LOCUS       NM_001290215            6887 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens C-terminal binding protein 2 (CTBP2), transcript
            variant 5, mRNA.
ACCESSION   NM_001290215 XM_005269563
VERSION     NM_001290215.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6887)
  AUTHORS   Pastoors,D., Havermans,M., Mulet-Lazaro,R., Brian,D., Noort,W.,
            Grasel,J., Hoogenboezem,R., Smeenk,L., Demmers,J.A.A., Milsom,M.D.,
            Enver,T., Groen,R.W.J., Bindels,E. and Delwel,R.
  TITLE     Oncogene EVI1 drives acute myeloid leukemia via a targetable
            interaction with CTBP2
  JOURNAL   Sci Adv 10 (20), eadk9076 (2024)
   PUBMED   38748792
  REMARK    GeneRIF: Oncogene EVI1 drives acute myeloid leukemia via a
            targetable interaction with CTBP2.
REFERENCE   2  (bases 1 to 6887)
  AUTHORS   Cheung,C.H.Y., Cheng,C.K., Leung,K.T., Zhang,C., Ho,C.Y., Luo,X.,
            Kam,A.Y.F., Xia,T., Wan,T.S.K., Pitts,H.A., Chan,N.P.H.,
            Cheung,J.S., Wong,R.S.M., Zhang,X.B. and Ng,M.H.L.
  TITLE     C-terminal binding protein 2 is a novel tumor suppressor targeting
            the MYC-IRF4 axis in multiple myeloma
  JOURNAL   Blood Adv 8 (9), 2217-2234 (2024)
   PUBMED   38457926
  REMARK    GeneRIF: C-terminal binding protein 2 is a novel tumor suppressor
            targeting the MYC-IRF4 axis in multiple myeloma.
REFERENCE   3  (bases 1 to 6887)
  AUTHORS   Li,K., Chen,J., Zhang,C., Cheng,M., Chen,S., Song,W., Yang,C.,
            Ling,R., Chen,Z., Wang,X., Xiong,G., Ma,J., Zhu,Y., Yuan,Q.,
            Liu,Q., Peng,L., Chen,Q. and Chen,D.
  TITLE     The CTBP2-PCIF1 complex regulates m6Am modification of mRNA in head
            and neck squamous cell carcinoma
  JOURNAL   J Clin Invest 133 (20), e170173 (2023)
   PUBMED   37643007
  REMARK    GeneRIF: The CTBP2-PCIF1 complex regulates m6Am modification of
            mRNA in head and neck squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6887)
  AUTHORS   Sekiya,M., Ma,Y., Kainoh,K., Saito,K., Yamazaki,D., Tsuyuzaki,T.,
            Chen,W., Adi Putri,P.I.P., Ohno,H., Miyamoto,T., Takeuchi,Y.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Motomura,K., Matsuzaka,T., Murata,K., Mizuno,S., Takahashi,S. and
            Shimano,H.
  TITLE     Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function
  JOURNAL   Cell Rep 42 (8), 112914 (2023)
   PUBMED   37557182
  REMARK    GeneRIF: Loss of CtBP2 may be a mechanistic link between metabolic
            derangements and progressive impairment of pancreatic beta cell
            function.
REFERENCE   5  (bases 1 to 6887)
  AUTHORS   Saito,K., Sekiya,M., Kainoh,K., Yoshino,R., Hayashi,A., Han,S.I.,
            Araki,M., Ohno,H., Takeuchi,Y., Tsuyuzaki,T., Yamazaki,D.,
            Wanpei,C., Hada,L., Watanabe,S., Paramita Adi Putri,P.I.,
            Murayama,Y., Sugano,Y., Osaki,Y., Iwasaki,H., Yahagi,N., Suzuki,H.,
            Miyamoto,T., Matsuzaka,T. and Shimano,H.
  TITLE     Obesity-induced metabolic imbalance allosterically modulates CtBP2
            to inhibit PPAR-alpha transcriptional activity
  JOURNAL   J Biol Chem 299 (7), 104890 (2023)
   PUBMED   37286039
  REMARK    GeneRIF: Obesity-induced metabolic imbalance allosterically
            modulates CtBP2 to inhibit PPAR-alpha transcriptional activity.
REFERENCE   6  (bases 1 to 6887)
  AUTHORS   Holmes,M., Turner,J., Fox,A., Chisholm,O., Crossley,M. and Chong,B.
