LOCUS       NM_001329               6989 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens C-terminal binding protein 2 (CTBP2), transcript
            variant 1, mRNA.
ACCESSION   NM_001329
VERSION     NM_001329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6989)
  AUTHORS   Pastoors,D., Havermans,M., Mulet-Lazaro,R., Brian,D., Noort,W.,
            Grasel,J., Hoogenboezem,R., Smeenk,L., Demmers,J.A.A., Milsom,M.D.,
            Enver,T., Groen,R.W.J., Bindels,E. and Delwel,R.
  TITLE     Oncogene EVI1 drives acute myeloid leukemia via a targetable
            interaction with CTBP2
  JOURNAL   Sci Adv 10 (20), eadk9076 (2024)
   PUBMED   38748792
  REMARK    GeneRIF: Oncogene EVI1 drives acute myeloid leukemia via a
            targetable interaction with CTBP2.
REFERENCE   2  (bases 1 to 6989)
  AUTHORS   Cheung,C.H.Y., Cheng,C.K., Leung,K.T., Zhang,C., Ho,C.Y., Luo,X.,
            Kam,A.Y.F., Xia,T., Wan,T.S.K., Pitts,H.A., Chan,N.P.H.,
            Cheung,J.S., Wong,R.S.M., Zhang,X.B. and Ng,M.H.L.
  TITLE     C-terminal binding protein 2 is a novel tumor suppressor targeting
            the MYC-IRF4 axis in multiple myeloma
  JOURNAL   Blood Adv 8 (9), 2217-2234 (2024)
   PUBMED   38457926
  REMARK    GeneRIF: C-terminal binding protein 2 is a novel tumor suppressor
            targeting the MYC-IRF4 axis in multiple myeloma.
REFERENCE   3  (bases 1 to 6989)
  AUTHORS   Li,K., Chen,J., Zhang,C., Cheng,M., Chen,S., Song,W., Yang,C.,
            Ling,R., Chen,Z., Wang,X., Xiong,G., Ma,J., Zhu,Y., Yuan,Q.,
            Liu,Q., Peng,L., Chen,Q. and Chen,D.
  TITLE     The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head
            and neck squamous cell carcinoma
  JOURNAL   J Clin Invest 133 (20), e170173 (2023)
   PUBMED   37643007
  REMARK    GeneRIF: The CTBP2-PCIF1 complex regulates m6Am modification of
            mRNA in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6989)
  AUTHORS   Sekiya,M., Ma,Y., Kainoh,K., Saito,K., Yamazaki,D., Tsuyuzaki,T.,
            Chen,W., Adi Putri,P.I.P., Ohno,H., Miyamoto,T., Takeuchi,Y.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Motomura,K., Matsuzaka,T., Murata,K., Mizuno,S., Takahashi,S. and
            Shimano,H.
  TITLE     Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function
  JOURNAL   Cell Rep 42 (8), 112914 (2023)
   PUBMED   37557182
  REMARK    GeneRIF: Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function.
REFERENCE   5  (bases 1 to 6989)
  AUTHORS   Saito,K., Sekiya,M., Kainoh,K., Yoshino,R., Hayashi,A., Han,S.I.,
            Araki,M., Ohno,H., Takeuchi,Y., Tsuyuzaki,T., Yamazaki,D.,
            Wanpei,C., Hada,L., Watanabe,S., Paramita Adi Putri,P.I.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Miyamoto,T., Matsuzaka,T. and Shimano,H.
  TITLE     Obesity-induced metabolic imbalance allosterically modulates CtBP2
            to inhibit PPAR-alpha transcriptional activity
  JOURNAL   J Biol Chem 299 (7), 104890 (2023)
   PUBMED   37286039
  REMARK    GeneRIF: Obesity-induced metabolic imbalance allosterically
            modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
REFERENCE   6  (bases 1 to 6989)
  AUTHORS   Holmes,M., Turner,J., Fox,A., Chisholm,O., Crossley,M. and Chong,B.
  TITLE     hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
            and modulates GATA-mediated activation
  JOURNAL   J Biol Chem 274 (33), 23491-23498 (1999)
   PUBMED   10438528
REFERENCE   7  (bases 1 to 6989)
  AUTHORS   Sewalt,R.G., Gunster,M.J., van der Vlag,J., Satijn,D.P. and
            Otte,A.P.
