LOCUS       NM_001031705            1441 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens cancer/testis antigen 55 (CT55), transcript variant 1,
            mRNA.
ACCESSION   NM_001031705 XM_939090
VERSION     NM_001031705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Zhang,G., Jiang,C., Yang,Y., Wang,Y., Zhou,H., Dai,S., Liu,M.,
            Yang,Y., Yang,L., Shen,Q., Zhang,T., Zhang,X., Yang,Y. and Shen,Y.
  TITLE     Deficiency of cancer/testis antigen gene CT55 causes male
            infertility in humans and mice
  JOURNAL   Cell Death Differ 30 (2), 500-514 (2023)
   PUBMED   36481789
  REMARK    GeneRIF: Deficiency of cancer/testis antigen gene CT55 causes male
            infertility in humans and mice.
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Aurriere,J., Goudenege,D., Baechler,S.A., Huang,S.N., Gueguen,N.,
            Desquiret-Dumas,V., Chabrun,F., Perrot,R., Chevrollier,A.,
            Charif,M., Baris,O.R., Pommier,Y., Lenaers,G. and Khiati,S.
  TITLE     Cancer/Testis Antigen 55 is required for cancer cell proliferation
            and mitochondrial DNA maintenance
  JOURNAL   Mitochondrion 64, 19-26 (2022)
   PUBMED   35189384
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Matsushita,M., Ozawa,K., Suzuki,T., Nakamura,M., Nakano,N.,
            Kanchi,S., Ichikawa,D., Matsuki,E., Sakurai,M., Karigane,D.,
            Kasahara,H., Tsukamoto,N., Shimizu,T., Mori,T., Nakajima,H.,
            Okamoto,S., Kawakami,Y. and Hattori,Y.
  TITLE     CXorf48 is a potential therapeutic target for achieving
            treatment-free remission in CML patients
  JOURNAL   Blood Cancer J 7 (9), e601 (2017)
   PUBMED   28862699
  REMARK    GeneRIF: the relapse rate of CXorf48-specific CTL-negative patients
            was 63.6%, compared to 0% in CXorf48-specific CTL-positive
            patients. These results indicate that CXorf48 could be a promising
            therapeutic target of LSCs for immunotherapy to obtain durable
            treatment-free remission in CML patients.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Tomiyoshi,G., Nakanishi,A., Takenaka,K., Yoshida,K. and Miki,Y.
  TITLE     Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction
            of apoptosis in response to DNA damage
  JOURNAL   Cancer Sci 99 (4), 747-754 (2008)
   PUBMED   18307534
  REMARK    GeneRIF: A novel BRCA2-interacting protein, BJ-HCC-20A, which is
            reported to be a potential cancer-testis antigen, was identified.
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF520814.2 and AY352211.1.
            
            On Dec 23, 2019 this sequence version replaced NM_001031705.2.
            
            Transcript Variant: This variant (1) represents the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF520814.2, BC020662.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276241.11/ ENSP00000276241.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1273              AF520814.2         430-1702
            1274-1441           AY352211.1         1990-2157
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1441
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /note="cancer/testis antigen 55"
                     /db_xref="GeneID:54967"
                     /db_xref="HGNC:HGNC:26047"
                     /db_xref="MIM:301105"
     exon            1..321
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..1022
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     BRCA2-interacting protein; tumor antigen BJ-HCC-20"
                     /codon_start=1
                     /product="cancer/testis antigen 55 isoform 1"
                     /protein_id="NP_001026875.1"
                     /db_xref="CCDS:CCDS35400.1"
                     /db_xref="GeneID:54967"
                     /db_xref="HGNC:HGNC:26047"
                     /db_xref="MIM:301105"
                     /translation="MLRLLRLALAFYGRTADPAERQGPQQQGLPQGDTQLTTVQGVVT
                     SFCGDYGMIDESIYFSSDVVTGNVPLKVGQKVNVVVEEDKPHYGLRAIKVDVVPRHLY
                     GAGPSDSGTRVLIGCVTSINEDNIYISNSIYFSIAIVSEDFVPYKGDLLEVEYSTEPG
                     ISNIKATSVKPIRCIHTEEVCITSVHGRNGVIDYTIFFTLDSVKLPDGYVPQVDDIVN
                     VVMVESIQFCFIWRAISITPVHKSSSGFQDDGGLGRPKRERRSQSI"
     exon            322..506
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
     exon            507..651
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
     exon            652..764
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
     exon            765..952
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1441
                     /gene="CT55"
                     /gene_synonym="BJHCC20A; CXorf48; SPGFX7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagggagaa gtcagcggag aagctgggag ctcctttgga ggctgcggtg tccctgactc
       61 tcctgagggg ggctcactaa cgggtgggtc ccatgccaca gtgtctgagg agaagcagga
      121 agtgagtccc tgaggagacg ccgtgacctg agggcttccc ttactgagga ggcctcgtgc
      181 ttcatctgcc acaagcggtg cccaggccgg tggtgacaac tgggacgatg ctcaggcttc
      241 tgagacttgc tttggccttc tacgggagga cggccgaccc tgcagagcga cagggcccac
      301 agcagcaggg cctcccacaa ggtgacaccc agttgacaac tgtgcaggga gttgtcacaa
      361 gtttctgtgg tgattatggc atgattgatg agtcgatcta cttcagtagt gatgttgtga
      421 ctggcaacgt gcctctaaaa gttggacaaa aagttaatgt ggttgtggaa gaagataaac
      481 cacattatgg attgagagca atcaaggtgg atgttgtgcc tcgccatctt tatggtgctg
      541 gaccctcaga ctcaggaacc agagttttaa ttggatgtgt tacttctata aatgaagata
      601 atatttatat tagtaacagc atttattttt ccatagccat tgtttctgaa gattttgtgc
      661 cttataaggg tgacttgtta gaagttgaat attccactga gccaggcatc tcaaacatca
      721 aggcaacttc tgtgaagccc atccgttgta ttcatacgga agaggtctgc attactagcg
      781 tacatggaag aaatggggtg atagattata ctattttttt caccttggat tctgtgaaac
      841 ttcctgatgg atacgtacct caagtagatg atatcgtcaa tgtggtcatg gtggagagca
      901 ttcagttctg ctttatttgg agagcgattt ctatcacccc agtgcataaa tccagcagcg
      961 gattccagga tgacggaggc ctgggacggc ccaaaaggga acgtcggagc caaagcattt
     1021 aactgaaaag gcatcaggga cagcatgtta aaggcatgat ttaaagttac aatttgactt
     1081 cagttttgag ccccgttatg ctgcctgtac aacctgtatt gttccatagc ctctttcatc
     1141 ttctgtcacc cacataactt gcggtgtttg ttgttttact tgttccttct tccccatgct
     1201 agaatgtaaa ctccacaatg gcaggatgtc ttttaatctg gttttttttt ttcttttttc
     1261 tttctttttt tttttctgtt gtcattaaag catcaccaag cacttagaag agtgcctggc
     1321 agactcaatg agcagataaa atgttattaa gttcaatgac tgaatgactg ggccagcaat
     1381 gatacttacc tgtggttcat tcatcactgg ttccttagga ataaaattgt tgagcaatgc
     1441 a
//
