LOCUS       NM_015235               4110 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cleavage stimulation factor subunit 2 tau variant
            (CSTF2T), mRNA.
ACCESSION   NM_015235
VERSION     NM_015235.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4110)
  AUTHORS   Li,Y., Yun,X., Li,J. and Bai,M.
  TITLE     CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote melanoma
            cell proliferation, migration, and invasion
  JOURNAL   Tissue Cell 81, 102029 (2023)
   PUBMED   36736099
  REMARK    GeneRIF: CSTF2T up-regulates IGHG1 by binding to ZEB1 to promote
            melanoma cell proliferation, migration, and invasion.
REFERENCE   2  (bases 1 to 4110)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4110)
  AUTHORS   Kargapolova,Y., Levin,M., Lackner,K. and Danckwardt,S.
  TITLE     sCLIP-an integrated platform to study RNA-protein interactomes in
            biomedical research: identification of CSTF2tau in alternative
            processing of small nuclear RNAs
  JOURNAL   Nucleic Acids Res 45 (10), 6074-6086 (2017)
   PUBMED   28334977
  REMARK    GeneRIF: CSTF2tau binds many previously not recognized RNAs
            including histone, snoRNA and snRNAs. CSTF2tau-binding is
            associated with internal oligoadenylation resulting in shortened
            snRNA isoforms subjected to rapid degradation. CSTF2tau controls
            the abundance of snRNAs resulting in alternative splicing of
            several RNAs with critical roles in tumorigenesis and cardiac
            function.
REFERENCE   4  (bases 1 to 4110)
  AUTHORS   Kariuki,S.N., Ghodke-Puranik,Y., Dorschner,J.M., Chrabot,B.S.,
            Kelly,J.A., Tsao,B.P., Kimberly,R.P., Alarcon-Riquelme,M.E.,
            Jacob,C.O., Criswell,L.A., Sivils,K.L., Langefeld,C.D.,
            Harley,J.B., Skol,A.D. and Niewold,T.B.
  TITLE     Genetic analysis of the pathogenic molecular sub-phenotype
            interferon-alpha identifies multiple novel loci involved in
            systemic lupus erythematosus
  JOURNAL   Genes Immun 16 (1), 15-23 (2015)
   PUBMED   25338677
REFERENCE   5  (bases 1 to 4110)
  AUTHORS   Lindstrom,S., Thompson,D.J., Paterson,A.D., Li,J., Gierach,G.L.,
            Scott,C., Stone,J., Douglas,J.A., dos-Santos-Silva,I.,
            Fernandez-Navarro,P., Verghase,J., Smith,P., Brown,J., Luben,R.,
            Wareham,N.J., Loos,R.J., Heit,J.A., Pankratz,V.S., Norman,A.,
            Goode,E.L., Cunningham,J.M., deAndrade,M., Vierkant,R.A., Czene,K.,
            Fasching,P.A., Baglietto,L., Southey,M.C., Giles,G.G., Shah,K.P.,
            Chan,H.P., Helvie,M.A., Beck,A.H., Knoblauch,N.W., Hazra,A.,
            Hunter,D.J., Kraft,P., Pollan,M., Figueroa,J.D., Couch,F.J.,
            Hopper,J.L., Hall,P., Easton,D.F., Boyd,N.F., Vachon,C.M. and
            Tamimi,R.M.
  TITLE     Genome-wide association study identifies multiple loci associated
            with both mammographic density and breast cancer risk
  JOURNAL   Nat Commun 5, 5303 (2014)
   PUBMED   25342443
  REMARK    Erratum:[Nat Commun. 2015 Sep 09;6:8358. doi: 10.1038/ncomms9358..
            PMID: 26349435]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4110)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4110)
  AUTHORS   Perez Canadillas,J.M. and Varani,G.
  TITLE     Recognition of GU-rich polyadenylation regulatory elements by human
            CstF-64 protein
  JOURNAL   EMBO J 22 (11), 2821-2830 (2003)
   PUBMED   12773396
  REMARK    GeneRIF: structure of the RNA-binding domain of CstF-64 containing
            an RNA recognition motif (RRM) augmented by N- and C-terminal
            helices
REFERENCE   8  (bases 1 to 4110)
  AUTHORS   Dass,B., McDaniel,L., Schultz,R.A., Attaya,E. and MacDonald,C.C.
