFILSLGRSHPAVTHVSIIVQVPAQLVWHRALR
                     PGTAYVLTELRVSKIRGQRQHVWMTSQSSRLLLLKPECVQELELELEGPLLEADPKPL
                     PMPSNSEDKKDPESLVRYSRLLSYSGAVTGVLNEPAGLYELDGQLGLCLAYQQFRGLR
                     RVMRPGVCLQLQDVHLLQSVGGGTRRPVLAPCLRGAVLLQSFSRQKPGAHSSRQAYGA
                     SLYEQLVWERQLGLPLYLWATKALEELACKLCPHVLRHHQFLQHSSPGSPSLGLQLLA
                     PTLDLLAPPGSPVRNAHNEILEEPHHCPLQKYTRLQTPSSFPTLATLKEEGQRKAWAS
                     FDPKALLPLPEASYLPSCQLNRRLAWSWLCLLPSAFCPAQVLLGVLVASSHKGCLQLR
                     DQSGSLPCLLLAKHSQPLSDPRLIGCLVRAERFQLIVERDVRSSFPSWKELSMPGFIQ
                     KQQARVYVQFFLADALILPVPRPCLHSATPSTPQTDPTGPEGPHLGQSRLFLLCHKEA
                     LMKRNFCVPPGASPEVPKPALSFYVLGSWLGGTQRKEGTGWGLPEPQGNDDNDQKVHL
                     IFFGSSVRWFEFLHPGQVYRLIAPGPATPMLFEKDGSSCISRRPLELAGCASCLTVQD
                     NWTLELESSQDIQDVLDANKSLPESSLTDLLSDNFTDSLVSFSAEILSRTLCEPLVAS
                     LWMKLGNTGAMRRCVKLTVALETAECEFPPHLDVYIEDPHLPPSLGLLPGARVHFSQL
                     EKRVSRSHNVYCCFRSSTYVQVLSFPPETTISIPLPHIYLAELLQGGQSPFQATASCH
                     IVSVFSLQLFWVCAYCTSICRQGKCTRLGSTCPTQTAISQAIIRLLVEDGTAEAVVTC
                     RNHHVAAALGLCPREWASLLDFVQVPGRVVLQFAGPGAQLESSARVDEPMTMFLWTLC
                     TSPSVLRPIVLSFELERKPSKIVPLEPPRLQRFQCGELPFLTHVNPRLRLSCLSIRES
                     EYSSSLGILASSC"
     exon            54..217
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            218..455
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            456..667
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            668..812
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1097
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1226
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1459
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1637
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..1838
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..1965
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            1966..2080
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2405
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2495
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2689
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..2778
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2953
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3031
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3176
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3241
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            3242..3407
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            3408..3534
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..7039
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4014..4019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="hexamer: AATGAA"
     polyA_site      4033
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="major polyA site"
     regulatory      7018..7023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="hexamer: AATAAA"
