LOCUS       NM_004388               6571 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chitobiase (CTBS), mRNA.
ACCESSION   NM_004388
VERSION     NM_004388.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6571)
  AUTHORS   Olszewski,S., Olszewska,E., Popko,J., Poskrobko,E., Sierakowski,S.
            and Zwierz,K.
  TITLE     Fibroblast-Like Synovial Cells in Rheumatoid Arthritis--the Impact
            of Infliximab on Hexosaminidase Activity
  JOURNAL   Adv Clin Exp Med 24 (5), 807-813 (2015)
   PUBMED   26768631
  REMARK    GeneRIF: Data indicate that infliximab changes the concentration of
            hexosaminidase (N-acetyl-beta-glucosaminidase; HEX) activity
            depending on the drug dose and time of administration.
REFERENCE   2  (bases 1 to 6571)
  AUTHORS   Aronson,N.N. and Halloran,B.A.
  TITLE     Optimum substrate size and specific anomer requirements for the
            reducing-end glycoside hydrolase di-N-acetylchitobiase
  JOURNAL   Biosci Biotechnol Biochem 70 (6), 1537-1541 (2006)
   PUBMED   16794344
  REMARK    GeneRIF: biochemical behavior of di-N-acetylchitobiase indicates it
            has three subsites, -2, -1, +1, in which the reducing-end trimer of
            any sized chitooligosaccharide is bound. The +1 site is specific
            for an alpha-anomer.
REFERENCE   3  (bases 1 to 6571)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   4  (bases 1 to 6571)
  AUTHORS   Hutchinson,T., Dwivedi,K., Rastogi,A., Prasad,R. and Pereira,B.M.
  TITLE     N-acetyl beta-D-glucosaminidase is not attached to human sperm
            membranes through the glycosylphosphatidyl inositol (GPI)-anchor
  JOURNAL   Asian J Androl 4 (1), 27-33 (2002)
   PUBMED   11907625
REFERENCE   5  (bases 1 to 6571)
  AUTHORS   Liu,B., Ahmad,W. and Aronson,N.N. Jr.
  TITLE     Structure of the human gene for lysosomal di-N-acetylchitobiase
  JOURNAL   Glycobiology 9 (6), 589-593 (1999)
   PUBMED   10336991
REFERENCE   6  (bases 1 to 6571)
  AUTHORS   Ahmad,W., Li,S., Chen,H., Tuck-Muller,C.M., Pittler,S.J. and
            Aronson,N.N. Jr.
  TITLE     Lysosomal chitobiase (CTB) and the G-protein gamma 5 subunit (GNG5)
            genes co-localize to human chromosome 1p22
  JOURNAL   Cytogenet Cell Genet 71 (1), 44-46 (1995)
   PUBMED   7606925
REFERENCE   7  (bases 1 to 6571)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Cloning and expression of the cDNA sequence encoding the lysosomal
            glycosidase di-N-acetylchitobiase
  JOURNAL   J Biol Chem 267 (27), 19607-19616 (1992)
   PUBMED   1527079
REFERENCE   8  (bases 1 to 6571)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Characterization of the cDNA and genomic sequence of a G protein
            gamma subunit (gamma 5)
  JOURNAL   Mol Cell Biol 12 (4), 1585-1591 (1992)
   PUBMED   1549114
REFERENCE   9  (bases 1 to 6571)
  AUTHORS   Aronson,N.N. Jr. and Kuranda,M.J.
  TITLE     Lysosomal degradation of Asn-linked glycoproteins
  JOURNAL   FASEB J 3 (14), 2615-2622 (1989)
   PUBMED   2531691
  REMARK    Review article
REFERENCE   10 (bases 1 to 6571)
  AUTHORS   Aronson,N.N. Jr., Backes,M. and Kuranda,M.J.
