LOCUS       NM_001012614            2488 bp    mRNA    linear   PRI 05-OCT-2024
DEFINITION  Homo sapiens C-terminal binding protein 1 (CTBP1), transcript
            variant 2, mRNA.
ACCESSION   NM_001012614
VERSION     NM_001012614.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Kong,Y., Yang,G., Feng,X., Ji,Z., Wang,X., Shao,Y., Meng,J.,
            Yao,G., Ren,C. and Yang,G.
  TITLE     CTBP1 links metabolic syndrome to polycystic ovary syndrome through
            interruption of aromatase and SREBP1
  JOURNAL   Commun Biol 7 (1), 1174 (2024)
   PUBMED   39294274
  REMARK    GeneRIF: CTBP1 links metabolic syndrome to polycystic ovary
            syndrome through interruption of aromatase and SREBP1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Zhou,J., Yan,X., Liu,Y. and Yang,J.
  TITLE     Succinylation of CTBP1 mediated by KAT2A suppresses its inhibitory
            activity on the transcription of CDH1 to promote the progression of
            prostate cancer
  JOURNAL   Biochem Biophys Res Commun 650, 9-16 (2023)
   PUBMED   36764210
  REMARK    GeneRIF: Succinylation of CTBP1 mediated by KAT2A suppresses its
            inhibitory activity on the transcription of CDH1 to promote the
            progression of prostate cancer.
REFERENCE   3  (bases 1 to 2488)
  AUTHORS   Lou,L.Q., Zhou,W.Q., Song,X. and Chen,Z.
  TITLE     Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1 complex
            targets ATXN1 to trigger NF-kappaB-dependent inflammation response
  JOURNAL   J Mol Med (Berl) 101 (3), 223-235 (2023)
   PUBMED   36629882
  REMARK    GeneRIF: Elevation of hsa-miR-7-5p level mediated by CtBP1-p300-AP1
            complex targets ATXN1 to trigger NF-kappaB-dependent inflammation
            response.
REFERENCE   4  (bases 1 to 2488)
  AUTHORS   Tseng,C., Han,Y., Lv,Z., Song,Q., Wang,K., Shen,H. and Chen,Z.
  TITLE     The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic
            signalling and promote intervertebral disc degeneration
  JOURNAL   J Mol Med (Berl) 101 (1-2), 171-181 (2023)
   PUBMED   36688959
  REMARK    GeneRIF: The CRL4[DCAF6] E3 ligase ubiquitinates CtBP1/2 to induce
            apoptotic signalling and promote intervertebral disc degeneration.
REFERENCE   5  (bases 1 to 2488)
  AUTHORS   Ferrarese,R., Izzo,A., Andrieux,G., Lagies,S., Bartmuss,J.P.,
            Masilamani,A.P., Wasilenko,A., Osti,D., Faletti,S., Schulzki,R.,
            Yuan,S., Kling,E., Ribecco,V., Heiland,D.H., Tholen,S., Prinz,M.,
            Pelicci,G., Kammerer,B., Boerries,M. and Carro,M.S.
  TITLE     ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs
            and LSD1 activity in glioblastoma
  JOURNAL   Life Sci Alliance 6 (1), e202201400 (2022)
   PUBMED   36414381
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2488)
  AUTHORS   Schaeper,U., Subramanian,T., Lim,L., Boyd,J.M. and Chinnadurai,G.
  TITLE     Interaction between a cellular protein that binds to the C-terminal
            region of adenovirus E1A (CtBP) and a novel cellular protein is
            disrupted by E1A through a conserved PLDLS motif
  JOURNAL   J Biol Chem 273 (15), 8549-8552 (1998)
   PUBMED   9535825
REFERENCE   7  (bases 1 to 2488)
  AUTHORS   Katsanis,N. and Fisher,E.M.
  TITLE     A novel C-terminal binding protein (CTBP2) is closely related to
            CTBP1, an adenovirus E1A-binding protein, and maps to human
            chromosome 21q21.3
  JOURNAL   Genomics 47 (2), 294-299 (1998)
   PUBMED   9479502
REFERENCE   8  (bases 1 to 2488)
  AUTHORS   Schaeper,U., Boyd,J.M., Verma,S., Uhlmann,E., Subramanian,T. and
            Chinnadurai,G.
