LOCUS       NM_001327                759 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cancer/testis antigen 1B (CTAG1B), mRNA.
ACCESSION   NM_001327 XM_001719185
VERSION     NM_001327.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Julve,M., Kennedy,O., Frampton,A.E., Bagwan,I. and Lythgoe,M.P.
  TITLE     Gene of the month: cancer testis antigen gene 1b (NY-ESO-1)
  JOURNAL   J Clin Pathol 77 (1), 1-7 (2023)
   PUBMED   37857483
  REMARK    GeneRIF: Gene of the month: cancer testis antigen gene 1b
            (NY-ESO-1).
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 759)
  AUTHORS   See,S.H.C., Smith,S.H., Finkelman,B.S., LaBoy,C., Novo,J.E.,
            Siziopikou,K.P. and Blanco,L.Z. Jr.
  TITLE     The role of PRAME and NY-ESO-1 as potential therapeutic and
            prognostic biomarkers in triple-negative breast carcinomas
  JOURNAL   Pathol Res Pract 241, 154299 (2023)
   PUBMED   36603407
  REMARK    GeneRIF: The role of PRAME and NY-ESO-1 as potential therapeutic
            and prognostic biomarkers in triple-negative breast carcinomas.
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Hashimoto,K., Nishimura,S., Ito,T., Oka,N., Kakinoki,R. and
            Akagi,M.
  TITLE     Clinicopathological assessment of cancer/testis antigens NY-ESO-1
            and MAGE-A4 in osteosarcoma
  JOURNAL   Eur J Histochem 66 (3), 3377 (2022)
   PUBMED   35736245
  REMARK    GeneRIF: Clinicopathological assessment of cancer/testis antigens
            NYESO1 and MAGEA4 in osteosarcoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Abdelaziz,M.M., Tayel,H.Y., Abdel-Bary,A. and Badawy,O.M.
  TITLE     Expression of CTAG1B clone EPR13780 versus DDIT3 gene rearrangement
            distinguishes myxoid liposarcoma from its mimics with detection of
            novel DDIT3 gene copy number variations
  JOURNAL   J Histotechnol 45 (2), 56-65 (2022)
   PUBMED   34845972
  REMARK    GeneRIF: Expression of CTAG1B clone EPR13780 versus DDIT3 gene
            rearrangement distinguishes myxoid liposarcoma from its mimics with
            detection of novel DDIT3 gene copy number variations.
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Gong,W., Wang,L., Stock,S., Ni,M., Schubert,M.L., Neuber,B.,
            Kleist,C., Huckelhoven-Krauss,A., Wu,D., Muller-Tidow,C.,
            Schmitt,A., Shiku,H., Schmitt,M. and Sellner,L.
  TITLE     Evaluation of Production Protocols for the Generation of
            NY-ESO-1-Specific T Cells
  JOURNAL   Cells 10 (1), 152 (2021)
   PUBMED   33466646
  REMARK    GeneRIF: Evaluation of Production Protocols for the Generation of
            NY-ESO-1-Specific T Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Schultz-Thater,E., Noppen,C., Gudat,F., Durmuller,U., Zajac,P.,
            Kocher,T., Heberer,M. and Spagnoli,G.C.
  TITLE     NY-ESO-1 tumour associated antigen is a cytoplasmic protein
            detectable by specific monoclonal antibodies in cell lines and
            clinical specimens
  JOURNAL   Br J Cancer 83 (2), 204-208 (2000)
   PUBMED   10901371
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Wang,R.F., Johnston,S.L., Zeng,G., Topalian,S.L.,
            Schwartzentruber,D.J. and Rosenberg,S.A.
  TITLE     A breast and melanoma-shared tumor antigen: T cell responses to
            antigenic peptides translated from different open reading frames
  JOURNAL   J Immunol 161 (7), 3598-3606 (1998)
   PUBMED   9759882
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Lethe,B., Lucas,S., Michaux,L., De Smet,C., Godelaine,D.,
            Serrano,A., De Plaen,E. and Boon,T.
  TITLE     LAGE-1, a new gene with tumor specificity
  JOURNAL   Int J Cancer 76 (6), 903-908 (1998)
   PUBMED   9626360
REFERENCE   9  (bases 1 to 759)
  AUTHORS   Chen,Y.T., Scanlan,M.J., Sahin,U., Tureci,O., Gure,A.O., Tsang,S.,
            Williamson,B., Stockert,E., Pfreundschuh,M. and Old,L.J.