  TITLE     The gene CSTF2T, encoding the human variant CstF-64 polyadenylation
            protein tauCstF-64, lacks introns and may be associated with male
            sterility
  JOURNAL   Genomics 80 (5), 509-514 (2002)
   PUBMED   12408968
  REMARK    GeneRIF: Radiation hybrid mapping places the human tauCstF-64 gene
            at 10q22-q23, which is the site of a translocation that has been
            associated with human neurological problems and male infertility.
REFERENCE   9  (bases 1 to 4110)
  AUTHORS   Dass,B., McMahon,K.W., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.
            and MacDonald,C.C.
  TITLE     The gene for a variant form of the polyadenylation protein CstF-64
            is on chromosome 19 and is expressed in pachytene spermatocytes in
            mice
  JOURNAL   J Biol Chem 276 (11), 8044-8050 (2001)
   PUBMED   11113135
REFERENCE   10 (bases 1 to 4110)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI962669.1, AL136747.1, BX455090.1, AB014589.1 and BU743103.1.
            
            On May 17, 2019 this sequence version replaced NM_015235.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803616.132899.1,
                                        SRR1660805.224807.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331173.6/ ENSP00000332444.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BI962669.1         1-4
            5-2343              AL136747.1         1-2339
            2344-2642           BX455090.1         198-496             c
            2643-2910           AB014589.1         2392-2659
            2911-4109           AB014589.1         2661-3859
            4110-4110           BU743103.1         18-18               c
FEATURES             Location/Qualifiers
     source          1..4110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..4110
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="cleavage stimulation factor subunit 2 tau variant"
                     /db_xref="GeneID:23283"
                     /db_xref="HGNC:HGNC:17086"
                     /db_xref="MIM:611968"
     exon            1..4110
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1897
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="tauCstF-64; cleavage stimulation factor, 3'
                     pre-RNA, subunit 2, tau; CF-1 64 kDa subunit tau; CSTF 64
                     kDa subunit tau; cleavage stimulation factor 64 kDa
                     subunit tau; cleavage stimulation factor, 3' pre-RNA,
                     subunit 2, 64kDa, tau; cleavage stimulation factor subunit
                     2, tau"
                     /codon_start=1
                     /product="cleavage stimulation factor subunit 2 tau
                     variant"
                     /protein_id="NP_056050.1"
                     /db_xref="CCDS:CCDS7245.1"
                     /db_xref="GeneID:23283"
                     /db_xref="HGNC:HGNC:17086"
                     /db_xref="MIM:611968"
                     /translation="MSSLAVRDPAMDRSLRSVFVGNIPYEATEEQLKDIFSEVGSVVS
                     FRLVYDRETGKPKGYGFCEYQDQETALSAMRNLNGREFSGRALRVDNAASEKNKEELK
