LOCUS       NM_172241               4317 bp    mRNA    linear   PRI 12-SEP-2020
DEFINITION  Homo sapiens cutaneous T cell lymphoma-associated antigen 1
            (CTAGE1), mRNA.
ACCESSION   NM_172241
VERSION     NM_172241.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4317)
  AUTHORS   Litvinov IV, Cordeiro B, Huang Y, Zargham H, Pehr K, Dore MA,
            Gilbert M, Zhou Y, Kupper TS and Sasseville D.
  TITLE     Ectopic expression of cancer-testis antigens in cutaneous T-cell
            lymphoma patients
  JOURNAL   Clin. Cancer Res. 20 (14), 3799-3808 (2014)
   PUBMED   24850846
  REMARK    GeneRIF: SYCP1, cTAGE1, and GTSF1 are expressed in cutaneous T-cell
            lymphoma, but not in normal skin or benign inflammatory dermatoses.
REFERENCE   2  (bases 1 to 4317)
  AUTHORS   Yuan E, Tsai PT, Greene-Colozzi E, Sahin M, Kwiatkowski DJ and
            Malinowska IA.
  TITLE     Graded loss of tuberin in an allelic series of brain models of TSC
            correlates with survival, and biochemical, histological and
            behavioral features
  JOURNAL   Hum. Mol. Genet. 21 (19), 4286-4300 (2012)
   PUBMED   22752306
  REMARK    GeneRIF: Loss of TSC2 in the brain correlates with survival and
            abnormal behavior.
REFERENCE   3  (bases 1 to 4317)
  AUTHORS   Thye T, Vannberg FO, Wong SH, Owusu-Dabo E, Osei I, Gyapong J,
            Sirugo G, Sisay-Joof F, Enimil A, Chinbuah MA, Floyd S, Warndorff
            DK, Sichali L, Malema S, Crampin AC, Ngwira B, Teo YY, Small K,
            Rockett K, Kwiatkowski D, Fine PE, Hill PC, Newport M, Lienhardt C,
            Adegbola RA, Corrah T, Ziegler A, Morris AP, Meyer CG, Horstmann RD
            and Hill AVS.
  CONSRTM   African TB Genetics Consortium; Wellcome Trust Case Control
            Consortium
  TITLE     Genome-wide association analyses identifies a susceptibility locus
            for tuberculosis on chromosome 18q11.2
  JOURNAL   Nat. Genet. 42 (9), 739-741 (2010)
   PUBMED   20694014
  REMARK    Erratum:[Nat Genet. 2011 Oct;43(10):1040]
REFERENCE   4  (bases 1 to 4317)
  AUTHORS   Usener D, Schadendorf D, Koch J, Dubel S and Eichmuller S.
  TITLE     cTAGE: a cutaneous T cell lymphoma associated antigen family with
            tumor-specific splicing
  JOURNAL   J. Invest. Dermatol. 121 (1), 198-206 (2003)
   PUBMED   12839582
  REMARK    GeneRIF: cTAGE-1 and cTAGE-5 are new cancer germline antigens and
            that tumor-specific splicing of cTAGE genes may lead to further
            candidate proteins for specific immunotherapy of cutaneous T cell
            lymphoma and other malignancies.
REFERENCE   5  (bases 1 to 4317)
  AUTHORS   Eichmuller S, Usener D, Dummer R, Stein A, Thiel D and Schadendorf
            D.
  TITLE     Serological detection of cutaneous T-cell lymphoma-associated
            antigens
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 98 (2), 629-634 (2001)
   PUBMED   11149944
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099849.4.
            
            On May 17, 2019 this sequence version replaced NM_172241.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF273058.1, BC031065.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000391403.4/ ENSP00000375220.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4317              AC099849.4         26105-30421         c
FEATURES             Location/Qualifiers
     source          1..4317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..4317
                     /gene="CTAGE1"
                     /gene_synonym="CT21.1; CT21.2; CTAGE; CTAGE-1; CTAGE-2"
                     /note="cutaneous T cell lymphoma-associated antigen 1"
                     /db_xref="GeneID:64693"
                     /db_xref="HGNC:HGNC:24346"
                     /db_xref="MIM:608856"
     exon            1..4317
                     /gene="CTAGE1"
