LOCUS       NM_001017417             823 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens cancer/testis antigen family 45 member A1 (CT45A1),
            mRNA.
ACCESSION   NM_001017417
VERSION     NM_001017417.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 823)
  AUTHORS   Meng,M., Guo,Y., Chen,Y., Li,X., Zhang,B., Xie,Z., Liu,J., Zhao,Z.,
            Liu,Y., Zhang,T., Qiao,Y., Shang,B. and Zhou,Q.
  TITLE     Cancer/testis-45A1 promotes cervical cancer cell tumorigenesis and
            drug resistance by activating oncogenic SRC and downstream
            signaling pathways
  JOURNAL   Cell Oncol (Dordr) 47 (2), 657-676 (2024)
   PUBMED   37924456
  REMARK    GeneRIF: Cancer/testis-45A1 promotes cervical cancer cell
            tumorigenesis and drug resistance by activating oncogenic SRC and
            downstream signaling pathways.
REFERENCE   2  (bases 1 to 823)
  AUTHORS   Niu,T., Wu,Z. and Xiao,W.
  TITLE     Uev1A promotes breast cancer cell migration by up-regulating CT45A
            expression via the AKT pathway
  JOURNAL   BMC Cancer 21 (1), 1012 (2021)
   PUBMED   34503444
  REMARK    GeneRIF: Uev1A promotes breast cancer cell migration by
            up-regulating CT45A expression via the AKT pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 823)
  AUTHORS   Wen,M., Ren,H., Zhang,S., Li,T., Zhang,J. and Ren,P.
  TITLE     CT45A1 promotes the metastasis of osteosarcoma cells in vitro and
            in vivo through beta-catenin
  JOURNAL   Cell Death Dis 12 (7), 650 (2021)
   PUBMED   34172717
  REMARK    GeneRIF: CT45A1 promotes the metastasis of osteosarcoma cells in
            vitro and in vivo through beta-catenin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 823)
  AUTHORS   Suzuki,I., Yoshida,S., Tabu,K., Kusunoki,S., Matsumura,Y.,
            Izumi,H., Asanoma,K., Yagi,H., Onoyama,I., Sonoda,K., Kohno,K.,
            Taga,T., Itakura,A., Takeda,S. and Kato,K.
  TITLE     YBX2 and cancer testis antigen 45 contribute to stemness,
            chemoresistance and a high degree of malignancy in human
            endometrial cancer
  JOURNAL   Sci Rep 11 (1), 4220 (2021)
   PUBMED   33602962
  REMARK    GeneRIF: YBX2 and cancer testis antigen 45 contribute to stemness,
            chemoresistance and a high degree of malignancy in human
            endometrial cancer.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 823)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 823)
  AUTHORS   Zhang,W., Barger,C.J., Link,P.A., Mhawech-Fauceglia,P., Miller,A.,
            Akers,S.N., Odunsi,K. and Karpf,A.R.
  TITLE     DNA hypomethylation-mediated activation of Cancer/Testis Antigen 45
            (CT45) genes is associated with disease progression and reduced
            survival in epithelial ovarian cancer
  JOURNAL   Epigenetics 10 (8), 736-748 (2015)
   PUBMED   26098711
  REMARK    GeneRIF: These data verify CT45 expression and promoter
            hypomethylation as possible prognostic biomarkers, and suggest CT45
            as an immunological or therapeutic target in Epithelial ovarian
            cancer
REFERENCE   7  (bases 1 to 823)
  AUTHORS   Shang,B., Gao,A., Pan,Y., Zhang,G., Tu,J., Zhou,Y., Yang,P.,
            Cao,Z., Wei,Q., Ding,Y., Zhang,J., Zhao,Y. and Zhou,Q.
  TITLE     CT45A1 acts as a new proto-oncogene to trigger tumorigenesis and
            cancer metastasis
  JOURNAL   Cell Death Dis 5 (6), e1285 (2014)
   PUBMED   24901056
  REMARK    GeneRIF: CT45A1 functions as a novel proto-oncogene to trigger
            oncogenesis and metastasis.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 823)
  AUTHORS   Chen,Y.T., Chadburn,A., Lee,P., Hsu,M., Ritter,E., Chiu,A.,
            Gnjatic,S., Pfreundschuh,M., Knowles,D.M. and Old,L.J.
  TITLE     Expression of cancer testis antigen CT45 in classical Hodgkin
            lymphoma and other B-cell lymphomas
  JOURNAL   Proc Natl Acad Sci U S A 107 (7), 3093-3098 (2010)
   PUBMED   20133697
  REMARK    GeneRIF: Hodgkin lymphoma has the highest CT45 expression among all
            malignancies tested, in diffuse large B-cell lymphomas it is
            similar to that seen in epithelial cancers, and not present in
            low-grade non-Hodgkin B-cell lymphomas.
