LOCUS       NM_172377                759 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens cancer/testis antigen 2 (CTAG2), transcript variant 1,
            mRNA.
ACCESSION   NM_172377 XM_001714637
VERSION     NM_172377.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Baroy,T., Kresse,S.H., Skarn,M., Stabell,M., Castro,R., Lauvrak,S.,
            Llombart-Bosch,A., Myklebost,O. and Meza-Zepeda,L.A.
  TITLE     Reexpression of LSAMP inhibits tumor growth in a preclinical
            osteosarcoma model
  JOURNAL   Mol Cancer 13, 93 (2014)
   PUBMED   24885297
  REMARK    GeneRIF: The tumor suppressor function of LSAMP is most likely
            exerted by reducing the proliferation rate of the tumor cells,
            possibly by indirectly upregulating one or more of the genes HES1,
            CTAG2 or KLF10.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Chen,Z., Tang,H., Qayyum,R., Schick,U.M., Nalls,M.A., Handsaker,R.,
            Li,J., Lu,Y., Yanek,L.R., Keating,B., Meng,Y., van Rooij,F.J.,
            Okada,Y., Kubo,M., Rasmussen-Torvik,L., Keller,M.F., Lange,L.,
            Evans,M., Bottinger,E.P., Linderman,M.D., Ruderfer,D.M.,
            Hakonarson,H., Papanicolaou,G., Zonderman,A.B., Gottesman,O.,
            Thomson,C., Ziv,E., Singleton,A.B., Loos,R.J., Sleiman,P.M.,
            Ganesh,S., McCarroll,S., Becker,D.M., Wilson,J.G., Lettre,G. and
            Reiner,A.P.
  CONSRTM   BioBank Japan Project; CHARGE Consortium
  TITLE     Genome-wide association analysis of red blood cell traits in
            African Americans: the COGENT Network
  JOURNAL   Hum Mol Genet 22 (12), 2529-2538 (2013)
   PUBMED   23446634
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Scanlan,M.J., Gure,A.O., Jungbluth,A.A., Old,L.J. and Chen,Y.T.
  TITLE     Cancer/testis antigens: an expanding family of targets for cancer
            immunotherapy
  JOURNAL   Immunol Rev 188, 22-32 (2002)
   PUBMED   12445278
  REMARK    Review article
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Aradhya,S., Bardaro,T., Galgoczy,P., Yamagata,T., Esposito,T.,
            Patlan,H., Ciccodicola,A., Munnich,A., Kenwrick,S., Platzer,M.,
            D'Urso,M. and Nelson,D.L.
  TITLE     Multiple pathogenic and benign genomic rearrangements occur at a 35
            kb duplication involving the NEMO and LAGE2 genes
  JOURNAL   Hum Mol Genet 10 (22), 2557-2567 (2001)
   PUBMED   11709543
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Rimoldi,D., Rubio-Godoy,V., Dutoit,V., Lienard,D., Salvi,S.,
            Guillaume,P., Speiser,D., Stockert,E., Spagnoli,G., Servis,C.,
            Cerottini,J.C., Lejeune,F., Romero,P. and Valmori,D.
  TITLE     Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and
            nonprimary open reading frame-derived CTL epitopes in melanoma
  JOURNAL   J Immunol 165 (12), 7253-7261 (2000)
   PUBMED   11120859
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Aarnoudse,C.A., van den Doel,P.B., Heemskerk,B. and Schrier,P.I.
  TITLE     Interleukin-2-induced, melanoma-specific T cells recognize CAMEL,
            an unexpected translation product of LAGE-1
  JOURNAL   Int J Cancer 82 (3), 442-448 (1999)
   PUBMED   10399963
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Lethe,B., Lucas,S., Michaux,L., De Smet,C., Godelaine,D.,
            Serrano,A., De Plaen,E. and Boon,T.
  TITLE     LAGE-1, a new gene with tumor specificity
  JOURNAL   Int J Cancer 76 (6), 903-908 (1998)
   PUBMED   9626360
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Chen,Y.T., Gure,A.O., Tsang,S., Stockert,E., Jager,E., Knuth,A. and
            Old,L.J.