     polyA_site      7033
                     /gene="CTC1"
                     /gene_synonym="AAF-132; AAF132; C17orf68; CRMCC;
                     tmp494178"
                     /note="major polyA site"
ORIGIN      
        1 gggcggagct ccggcgcatc atggcggctg gccgggccca ggtcccttcc tccgaacaag
       61 cctggcttga ggatgctcag gtcttcatcc aaaagaccct gtgtccagct gtcaaggagc
      121 ctaatgtcca gttgactcca ttggtaattg attgtgtgaa gactgtctgg ttgtcccagg
      181 gaaggaacca aggttctaca ctgcccctca gctatagctt cgtctcagta caggacctca
      241 agactcacca gcgtctccca tgctgcagcc acctgtcgtg gagcagtagt gcataccagg
      301 cctgggccca agaggctgga ccaaatggga accccctgcc ccgagagcag ctgttacttt
      361 tagggacact aacagaccta tcggcagact tggaacaaga gtgcaggaac ggaagcctct
      421 atgtgagaga taacactggc gtcctgagct gtgagctcat agacctggac ctttcttggt
      481 tgggccatct ttttctgttc ccccgttgga gttacctccc tcctgccagg tggaattcct
      541 caggggaagg gcacttggag ctgtgggatg cccctgtgcc agtgtttcct ttgaccatca
      601 gtcctggccc cgtcacgcct atccctgtcc tctacccaga gagtgcttcc tgcctgctca
      661 ggctcagaaa caagctcaga ggtgtgcagc gaaacctggc tgggagtcta gttcgattga
      721 gtgctctggt gaaaagtaaa cagaaagctt acttcatcct gtctcttggt agatcacacc
      781 cagctgtcac ccacgtgtcc atcatcgtgc aggtccctgc ccagctggtg tggcacagag
      841 cccttcggcc tggtacagcc tatgtgctga cagaactgcg agtgtccaag atccgtggtc
      901 agcgccagca tgtttggatg accagtcagt cctcccgtct gttgctgctg aaaccagaat
      961 gtgtgcagga gctggaactg gagctggaag gacccctctt agaggctgac cccaagccac
     1021 tccccatgcc cagcaactcg gaggacaaga aggatccaga aagtcttgtc cggtattcta
     1081 gactcctatc ctattcggga gcagtcactg gcgtgttgaa tgagcccgct ggcctctatg
     1141 agctggatgg gcagctgggg ctctgccttg cctaccagca gttccgtggc cttaggcggg
     1201 tgatgcgacc tggagtgtgt ctgcagctcc aggatgttca cctgctccag tcagtgggag
     1261 gggggacaag aaggccagtg ctcgccccct gcctccgtgg cgccgttctg cttcaaagct
     1321 tctctcgtca gaagcctggg gctcactcat cccgtcaagc ctacggggcc tccctgtacg
     1381 agcagctggt gtgggaacgt cagttaggac ttcccctcta cctgtgggct accaaggccc
     1441 tggaggagct ggcctgcaag ctgtgtcccc atgtgctgag acaccaccag ttcctgcaac
     1501 attcctctcc tgggagcccc agcctgggac tgcaactcct ggctcctacc ctggatcttc
     1561 tagctccgcc aggcagccct gttcggaatg cacacaatga gatccttgaa gagccacatc
     1621 actgtcccct ccagaaatac actcggctgc agactccctc ctccttcccc actctggcca
     1681 ccctgaaaga agaaggacag cgtaaggcct gggcctcctt tgaccctaag gcccttctgc
     1741 ccctcccgga ggcctcctac ctgcccagct gccaactcaa tcgccgcctg gcttggtcct
     1801 ggctctgtct gctgccctct gccttctgcc cagcccaggt tttacttggg gttctggtgg
     1861 cttcatctca taaaggttgt ctgcaacttc gggaccaaag tggttccctg ccctgcctgc
     1921 tcctggccaa gcactctcaa cccctcagtg acccacggct gataggctgc ctggtgcggg
     1981 cagagaggtt tcagttgatc gtagagaggg acgtgagaag cagcttccct tcctggaagg
     2041 agctgagcat gccaggcttc atccagaagc agcaggccag agtctatgtc cagttctttc
     2101 tggctgatgc cctgatcctg cctgtgccca gaccctgcct tcattcagca acaccctcaa
     2161 cacctcagac agatcccacc ggcccagagg gaccccacct aggacagagc cggctcttct