  TITLE     C-Terminal binding protein is a transcriptional repressor that
            interacts with a specific class of vertebrate Polycomb proteins
  JOURNAL   Mol Cell Biol 19 (1), 777-787 (1999)
   PUBMED   9858600
REFERENCE   8  (bases 1 to 6989)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   9  (bases 1 to 6989)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   10 (bases 1 to 6989)
  AUTHORS   Schaeper,U., Boyd,J.M., Verma,S., Uhlmann,E., Subramanian,T. and
            Chinnadurai,G.
  TITLE     Molecular cloning and characterization of a cellular phosphoprotein
            that interacts with a conserved C-terminal domain of adenovirus E1A
            involved in negative modulation of oncogenic transformation
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10467-10471 (1995)
   PUBMED   7479821
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL157888.16, BM712328.1,
            AL833398.1 and AL731571.3.
            
            On Jun 1, 2019 this sequence version replaced NM_001329.3.
            
            Summary: This gene produces alternative transcripts encoding two
            distinct proteins. One protein is a transcriptional repressor,
            while the other isoform is a major component of specialized
            synapses known as synaptic ribbons. Both proteins contain a NAD+
            binding domain similar to NAD+-dependent 2-hydroxyacid
            dehydrogenases. A portion of the 3' untranslated region was used to
            map this gene to chromosome 21q21.3; however, it was noted that
            similar loci elsewhere in the genome are likely. Blast analysis
            shows that this gene is present on chromosome 10. Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) contains a distinct 5' UTR and
            5' CDS, compared to variant 2. Variants 1, 3, 4, and 5-8 all encode
            the same isoform (1), which has a distinct N-terminus that is 540
            aa shorter than the N-terminus of isoform 2. The protein is thought
            to bind to the C-terminus of the adenovirus E1A proteins. Studies
            in mice suggest that this protein is involved in transcriptional
            repression.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833398.1, BC002486.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337195.11/ ENSP00000338615.5
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AL157888.16        78514-78535         c
            23-50               BM712328.1         9-36
            51-2971             AL833398.1         1-2921
            2972-6989           AL731571.3         8896-12913          c
FEATURES             Location/Qualifiers
     source          1..6989
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..6989
                     /gene="CTBP2"
                     /note="C-terminal binding protein 2"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
     exon            1..245
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            246..349
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            350..508
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1788
                     /gene="CTBP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ribeye"
                     /codon_start=1
                     /product="C-terminal-binding protein 2 isoform 1"
                     /protein_id="NP_001320.1"
                     /db_xref="CCDS:CCDS7643.1"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