  TITLE     Molecular cloning and characterization of a cellular phosphoprotein
            that interacts with a conserved C-terminal domain of adenovirus E1A
            involved in negative modulation of oncogenic transformation
  JOURNAL   Proc Natl Acad Sci U S A 92 (23), 10467-10471 (1995)
   PUBMED   7479821
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
REFERENCE   9  (bases 1 to 2488)
  AUTHORS   Boyd,J.M., Subramanian,T., Schaeper,U., La Regina,M., Bayley,S. and
            Chinnadurai,G.
  TITLE     A region in the C-terminus of adenovirus 2/5 E1a protein is
            required for association with a cellular phosphoprotein and
            important for the negative modulation of T24-ras mediated
            transformation, tumorigenesis and metastasis
  JOURNAL   EMBO J 12 (2), 469-478 (1993)
   PUBMED   8440238
REFERENCE   10 (bases 1 to 2488)
  AUTHORS   Battaglia,A., Carey,J.C. and South,S.T.
  TITLE     Wolf-Hirschhorn Syndrome - RETIRED CHAPTER, FOR HISTORICAL
            REFERENCE ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301362
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092535.4, BU553431.1,
            BC053320.1, BC011655.2 and BM989059.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001012614.1.
            
            Summary: This gene encodes a protein that binds to the C-terminus
            of adenovirus E1A proteins. This phosphoprotein is a
            transcriptional repressor and may play a role during cellular
            proliferation. This protein and the product of a second closely
            related gene, CTBP2, can dimerize. Both proteins can also interact
            with a polycomb group protein complex which participates in
            regulation of gene expression during development. Alternative
            splicing of transcripts from this gene results in multiple
            transcript variants. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.509200.1,
                                           SRR1163655.31102.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154405 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382952.8/ ENSP00000372411.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC092535.4         149893-149902       c
            11-18               BU553431.1         1-8
            19-2053             BC053320.1         1-2035
            2054-2468           BC011655.2         1722-2136
            2469-2488           BM989059.1         24-43               c
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.3"
     gene            1..2488
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /note="C-terminal binding protein 1"
                     /db_xref="GeneID:1487"
                     /db_xref="HGNC:HGNC:2494"
                     /db_xref="MIM:602618"
     exon            1..215
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            216..410
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..1693
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /note="isoform 2 is encoded by transcript variant 2;
                     brefeldin A-ribosylated substrate"
                     /codon_start=1
                     /product="C-terminal-binding protein 1 isoform 2"
                     /protein_id="NP_001012632.1"
                     /db_xref="CCDS:CCDS43203.1"
                     /db_xref="GeneID:1487"
                     /db_xref="HGNC:HGNC:2494"
                     /db_xref="MIM:602618"
                     /translation="MSGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCD
                     AQSTQEIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDL
                     GIAVCNVPAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAAR
                     IRGETLGIIGLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFH
                     SDCVTLHCGLNEHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGA
                     ALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPD
                     SLKNCVNKDHLTAATHWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPS
                     AMSLSHGLPPVAHPPHAPSPGQTVKPEADRDHASDQL"