  TITLE     Rat liver chitobiase: purification, properties, and role in the
            lysosomal degradation of Asn-linked glycoproteins
  JOURNAL   Arch Biochem Biophys 272 (2), 290-300 (1989)
   PUBMED   2751306
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC126335.1, BC065191.1, AI339601.1 and AL359762.24.
            
            On Nov 23, 2018 this sequence version replaced NM_004388.2.
            
            Summary: Chitobiase is a lysosomal glycosidase involved in
            degradation of asparagine-linked oligosaccharides on glycoproteins
            (Aronson and Kuranda, 1989 [PubMed 2531691]).[supplied by OMIM, Nov
            2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298703.1, SRR1660809.252331.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370630.6/ ENSP00000359664.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1624              BC126335.1         17-1640
            1625-2602           BC065191.1         1393-2370
            2603-3031           AI339601.1         29-457              c
            3032-3061           BC065191.1         2800-2829
            3062-6571           AL359762.24        59856-63365         c
FEATURES             Location/Qualifiers
     source          1..6571
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..6571
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="chitobiase"
                     /db_xref="GeneID:1486"
                     /db_xref="HGNC:HGNC:2496"
                     /db_xref="MIM:600873"
     exon            1..202
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..1183
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /EC_number="3.2.1.-"
                     /note="di-N-acetylchitobiase; chitobiase, di-N-acetyl-"
                     /codon_start=1
                     /product="di-N-acetylchitobiase precursor"
                     /protein_id="NP_004379.1"
                     /db_xref="CCDS:CCDS698.1"
                     /db_xref="GeneID:1486"
                     /db_xref="HGNC:HGNC:2496"
                     /db_xref="MIM:600873"
                     /translation="MSRPQLRRWRLVSSPPSGVPGLALLALLALLALRLAAGTDCPCP
                     EPELCRPIRHHPDFEVFVFDVGQKTWKSYDWSQITTVATFGKYDSELMCYAHSKGARV
                     VLKGDVSLKDIIDPAFRASWIAQKLNLAKTQYMDGINIDIEQEVNCLSPEYDALTALV
                     KETTDSFHREIEGSQVTFDVAWSPKNIDRRCYNYTGIADACDFLFVMSYDEQSQIWSE
                     CIAAANAPYNQTLTGYNDYIKMSINPKKLVMGVPWYGYDYTCLNLSEDHVCTIAKVPF
                     RGAPCSDAAGRQVPYKTIMKQINSSISGNLWDKDQRAPYYNYKDPAGHFHQVWYDNPQ
                     SISLKATYIQNYRLRGIGMWNANCLDYSGDAVAKQQTEEMWEVLKPKLLQR"
     exon            203..341
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            342..550
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            551..722
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            723..820
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            821..982
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     exon            983..6571
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1621..1626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="hexamer: AATAAA"