  TITLE     Identification of multiple cancer/testis antigens by allogeneic
            antibody screening of a melanoma cell line library
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6919-6923 (1998)
   PUBMED   9618514
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AJ223040.1 and BC113998.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 14, 2020 this sequence version replaced NM_172377.4.
            
            Summary: This gene encodes an autoimmunogenic tumor antigen that
            belongs to the ESO/LAGE family of cancer-testis antigens. This
            protein is expressed in a wide array of cancers including melanoma,
            breast cancer, bladder cancer and prostate cancer. This protein is
            also expressed in normal testis tissue. An alternative open reading
            frame product of this gene has been described in PMID:10399963.
            This alternate protein, termed CAMEL, is a tumor antigen that is
            recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate
            splicing results in multiple transcript variants. [provided by
            RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes isoform LAGE-1a (also
            known as LAGE-1S).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ012834.1, AJ223041.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369585.4/ ENSP00000358598.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AJ223040.1         1-20
            21-726              BC113998.1         1-706
            727-759             AJ223040.1         956-988
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..759
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /note="cancer/testis antigen 2"
                     /db_xref="GeneID:30848"
                     /db_xref="HGNC:HGNC:2492"
                     /db_xref="MIM:300396"
     exon            1..333
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..607
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /note="isoform LAGE-1a is encoded by transcript variant 1;
                     cancer/testis antigen family 6, member 2a; cancer/testis
                     antigen family 6, member 2b; LAGE-1a protein;
                     CTL-recognized antigen on melanoma; cancer/testis antigen
                     6.2; l antigen family member 1; autoimmunogenic
                     cancer/testis antigen NY-ESO-2"
                     /codon_start=1
                     /product="cancer/testis antigen 2 isoform LAGE-1a"
                     /protein_id="NP_758965.2"
                     /db_xref="CCDS:CCDS35455.1"
                     /db_xref="GeneID:30848"
                     /db_xref="HGNC:HGNC:2492"
                     /db_xref="MIM:300396"
                     /translation="MQAEGRGTGGSTGDADGPGGPGIPDGPGGNAGGPGEAGATGGRG
                     PRGAGAARASGPRGGAPRGPHGGAASAQDGRCPCGARRPDSRLLELHITMPFSSPMEA
                     ELVRRILSRDAAPLPRPGAVLKDFTVSGNLLFIRLTAADHRQLQLSISSCLQQLSLLM
                     WITQCFLPVFLAQAPSGQRR"
     exon            334..468
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /inference="alignment:Splign:2.1.0"
     exon            469..759
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      742..747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="CTAG2"
                     /gene_synonym="CAMEL; CT2; CT6.2; CT6.2a; CT6.2b; ESO2;
                     LAGE-1; LAGE2B"
                     /note="major polyA site"
ORIGIN      
        1 tctgcctccg catcctcgtg ggccctgacc ttctctctga gagccgggca gaggctccgg
       61 agccatgcag gccgaaggcc ggggcacagg gggttcgacg ggcgatgctg atggcccagg
      121 aggccctggc attcctgatg gcccaggggg caatgctggc ggcccaggag aggcgggtgc
      181 cacgggcggc agaggtcccc ggggcgcagg ggcagcaagg gcctcggggc cgagaggagg
      241 cgccccgcgg ggtccgcatg gcggtgccgc ttctgcgcag gatggaaggt gcccctgcgg
      301 ggccaggagg ccggacagcc gcctgcttga gttgcacatc acgatgcctt tctcgtcgcc
      361 catggaagcg gagctggtcc gcaggatcct gtcccgggat gccgcaccgc tcccccgacc
      421 aggggcggtt ctgaaggact tcaccgtgtc cggcaaccta ctgtttatcc gactgactgc
      481 tgcagaccac cgccaactgc agctctccat cagctcctgt ctccagcagc tttccctgtt
      541 gatgtggatc acgcagtgct ttctgcccgt gtttttggct caggctccct cagggcagag
      601 gcgctaagcc cagcctggcg ccccttccta ggtcatgcct cctcccctag ggaatggtcc
      661 cagcacgagt ggccagttca ttgtgggggc ctgattgttt gtcgctggag gaggacggct
      721 tacatgtttg tttctgtaga aaataaagct gagctacga
//