  TITLE     A testicular antigen aberrantly expressed in human cancers detected
            by autologous antibody screening
  JOURNAL   Proc Natl Acad Sci U S A 94 (5), 1914-1918 (1997)
   PUBMED   9050879
REFERENCE   10 (bases 1 to 759)
  AUTHORS   Chen,Y.T., Boyer,A.D., Viars,C.S., Tsang,S., Old,L.J. and
            Arden,K.C.
  TITLE     Genomic cloning and localization of CTAG, a gene encoding an
            autoimmunogenic cancer-testis antigen NY-ESO-1, to human chromosome
            Xq28
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 237-240 (1997)
   PUBMED   9605863
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244107.3 and U87459.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001327.2.
            
            Summary: The protein encoded by this gene is an antigen that is
            overexpressed in many cancers but that is also expressed in normal
            testis. This gene is found in a duplicated region of the
            X-chromosome and therefore has a neighboring gene of identical
            sequence. [provided by RefSeq, Jan 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL553953.3, DRR138508.17953.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328435.3/ ENSP00000332602.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC244107.3         133738-133748       c
            12-759              U87459.1           1-748
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..759
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /note="cancer/testis antigen 1B"
                     /db_xref="GeneID:1485"
                     /db_xref="HGNC:HGNC:2491"
                     /db_xref="MIM:300156"
     exon            1..333
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..607
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /note="cancer antigen 3; New York esophageal squamous cell
                     carcinoma 1; cancer/testis antigen 6.1; l antigen family
                     member 2; autoimmunogenic cancer/testis antigen NY-ESO-1"
                     /codon_start=1
                     /product="cancer/testis antigen 1"
                     /protein_id="NP_001318.1"
                     /db_xref="CCDS:CCDS14758.1"
                     /db_xref="GeneID:1485"
                     /db_xref="HGNC:HGNC:2491"
                     /db_xref="MIM:300156"
                     /translation="MQAEGRGTGGSTGDADGPGGPGIPDGPGGNAGGPGEAGATGGRG
                     PRGAGAARASGPGGGAPRGPHGGAASGLNGCCRCGARGPESRLLEFYLAMPFATPMEA
                     ELARRSLAQDAPPLPVPGVLLKEFTVSGNILTIRLTAADHRQLQLSISSCLQQLSLLM
                     WITQCFLPVFLAQPPSGQRR"
     exon            334..468
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..759
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      742..747
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /note="hexamer: AATAAA"
     polyA_site      759
                     /gene="CTAG1B"
                     /gene_synonym="CT6.1; CTAG; CTAG1; ESO1; LAGE-2; LAGE2B;
                     NY-ESO-1"
                     /note="major polyA site"
ORIGIN      
        1 tctgcctccg catcctcgtg ggccctgacc ttctctctga gagccgggca gaggctccgg
       61 agccatgcag gccgaaggcc ggggcacagg gggttcgacg ggcgatgctg atggcccagg
      121 aggccctggc attcctgatg gcccaggggg caatgctggc ggcccaggag aggcgggtgc
      181 cacgggcggc agaggtcccc ggggcgcagg ggcagcaagg gcctcggggc cgggaggagg
      241 cgccccgcgg ggtccgcatg gcggcgcggc ttcagggctg aatggatgct gcagatgcgg
      301 ggccaggggg ccggagagcc gcctgcttga gttctacctc gccatgcctt tcgcgacacc
      361 catggaagca gagctggccc gcaggagcct ggcccaggat gccccaccgc ttcccgtgcc
      421 aggggtgctt ctgaaggagt tcactgtgtc cggcaacata ctgactatcc gactgactgc
      481 tgcagaccac cgccaactgc agctctccat cagctcctgt ctccagcagc tttccctgtt
      541 gatgtggatc acgcagtgct ttctgcccgt gtttttggct cagcctccct cagggcagag
      601 gcgctaagcc cagcctggcg ccccttccta ggtcatgcct cctcccctag ggaatggtcc
      661 cagcacgagt ggccagttca ttgtgggggc ctgattgttt gtcgctggag gaggacggct
      721 tacatgtttg tttctgtaga aaataaaact gagctacga
//
