LOCUS       NM_001321013            6783 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens C-terminal binding protein 2 (CTBP2), transcript
            variant 7, mRNA.
ACCESSION   NM_001321013 XM_011539356
VERSION     NM_001321013.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6783)
  AUTHORS   Pastoors,D., Havermans,M., Mulet-Lazaro,R., Brian,D., Noort,W.,
            Grasel,J., Hoogenboezem,R., Smeenk,L., Demmers,J.A.A., Milsom,M.D.,
            Enver,T., Groen,R.W.J., Bindels,E. and Delwel,R.
  TITLE     Oncogene EVI1 drives acute myeloid leukemia via a targetable
            interaction with CTBP2
  JOURNAL   Sci Adv 10 (20), eadk9076 (2024)
   PUBMED   38748792
  REMARK    GeneRIF: Oncogene EVI1 drives acute myeloid leukemia via a
            targetable interaction with CTBP2.
REFERENCE   2  (bases 1 to 6783)
  AUTHORS   Cheung,C.H.Y., Cheng,C.K., Leung,K.T., Zhang,C., Ho,C.Y., Luo,X.,
            Kam,A.Y.F., Xia,T., Wan,T.S.K., Pitts,H.A., Chan,N.P.H.,
            Cheung,J.S., Wong,R.S.M., Zhang,X.B. and Ng,M.H.L.
  TITLE     C-terminal binding protein 2 is a novel tumor suppressor targeting
            the MYC-IRF4 axis in multiple myeloma
  JOURNAL   Blood Adv 8 (9), 2217-2234 (2024)
   PUBMED   38457926
  REMARK    GeneRIF: C-terminal binding protein 2 is a novel tumor suppressor
            targeting the MYC-IRF4 axis in multiple myeloma.
REFERENCE   3  (bases 1 to 6783)
  AUTHORS   Li,K., Chen,J., Zhang,C., Cheng,M., Chen,S., Song,W., Yang,C.,
            Ling,R., Chen,Z., Wang,X., Xiong,G., Ma,J., Zhu,Y., Yuan,Q.,
            Liu,Q., Peng,L., Chen,Q. and Chen,D.
  TITLE     The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head
            and neck squamous cell carcinoma
  JOURNAL   J Clin Invest 133 (20), e170173 (2023)
   PUBMED   37643007
  REMARK    GeneRIF: The CTBP2-PCIF1 complex regulates m6Am modification of
            mRNA in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6783)
  AUTHORS   Sekiya,M., Ma,Y., Kainoh,K., Saito,K., Yamazaki,D., Tsuyuzaki,T.,
            Chen,W., Adi Putri,P.I.P., Ohno,H., Miyamoto,T., Takeuchi,Y.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Motomura,K., Matsuzaka,T., Murata,K., Mizuno,S., Takahashi,S. and
            Shimano,H.
  TITLE     Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function
  JOURNAL   Cell Rep 42 (8), 112914 (2023)
   PUBMED   37557182
  REMARK    GeneRIF: Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function.
REFERENCE   5  (bases 1 to 6783)
  AUTHORS   Saito,K., Sekiya,M., Kainoh,K., Yoshino,R., Hayashi,A., Han,S.I.,
            Araki,M., Ohno,H., Takeuchi,Y., Tsuyuzaki,T., Yamazaki,D.,
            Wanpei,C., Hada,L., Watanabe,S., Paramita Adi Putri,P.I.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Miyamoto,T., Matsuzaka,T. and Shimano,H.
  TITLE     Obesity-induced metabolic imbalance allosterically modulates CtBP2
            to inhibit PPAR-alpha transcriptional activity
  JOURNAL   J Biol Chem 299 (7), 104890 (2023)
   PUBMED   37286039
  REMARK    GeneRIF: Obesity-induced metabolic imbalance allosterically
            modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
REFERENCE   6  (bases 1 to 6783)
  AUTHORS   Holmes,M., Turner,J., Fox,A., Chisholm,O., Crossley,M. and Chong,B.