     polyA_site      1644
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="major polyA site"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="hexamer: AATAAA"
     polyA_site      3061
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="major polyA site"
     regulatory      3952..3957
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="hexamer: AATAAA"
     polyA_site      3972
                     /gene="CTBS"
                     /gene_synonym="CTB"
     regulatory      5884..5889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="hexamer: ACTAAA"
     polyA_site      5906
                     /gene="CTBS"
                     /gene_synonym="CTB"
     regulatory      6377..6382
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBS"
                     /gene_synonym="CTB"
                     /note="hexamer: AATAAA"
     polyA_site      6396
                     /gene="CTBS"
                     /gene_synonym="CTB"
ORIGIN      
        1 actccggccc gctagacctg ctgctatgtc ccggccgcag cttcgacgct ggcgcctcgt
       61 ctctagcccg ccgagcggcg tcccgggtct agcgctgctg gcgctgctgg cgctgctggc
      121 gctgcggctc gcggccggga ccgactgccc atgcccggag cctgagctct gccgcccgat
      181 tcgccaccat ccagatttcg aggtctttgt gtttgatgtt ggacagaaaa cttggaaatc
      241 ttatgattgg tcacagatta caactgtggc aacatttgga aaatatgact cagaacttat
      301 gtgctacgct cattcaaaag gagccagagt agtacttaaa ggagatgtat ccttaaagga
      361 tatcattgat cctgctttca gagcatcctg gatagctcaa aaacttaatt tggccaaaac
      421 acaatatatg gatggaatta atatagatat agagcaagaa gttaattgtt tatcacctga
      481 atatgatgca ttaactgctt tagtcaaaga aactacagac tctttccatc gtgaaattga
      541 gggatcacag gtaacctttg atgtagcttg gtctccaaag aacatagaca gaagatgcta
      601 taattatact ggaatcgcag atgcttgtga cttcctcttt gtgatgtctt atgatgaaca
      661 aagtcagatc tggtcagaat gtattgcagc agccaatgct ccctataatc agacattaac
      721 tggatataat gactacatca agatgagcat taatcctaag aaacttgtaa tgggtgttcc
      781 ttggtatggt tatgattata cctgcctgaa tctgtctgag gatcatgttt gtaccattgc
      841 aaaagtccct ttccgggggg ctccttgtag tgacgctgca ggacgtcagg tgccctacaa
      901 aacgatcatg aagcaaataa atagttctat ttctggaaac ctatgggata aagatcagcg
      961 ggctccttat tataactata aagatcctgc tggccacttt catcaagtat ggtatgataa
     1021 ccctcagagt atttctttaa aggcaacata tatacaaaac tatcgcttac ggggcattgg
     1081 catgtggaat gcaaactgtc ttgactactc tggagatgct gtagccaaac agcaaactga
     1141 agaaatgtgg gaagtcttaa agccaaagct gttacagaga tgaacatctt ttgtcaaacc
     1201 attaagagtt agaaagatga tctgtatcaa cagatctagt ttcttgcatt tttattatgt
     1261 tgctatatac ttttgttatc cgtatactaa aaaaaaagaa taaataaatg ttttgattgt
     1321 ttgaatttga aaaatacaca cgaatgtcct cagtatccag gaacataaag gcaagaagca
     1381 agtcaactta cctattaaat attcctctat tagatgtttc aacactataa tttaattggg
     1441 aaaaattgct ttcagaattt tattatgcca tatttccctt cattatagta aaatatatgc
     1501 tcacgaatca atgctgattt ttaaaatatg tataatctga agtggaaatt gtttgcttag
     1561 agtttttaaa aacctagtct ttgaaaagca gtttgtgcta tacttttccc ccaaccctcc
     1621 aataaatctt aaatttaaaa cctacaatgt agtgtctccc ctttaggttc atcaaactga
