LOCUS       NM_152582               1321 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cancer/testis antigen family 45 member A2 (CT45A2),
            mRNA.
ACCESSION   NM_152582 XM_001128791
VERSION     NM_152582.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1321)
  AUTHORS   Yang,K., Chen,Y., Zhou,J., Ma,L., Shan,Y., Cheng,X., Wang,Y.,
            Zhang,Z., Ji,X., Chen,L., Dai,H., Zhu,B., Li,C., Tao,Z., Hu,X. and
            Yin,W.
  TITLE     Ursolic acid promotes apoptosis and mediates transcriptional
            suppression of CT45A2 gene expression in non-small-cell lung
            carcinoma harbouring EGFR T790M mutations
  JOURNAL   Br J Pharmacol 176 (24), 4609-4624 (2019)
   PUBMED   31322286
  REMARK    GeneRIF: Ursolic acid promotes apoptosis and mediates
            transcriptional suppression of CT45A2 gene expression in
            non-small-cell lung carcinoma harbouring EGFR T790M mutations.
REFERENCE   2  (bases 1 to 1321)
  AUTHORS   Cerveira,N., Meyer,C., Santos,J., Torres,L., Lisboa,S.,
            Pinheiro,M., Bizarro,S., Correia,C., Norton,L., Marschalek,R. and
            Teixeira,M.R.
  TITLE     A novel spliced fusion of MLL with CT45A2 in a pediatric
            biphenotypic acute leukemia
  JOURNAL   BMC Cancer 10, 518 (2010)
   PUBMED   20920256
  REMARK    GeneRIF: CT45A2 is a novel spliced MLL fusion partner in de novo
            biphenotypic acute leukemia [case report]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1321)
  AUTHORS   Chen,Y.T., Scanlan,M.J., Venditti,C.A., Chua,R., Theiler,G.,
            Stevenson,B.J., Iseli,C., Gure,A.O., Vasicek,T., Strausberg,R.L.,
            Jongeneel,C.V., Old,L.J. and Simpson,A.J.
  TITLE     Identification of cancer/testis-antigen genes by massively parallel
            signature sequencing
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7940-7945 (2005)
   PUBMED   15905330
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC240441.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_152582.6.
            
            Summary: This gene represents one of a cluster of several similar
            genes located on the q arm of chromosome X. The genes in this
            cluster encode members of the cancer/testis (CT) family of
            antigens, and are distinct from other CT antigens. These antigens
            are thought to be novel therapeutic targets for human cancers.
            [provided by RefSeq, Apr 2014].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138506.53341.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000612907.2/ ENSP00000483619.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC240441.2         85453-85691         c
            240-414             AC240441.2         81776-81950         c
            415-663             AC240441.2         79607-79855         c
            664-757             AC240441.2         79133-79226         c
            758-1321            AC240441.2         77347-77910         c
FEATURES             Location/Qualifiers
     source          1..1321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..1321
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /note="cancer/testis antigen family 45 member A2"
                     /db_xref="GeneID:728911"
                     /db_xref="HGNC:HGNC:28400"
                     /db_xref="MIM:300793"
     exon            1..239
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /inference="alignment:Splign:2.1.0"
     exon            240..414
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..815
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /note="cancer/testis antigen CT45; cancer/testis antigen
                     45-2; cancer/testis antigen 45A2; Cancer/testis antigen
                     family 45 member A8; Cancer/testis antigen 45A8;
                     Cancer/testis antigen family 45 member A9; Cancer/testis
                     antigen 45A9"
                     /codon_start=1
                     /product="cancer/testis antigen family 45 member A2"
                     /protein_id="NP_689795.4"
                     /db_xref="CCDS:CCDS76031.1"
                     /db_xref="GeneID:728911"
                     /db_xref="HGNC:HGNC:28400"
                     /db_xref="MIM:300793"
                     /translation="MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGD
                     SLIAGSAMSKEKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSF
                     SGDDLECRETAFSPKSQQEINADIKRQLVKELRCVGQKYEKIFEMLEGVQGPTAVRKR
                     FFESIIKEAARCMRRDFVKHLKKKLKRMI"
     exon            415..663
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /inference="alignment:Splign:2.1.0"
     exon            664..757
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1321
                     /gene="CT45A2"
                     /gene_synonym="CT45-2; CT45.2; CT45A8; CT45A9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttcggc tggggcaggc acgctgtggc tggctacttc ccttcctccc atcccccttg
       61 ggccaaacgg gatcggtgct tctggtgaga cgcctcccca tgcacatcac tcccaggtgc
      121 cctagggggc acatttccca caactcccag agggcaggtt tctagaaagt gccaccagtg
      181 gggaggcgcc acaacttcac tgccattttg tgaggtgccg ccgtctctcc tccagcaagg
      241 aaacaatgac cgataaaaca gagaaggtgg ctgtagatcc tgaaactgtg tttaaacgtc
      301 ccagggaatg tgacagtcct tcgtatcaga aaaggcagag gatggccctg ttggcaagga
      361 aacaaggagc aggagacagc cttattgcag gctctgccat gtccaaagaa aagaagctta
      421 tgacaggaca tgctattcca cccagccaat tggattctca gattgatgac ttcactggtt
      481 tcagcaaaga taggatgatg cagaaacctg gtagcaatgc acctgtggga ggaaacgtta
      541 ccagcagttt ctctggagat gacctagaat gcagagaaac agccttctct cccaaaagcc
      601 aacaagaaat taatgctgat ataaaacgtc aattagtgaa ggaactccga tgcgttggac
      661 aaaaatatga aaaaatcttc gaaatgcttg aaggagtgca aggacctact gcagtcagga
      721 aacgattttt tgaatccatc atcaaggaag cagcaagatg tatgagacga gactttgtta
      781 agcaccttaa gaagaaactg aaacgtatga tttgagaata cttgtccctg gaggattatc
      841 acaccccaaa tgcataatct cattaatgat tgaggagaga aaaggatcag attgctgttt
      901 tctacaatgg agcaggatat tgctgaagtc tcctggcata tgttaccgaa tcaactggcc
      961 ttccagaggc taagaaattt ctgttagtaa aagatgttct ttttcccaaa gcgttttatt
     1021 tgaaaggata acttgtgttt tggttatttt gtattcccac ctgtgctggt agatattatt
     1081 aacccattag gtaaatacta ttacagtcgt ggtttctgca gcagctcaca ctgatgtagc
     1141 tggcgtttat aactaccttc tttcgctacc cgtttcgcat tccctttgcc ctgagatagc
     1201 atgtcagttg gtcatgatgc ttggcctggc aggatgactc aaaccttcat tacagaagag
     1261 tctgaaccat tagatatcct gcctggatgg ggttgctgtg attttccatt aactctaatc
     1321 g
//