  TITLE     hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
            and modulates GATA-mediated activation
  JOURNAL   J Biol Chem 274 (33), 23491-23498 (1999)
   PUBMED   10438528
REFERENCE   7  (bases 1 to 6783)
  AUTHORS   Sewalt,R.G., Gunster,M.J., van der Vlag,J., Satijn,D.P. and
            Otte,A.P.
  TITLE     C-Terminal binding protein is a transcriptional repressor that
            interacts with a specific class of vertebrate Polycomb proteins
  JOURNAL   Mol Cell Biol 19 (1), 777-787 (1999)
   PUBMED   9858600
REFERENCE   8  (bases 1 to 6783)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   9  (bases 1 to 6783)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   10 (bases 1 to 6783)
  AUTHORS   Schaeper,U., Boyd,J.M., Verma,S., Uhlmann,E., Subramanian,T. and
            Chinnadurai,G.
  TITLE     Molecular cloning and characterization of a cellular phosphoprotein
            that interacts with a conserved C-terminal domain of adenovirus E1A
            involved in negative modulation of oncogenic transformation
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10467-10471 (1995)
   PUBMED   7479821
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY046871.1, BM800106.1,
            AL731571.3 and BE671217.1.
            
            On May 31, 2019 this sequence version replaced NM_001321013.1.
            
            Summary: This gene produces alternative transcripts encoding two
            distinct proteins. One protein is a transcriptional repressor,
            while the other isoform is a major component of specialized
            synapses known as synaptic ribbons. Both proteins contain a NAD+
            binding domain similar to NAD+-dependent 2-hydroxyacid
            dehydrogenases. A portion of the 3' untranslated region was used to
            map this gene to chromosome 21q21.3; however, it was noted that
            similar loci elsewhere in the genome are likely. Blast analysis
            shows that this gene is present on chromosome 10. Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Feb 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2294562.1,
                                           SRR14038196.2322341.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               HY046871.1         32-290
            260-818             BM800106.1         116-674
            819-1024            AL731571.3         19048-19253         c
            1025-1155           AL731571.3         18434-18564         c
            1156-1283           AL731571.3         17781-17908         c
            1284-1401           AL731571.3         17274-17391         c
            1402-2983           AL731571.3         12696-14277         c
            2984-3251           BE671217.1         3-270               c
            3252-6783           AL731571.3         8896-12427          c
FEATURES             Location/Qualifiers
     source          1..6783
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..6783
                     /gene="CTBP2"
                     /note="C-terminal binding protein 2"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
     exon            1..143
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..302
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1582
                     /gene="CTBP2"
                     /note="isoform 1 is encoded by transcript variant 7;
                     ribeye"
                     /codon_start=1
                     /product="C-terminal-binding protein 2 isoform 1"