     2221 tgctctgcca caaggaggcc ctcatgaagc gtaatttttg tgtcccccca ggagcaagtc
     2281 cagaggtgcc caagcccgcc ctcagtttct atgtgttggg gagctggctt gggggcaccc
     2341 agaggaagga gggtactgga tgggggctgc ccgagcccca gggaaatgac gacaatgatc
     2401 agaaggttca cctcattttc tttggctctt cagtccgctg gtttgagttc ttgcacccgg
     2461 gacaggtgta ccgactcata gctcctggcc ccgctacacc aatgttgttt gaaaaggatg
     2521 gttcatcctg catatctcgg cgtcctctgg agttggctgg ctgtgcatcc tgcctcactg
     2581 tccaggacaa ctggactctg gagcttgaaa gctcccagga tatccaagat gtgctggatg
     2641 caaacaagtc attgcctgaa tcctcactga ccgacctgct cagtgacaat ttcacagatt
     2701 ccttggtgtc tttctccgct gagattttgt cacggacact atgtgaaccc cttgtggcgt
     2761 ctctctggat gaaactgggg aacacggggg ccatgagaag gtgtgtgaag ctaacagtcg
     2821 ctcttgagac tgctgaatgt gaattccccc ctcacctgga tgtatatata gaagacccac
     2881 acttgcctcc ctcactagga ctacttccag gagcccgggt ccacttcagc cagttggaga
     2941 aaagggtttc cagatctcac aatgtttatt gttgtttccg gtcatccact tatgtgcagg
     3001 tcctgagttt tccccctgag accaccatca gcattcccct gccccacatc tacctggctg
     3061 aacttctgca gggtggtcag tccccattcc aggccactgc ctcttgccat atcgtctctg
     3121 tcttcagcct tcagctcttc tgggtgtgtg cttattgtac cagcatctgc cggcagggaa
     3181 agtgcactcg cctgggctcc acttgcccta cgcagacagc tataagccag gccatcatca
     3241 ggctcctggt ggaggatggg actgccgaag ccgtggtgac ctgtaggaat caccatgtgg
     3301 cagcagcact agggctgtgt cctagagagt gggcctccct cctagatttc gtccaagtgc
     3361 caggcagagt ggtcttgcag tttgcagggc ctggagccca acttgagtct tcagccaggg
     3421 ttgacgagcc catgaccatg ttcctctgga cactttgtac tagcccctct gtcctccgtc
     3481 ctattgtgct ttcttttgag ctggaaagga aaccgtcgaa gatcgtccca ttagaacctc
     3541 ctcggctaca gcgattccag tgtggagagc tccctttcct gactcacgtg aaccccaggc
     3601 tccgattgtc ctgcctttct atccgagagt cagagtactc cagctctctg gggatccttg
     3661 cttcctcctg ttaactgaac tgcaaggatg gcctgagagt ccttccttgc tgaaaacctg
     3721 aaggcctagg tcctggctcc tctccctact tgttctgtga ttgaaccaag gactccagat
     3781 tcacaaactg ctactccact ataatttccc ttctttggtg ttctggtgcc agcctgcctt
     3841 ggcaaaattg tggcaacagg aaatcatggc cctattaata tgtcctctga ttgggacaag
     3901 gcacctgcat tcacaggcgg ccctgagcac ctgggttctg actttgtcgc aggagctgag
     3961 ggaacaaaag acttgctcgc tgtggggtga tggtgacagg cctattgacc tgcaatgaag
     4021 ccctctggtg tcatttctca ctggtactca tctctggggt cccaggcctc ctgactccta
     4081 gttgtccacc tcctaggaac tcctagtcgt tcatcatcat ttcagccctt tgccgccagg
     4141 gccaaaggtg gaaagtgatt tggaagagaa gagcttttcg tccagcagaa gaaatggtac
     4201 caaaatcagt ctgtaaagga agtaaattgg ggagttggcg gcaaggcaga gagcatagct
     4261 atgatggtct cagtcagtaa ggctgggccc tgcaggaagt caaatatgaa tgcctagagg
     4321 tgttcacaag cacaaagaag gtgtaggggg aggcaagtgc caggcacaag caggggcagg
     4381 tgaggactct gggtgactgt gctatagggc cccaggctac ggttagccct gtaggtttcc
     4441 caagggcctg gcctaaggca gatccttgat cgatatacct tgagaccaga aggtgctccg
     4501 aaatcacaac cgtacaatta ggggatctag gaacaattct ttggagatac caatgccttt
     4561 ggctggtgtt gctgcatttc tttactgggg actgatagat ggagaggtgg aaagatgagc