                     /translation="MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDC
                     TVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIV
                     RIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGT
                     RVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE
                     RSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLV
                     DEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMR
                     EAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIV
                     GVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ"
     exon            509..663
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..808
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            809..1015
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1230
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1361
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1489
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1607
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..6989
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2951..2956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2976
                     /gene="CTBP2"
                     /note="major polyA site"
     polyA_site      2990
                     /gene="CTBP2"
                     /note="major polyA site"
     regulatory      3534..3539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3553
                     /gene="CTBP2"
     regulatory      6963..6968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     polyA_site      6989
                     /gene="CTBP2"
                     /note="major polyA site"
ORIGIN      
        1 aagtttttgt gtgtgtgtcc ctgtgtgcgt gtgtcatttt aaggtggctc gggagcggcc
       61 cggaggagcc ggcggcggcc cgaggagcga gggaccgaac cgggagccat gccgcgctga
      121 gggggggccg cacagccgcc gccaccgcca ccgccgccgg gtggggtggg aggggcggga
      181 gacgccgccg ccgccgcctc cagggtgggc gcctttcgcc gtggacgccg accgtccggg
      241 acgagggttt catcacctta aatggttttg aaccaatgaa ggtgtattcc cttaaaaaga
      301 cggacagccc atcgtgtgaa ctatagagtt tgtggacaga tttatattgg gttcatagtg
      361 gcgtcatgca cgcagactcc tgcaagttcc cctaagttct tagaggactg ctttgccttt
      421 tgatctgaga gttgcaaagt tccataaaga atggcccttg tggataagca caaagtcaag
      481 agacagcgat tggacagaat ttgtgaaggt atccgccccc agatcatgaa cggccccctg
      541 cacccccgcc ccctggtggc gctgctggac ggccgcgact gcactgtgga gatgcccatc
      601 ctgaaggacc tggccactgt ggccttctgt gacgcgcagt cgacgcagga aatccacgag
      661 aaggttctaa acgaagccgt gggcgccatg atgtaccaca ccatcaccct caccagggag
      721 gacctggaga agttcaaggc cctgagagtg atcgtgcgga taggcagtgg ctatgacaac
      781 gtggacatca aggctgccgg cgagctcgga attgccgtgt gcaacatccc gtctgcagcc
      841 gtggaagaga cagcggactc taccatctgc cacatcctca acctgtaccg gaggaacacg
      901 tggctgtacc aggcactgcg ggaaggcacg cgggttcaga gcgtggagca gatccgcgag
      961 gtggcctcgg gagcggcccg catccgtggg gagacgctgg gcctcattgg ctttggtcgc
     1021 acggggcagg cggttgcagt tcgagccaag gcctttggat tcagcgtcat attttatgac
     1081 ccctacttgc aggatgggat cgagcggtcc ctgggcgtgc agagggtcta caccctgcag
     1141 gatttgctgt atcagagcga ctgcgtctcc ttgcactgca atctcaacga acataaccac
     1201 cacctcatca atgactttac cataaagcag atgaggcagg gagcattcct tgtgaacgca
     1261 gcccgtggcg gcctggtgga cgagaaagcc ttagcacaag ccctcaagga gggcaggata
     1321 cgaggggcag ccctcgacgt gcatgagtca gagcccttca gctttgctca gggtccgttg
     1381 aaagatgccc cgaatctcat ctgcactcct cacactgcct ggtacagtga gcaggcgtca
