LOCUS       NM_001017978             517 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cancer/testis antigen 83 (CT83), mRNA.
ACCESSION   NM_001017978 XM_117548
VERSION     NM_001017978.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 517)
  AUTHORS   Kang,Y., Gan,Y., Jiang,Y., You,J., Huang,C., Chen,Q., Xu,X.,
            Chen,F. and Chen,L.
  TITLE     Cancer-testis antigen KK-LC-1 is a potential biomarker associated
            with immune cell infiltration in lung adenocarcinoma
  JOURNAL   BMC Cancer 22 (1), 834 (2022)
   PUBMED   35907786
  REMARK    GeneRIF: Cancer-testis antigen KK-LC-1 is a potential biomarker
            associated with immune cell infiltration in lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 517)
  AUTHORS   Wang,Y., Zhang,G. and Wang,R.
  TITLE     Six CT83-related Genes-based Prognostic Signature for Lung
            Adenocarcinoma
  JOURNAL   Comb Chem High Throughput Screen 25 (9), 1565-1575 (2022)
   PUBMED   34259140
  REMARK    GeneRIF: Six CT83-related Genes-based Prognostic Signature for Lung
            Adenocarcinoma.
REFERENCE   3  (bases 1 to 517)
  AUTHORS   Chen,C., Gao,D., Huo,J., Qu,R., Guo,Y., Hu,X. and Luo,L.
  TITLE     Multiomics analysis reveals CT83 is the most specific gene for
            triple negative breast cancer and its hypomethylation is oncogenic
            in breast cancer
  JOURNAL   Sci Rep 11 (1), 12172 (2021)
   PUBMED   34108519
  REMARK    GeneRIF: Multiomics analysis reveals CT83 is the most specific gene
            for triple negative breast cancer and its hypomethylation is
            oncogenic in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 517)
  AUTHORS   Ji,J., Chen,J., Wang,A., Zhang,W., Ju,H., Liu,Y. and Li,L.
  TITLE     KK-LC-1 may be an effective prognostic biomarker for gastric cancer
  JOURNAL   BMC Cancer 21 (1), 267 (2021)
   PUBMED   33711953
  REMARK    GeneRIF: KK-LC-1 may be an effective prognostic biomarker for
            gastric cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 517)
  AUTHORS   Chen,Z., Zuo,X., Pu,L., Zhang,Y., Han,G., Zhang,L., Wu,Z., You,W.,
            Qin,J., Dai,X., Shen,H., Wang,X. and Wu,J.
  TITLE     Hypomethylation-mediated activation of cancer/testis antigen
            KK-LC-1 facilitates hepatocellular carcinoma progression through
            activating the Notch1/Hes1 signalling
  JOURNAL   Cell Prolif 52 (3), e12581 (2019)
   PUBMED   30895661
  REMARK    GeneRIF: We defined the KK-LC-1/presenilin-1/Notch1/Hes1 as a novel
            signalling pathway that was involved in the growth and metastasis
            of hepatocellular carcinoma.
REFERENCE   6  (bases 1 to 517)
  AUTHORS   Fukuyama,T., Futawatari,N., Ichiki,Y., Shida,A., Yamazaki,T.,
            Nishi,Y., Nonoguchi,H., Takahashi,Y., Yamazaki,H. and Kobayashi,N.
  TITLE     Correlation Between Expression of the Cancer/Testis Antigen KK-LC-1
            and Helicobacter pylori Infection in Gastric Cancer
  JOURNAL   In Vivo 31 (3), 403-407 (2017)
   PUBMED   28438869
  REMARK    GeneRIF: KK-LC-1 was frequently expressed in gastric cancer caused
            by H. pylori infection.
REFERENCE   7  (bases 1 to 517)
  AUTHORS   Paret,C., Simon,P., Vormbrock,K., Bender,C., Kolsch,A.,
            Breitkreuz,A., Yildiz,O., Omokoko,T., Hubich-Rau,S., Hartmann,C.,
            Hacker,S., Wagner,M., Roldan,D.B., Selmi,A., Tureci,O. and Sahin,U.