  TITLE     hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2
            and modulates GATA-mediated activation
  JOURNAL   J Biol Chem 274 (33), 23491-23498 (1999)
   PUBMED   10438528
REFERENCE   7  (bases 1 to 6887)
  AUTHORS   Sewalt,R.G., Gunster,M.J., van der Vlag,J., Satijn,D.P. and
            Otte,A.P.
  TITLE     C-Terminal binding protein is a transcriptional repressor that
            interacts with a specific class of vertebrate Polycomb proteins
  JOURNAL   Mol Cell Biol 19 (1), 777-787 (1999)
   PUBMED   9858600
REFERENCE   8  (bases 1 to 6887)
  AUTHORS   Turner,J. and Crossley,M.
  TITLE     Cloning and characterization of mCtBP2, a co-repressor that
            associates with basic Kruppel-like factor and other mammalian
            transcriptional regulators
  JOURNAL   EMBO J 17 (17), 5129-5140 (1998)
   PUBMED   9724649
REFERENCE   9  (bases 1 to 6887)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   10 (bases 1 to 6887)
  AUTHORS   Schaeper,U., Boyd,J.M., Verma,S., Uhlmann,E., Subramanian,T. and
            Chinnadurai,G.
  TITLE     Molecular cloning and characterization of a cellular phosphoprotein
            that interacts with a conserved C-terminal domain of adenovirus E1A
            involved in negative modulation of oncogenic transformation
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10467-10471 (1995)
   PUBMED   7479821
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY147073.1, AK290390.1 and
            AL731571.3.
            
            On Jun 1, 2019 this sequence version replaced NM_001290215.2.
            
            Summary: This gene produces alternative transcripts encoding two
            distinct proteins. One protein is a transcriptional repressor,
            while the other isoform is a major component of specialized
            synapses known as synaptic ribbons. Both proteins contain a NAD+
            binding domain similar to NAD+-dependent 2-hydroxyacid
            dehydrogenases. A portion of the 3' untranslated region was used to
            map this gene to chromosome 21q21.3; however, it was noted that
            similar loci elsewhere in the genome are likely. Blast analysis
            shows that this gene is present on chromosome 10. Several
            transcript variants encoding two different isoforms have been found
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (5) contains a distinct 5' UTR and
            5' CDS, compared to variant 2. Variants 1, 3, 4, and 5-8 all encode
            the same isoform (1), which has a distinct N-terminus that is 540
            aa shorter than the N-terminus of isoform 2. The protein is thought
            to bind to the C-terminus of the adenovirus E1A proteins. Studies
            in mice suggest that this protein is involved in transcriptional
            repression.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290390.1, SRR14372080.1458172.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                HY147073.1         376-436
            62-1697             AK290390.1         3-1638
            1698-6887           AL731571.3         8896-14085          c
FEATURES             Location/Qualifiers
     source          1..6887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..6887
                     /gene="CTBP2"
                     /note="C-terminal binding protein 2"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
     exon            1..143
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            144..247
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..406
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1686
                     /gene="CTBP2"