                     /protein_id="NP_001307942.1"
                     /db_xref="CCDS:CCDS7643.1"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
                     /translation="MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDC
                     TVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIV
                     RIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGT
                     RVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE
                     RSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLV
                     DEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMR
                     EAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIV
                     GVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ"
     exon            303..457
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..602
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            603..809
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1024
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1155
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1283
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1401
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..6783
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2745..2750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     regulatory      2756..2761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2770
                     /gene="CTBP2"
                     /note="major polyA site"
     polyA_site      2784
                     /gene="CTBP2"
                     /note="major polyA site"
     regulatory      3328..3333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3347
                     /gene="CTBP2"
     regulatory      6757..6762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     polyA_site      6783
                     /gene="CTBP2"
                     /note="major polyA site"
ORIGIN      
        1 agttggctgc agaggacccc acgtttagga ttttataggg aagaggagga atttttcgta
       61 gaaatccccg ctctgcgtgc tcgtggtgga ggctgctggc aatggcctac gtcgtcatac
      121 cgggcttcct tgccctgtcc gggggttcat agtggcgtca tgcacgcaga ctcctgcaag
      181 ttcccctaag ttcttagagg actgctttgc cttttgatct gagagttgca aagttccata
      241 aagaatggcc cttgtggata agcacaaagt caagagacag cgattggaca gaatttgtga
      301 aggtatccgc ccccagatca tgaacggccc cctgcacccc cgccccctgg tggcgctgct
      361 ggacggccgc gactgcactg tggagatgcc catcctgaag gacctggcca ctgtggcctt
      421 ctgtgacgcg cagtcgacgc aggaaatcca cgagaaggtt ctaaacgaag ccgtgggcgc
      481 catgatgtac cacaccatca ccctcaccag ggaggacctg gagaagttca aggccctgag
      541 agtgatcgtg cggataggca gtggctatga caacgtggac atcaaggctg ccggcgagct
      601 cggaattgcc gtgtgcaaca tcccgtctgc agccgtggaa gagacagcgg actctaccat
      661 ctgccacatc ctcaacctgt accggaggaa cacgtggctg taccaggcac tgcgggaagg
      721 cacgcgggtt cagagcgtgg agcagatccg cgaggtggcc tcgggagcgg cccgcatccg
      781 tggggagacg ctgggcctca ttggctttgg tcgcacgggg caggcggttg cagttcgagc
      841 caaggccttt ggattcagcg tcatatttta tgacccctac ttgcaggatg ggatcgagcg
      901 gtccctgggc gtgcagaggg tctacaccct gcaggatttg ctgtatcaga gcgactgcgt
      961 ctccttgcac tgcaatctca acgaacataa ccaccacctc atcaatgact ttaccataaa
     1021 gcagatgagg cagggagcat tccttgtgaa cgcagcccgt ggcggcctgg tggacgagaa
     1081 agccttagca caagccctca aggagggcag gatacgaggg gcagccctcg acgtgcatga
     1141 gtcagagccc ttcagctttg ctcagggtcc gttgaaagat gccccgaatc tcatctgcac