                     /gene_synonym="CT21.1; CT21.2; CTAGE; CTAGE-1; CTAGE-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2342
                     /gene="CTAGE1"
                     /gene_synonym="CT21.1; CT21.2; CTAGE; CTAGE-1; CTAGE-2"
                     /note="cutaneous T-cell lymphoma-associated antigen 2;
                     cancer/testis antigen family 21, member 1; cancer/testis
                     antigen family 21, member 2; cancer/testis antigen 21.2;
                     protein cTAGE-2"
                     /codon_start=1
                     /product="cTAGE family member 2"
                     /protein_id="NP_758441.2"
                     /db_xref="CCDS:CCDS45837.1"
                     /db_xref="GeneID:64693"
                     /db_xref="HGNC:HGNC:24346"
                     /db_xref="MIM:608856"
                     /translation="MRPDSHPYGFPWELVIRAAVAGFFAVLFLWRSFRSVTSRLYVRR
                     EKKFAVALSGLIEEKCKLLEKFSLVQKEYEGYEVESSLKNASFEKEATEAQSLEATCE
                     KLNRFNSELVHEILCLEKELKEEKSKHSEQNELMADISKRIQSLEDESKSLKSQVAEA
                     KMTFKRFQANEERLEIEIQDAWKENSELQESQKQLLQEAEVWKEQVSELIKQKRTFED
                     SKVHAEQVLNDKENHIKTLTERLLKMKDGVAMLEEDVTDDDNLELEMNSESEDGAYLD
                     NPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASL
                     QSENTHFESENQKLQQKLKVMTELYQENEMKLYRKLIVEEKCRLEKEEKLSKVDEMIS
                     HATEELETYRKRAKDLKEFEKTIHFYQKKIILHEKKAHDNWSAAWTAERNLNDLRKEN
                     AHNRQKLTEIEFKIKLLEKDPYGLDVPNTAFGRQHSPYGPSPLGWPSSETRASLYPPT
                     LLEGPLRLSPLLPRGGGRGSRGPGNPPDHQITKERGESSCDRLTDPHRAPSDAGPLAP
                     PWEQDYRMMFPPPGQSYPDSALPPQRQDRFYSNCARLSGPAELRSFNMPSLDKMDGSM
                     PSEMESSRNDTKDNLGNLKVPDSSLPAENEATGPGFVPPPLAPIRGLLFPVDTRGPFI
                     RRGPPFPPPPPGTVFGASPDYFSPRDVPGPPRAPFAMRNVYLPRGFLPYRPPRPAFFP
                     PAPTF"
     regulatory      4289..4294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTAGE1"
                     /gene_synonym="CT21.1; CT21.2; CTAGE; CTAGE-1; CTAGE-2"
                     /note="hexamer: AATAAA"
     polyA_site      4317
                     /gene="CTAGE1"
                     /gene_synonym="CT21.1; CT21.2; CTAGE; CTAGE-1; CTAGE-2"
                     /note="major polyA site"
ORIGIN      
        1 agagcagcct tggcgctacg gaggagccta gggctaaccc tcagccatac ctggggctgg
       61 tcctggagtt gctacgcagg gttgtggcag cactgactga aggtatgaga cccgattctc
      121 atccttatgg ttttccatgg gaattggtga tacgtgcagc tgttgctgga ttttttgctg
      181 ttctcttctt gtggagaagt tttagatcag ttacgagtcg gctttatgtg agaagagaga
      241 aaaagtttgc tgtggcactt tctggactaa ttgaagaaaa atgtaaacta cttgaaaaat
      301 ttagccttgt tcaaaaagag tatgaaggct atgaagtaga gtcatcttta aagaatgcca
      361 gctttgagaa ggaggcaaca gaagcacaaa gtttggaggc aacctgcgaa aagctgaaca
      421 ggttcaattc tgaacttgtg catgaaatac tctgtctaga aaaagagtta aaagaagaga
      481 aatctaaaca ttctgaacaa aatgaattga tggcggatat ttccaaaagg atacagtcgc
      541 tagaagatga gtcaaaatcc ctcaaatcac aagtagctga agccaaaatg accttcaaga
      601 gatttcaagc gaatgaagaa cggttggaga tagaaataca agatgcttgg aaagaaaatt
      661 ctgaacttca ggaaagccag aaacagcttt tgcaagaagc tgaagtatgg aaagaacaag
      721 tgagtgaact tattaaacag aaaagaacat ttgaagactc caaagtacat gcagaacaag
      781 ttctaaatga taaagaaaat cacatcaaga ctctgactga acgcttgcta aagatgaaag
      841 atggggttgc tatgcttgaa gaagatgtaa cggatgatga taacttggaa ttagaaatga
      901 acagtgaatc ggaagatggt gcttacttag ataatcctcc aaaaggagct ttgaagaaac
      961 tgattcatgc tgctaagtta aatgcttcct taaaaacctt agaaggagaa agaaaccaaa
     1021 tttatattca attatctgaa gttgataaaa caaaggaaga gcttacagag catattaaaa
     1081 atcttcagac tgaacaagca tctttgcagt cagaaaacac acattttgaa agtgagaatc
     1141 agaagcttca gcagaaactt aaagtaatga ctgaattata tcaagaaaat gaaatgaaac
     1201 tctacaggaa attaatagta gaggaaaaat gccggttaga gaaagaagag aaactttcta