                     /note="isoform 1 is encoded by transcript variant 5;
                     ribeye"
                     /codon_start=1
                     /product="C-terminal-binding protein 2 isoform 1"
                     /protein_id="NP_001277144.1"
                     /db_xref="CCDS:CCDS7643.1"
                     /db_xref="GeneID:1488"
                     /db_xref="HGNC:HGNC:2495"
                     /db_xref="MIM:602619"
                     /translation="MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDC
                     TVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIV
                     RIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGT
                     RVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIE
                     RSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLV
                     DEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMR
                     EAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIV
                     GVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ"
     exon            407..561
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..706
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..913
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1128
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1259
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1387
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1505
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..6887
                     /gene="CTBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2849..2854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      2874
                     /gene="CTBP2"
                     /note="major polyA site"
     polyA_site      2888
                     /gene="CTBP2"
                     /note="major polyA site"
     regulatory      3432..3437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: ATTAAA"
     polyA_site      3451
                     /gene="CTBP2"
     regulatory      6861..6866
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP2"
                     /note="hexamer: AATAAA"
     polyA_site      6887
                     /gene="CTBP2"
                     /note="major polyA site"
ORIGIN      
        1 agttggctgc agaggacccc acgtttagga ttttataggg aagaggagga atttttcgta
       61 gaaatccccg ctctgcgtgc tcgtggtgga ggctgctggc aatggcctac gtcgtcatac
      121 cgggcttcct tgccctgtcc gggggtttca tcaccttaaa tggttttgaa ccaatgaagg
      181 tgtattccct taaaaagacg gacagcccat cgtgtgaact atagagtttg tggacagatt
      241 tatattgggt tcatagtggc gtcatgcacg cagactcctg caagttcccc taagttctta
      301 gaggactgct ttgccttttg atctgagagt tgcaaagttc cataaagaat ggcccttgtg
      361 gataagcaca aagtcaagag acagcgattg gacagaattt gtgaaggtat ccgcccccag
      421 atcatgaacg gccccctgca cccccgcccc ctggtggcgc tgctggacgg ccgcgactgc
      481 actgtggaga tgcccatcct gaaggacctg gccactgtgg ccttctgtga cgcgcagtcg
      541 acgcaggaaa tccacgagaa ggttctaaac gaagccgtgg gcgccatgat gtaccacacc
      601 atcaccctca ccagggagga cctggagaag ttcaaggccc tgagagtgat cgtgcggata
      661 ggcagtggct atgacaacgt ggacatcaag gctgccggcg agctcggaat tgccgtgtgc
      721 aacatcccgt ctgcagccgt ggaagagaca gcggactcta ccatctgcca catcctcaac
      781 ctgtaccgga ggaacacgtg gctgtaccag gcactgcggg aaggcacgcg ggttcagagc
      841 gtggagcaga tccgcgaggt ggcctcggga gcggcccgca tccgtgggga gacgctgggc
      901 ctcattggct ttggtcgcac ggggcaggcg gttgcagttc gagccaaggc ctttggattc
      961 agcgtcatat tttatgaccc ctacttgcag gatgggatcg agcggtccct gggcgtgcag
     1021 agggtctaca ccctgcagga tttgctgtat cagagcgact gcgtctcctt gcactgcaat