     4621 tgaggcacat ctttcagagc tactgggagg ccatttcttc ctggctgtta ggatttgttc
     4681 gtgtttggga gacctttaga gcgtggttaa acccatatgt tgggatttat gctgctttta
     4741 tggtagcaat accctatatt aagatttgaa gtagacccgg aaagttagtg gccggttagc
     4801 tcagttggtt agagcgtggt gctaataacg ccaaggtcgc gggttcgaac cccgtacggg
     4861 ccagtgggtg gctttttttt gtgtgtgttt tgttttctga ccctctgctg ttatccggaa
     4921 gtttctaccc ggagccagtt gccttctggt aacagaatta tattgcacct actgcttcct
     4981 attccctgaa tcactagcgc tcccgaaggc ttggagggag gagtctctgg gcacccgggt
     5041 gaaaggaagg ttcacgtgca accgccgcgt ctttttttcc ctgaagcgct ttcatggagg
     5101 cagatgtttg tcagtcaagg gaagtaagaa aggcattgga tgaaaacgaa gccctaagcc
     5161 tcgtagtcgt ggccgagtgg ttaaggcgat ggactagaaa tccattgggg tctccccgcg
     5221 caggttcgaa tcctgccgac tacgtcatat ttttttcttc agcatactga ccatatttct
     5281 ctccaggatg ggatgatcca gtcggcaccc tccaaacctc tcatctagga actctagaat
     5341 cgagaatttg atttagagtc tatgattttg gtttgaaatc tatgattaac gtctttggac
     5401 attgaaggaa atccgaggaa tggacaagtg atgcaagagc cagttgagtt accaaattag
     5461 ttctagaaag atctgaaaaa gctcggtccg ggttcctagc tctatattct tgtagatgaa
     5521 tttcaggaac ctttatggca gcttcggcgc cgtggcttag ttggttaaag cgcctgtcta
     5581 gtaaacagga gatcctgggt tcgaatccca gcggtgcctt tattcaattg aaacagcgtg
     5641 attttgcggc taaatccaca tcctttcatg tattgttttt atatcagaac gcgtaagagt
     5701 ttctgttctg cactcatagc acccacattt cctgcagagt caagctgcca ctcccatgag
     5761 atcgccactc taaaaggtgg ttctctaact taggggcaga aatgttgcat aggcctaagg
     5821 gtcctttgct taactgatgc cacaccccac tggtgcaggt ggactgggtc aggcggccgc
     5881 cccaccctcg atggaagggg ctgcccacct tccaggcctc tttctccacc ctaggacgtc
     5941 ccctagaacc tgagccactt tgttttgttt ggctcttcat tatagttctt tgggtttggt
     6001 ggctcataat gttatatata tagtatataa tataaaaata tatatttaaa tatacagtat
     6061 ttaaaatttg gcacagcttc cagatgcggt cctctaactg gtctttcact tgcagttacc
     6121 tccatccctc tccaccagcg ggatgtcagg gtaaggagta agcagggatc cggctggcct
     6181 ggcctggcct ggcaccaggt ttcgtgcagc agggtgcaga agggctgagg ccatgtgaac
     6241 agagtccaag aaagcatcat tcgggagtcg ctagggatcc tggtgtggaa gggcagggca
     6301 cttttctgga gcactgaagc taggctggtt aaggaagaaa taaatgccag agataaggca
     6361 agaaatagga tctgtgagct cttggcagga cctaaacctc cttggaagat aggcagaaag
     6421 ctctcgacac cattccatgg cccacgaacc aatgtaagat gagcaaatgg cttgaaggaa
     6481 ttgctacctc caggtcaagc cagggatgca gcactgccga gaccacgttt gtgccaagca
     6541 ctgggctgga ccctgtgcag aaccaaatga acaaggcacg ttcccctttc agcactaacg
     6601 gcactgtaag aacagggaga agtggaatct aatctggcct gagggtagag ggtgatcagc
     6661 taagtctgaa acaccatgta gaaacttgcc atgtatggcc gggcgcggtg gctcacgcct
     6721 gtaatcccag cgctttggga ggccaaggtg ggcggatcac gaggtcagga gttccagacc
     6781 agcagcctgg ccaacatagt gaaacctggt aacatagtga aacctcgtct ctactaaaaa
     6841 tgcaaaaaat tagccaggcg tggtggcagg cgcctgcagt cctagctact tgggaggctg
     6901 aggcaagaga atcgcttcaa ccttggaggg gggaggaggt gttgtcagcc gagatcgcgc
     6961 cactgcatcc cagcctgggc aacaagagtg aaactccgtc tcaaaaaaat gaaataaaat
     7021 aaacgaatga tcagctgtt
//
