LOCUS       NM_005213                744 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cystatin A (CSTA), mRNA.
ACCESSION   NM_005213
VERSION     NM_005213.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 744)
  AUTHORS   Liu,Z.J., Zheng,L.S., Li,C.Z., Peng,L.X., Mei,Y., Lang,Y.H., Xu,L.,
            Meng,D.F., Peng,X.S., Wang,M.D., Xie,D.H., Guo,L.L., Ding,L.Y.,
            Huang,B.J. and Qian,C.N.
  TITLE     Correlated with better prognosis, CSTA inhibits metastasis of
            nasopharyngeal carcinoma cells via suppressing AKT signaling
            through promoting METTL3 degradation
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166696 (2023)
   PUBMED   36963524
  REMARK    GeneRIF: Correlated with better prognosis, CSTA inhibits metastasis
            of nasopharyngeal carcinoma cells via suppressing AKT signaling
            through promoting METTL3 degradation.
REFERENCE   2  (bases 1 to 744)
  AUTHORS   Rudzinska-Radecka,M., Frolova,A.S., Balakireva,A.V.,
            Gorokhovets,N.V., Pokrovsky,V.S., Sokolova,D.V., Korolev,D.O.,
            Potoldykova,N.V., Vinarov,A.Z., Parodi,A. and Zamyatnin,A.A. Jr.
  TITLE     In Silico, In Vitro, and Clinical Investigations of Cathepsin B and
            Stefin A mRNA Expression and a Correlation Analysis in Kidney
            Cancer
  JOURNAL   Cells 11 (9), 1455 (2022)
   PUBMED   35563761
  REMARK    GeneRIF: In Silico, In Vitro, and Clinical Investigations of
            Cathepsin B and Stefin A mRNA Expression and a Correlation Analysis
            in Kidney Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 744)
  AUTHORS   Wang,Y., Wang,L., Li,X., Qu,X., Han,N., Ruan,M. and Zhang,C.
  TITLE     Decreased CSTA expression promotes lymphatic metastasis and
            predicts poor survival in oral squamous cell carcinoma
  JOURNAL   Arch Oral Biol 126, 105116 (2021)
   PUBMED   33831734
  REMARK    GeneRIF: Decreased CSTA expression promotes lymphatic metastasis
            and predicts poor survival in oral squamous cell carcinoma.
REFERENCE   4  (bases 1 to 744)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 744)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 744)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 744)
  AUTHORS   Madsen,P., Rasmussen,H.H., Leffers,H., Honore,B., Dejgaard,K.,
            Olsen,E., Kiil,J., Walbum,E., Andersen,A.H., Basse,B. et al.
  TITLE     Molecular cloning, occurrence, and expression of a novel partially
            secreted protein 'psoriasin' that is highly up-regulated in
            psoriatic skin
  JOURNAL   J Invest Dermatol 97 (4), 701-712 (1991)
   PUBMED   1940442
REFERENCE   8  (bases 1 to 744)
  AUTHORS   Hsieh,W.T., Fong,D., Sloane,B.F., Golembieski,W. and Smith,D.I.
  TITLE     Mapping of the gene for human cysteine proteinase inhibitor stefin
            A, STF1, to chromosome 3cen-q21
  JOURNAL   Genomics 9 (1), 207-209 (1991)
   PUBMED   2004763
REFERENCE   9  (bases 1 to 744)
  AUTHORS   Rasanen,O., Jarvinen,M. and Rinne,A.
  TITLE     Localization of the human SH-protease inhibitor in the epidermis.
            Immunofluorescent studies
  JOURNAL   Acta Histochem 63 (2), 193-196 (1978)
   PUBMED   107703
REFERENCE   10 (bases 1 to 744)
  AUTHORS   Rinne,A., Jarvinen,M. and Rasanen,O.