     1261 aagtagacga aatgatcagc catgccactg aagagctgga gacctaccga aagcgagcca
     1321 aagatcttaa agaatttgag aaaactattc atttttatca aaagaagatt attctccatg
     1381 agaaaaaagc acatgataat tggtcggcag cttggactgc tgaaagaaac ctcaatgatt
     1441 taaggaaaga aaatgctcac aacagacaaa aattaactga aatagagttt aaaataaaac
     1501 ttttagaaaa agatccttat ggacttgatg ttccaaatac agcatttggc agacagcatt
     1561 ccccatatgg tccctcacca ttgggttggc cttcatctga aacgagagct tctctctatc
     1621 ctccaacttt gttggaaggt cctctcagac tctcaccttt gcttccacgg ggaggaggaa
     1681 gaggctccag aggcccaggg aatcctccgg accatcagat taccaaagaa agaggagaat
     1741 caagctgtga taggttaact gatcctcaca gggctccttc tgacgctggg cccctggcac
     1801 ctccgtggga acaggactat aggatgatgt ttcctccacc aggacaatca tatcctgatt
     1861 cagctctccc tccacaaagg caagacagat tttattctaa ttgtgctaga ctctctggac
     1921 cagcagaact cagaagtttt aatatgcctt ctttggataa aatggatggg tcaatgcctt
     1981 cagaaatgga atccagtaga aatgatacca aagataatct tggtaattta aaggtgcctg
     2041 attcatctct ccccgctgaa aatgaagcaa ctggccctgg ctttgttcct ccacctcttg
     2101 ctccaatcag aggtttattg tttccagtag atacaagggg cccgttcata agaagaggac
     2161 ctcctttccc cccacctcct ccaggaaccg tgtttggagc ttctccagat tatttttctc
     2221 caagggatgt cccaggtcca ccacgtgctc catttgcaat gagaaatgtc tatttaccga
     2281 gaggttttct tccttaccgt cccccaagac ctgcattttt ccccccagcc cccacattct
     2341 gaaggtagaa tgagtttcca tcagggttga gtccgacttc aaatgagcct gctgctgaac
     2401 atccagaacg acagcaagaa acctaacaac atgtttgccc tcttcaaaag taattttgac
     2461 tgatctcatt ttcagtttaa gtaactgctg ttacttaagt gattacactt ttgttcagat
     2521 tgaaacttaa tggaactata attcccagga tagtattttg taaatgagga tgatttaaat
     2581 atgaatctta tgagtaaatt atttcatttt attttattct agatagtata acttttaatt
     2641 tgattaatcc actattatat aaagaatggt gggagcttta tatatgtaat cttgcaggtg
     2701 gggaggcttt aaattgtctt tatgtcaaga actgtattta ctgtggttgt agacaaatgt
     2761 gaaagtaact ttatgcttaa ataagtttta gttgattaaa aaaatttaaa aaatttaaaa
     2821 aaagaaatat ataaatatgc acaggtggga aggtagaata ctatgtaact gttagaatat
     2881 ttcactttaa accaagatga tcttggatct cctgtcttat agattttata tcctctttca
     2941 gtactttgag agtgtaaaac atttatagca gaaagtattc gtgtttcctc tgttttcctc
     3001 aagaatggtt tcttcgccct ccctttcctt cccttcgtct tccctaagct aatttcttcc
     3061 tatgtttgtc atcatatcat tacataattg tgttgttatt tcttttgttt tatttttatt
     3121 tggtgggaac aactttatcc agaactttta cttgccccag aattatatag atcagtttct
     3181 cctgacttct ttcccaacct ttacctctgt tggtgttcta atagttttag ttttatgttc
     3241 tgcttttctc ttgctgtggc aaggggaagg agtaaatcta agatagtgct taattgcagt
     3301 tggtgaattt gatctctgat tgagctctct tctctggaat tctgttaaaa gatgaaatgt
     3361 atcgtgttcc ctgagagacg ccctcaaatt ttggattagt ccttcatgca agctgggcca
     3421 ccaagccatt gcttcttttg gggacaacct gccctcactt ttaaaaagca tcctagctca
     3481 catgcctccc ctagcagtta atgccactcc agtctctgct tgaatgtaat aaaataaaag
     3541 aaaagtaact atttgagaca tgaggtgccc ttattgtaca ctggggcttc ctatacattt
     3601 tccgtcttcc cttgaaccac cactatcctc agctacttta tgcttctgtt ctgttaaagc
     3661 cctatttgct agtggaaaaa tttaactcct ggtgattttt ttaatactag gcctcttgcc
     3721 ttccttccag tgagagaaaa atagaatggt aagcctagtg gtttcttcct tcactgttga
     3781 atactattta tccaaggtat caaggaagaa cttctaatca gaaaagacat gtattatttt
     3841 cacaactggg tagcatatct cactcccaga atggaagtta ggtgggaatt gcaagattaa
     3901 ggagattttt ctggatttct gtctatgtat catatccaca gaactctttc tagaggaatt
     3961 ttatattgag ccaggcatcc atttccacag tcttgcattt ctagatactt ccaaagttat
     4021 agcactgttc ctaaatcatt tttggcttta tttattaatt tattgttcac ttcatttcat
     4081 taggttcagt atgaaacagg tattgtcatc tctttgtgtc tactttgcca cctttcccca
     4141 gaataggcct gaatgagatt gaaaacgtta cttcagttcc ttgtgtctga cattgcttgt
     4201 ttgtaactaa gaaaaataat atttgctttt gttgaatgac tactaatttt tttccatgaa
     4261 cctaataaac taaaaagaaa gttgaaataa taaagagtga ataagtataa aaatcca
//