     1081 ctcaacgaac ataaccacca cctcatcaat gactttacca taaagcagat gaggcaggga
     1141 gcattccttg tgaacgcagc ccgtggcggc ctggtggacg agaaagcctt agcacaagcc
     1201 ctcaaggagg gcaggatacg aggggcagcc ctcgacgtgc atgagtcaga gcccttcagc
     1261 tttgctcagg gtccgttgaa agatgccccg aatctcatct gcactcctca cactgcctgg
     1321 tacagtgagc aggcgtcact ggagatgagg gaggcagctg ccaccgagat ccgccgagcc
     1381 atcacaggtc gcatcccaga aagcttaaga aattgtgtga acaaggaatt ctttgtcaca
     1441 tcagcgcctt ggtcagtaat agaccagcaa gcaattcatc ctgagctcaa tggtgccaca
     1501 tacagatatc cgccaggcat cgtgggtgtg gctccaggag gacttcctgc agccatggaa
     1561 gggatcatcc ctggaggcat cccagtgact cacaacctcc cgacagtggc acatccttcc
     1621 caagcgccct ctcccaacca gcccacaaaa cacggggaca atcgagagca ccccaacgag
     1681 caatagcaga gaatgccaga aggtaatcac tcagatacac ttgggaccaa gagacagtga
     1741 aaaatagatg aactaagaga aaaagaatcg gatggtcttt gtaactgatt ctggacatat
     1801 gcatcattga tgttgcagtg ttgaaactac aagagctaga aaactgaaga tgtcgtctgc
     1861 ttacggaagc gctgaaagac taggatgtga tttattaacg accaacttct gttattgtgt
     1921 gttaagtttt tcatctgtgc atcaaatcac aaaaagaata aatagagctt tttcctttat
     1981 cagtcccttg ggcacagcag gtcctgaaca ccctgctcta caatgttgca tcaagagttc
     2041 aaacaacaaa ataaaaaata ttaagaggaa atccccatcc tgtgacttga gtcccttaag
     2101 tctacagggg ctggtgacct ctttttgcta ataggaaaat cacattacta caaaatgggg
     2161 agaaaactgt ttgcctgtgg tagacacctg cacgcatagg attgaagaca gtacaggctg
     2221 ctgtacagag aagcgcctct cacatctgaa ctgcatactg agcgggcaag tcggttgtaa
     2281 gttcagtaaa accctctgat gatgcaaaaa aaaaaaaaaa agtattaagt ttcacaagct
     2341 gtttgtactc aaatatattt tctcagtttc agatcctctg ctattttatt gagtggaaag
     2401 tcttgagcta aaagggttca agaagaataa tgttgcattt ccttatgtct caggaaacac
     2461 tttttatggt aacttgtcag attgtctatg aacaaaccca cttttttaga cattgataaa
     2521 gtcttctttt cttcacgtga tattttatac aagaacactt cagatgtatt agatgtgact
     2581 gattttaaca aatcctatta gatttgtatc aactagttac atgttctatt catagtcttt
     2641 tgtgaatcat tgcctttttg tttaaaaaga tggcctattt tgagcctttg tataggtaca
     2701 ttcctgtttt tgtgacaaaa gaaaaacttt aaaattgtcc caaacagaaa aataatggct
     2761 atcagaagta tgttttgttt tagtgtgagt taccgttact gtatttgttt attgtaaagg
     2821 tggacattta gcgttcagtg cagttttcaa taaaaagtaa ttaaaatttg ttaagttctg
     2881 aaattcaagt acatctcact aatgtaaatg ttctctactt gagatgttta aggcaattgc
     2941 attgtcaatt agccaatttc cagctcttgt tactacaggg ttccataacc agactcaaga
     3001 ccgctgacaa ttaattacct gtgataacaa aaagtttaat tgaaaaatca aaacctcaca
     3061 caagtccatc attatcacgt catgccatcc ttaagatgca atggtgggtt agtgctaaat
     3121 caattcaaaa aaaaacaaag ttgctcaact tttagagttc tgactttaat ctaccccaaa
     3181 gcaaaatgac ctggacctgg ttcaagggag ggaagtgaac cttgaaactg ttttgccaat
     3241 aacctaacaa acaaaatgat atttacaaag aagtgttgca aatagtccca tgagttaaga
     3301 gcttgattta atggatcttc tttttaaata gaattaaacc tttatactaa aagtatttgc
     3361 aagtgtcaat taagtccaac aattccaggt atgaaactcc ctctgagctc ttccttatac
     3421 ttcccttccc aattaaaaca aaacaagaaa atcatggtgt cttaaagcct ttggcttgcc
     3481 tggccttgtc tgctcactca ttttaaggtg gtggccccat cccaactcta ccataaaagt
     3541 gtctattaac acaagctcac atggagagag acggcgctca tagttactga cctattaccc
     3601 cagggaacaa aaaggtagtt taacgtcttc gtaaccactc atcaaagagg caatgaaata
     3661 tgcgtgaaaa ggaggccaag cgcacacaga atatcttacc ttcacgaata tgtgaagaag
     3721 tctgggacac gatgaaccta agagtcaaaa acataaaaag gcaggtctga atccatggtc
     3781 cacctgggtt ttaattatta gatcttggtc gcccaaacaa aaatttatat atatatatat
     3841 aaatttgacc ccaaggaaga acaagtcaaa acaaaatgcc acgctctgtt tgctctagaa
     3901 aaagaaccat caagtccaca gagtgcaggt atgacttact ctccagagtc agtcattaat
     3961 gtctgtcacc tagccacgta taatcatctt tgaaaaagga ctatattcta tcttgggaca