  TITLE     A protein reminiscent of the epidermal SH-protease inhibitor occurs
            in squamous epithelia of man and rat
  JOURNAL   Acta Histochem 63 (2), 183-192 (1978)
   PUBMED   107702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV716538.1, BC010379.1,
            AV717631.1 and BG213814.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005213.3.
            
            Summary: The cystatin superfamily encompasses proteins that contain
            multiple cystatin-like sequences. Some of the members are active
            cysteine protease inhibitors, while others have lost or perhaps
            never acquired this inhibitory activity. There are three inhibitory
            families in the superfamily, including the type 1 cystatins
            (stefins), type 2 cystatins, and kininogens. This gene encodes a
            stefin that functions as a cysteine protease inhibitor, forming
            tight complexes with papain and the cathepsins B, H, and L. The
            protein is one of the precursor proteins of cornified cell envelope
            in keratinocytes and plays a role in epidermal development and
            maintenance. Stefins have been proposed as prognostic and
            diagnostic tools for cancer. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279841.688.1, AV717631.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264474.4/ ENSP00000264474.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AV716538.1         99-248
            151-437             BC010379.1         155-441
            438-445             AV717631.1         432-439
            446-547             BG213814.1         337-438
            548-551             AV717631.1         542-545
            552-744             BG213814.1         443-635
FEATURES             Location/Qualifiers
     source          1..744
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..744
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /note="cystatin A"
                     /db_xref="GeneID:1475"
                     /db_xref="HGNC:HGNC:2481"
                     /db_xref="MIM:184600"
     exon            1..111
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..342
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /note="cystatin AS; cystatin A (stefin A)"
                     /codon_start=1
                     /product="cystatin-A"
                     /protein_id="NP_005204.1"
                     /db_xref="CCDS:CCDS3011.1"
                     /db_xref="GeneID:1475"
                     /db_xref="HGNC:HGNC:2481"
                     /db_xref="MIM:184600"
                     /translation="MIPGGLSEAKPATPEIQEIVDKVKPQLEEKTNETYGKLEAVQYK
                     TQVVAGTNYYIKVRAGDNKYMHLKVFKSLPGQNEDLVLTGYQVDKNKDDELTGF"
     exon            112..213
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /inference="alignment:Splign:2.1.0"
     exon            214..744
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      418..423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /note="hexamer: AATAAA"
     polyA_site      441
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /note="major polyA site"
     regulatory      723..728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
                     /note="hexamer: ATTAAA"
     polyA_site      744
                     /gene="CSTA"
                     /gene_synonym="AREI; PSS4; STF1; STFA"
ORIGIN      
        1 actttggttc cagcatcctg tccagcaaag aagcaatcag ccaaaatgat acctggaggc
       61 ttatctgagg ccaaacccgc cactccagaa atccaggaga ttgttgataa ggttaaacca
      121 cagcttgaag aaaaaacaaa tgagacttac ggaaaattgg aagctgtgca gtataaaact
      181 caagttgttg ctggaacaaa ttactacatt aaggtacgag caggtgataa taaatatatg
      241 cacttgaaag tattcaaaag tcttcccgga caaaatgagg acttggtact tactggatac
      301 caggttgaca aaaacaagga tgacgagctg acgggctttt agcagcatgt acccaaagtg
      361 ttctgattcc ttcaactggc tactgagtca tgatccttgc tgataaatat aaccatcaat
      421 aaagaagcat tcttttccaa agaaattatt tcttcaatta tttctcattt attgtattaa
      481 gcagaaatta ccttttcttt ctcaaaatca gtgttattgc tttagagtat aaactccata
      541 taaattgatg gcaattggaa atcttataaa aactagtcaa gcctaatgca actggctaaa
      601 ggatagtacc accctcaccc ccaccatagg caggctggat cgtggactat caattcacca
      661 gcctccttgt tccctgtggc tgctgataac ccaacattcc atctctaccc tcatacttca
      721 aaattaaatc aagtatttta caaa
//