     1681 tgaaaataat ttttctgctt cctgactcca tatagtattt atgttctctg aggtacttga
     1741 actaaatctt tggacagtga gtgagaatta aaaagaatcc agaagattaa atgtattcac
     1801 aaaatagaag aatgtaacag taatattttg aattggtaag ttagaactac ctaatatttt
     1861 ccaactacat tatttttatg aggctcattt gtaaaatttt taataatagg aataacttgc
     1921 agttgaactt gattctgttc actgtcacac ttctaattat tcatttcttc atttatggac
     1981 atatataatt tatttcttgg ctagcttgct tacatggtta aatttttctt tctacatctg
     2041 caatgtatct tttttatttt tattttttgt agagacaggg tctcgctatg ttgtccagat
     2101 gggtctccaa ctcctgggct caagcactcc tcctgccttg gcttcctaaa gagctgggat
     2161 tacaggcatg agctgcattg tgcttttaat gatctaaaga cactgattag cttctcaact
     2221 agttctcttt ctaaaagatc aattttatac aaataagttt tctaaatgta ataaagtctg
     2281 ttttctttct ccagggaatt aagaacaaca ttgtgctgcc cttattagtt cctaattaca
     2341 gattaaaaat ctgtatcttt gaactctaga tttacataaa tcctggcttc cctgcacatt
     2401 ttgcccctgt aaattggaat acatgatgat tgaaccatct gttatgagaa tattacattt
     2461 cctatttaca caattgtttg tgacagagta aaaaccattt tcatagtata tgttggatca
     2521 ctgttgtctt catatttcta aaataaatga attaaaaaat ttaaattctt agatgcttat
     2581 ctctatcata gctcagaatg caacttcaat acccccattc ttttatattt ccagatttct
     2641 tttaattaag atataatgaa caaattaagt taaatgaagt ctgtattttc atgcaaatat
     2701 attagtattc attaatatac atttattctt tgcaaataga ttttagttat attagctctt
     2761 aaattgttaa ataaattatt attgaatttt attattaaat tattaaaatg aaaattataa
     2821 aattagcact gtaaaataat atgtaaagga cttggaatgt taaaaataac cattcatcat
     2881 tttgctttat attacatcta atatttcctg aaacattttg taatacccac atggaaagtg
     2941 gagaaagaga aaccttgtgc tttttataaa acattgccaa ggagaataat ggttaaacaa
     3001 atctgttcaa atacatattt aaattttttt acaaataaaa gttttaaatt aacataccta
     3061 attgagattg tagagatgta ttattttttt tttctgtgcc agttcagttt tcaatgttcg
     3121 taaatctgaa actgcttgtt ttctcatcta taaaaagaat tacttttcaa aaatgaactt
     3181 catcataccc ttctaaaagt acatcatagt tgtcatgtaa acagggtttt tgtaaccgct
     3241 ttaactgtct tctctcattt ggcttcagtg ctttcaactc ccactggatt actacagtaa
     3301 atgtgtagat tatgaatgct gtttaataag catgcttatc tactggtgag atatgctata
     3361 aggtaacctt gtttatgagt agatagggac aatacaattg aactgttcta aaaactagag
     3421 tgagaaagaa ttttatgttt tgcttaaact tcaaaacctg ttgttctcaa tgtgtaaaga
     3481 aaatagtgaa aacaacaaga aaacaaaata caaaaaaaac ccttaattcc tagcccttag
     3541 gaacggaata gatatttcag aaatatagtg tttactctgt ggcaagcact cttctaagtg
     3601 tattagtctc ttattttttt ttcaaaaatt ttacagaatc agatactagt atttatcccc
     3661 attttacagt tgaaatggag acctttagag gctaagtaac ttgctcaaga taaaaaacta
     3721 gtaagtgaag tgggtacagc caggattcaa attcaaacca cctggtacca gagcccttac
     3781 tattccaagt gttgtctgtg gacagcagca ttagcatcag ttgggagctt gttaggtagg
     3841 aagaatctca ggctgcaccc agacctactg agtcagatcc tgcattttta aacaggatcc
     3901 tcagatgata tattaaactt tgagaagcac tacttatgct atactatctt gaataaatat
     3961 ggttgcaaga gactcaggct gggttttttt tgtcccttag ttctgaatct tataggtagt
     4021 gctgttttgg ggagatcatt cagaaatcaa taaaacttct taaataatgt ctgttatgtg
     4081 tcaatcaggc actatggtta aatacaggat tttttccccc cagcctataa gctgaaaact