     4021 ataattatgg ctgttttaat agttcaagag cataatatag cattgattta ccaaaatttt
     4081 tggcctttaa cagccagtct atgaaaacca tttagagccc cattcctgtc tgtagcctag
     4141 gaaatggaac catctttaat tctttcccac agggaagaat gctgcaccta tcacactatg
     4201 tggtcagggt cactgattga taataaataa ataaataata gagcgctcag gggaaacaac
     4261 actcaccaga ccacaacaca cagtagaagc taagtgctga gcgtgtactc tggacaacgc
     4321 tggctgcaat gcagactgca atggctacat gcttttccct ctaacaattc tctttggctt
     4381 tttcaattgg gagggcagat tttgcttaac aggcaactag aacaggatct ctgcccacta
     4441 aaaaattatc cctatacata gagaaattac tacagatgct aagtagtcag aatgctaaca
     4501 ttttctacaa acttgattac ttattggcca aaatgaaagc aaacagccaa tttttaacaa
     4561 cacattcacc acttgaaaca aacagcagca tttacattat atcaaagatt catttctaca
     4621 gaatcgtact aaaaaatcat ttttcctgca agatttagca tgcagcaaaa aatgatcttt
     4681 tcatcctggg aacacctttt tactgagttt tcggggggaa agaactaaag acatgacagt
     4741 tttgtgggta tttttctatt tttagtattc tggcagcaaa tttgaggttg tacacatttc
     4801 attatcaact aaacaaaaca agaagcaagc aaatacttta aggttttcac agcctttttc
     4861 atcacaggga aggaaaaaac tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgcgcgcgcg
     4921 cgcgtgcgtg tgtcgtcttt ccaaattcct ggccacatca atagtctaga aagtgcttat
     4981 caggacacca aatatttctg tgttcctgag ataggtctga aatttttacc cagtattgaa
     5041 tgtatacctg aagtggtcaa ataatacttc ttataaaaaa gtttttctac ctaagattat
     5101 agttttaact ttaaattaaa gaatggccac aattaaccaa catgcaaaaa ttctcagact
     5161 aaacactgag aaattcttca tacaatgcat ttgccacctt attgcatttt taaaatcttt
     5221 attctgtagt gaattggtat tcccaatctg cctaagcaaa ggcatgccct tctaacaaga
     5281 tttgcttaga gcagaggtga tagaaggaag aatccgaaga ccctctggca tggcaatctg
     5341 ggagcagcac attgttgatg gagtccaagt gagcacattt cacacaattc atttagtgac
     5401 aagtgggctt gctccctttt catccaggaa aaaaactact cacagaccac tgcccagaat
     5461 ctggaataag aaccctcatt ttaaggtatt cttcccaaca aataaatatc taaatattga
     5521 aagggggcat atcagaaaac ttaaagacac aataaccaaa accaaaaccc tcttcaaaac
     5581 aagtaagcaa tgtctgtatt tagttcactc taaaacattc ttagcttttc ttgcagtttg
     5641 ttcctaaaag atttgattgg gcacaagagg aacgaaatta ttaataaaat aaaagcttat
     5701 ttttgttttg ctgtggataa tcggtacaaa acgtttccag atctgagact tagatggatc
     5761 ttttaaggtg aaagtagaat gccaggttct actgaaataa tatctgaaag gaacaaagag
     5821 ccatttgcca tgtgcttttt ctaagtgccc atgctggaaa aaattttctc aataatatga
     5881 agatgctggt acaacttttc ctattaaaca atgtcttaca caaccacatg cgttacattt
     5941 atagacagat ttacaatttg gaaggaaaaa aagttctgtc ttaataaaat tagttttttt
     6001 tacaaactgt agtccaacta aagttctctg tctcctcacg cagcagaggc attatctcca
     6061 taaggtgtgt gtggtccagg aaaacacttc cccgagcaga tcctgccaga tttggttcat
     6121 tccatgatgt cgactctgct tggagcacca cactaacttt agggtcatta cagatctgat
     6181 gccttggtct tctgctgttt gatttttttt ttcattcatc ttcatcatcc tcatcttcct
     6241 ctccatcaga cagggatgta cacggccgga tctgtcggta gcggtcaagc catttttcta
     6301 ccatctgagt gaccaggggg tgatttcgcc gccgagaact cttctgcatg gcaaccagaa
     6361 ctcccccctc cgtcacacag cagtccagcc actccctgag cagtttttct tgctgttcct
     6421 cattacctag cttttggagg aatatgaaga caaagggaaa atcatacaac agatcagaga
     6481 cttggtagga atgtgacatg gaaacctaca gctggtatgc taactcatga aaaggccaaa
     6541 gcaatcaact tttcacatgg ttttgacctc ttggaagttt tgtgattaaa gtccagtttg
     6601 ctctggttaa atttaaaaag acataaatgg gaaatttctc agaaaaaaac taaagaggag
     6661 cacactagag ggtaatttgt tagataaaat aaaaaacaaa tgtcctaata aactgatcct
     6721 ggcaagccac agcttcaaac acatgacaag gtaagtttac ttagtcaatt atgtacaagc
     6781 tgaaattata caagttacgg tctatgaact ttttttcttc atgttgtgat tataaacgtt
     6841 ttataattac tagtatatta aataaaagac caatactttt ataagaa
//