                     SLGPAAPIIDSPYGDPIDPEDAPESITRAVASLPPEQMFELMKQMKLCVQNSHQEARN
                     MLLQNPQLAYALLQAQVVMRIMDPEIALKILHRKIHVTPLIPGKSQSVSVSGPGPGPG
                     PGLCPGPNVLLNQQNPPAPQPQHLARRPVKDIPPLMQTPIQGGIPAPGPIPAAVPGAG
                     PGSLTPGGAMQPQLGMPGVGPVPLERGQVQMSDPRAPIPRGPVTPGGLPPRGLLGDAP
                     NDPRGGTLLSVTGEVEPRGYLGPPHQGPPMHHASGHDTRGPSSHEMRGGPLGDPRLLI
                     GEPRGPMIDQRGLPMDGRGGRDSRAMETRAMETEVLETRVMERRGMETCAMETRGMEA
                     RGMDARGLEMRGPVPSSRGPMTGGIQGPGPINIGAGGPPQGPRQVPGISGVGNPGAGM
                     QGTGIQGTGMQGAGIQGGGMQGAGIQGVSIQGGGIQGGGIQGASKQGGSQPSSFSPGQ
                     SQVTPQDQEKAALIMQVLQLTADQIAMLPPEQRQSILILKEQIQKSTGAS"
     regulatory      2319..2324
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="hexamer: AATAAA"
     polyA_site      2340
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="major polyA site"
     regulatory      4088..4093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="hexamer: AATAAA"
     polyA_site      4110
                     /gene="CSTF2T"
                     /gene_synonym="CstF-64T"
                     /note="major polyA site"
ORIGIN      
        1 agacgcctcg aagaatccgc tatcggctgt ctgcacaacc ggaatcatgt cgagtttggc
       61 ggtgagagac ccggcaatgg atcgatcact gcgttccgtg ttcgtgggga acattccata
      121 tgaggcaact gaggagcagt taaaggacat tttctcggag gttggttctg ttgtcagttt
      181 ccggctggta tacgatagag agacgggaaa acccaagggc tatggcttct gcgaatacca
      241 agaccaggag accgcgctta gtgccatgcg gaacctcaat gggcgggagt tcagtgggag
      301 agcgcttcgg gtggacaatg ctgccagtga aaagaataag gaggagttaa agagccttgg
      361 gcctgcagcg cccattattg actcacccta tggggatccc atcgatccag aagatgcccc
      421 tgaatcgatt accagagcag tagccagtct ccccccggag cagatgtttg agctgatgaa
      481 gcagatgaag ctctgtgtcc aaaacagcca ccaggaagct cgaaacatgt tacttcaaaa
      541 tccacaactg gcttatgcac tgttgcaggc acaagtagtg atgagaatca tggatccaga
      601 gattgctctg aaaattctgc atcggaagat acatgtcaca ccactgatcc caggcaaatc
      661 tcagtctgtg tctgtctctg gccctggccc tggccctggc cctgggctct gcccaggacc
      721 taatgttctg ctgaaccagc agaatcctcc agctcctcag cctcagcatt tggctagaag
      781 acctgtgaag gacattcctc ctctgatgca gactcctatc cagggtggaa ttccagctcc
      841 agggccaata ccagctgcag ttcccggagc tggtcctggt tccttaactc ctggaggagc
      901 aatgcagccc caacttggaa tgccaggggt tggcccagtg cctttagagc ggggacaagt
      961 gcagatgtca gatcctagag ctcctatacc tcgcggaccc gtgactcctg gtggtctgcc
     1021 tcctcgagga ctgttaggag atgctccaaa tgacccacgt ggagggactt tgctttcagt
     1081 cactggagaa gtggagccca gaggttatct gggtccaccc catcagggtc cccccatgca
     1141 tcatgcctct ggtcatgaca ctcgtggccc ttcctcacat gagatgaggg gagggccatt
     1201 aggagatccc agactgctaa ttggagagcc cagaggcccc atgatagatc aaaggggtct
     1261 acctatggat ggtagaggtg gtagagattc tcgagcgatg gagactcgtg ccatggaaac
     1321 tgaggtctta gagacacgtg taatggagag gagaggaatg gagacctgtg cgatggaaac
     1381 cagagggatg gaagcaaggg gcatggatgc aagaggattg gagatgaggg gccctgtccc
     1441 cagttcaaga ggccctatga ctggtggaat tcagggtcct ggtcccatta atataggggc
     1501 aggtggccct cctcagggac ccagacaggt cccaggcatt tcaggggtgg ggaatcctgg
     1561 agctggtatg cagggtacag gcatacaagg aacaggcatg cagggagcag gcatacaagg