     1201 tcctcacact gcctggtaca gtgagcaggc gtcactggag atgagggagg cagctgccac
     1261 cgagatccgc cgagccatca caggtcgcat cccagaaagc ttaagaaatt gtgtgaacaa
     1321 ggaattcttt gtcacatcag cgccttggtc agtaatagac cagcaagcaa ttcatcctga
     1381 gctcaatggt gccacataca gatatccgcc aggcatcgtg ggtgtggctc caggaggact
     1441 tcctgcagcc atggaaggga tcatccctgg aggcatccca gtgactcaca acctcccgac
     1501 agtggcacat ccttcccaag cgccctctcc caaccagccc acaaaacacg gggacaatcg
     1561 agagcacccc aacgagcaat agcagagaat gccagaaggt aatcactcag atacacttgg
     1621 gaccaagaga cagtgaaaaa tagatgaact aagagaaaaa gaatcggatg gtctttgtaa
     1681 ctgattctgg acatatgcat cattgatgtt gcagtgttga aactacaaga gctagaaaac
     1741 tgaagatgtc gtctgcttac ggaagcgctg aaagactagg atgtgattta ttaacgacca
     1801 acttctgtta ttgtgtgtta agtttttcat ctgtgcatca aatcacaaaa agaataaata
     1861 gagctttttc ctttatcagt cccttgggca cagcaggtcc tgaacaccct gctctacaat
     1921 gttgcatcaa gagttcaaac aacaaaataa aaaatattaa gaggaaatcc ccatcctgtg
     1981 acttgagtcc cttaagtcta caggggctgg tgacctcttt ttgctaatag gaaaatcaca
     2041 ttactacaaa atggggagaa aactgtttgc ctgtggtaga cacctgcacg cataggattg
     2101 aagacagtac aggctgctgt acagagaagc gcctctcaca tctgaactgc atactgagcg
     2161 ggcaagtcgg ttgtaagttc agtaaaaccc tctgatgatg caaaaaaaaa aaaaaaagta
     2221 ttaagtttca caagctgttt gtactcaaat atattttctc agtttcagat cctctgctat
     2281 tttattgagt ggaaagtctt gagctaaaag ggttcaagaa gaataatgtt gcatttcctt
     2341 atgtctcagg aaacactttt tatggtaact tgtcagattg tctatgaaca aacccacttt
     2401 tttagacatt gataaagtct tcttttcttc acgtgatatt ttatacaaga acacttcaga
     2461 tgtattagat gtgactgatt ttaacaaatc ctattagatt tgtatcaact agttacatgt
     2521 tctattcata gtcttttgtg aatcattgcc tttttgttta aaaagatggc ctattttgag
     2581 cctttgtata ggtacattcc tgtttttgtg acaaaagaaa aactttaaaa ttgtcccaaa
     2641 cagaaaaata atggctatca gaagtatgtt ttgttttagt gtgagttacc gttactgtat
     2701 ttgtttattg taaaggtgga catttagcgt tcagtgcagt tttcaataaa aagtaattaa
     2761 aatttgttaa gttctgaaat tcaagtacat ctcactaatg taaatgttct ctacttgaga
     2821 tgtttaaggc aattgcattg tcaattagcc aatttccagc tcttgttact acagggttcc
     2881 ataaccagac tcaagaccgc tgacaattaa ttacctgtga taacaaaaag tttaattgaa
     2941 aaatcaaaac ctcacacaag tccatcatta tcacgtcatg ccatccttaa gatgcaatgg
     3001 tgggttagtg ctaaatcaat tcaaaaaaaa acaaagttgc tcaactttta gagttctgac
     3061 tttaatctac cccaaagcaa aatgacctgg acctggttca agggagggaa gtgaaccttg
     3121 aaactgtttt gccaataacc taacaaacaa aatgatattt acaaagaagt gttgcaaata
     3181 gtcccatgag ttaagagctt gatttaatgg atcttctttt taaatagaat taaaccttta
     3241 tactaaaagt atttgcaagt gtcaattaag tccaacaatt ccaggtatga aactccctct
     3301 gagctcttcc ttatacttcc cttcccaatt aaaacaaaac aagaaaatca tggtgtctta
     3361 aagcctttgg cttgcctggc cttgtctgct cactcatttt aaggtggtgg ccccatccca
     3421 actctaccat aaaagtgtct attaacacaa gctcacatgg agagagacgg cgctcatagt
     3481 tactgaccta ttaccccagg gaacaaaaag gtagtttaac gtcttcgtaa ccactcatca
     3541 aagaggcaat gaaatatgcg tgaaaaggag gccaagcgca cacagaatat cttaccttca
     3601 cgaatatgtg aagaagtctg ggacacgatg aacctaagag tcaaaaacat aaaaaggcag
     3661 gtctgaatcc atggtccacc tgggttttaa ttattagatc ttggtcgccc aaacaaaaat
     3721 ttatatatat atatataaat ttgaccccaa ggaagaacaa gtcaaaacaa aatgccacgc
     3781 tctgtttgct ctagaaaaag aaccatcaag tccacagagt gcaggtatga cttactctcc
     3841 agagtcagtc attaatgtct gtcacctagc cacgtataat catctttgaa aaaggactat
     3901 attctatctt gggacaataa ttatggctgt tttaatagtt caagagcata atatagcatt
     3961 gatttaccaa aatttttggc ctttaacagc cagtctatga aaaccattta gagccccatt