     1441 ctggagatga gggaggcagc tgccaccgag atccgccgag ccatcacagg tcgcatccca
     1501 gaaagcttaa gaaattgtgt gaacaaggaa ttctttgtca catcagcgcc ttggtcagta
     1561 atagaccagc aagcaattca tcctgagctc aatggtgcca catacagata tccgccaggc
     1621 atcgtgggtg tggctccagg aggacttcct gcagccatgg aagggatcat ccctggaggc
     1681 atcccagtga ctcacaacct cccgacagtg gcacatcctt cccaagcgcc ctctcccaac
     1741 cagcccacaa aacacgggga caatcgagag caccccaacg agcaatagca gagaatgcca
     1801 gaaggtaatc actcagatac acttgggacc aagagacagt gaaaaataga tgaactaaga
     1861 gaaaaagaat cggatggtct ttgtaactga ttctggacat atgcatcatt gatgttgcag
     1921 tgttgaaact acaagagcta gaaaactgaa gatgtcgtct gcttacggaa gcgctgaaag
     1981 actaggatgt gatttattaa cgaccaactt ctgttattgt gtgttaagtt tttcatctgt
     2041 gcatcaaatc acaaaaagaa taaatagagc tttttccttt atcagtccct tgggcacagc
     2101 aggtcctgaa caccctgctc tacaatgttg catcaagagt tcaaacaaca aaataaaaaa
     2161 tattaagagg aaatccccat cctgtgactt gagtccctta agtctacagg ggctggtgac
     2221 ctctttttgc taataggaaa atcacattac tacaaaatgg ggagaaaact gtttgcctgt
     2281 ggtagacacc tgcacgcata ggattgaaga cagtacaggc tgctgtacag agaagcgcct
     2341 ctcacatctg aactgcatac tgagcgggca agtcggttgt aagttcagta aaaccctctg
     2401 atgatgcaaa aaaaaaaaaa aaagtattaa gtttcacaag ctgtttgtac tcaaatatat
     2461 tttctcagtt tcagatcctc tgctatttta ttgagtggaa agtcttgagc taaaagggtt
     2521 caagaagaat aatgttgcat ttccttatgt ctcaggaaac actttttatg gtaacttgtc
     2581 agattgtcta tgaacaaacc cactttttta gacattgata aagtcttctt ttcttcacgt
     2641 gatattttat acaagaacac ttcagatgta ttagatgtga ctgattttaa caaatcctat
     2701 tagatttgta tcaactagtt acatgttcta ttcatagtct tttgtgaatc attgcctttt
     2761 tgtttaaaaa gatggcctat tttgagcctt tgtataggta cattcctgtt tttgtgacaa
     2821 aagaaaaact ttaaaattgt cccaaacaga aaaataatgg ctatcagaag tatgttttgt
     2881 tttagtgtga gttaccgtta ctgtatttgt ttattgtaaa ggtggacatt tagcgttcag
     2941 tgcagttttc aataaaaagt aattaaaatt tgttaagttc tgaaattcaa gtacatctca
     3001 ctaatgtaaa tgttctctac ttgagatgtt taaggcaatt gcattgtcaa ttagccaatt
     3061 tccagctctt gttactacag ggttccataa ccagactcaa gaccgctgac aattaattac
     3121 ctgtgataac aaaaagttta attgaaaaat caaaacctca cacaagtcca tcattatcac
     3181 gtcatgccat ccttaagatg caatggtggg ttagtgctaa atcaattcaa aaaaaaacaa
     3241 agttgctcaa cttttagagt tctgacttta atctacccca aagcaaaatg acctggacct
     3301 ggttcaaggg agggaagtga accttgaaac tgttttgcca ataacctaac aaacaaaatg
     3361 atatttacaa agaagtgttg caaatagtcc catgagttaa gagcttgatt taatggatct
     3421 tctttttaaa tagaattaaa cctttatact aaaagtattt gcaagtgtca attaagtcca
     3481 acaattccag gtatgaaact ccctctgagc tcttccttat acttcccttc ccaattaaaa
     3541 caaaacaaga aaatcatggt gtcttaaagc ctttggcttg cctggccttg tctgctcact
     3601 cattttaagg tggtggcccc atcccaactc taccataaaa gtgtctatta acacaagctc
     3661 acatggagag agacggcgct catagttact gacctattac cccagggaac aaaaaggtag
     3721 tttaacgtct tcgtaaccac tcatcaaaga ggcaatgaaa tatgcgtgaa aaggaggcca
     3781 agcgcacaca gaatatctta ccttcacgaa tatgtgaaga agtctgggac acgatgaacc
     3841 taagagtcaa aaacataaaa aggcaggtct gaatccatgg tccacctggg ttttaattat
     3901 tagatcttgg tcgcccaaac aaaaatttat atatatatat ataaatttga ccccaaggaa
     3961 gaacaagtca aaacaaaatg ccacgctctg tttgctctag aaaaagaacc atcaagtcca
     4021 cagagtgcag gtatgactta ctctccagag tcagtcatta atgtctgtca cctagccacg
     4081 tataatcatc tttgaaaaag gactatattc tatcttggga caataattat ggctgtttta
     4141 atagttcaag agcataatat agcattgatt taccaaaatt tttggccttt aacagccagt