     4141 ttgttctctt tttttcctct tattccactt gtccttactg tttttgtatg aacaattcta
     4201 atttgagttc aaaccatgag tgacatttgt aatgttaaaa tatacaaaga ttacaagtaa
     4261 tgtgcatgct ttccagaaga aaacagcatg aggggagtca taatccaagc ctctgggggc
     4321 atttttatta ctccttccta cctacccaat tattaagtgt acaagtttac atattggctt
     4381 tatctccata tattgaatag acagttttcc ttcattgaac aaattatttt ttgagtgcat
     4441 atttaactga tattttgtta aaaattatcc tctgctcttt tccttttcta ttttaagttt
     4501 taagcttctc agtgccaaac cagggcttat ttagcctcga gaatgctgct tgtaaaaaga
     4561 atctagaact gcactgtcca gtatagtaga agccagttgc catatgtaac tactaaactt
     4621 aaattaacta aaattaaata aaatttaaaa ttcagttcct cagtcacaca aactacattt
     4681 caagtgctca atatcaatag gtggctagtg ggtaccaatc tgacagtgca ggcatagaac
     4741 atttctatca tcacataagt tctgttggac agtgctaatt ctattttttt atttttaaat
     4801 tttatttatt tttattttta tctgaaaccg aggacagtac tgattttctt ttttcttttt
     4861 aaaatttttt taaaaagagc taattctaga atgcagtcat tattctgtgt cataaagctg
     4921 tttctgataa agaaatgaga gcattcatat aattatcgtt ctcattttcc tgccttgctg
     4981 tgggtacttg tatgaaaatg tataatcttc tgttttctgt tcaacaaaaa agctttttaa
     5041 tacatatgta cttcacagat aatttctatg atgtaattag ttgtacacaa ttctcaccaa
     5101 atagagcatg cccagaagcc tctactaagc atctgctata caaaaggtcc catgggagaa
     5161 acaaagttaa ctaaggcata gtctctgcca ggaaggaaac ttaacatcta gtagaagaca
     5221 cattattcat atttaaataa tagaatacat atgaaaataa ccagaaaaaa tgaaacgatt
     5281 acccataaaa aattaaatgt cagttcagag gagagctcag tggtttatca gacttaataa
     5341 ttctaataca ggaaaactac ttaaaatttt ttttgagaat atattgactc acaggttcct
     5401 tttcctttaa ttcttcctag taaaatttta ctaaatttta ctttggcttt attatatcat
     5461 gtatcttttc acaggtttag tttttcttcc tgcatttttt ttttcaccta tgctctttac
     5521 tgttaaggta acaattttaa tacagtcaat cctggctacc cttatattat tgacacccaa
     5581 agttaaaaca ccaaaatatt ttatttcaag ataaatgtta taataatctg attaggaaaa
     5641 atgtaaatta ccttaacttc tactatgagt ttcattttgt cagtatctag ttttctctta
     5701 agctggtcaa ttgcatgctg tacctcagtg atctggatta ttaggtaatt ctgtgtggat
     5761 agatagatat ttatttagta taacatataa acatttttat ttttaactgc cttgtgaaca
     5821 taaactatga aatgataaag atcaaaagag taaatcatga aaataaccta ttccgtaaag
     5881 taaactaaat tgctttggag aaattactat ttgtttctgt tgatttcttg cattttaggg
     5941 aacactttct ctaaagttac cattaaatta gcatcgtaaa aaccaacaac tattactatg
     6001 aaaggaataa tatcttagtt attagcaaga ctttaaaatt gtcataatgc tttatcagct
     6061 gaataagatt agaattattt taaaatactt aataatatga tactatattt tatatgcaaa
     6121 aactaattta atacaagaaa acctatttaa aataagaaga ctttttggtt tttgtccaga
     6181 aaagtttatg agttatagtg gtcctcgcta aagaagttat ttaagagttt taaactggct
     6241 ttgtgaaaaa attcttatat tgaactgatt aaacagtaag ataaagtata agctatgcta
     6301 aaaaaaaaag taccaactac tatggacaaa ccattacttg agcctatttg gactttatat
     6361 taaatttatt taaaataata aacttttaat atttcatctt gtctaaagtt aaatccttac
     6421 ttttaatcat agttaacata ttttaaaatt acttttggat aagtgggatt gatccaaccc
     6481 aaatcaaatt gttaaatgcc ctcttgaatt tttttgtctg ttatttaatt atatggtgga
     6541 attaataata aaataaactt catgtctctg a
//