     4021 cctgtctgta gcctaggaaa tggaaccatc tttaattctt tcccacaggg aagaatgctg
     4081 cacctatcac actatgtggt cagggtcact gattgataat aaataaataa ataatagagc
     4141 gctcagggga aacaacactc accagaccac aacacacagt agaagctaag tgctgagcgt
     4201 gtactctgga caacgctggc tgcaatgcag actgcaatgg ctacatgctt ttccctctaa
     4261 caattctctt tggctttttc aattgggagg gcagattttg cttaacaggc aactagaaca
     4321 ggatctctgc ccactaaaaa attatcccta tacatagaga aattactaca gatgctaagt
     4381 agtcagaatg ctaacatttt ctacaaactt gattacttat tggccaaaat gaaagcaaac
     4441 agccaatttt taacaacaca ttcaccactt gaaacaaaca gcagcattta cattatatca
     4501 aagattcatt tctacagaat cgtactaaaa aatcattttt cctgcaagat ttagcatgca
     4561 gcaaaaaatg atcttttcat cctgggaaca cctttttact gagttttcgg ggggaaagaa
     4621 ctaaagacat gacagttttg tgggtatttt tctattttta gtattctggc agcaaatttg
     4681 aggttgtaca catttcatta tcaactaaac aaaacaagaa gcaagcaaat actttaaggt
     4741 tttcacagcc tttttcatca cagggaagga aaaaactgtg tgtgtgtgtg tgtgtgtgtg
     4801 tgtgtgtgcg cgcgcgcgcg tgcgtgtgtc gtctttccaa attcctggcc acatcaatag
     4861 tctagaaagt gcttatcagg acaccaaata tttctgtgtt cctgagatag gtctgaaatt
     4921 tttacccagt attgaatgta tacctgaagt ggtcaaataa tacttcttat aaaaaagttt
     4981 ttctacctaa gattatagtt ttaactttaa attaaagaat ggccacaatt aaccaacatg
     5041 caaaaattct cagactaaac actgagaaat tcttcataca atgcatttgc caccttattg
     5101 catttttaaa atctttattc tgtagtgaat tggtattccc aatctgccta agcaaaggca
     5161 tgcccttcta acaagatttg cttagagcag aggtgataga aggaagaatc cgaagaccct
     5221 ctggcatggc aatctgggag cagcacattg ttgatggagt ccaagtgagc acatttcaca
     5281 caattcattt agtgacaagt gggcttgctc ccttttcatc caggaaaaaa actactcaca
     5341 gaccactgcc cagaatctgg aataagaacc ctcattttaa ggtattcttc ccaacaaata
     5401 aatatctaaa tattgaaagg gggcatatca gaaaacttaa agacacaata accaaaacca
     5461 aaaccctctt caaaacaagt aagcaatgtc tgtatttagt tcactctaaa acattcttag
     5521 cttttcttgc agtttgttcc taaaagattt gattgggcac aagaggaacg aaattattaa
     5581 taaaataaaa gcttattttt gttttgctgt ggataatcgg tacaaaacgt ttccagatct
     5641 gagacttaga tggatctttt aaggtgaaag tagaatgcca ggttctactg aaataatatc
     5701 tgaaaggaac aaagagccat ttgccatgtg ctttttctaa gtgcccatgc tggaaaaaat
     5761 tttctcaata atatgaagat gctggtacaa cttttcctat taaacaatgt cttacacaac
     5821 cacatgcgtt acatttatag acagatttac aatttggaag gaaaaaaagt tctgtcttaa
     5881 taaaattagt tttttttaca aactgtagtc caactaaagt tctctgtctc ctcacgcagc
     5941 agaggcatta tctccataag gtgtgtgtgg tccaggaaaa cacttccccg agcagatcct
     6001 gccagatttg gttcattcca tgatgtcgac tctgcttgga gcaccacact aactttaggg
     6061 tcattacaga tctgatgcct tggtcttctg ctgtttgatt ttttttttca ttcatcttca
     6121 tcatcctcat cttcctctcc atcagacagg gatgtacacg gccggatctg tcggtagcgg
     6181 tcaagccatt tttctaccat ctgagtgacc agggggtgat ttcgccgccg agaactcttc
     6241 tgcatggcaa ccagaactcc cccctccgtc acacagcagt ccagccactc cctgagcagt
     6301 ttttcttgct gttcctcatt acctagcttt tggaggaata tgaagacaaa gggaaaatca
     6361 tacaacagat cagagacttg gtaggaatgt gacatggaaa cctacagctg gtatgctaac
     6421 tcatgaaaag gccaaagcaa tcaacttttc acatggtttt gacctcttgg aagttttgtg
     6481 attaaagtcc agtttgctct ggttaaattt aaaaagacat aaatgggaaa tttctcagaa
     6541 aaaaactaaa gaggagcaca ctagagggta atttgttaga taaaataaaa aacaaatgtc
     6601 ctaataaact gatcctggca agccacagct tcaaacacat gacaaggtaa gtttacttag
     6661 tcaattatgt acaagctgaa attatacaag ttacggtcta tgaacttttt ttcttcatgt
     6721 tgtgattata aacgttttat aattactagt atattaaata aaagaccaat acttttataa
     6781 gaa
//