     4201 ctatgaaaac catttagagc cccattcctg tctgtagcct aggaaatgga accatcttta
     4261 attctttccc acagggaaga atgctgcacc tatcacacta tgtggtcagg gtcactgatt
     4321 gataataaat aaataaataa tagagcgctc aggggaaaca acactcacca gaccacaaca
     4381 cacagtagaa gctaagtgct gagcgtgtac tctggacaac gctggctgca atgcagactg
     4441 caatggctac atgcttttcc ctctaacaat tctctttggc tttttcaatt gggagggcag
     4501 attttgctta acaggcaact agaacaggat ctctgcccac taaaaaatta tccctataca
     4561 tagagaaatt actacagatg ctaagtagtc agaatgctaa cattttctac aaacttgatt
     4621 acttattggc caaaatgaaa gcaaacagcc aatttttaac aacacattca ccacttgaaa
     4681 caaacagcag catttacatt atatcaaaga ttcatttcta cagaatcgta ctaaaaaatc
     4741 atttttcctg caagatttag catgcagcaa aaaatgatct tttcatcctg ggaacacctt
     4801 tttactgagt tttcgggggg aaagaactaa agacatgaca gttttgtggg tatttttcta
     4861 tttttagtat tctggcagca aatttgaggt tgtacacatt tcattatcaa ctaaacaaaa
     4921 caagaagcaa gcaaatactt taaggttttc acagcctttt tcatcacagg gaaggaaaaa
     4981 actgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgcgcgcg cgcgcgtgcg tgtgtcgtct
     5041 ttccaaattc ctggccacat caatagtcta gaaagtgctt atcaggacac caaatatttc
     5101 tgtgttcctg agataggtct gaaattttta cccagtattg aatgtatacc tgaagtggtc
     5161 aaataatact tcttataaaa aagtttttct acctaagatt atagttttaa ctttaaatta
     5221 aagaatggcc acaattaacc aacatgcaaa aattctcaga ctaaacactg agaaattctt
     5281 catacaatgc atttgccacc ttattgcatt tttaaaatct ttattctgta gtgaattggt
     5341 attcccaatc tgcctaagca aaggcatgcc cttctaacaa gatttgctta gagcagaggt
     5401 gatagaagga agaatccgaa gaccctctgg catggcaatc tgggagcagc acattgttga
     5461 tggagtccaa gtgagcacat ttcacacaat tcatttagtg acaagtgggc ttgctccctt
     5521 ttcatccagg aaaaaaacta ctcacagacc actgcccaga atctggaata agaaccctca
     5581 ttttaaggta ttcttcccaa caaataaata tctaaatatt gaaagggggc atatcagaaa
     5641 acttaaagac acaataacca aaaccaaaac cctcttcaaa acaagtaagc aatgtctgta
     5701 tttagttcac tctaaaacat tcttagcttt tcttgcagtt tgttcctaaa agatttgatt
     5761 gggcacaaga ggaacgaaat tattaataaa ataaaagctt atttttgttt tgctgtggat
     5821 aatcggtaca aaacgtttcc agatctgaga cttagatgga tcttttaagg tgaaagtaga
     5881 atgccaggtt ctactgaaat aatatctgaa aggaacaaag agccatttgc catgtgcttt
     5941 ttctaagtgc ccatgctgga aaaaattttc tcaataatat gaagatgctg gtacaacttt
     6001 tcctattaaa caatgtctta cacaaccaca tgcgttacat ttatagacag atttacaatt
     6061 tggaaggaaa aaaagttctg tcttaataaa attagttttt tttacaaact gtagtccaac
     6121 taaagttctc tgtctcctca cgcagcagag gcattatctc cataaggtgt gtgtggtcca
     6181 ggaaaacact tccccgagca gatcctgcca gatttggttc attccatgat gtcgactctg
     6241 cttggagcac cacactaact ttagggtcat tacagatctg atgccttggt cttctgctgt
     6301 ttgatttttt ttttcattca tcttcatcat cctcatcttc ctctccatca gacagggatg
     6361 tacacggccg gatctgtcgg tagcggtcaa gccatttttc taccatctga gtgaccaggg
     6421 ggtgatttcg ccgccgagaa ctcttctgca tggcaaccag aactcccccc tccgtcacac
     6481 agcagtccag ccactccctg agcagttttt cttgctgttc ctcattacct agcttttgga
     6541 ggaatatgaa gacaaaggga aaatcataca acagatcaga gacttggtag gaatgtgaca
     6601 tggaaaccta cagctggtat gctaactcat gaaaaggcca aagcaatcaa cttttcacat
     6661 ggttttgacc tcttggaagt tttgtgatta aagtccagtt tgctctggtt aaatttaaaa
     6721 agacataaat gggaaatttc tcagaaaaaa actaaagagg agcacactag agggtaattt
     6781 gttagataaa ataaaaaaca aatgtcctaa taaactgatc ctggcaagcc acagcttcaa
     6841 acacatgaca aggtaagttt acttagtcaa ttatgtacaa gctgaaatta tacaagttac
     6901 ggtctatgaa ctttttttct tcatgttgtg attataaacg ttttataatt actagtatat
     6961 taaataaaag accaatactt ttataagaa
//