     1621 aggagggatg cagggggcag gcatacaagg agtcagtata caaggaggag gtatacaagg
     1681 aggaggtata cagggggcaa gcaagcaagg tggaagccag cctagcagtt ttagtcctgg
     1741 gcagagccag gtcactccac aggatcagga gaaggcagct ttgatcatgc aggttcttca
     1801 actgactgca gatcagattg ccatgctgcc ccctgagcaa aggcagagta tcctgatttt
     1861 aaaggaacaa atccagaaat ccactggagc gtcttgaaag gttttagaaa atatttggct
     1921 gtagtctcaa attttattct gtagcatgga gaatgggtgc aaaaagctga cttctgtatc
     1981 cccacacttg gattagggtt tccctcctcc tagaacctaa tcttattttt tgttcttttt
     2041 ctttctttct gttttccttt tttttttaat tgagggtggg gggaggaggg agtgcgtctg
     2101 ttcactttaa gttactttaa aataactctg aacatgatta tattatgcca aataagatta
     2161 caaagaataa gcagcaatat tgaagcatct acagtatgtt aactacattt tttaaatgtc
     2221 gagtaaaact tcgtgaaaac tgctcataaa gactaaaagt tgacctgtta aaacgttaat
     2281 gtactaagat agttttaaga tttttggttg tataacaaaa taaaagttta cccaaaagta
     2341 taagatacat tttttggtaa accatttaaa atacaaaatc ctattttgga ggcaatagga
     2401 taagcattgt cttagtgttt tagaattatt tttgaaacag agttaacagg ataaggttac
     2461 acttgtatta gaattgtttt tttctaaagt tatgttacct gaaaaatcaa ggagtgcacc
     2521 tgatttactg ttgcttcatt tatcccatcc ttcagagacc agcaaggttc tgccaggccc
     2581 caagcatctg agcatgatga ttttgctgtg acaattctaa gatcaaccag gttacttaag
     2641 tccgctctga tgaaacccag tctctcaata ccttcctatt tctcaatagt ctttaagccc
     2701 taaatctgag tcagtaattc tctaaaaatc cttcccaaaa atcagtgtct agggactggt
     2761 tgatctagat gagttataaa tggtatttga cttttcataa gtagtggaag gtttcactaa
     2821 gtaaagatct gagtttcttg gtatctgacg tttgtataca gatggtgtcc atttgctcaa
     2881 ccagacagga gttaacttgt attagaattg ttttttctaa agttatgtta cctgagaaat
     2941 taaggactgc acctggttta atgttgcttc acttatccca ccctacagag accagcaagg
     3001 ttctgccagg cctcgagcat ccaagcatga ttttgctgtg acaaatctaa aatcaaccag
     3061 gctacttaag tctgctctga tgaaacccaa taatctctca ataccttcct atttctcaat
     3121 agtctttaaa ccctaaatct gagtcagtaa ttctcttaca tccttcccaa aaatcagtgt
     3181 ctagggacta gttgatctgg atgagttata catgatattt gacttttcat aagtagtgga
     3241 aggtttcact aagtaaaact ctcagtttct tggtatctgg ctttcttata cagatggtgt
     3301 ccatttgctc caccagacag gagttaaaaa cctttaaaga gcatttaaca tgccttttag
     3361 ttttcttatt tcataatcta cttttctatc attaatcatc ttaccaggaa taatcaaggc
     3421 ccaggtaggt agaagttttt atatagcctg aatactcact tgacttactg ctcattttac
     3481 tttttgcatg gaatacagcc atttagtcct aatatacata ccaatgagac aattaaaaat
     3541 tggttggaag atggagctta tcacattgtg ctactacgac tttatttttt cttgaaaata
     3601 aagccttgag gatgtgaaca taaatgttgg tatcataaaa caagtagtaa taaaagcata
     3661 aattatcaaa tatcaggtga tcttactatg gagaagaaaa accaatatct agttacagat
     3721 gaaaaaatgt ttaatacaaa gagctgaaaa tgtagaaatt gagttatctt ccctttgcaa
     3781 aatttttaca ctttaaatta gtaattcttt gtttgcaagg ttttcatccc tatgctgttg
     3841 ttttctacta cctgttttac tcttgttcat actgctactt tcccatgttt cctatatgcc
     3901 tcccctatat tggagaggat aactcgcgtt tacatatgtg atagttatgc ttaatactaa
     3961 ttcacagagt tggctcgatc attttgagat tctagttgct ttatctcaaa gctttcactg
     4021 aagggctgta actgaaaatt attaaatgtt agtctttagt caaatctctg cattgtttca
     4081 tgcagaaaat aaagatacaa ttaaggctga
//