     exon            411..565
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            566..710
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            711..917
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1132
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1263
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1391
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1509
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..2488
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2462..2467
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /note="hexamer: AAGAAA"
     regulatory      2466..2471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /note="hexamer: AATAAA"
     polyA_site      2473
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
     polyA_site      2488
                     /gene="CTBP1"
                     /gene_synonym="BARS; HADDTS"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcgcgg tcgtcggagc gcggctcagc ggcgcggcgg agactcggca cggcggcggc
       61 caggcgcagg cgggcgggcg gagcagcgga cggcgccgag gccgccccac gcgccgggct
      121 cgcggcggcg cagcgcgccg gagtggtcgg ggcccgcggc cgctcgcgcc tctcgatggg
      181 cagctcgcac ttgctcaaca agggcctgcc gcttgtaaga ctttgacccc gacgcaggct
      241 tcagtgattg ccgcggatca gaagcctgag cactttggct cgagacaatt aaggacgtgg
      301 gatgaggctc cgagacagga cgcggttctg cctggggatc ctgaagataa aaagctttga
      361 aaagtcgaat tcatggtcgt ggaagctgag cccatattaa gagatgtcag gcgtccgacc
      421 tccgatcatg aacgggcccc tgcacccgcg gcccctggtg gcattgctgg atggccggga
      481 ctgcacagtg gagatgccca tcctgaagga cgtggccact gtggccttct gcgacgcgca
      541 gtccacgcag gagatccatg agaaggtcct gaacgaggct gtgggggccc tgatgtacca
      601 caccatcact ctcaccaggg aggacctgga gaagttcaaa gccctccgca tcatcgtccg
      661 gattggcagt ggttttgaca acatcgacat caagtcggcc ggggatttag gcattgccgt
      721 ctgcaacgtg cccgcggcgt ctgtggagga gacggccgac tcgacgctgt gccacatcct
      781 gaacctgtac cggcgggcca cctggctgca ccaggcgctg cgggagggca cacgagtcca
      841 gagcgtcgag cagatccgcg aggtggcgtc cggcgctgcc aggatccgcg gggagacctt
      901 gggcatcatc ggacttggtc gcgtggggca ggcagtggcg ctgcgggcca aggccttcgg
      961 cttcaacgtg ctcttctacg acccttactt gtcggatggc gtggagcggg cgctggggct
     1021 gcagcgtgtc agcaccctgc aggacctgct cttccacagc gactgcgtga ccctgcactg
     1081 cggcctcaac gagcacaacc accacctcat caacgacttc accgtcaagc agatgagaca
     1141 aggggccttc ctggtgaaca cagcccgggg tggcctggtg gatgagaagg cgctggccca
     1201 ggccctgaag gagggccgga tccgcggcgc ggccctggat gtgcacgagt cggaaccctt
     1261 cagctttagc cagggccctc tgaaggatgc acccaacctc atctgcaccc cccatgctgc
     1321 atggtacagc gagcaggcat ccatcgagat gcgagaggag gcggcacggg agatccgcag
     1381 agccatcaca ggccggatcc cagacagcct gaagaactgt gtcaacaagg accatctgac
     1441 agccgccacc cactgggcca gcatggaccc cgccgtcgtg caccctgagc tcaatggggc
     1501 tgcctatagg taccctccgg gcgtggtggg cgtggccccc actggcatcc cagctgctgt
     1561 ggaaggtatc gtccccagcg ccatgtccct gtcccacggc ctgccccctg tggcccaccc
     1621 gccccacgcc ccttctcctg gccaaaccgt caagcccgag gcggatagag accacgccag
     1681 tgaccagttg tagcccggga ggagctctcc agcctcggcg cctgggcaga gggcccggaa
     1741 accctcggac cagagtgtgt ggaggaggca tctgtgtggt ggccctggca ctgcagagac
     1801 tggtccgggc tgtcaggagg cgggaggggg cagcgctggg cctcgtgtcg cttgtcgtcg
     1861 tccgtcctgt gggcgctctg ccctgtgtcc ttcgcgttcc tcgttaagca gaagaagtca
     1921 gtagttattc tcccatgaac gttcttgtct gtgtacagtt tttagaacat tacaaaggat
     1981 ctgtttgctt agctgtcaac aaaaagaaaa cctgaaggag catttggaag tcaatttgag
     2041 gttttttttt ttgttttttt tttttttgta tgttggaacg tgccccagaa tgaggcagtt
     2101 ggcaaacttc tcaggacaat gaatccttcc cgtttttctt tttatgccac acagtgcatt
     2161 gttttttcta cctgcttgtc ttatttttag aataatttag aaaaacaaaa caaaggctgt
     2221 ttttcctaat tttggcatga accccccctt gttccaaatg aagacggcat cacgaagcag
     2281 ctccaaaagg aaaagcttgg gcggtgccca gcgtgcccgc tgcccatcga cgtctgtcct
     2341 ggggacgtgg agggtggcag cgtccccgcc tgcaccagtg ccgtcctgct gatgtggtag
     2401 gctagcaata ttttggttaa aatcatgttt gtgactgtaa ccatttgtat gaattatttt
     2461 aaagaaataa aaatcctgga aagagcca
//