REFERENCE   9  (bases 1 to 823)
  AUTHORS   Chen,Y.T., Hsu,M., Lee,P., Shin,S.J., Mhawech-Fauceglia,P.,
            Odunsi,K., Altorki,N.K., Song,C.J., Jin,B.Q., Simpson,A.J. and
            Old,L.J.
  TITLE     Cancer/testis antigen CT45: analysis of mRNA and protein expression
            in human cancer
  JOURNAL   Int J Cancer 124 (12), 2893-2898 (2009)
   PUBMED   19296537
  REMARK    GeneRIF: Over-expression of CT45 is associated with cancer.
REFERENCE   10 (bases 1 to 823)
  AUTHORS   Chen,Y.T., Scanlan,M.J., Venditti,C.A., Chua,R., Theiler,G.,
            Stevenson,B.J., Iseli,C., Gure,A.O., Vasicek,T., Strausberg,R.L.,
            Jongeneel,C.V., Old,L.J. and Simpson,A.J.
  TITLE     Identification of cancer/testis-antigen genes by massively parallel
            signature sequencing
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7940-7945 (2005)
   PUBMED   15905330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC240442.3.
            
            On Sep 16, 2020 this sequence version replaced NM_001017417.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY743709.1, BC140913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000594565.6/ ENSP00000472303.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC240442.3         25136-25187         c
            53-227              AC240442.3         19717-19891         c
            228-476             AC240442.3         17550-17798         c
            477-570             AC240442.3         17075-17168         c
            571-823             AC240442.3         15598-15850         c
FEATURES             Location/Qualifiers
     source          1..823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..823
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /note="cancer/testis antigen family 45 member A1"
                     /db_xref="GeneID:541466"
                     /db_xref="HGNC:HGNC:33267"
                     /db_xref="MIM:300648"
     exon            1..52
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /inference="alignment:Splign:2.1.0"
     exon            53..227
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..628
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /note="cancer/testis antigen CT45-1; cancer/testis antigen
                     45-1; cancer/testis antigen 45A1"
                     /codon_start=1
                     /product="cancer/testis antigen family 45 member A1"
                     /protein_id="NP_001017417.1"
                     /db_xref="CCDS:CCDS48174.1"
                     /db_xref="GeneID:541466"
                     /db_xref="HGNC:HGNC:33267"
                     /db_xref="MIM:300648"
                     /translation="MTDKTEKVAVDPETVFKRPRECDSPSYQKRQRMALLARKQGAGD
                     SLIAGSAMSKAKKLMTGHAIPPSQLDSQIDDFTGFSKDRMMQKPGSNAPVGGNVTSSF
                     SGDDLECRETASSPKSQREINADIKRKLVKELRCVGQKYEKIFEMLEGVQGPTAVRKR
                     FFESIIKEAARCMRRDFVKHLKKKLKRMI"
     exon            228..476
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..570
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..823
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      799..804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /note="hexamer: AGTAAA"
     polyA_site      823
                     /gene="CT45A1"
                     /gene_synonym="CT45; CT45-1; CT45.1"
                     /note="major polyA site"
ORIGIN      
        1 gccacaactt cactgccatt ttgtgaggtg ctgctgtctc tcctccagca aggaaacaat
       61 gaccgataaa acagagaagg tggctgtaga tcctgaaact gtgtttaaac gtcccaggga
      121 atgtgacagt ccttcgtatc agaaaaggca gaggatggcc ctgttggcaa ggaaacaagg
      181 agcaggagac agccttattg caggctctgc catgtccaaa gcaaagaagc ttatgacagg
      241 acatgctatt ccacccagcc aattggattc tcagattgat gacttcactg gtttcagcaa
      301 agataggatg atgcagaaac ctggtagcaa tgcacctgtg ggaggaaacg ttaccagcag
      361 tttctctgga gatgacctag aatgcagaga aacagcctcc tctcccaaaa gccaacgaga
      421 aattaatgct gatataaaac gtaaattagt gaaggaactc cgatgcgttg gacaaaaata
      481 tgaaaaaatc ttcgaaatgc ttgaaggagt gcaaggacct actgcagtca ggaagcgatt
      541 ttttgaatcc atcatcaagg aagcagcaag atgtatgaga cgagactttg ttaagcacct
      601 taagaagaaa ctgaaacgta tgatttgaga atacttgtcc ctggaggatt atcacacccc
      661 aaatgcataa tctcgttaat gattgaggag agaaaaggat cagattgctg ttttctacaa
      721 tggagcagga tattgctgaa gtctcctggc atatgttacc gaatcaaata gccttccaga
      781 ggctaagaaa tttctgttag taaaagatgt tctttttccc aaa
//