  TITLE     CXorf61 is a target for T cell based immunotherapy of
            triple-negative breast cancer
  JOURNAL   Oncotarget 6 (28), 25356-25367 (2015)
   PUBMED   26327325
  REMARK    GeneRIF: CXorf61 is a target for T cell based immunotherapy of
            triple-negative breast cancer.
REFERENCE   8  (bases 1 to 517)
  AUTHORS   Shida,A., Futawatari,N., Fukuyama,T., Ichiki,Y., Takahashi,Y.,
            Nishi,Y., Kobayashi,N., Yamazaki,H. and Watanabe,M.
  TITLE     Frequent High Expression of Kita-Kyushu Lung Cancer Antigen-1
            (KK-LC-1) in Gastric Cancer
  JOURNAL   Anticancer Res 35 (6), 3575-3579 (2015)
   PUBMED   26026129
  REMARK    GeneRIF: The frequency of KK-LC-1 expression was higher than that
            of the other CTAs. KK-LC-1 might be a useful target for
            immunotherapy and in diagnosis of gastric cancer.
REFERENCE   9  (bases 1 to 517)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   10 (bases 1 to 517)
  AUTHORS   Fukuyama,T., Hanagiri,T., Takenoyama,M., Ichiki,Y., Mizukami,M.,
            So,T., Sugaya,M., So,T., Sugio,K. and Yasumoto,K.
  TITLE     Identification of a new cancer/germline gene, KK-LC-1, encoding an
            antigen recognized by autologous CTL induced on human lung
            adenocarcinoma
  JOURNAL   Cancer Res 66 (9), 4922-4928 (2006)
   PUBMED   16651449
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK026566.1 and AC241580.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001017978.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000618.1, AK026566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371894.5/ ENSP00000360961.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AK026566.1         28-302
            276-276             AC241580.2         97109-97109         c
            277-517             AK026566.1         304-544
FEATURES             Location/Qualifiers
     source          1..517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq23"
     gene            1..517
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /note="cancer/testis antigen 83"
                     /db_xref="GeneID:203413"
                     /db_xref="HGNC:HGNC:33494"
                     /db_xref="MIM:300625"
     exon            1..195
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..462
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /codon_start=1
                     /product="kita-kyushu lung cancer antigen 1"
                     /protein_id="NP_001017978.1"
                     /db_xref="CCDS:CCDS35372.1"
                     /db_xref="GeneID:203413"
                     /db_xref="HGNC:HGNC:33494"
                     /db_xref="MIM:300625"
                     /translation="MNFYLLLASSILCALIVFWKYRRFQRNTGEMSSNSTALALVRPS
                     SSGLINSNTDNNLAVYDLSRDILNNFPHSIARQKRILVNLSMVENKLVELEHTLLSKG
                     FRGASPHRKST"
     exon            196..517
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      497..502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /note="hexamer: ATTAAA"
     polyA_site      517
                     /gene="CT83"
                     /gene_synonym="CXorf61; KK-LC-1; KKLC1"
                     /note="major polyA site"
ORIGIN      
        1 agttacacca ggcatcctgg cccaaagttt cccaaatcca ggcggctaga ggcccactgc
       61 ttcccaacta ccagctgagg gggtccgtcc cgagaaggga gaagaggccg aagaggaaac
      121 atgaacttct atttactcct agcgagcagc attctgtgtg ccttgattgt cttctggaaa
      181 tatcgccgct ttcagagaaa cactggcgaa atgtcatcaa attcaactgc tcttgcacta
      241 gtgagaccct cttcttctgg gttaattaac agcaatacag acaacaatct tgcagtctac
      301 gacctctctc gggatatttt aaataatttc ccacactcaa tagccaggca gaagcgaata
      361 ttggtaaacc tcagtatggt ggaaaacaag ctggttgaac tggaacatac tctacttagc
      421 aagggtttca gaggtgcatc acctcaccgg aaatccacct aaaagcgtac aggatgtaat
      481 gccagtggtg gaaatcatta aagacacttt gagtaga
//
