LOCUS       NM_001008693            1633 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens cystatin 9 (CST9), mRNA.
ACCESSION   NM_001008693
VERSION     NM_001008693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1633)
  AUTHORS   Eaves-Pyles,T., Patel,J., Arigi,E., Cong,Y., Cao,A., Garg,N.,
            Dhiman,M., Pyles,R.B., Arulanandam,B., Miller,A.L., Popov,V.L.,
            Soong,L., Carlsen,E.D., Coletta,C., Szabo,C. and Almeida,I.C.
  TITLE     Immunomodulatory and antibacterial effects of cystatin 9 against
            Francisella tularensis
  JOURNAL   Mol Med 19 (1), 263-275 (2013)
   PUBMED   23922243
  REMARK    GeneRIF: The current report is the first to show the
            immunomodulatory and antimicrobial functions of rCST9 against
            Francisella tularensis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1633)
  AUTHORS   Frygelius,J., Arvestad,L., Wedell,A. and Tohonen,V.
  TITLE     Evolution and human tissue expression of the Cres/Testatin subgroup
            genes, a reproductive tissue specific subgroup of the type 2
            cystatins
  JOURNAL   Evol Dev 12 (3), 329-342 (2010)
   PUBMED   20565543
REFERENCE   3  (bases 1 to 1633)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   4  (bases 1 to 1633)
  AUTHORS   Hwang,S.J., Yang,Q., Meigs,J.B., Pearce,E.N. and Fox,C.S.
  TITLE     A genome-wide association for kidney function and endocrine-related
            traits in the NHLBI's Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S10 (2007)
   PUBMED   17903292
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1633)
  AUTHORS   Puente,X.S. and Lopez-Otin,C.
  TITLE     A genomic analysis of rat proteases and protease inhibitors
  JOURNAL   Genome Res 14 (4), 609-622 (2004)
   PUBMED   15060002
REFERENCE   6  (bases 1 to 1633)
  AUTHORS   Sun,H., Li,N., Wang,X., Liu,S., Chen,T., Zhang,L., Wan,T. and
            Cao,X.
  TITLE     Molecular cloning and characterization of a novel cystatin-like
            molecule, CLM, from human bone marrow stromal cells
  JOURNAL   Biochem Biophys Res Commun 301 (1), 176-182 (2003)
   PUBMED   12535658
  REMARK    GeneRIF: Data report the cloning of a novel human cystatin-like
            molecule (CLM) from human bone marrow stromal cell (BMSC) cDNA
            library.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121894.26.
            
            On Nov 22, 2019 this sequence version replaced NM_001008693.2.
            
            Summary: The cystatin superfamily encompasses proteins that contain
            multiple cystatin-like sequences. Some of the members are active
            cysteine protease inhibitors, while others have lost or perhaps
            never acquired this inhibitory activity. There are three inhibitory
            families in the superfamily, including the type 1 cystatins
            (stefins), type 2 cystatins and the kininogens. The type 2 cystatin
            proteins are a class of cysteine proteinase inhibitors found in a
            variety of human fluids and secretions, where they appear to
            provide protective functions. The cystatin locus on chromosome 20
            contains the majority of the type 2 cystatin genes and pseudogenes.
            This gene is located in the cystatin locus and encodes a secreted
            protein that may play a role in hematopoietic differentiation or
            inflammation. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF494536.1, BC137303.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376971.4/ ENSP00000366170.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-308               AL121894.26        75181-75488         c
            309-1633            AL121894.26        71981-73305         c
FEATURES             Location/Qualifiers
     source          1..1633
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..1633
                     /gene="CST9"
                     /gene_synonym="CLM; CTES7A"
                     /note="cystatin 9"
                     /db_xref="GeneID:128822"
                     /db_xref="HGNC:HGNC:13261"
                     /db_xref="MIM:616543"
     exon            1..308
                     /gene="CST9"
                     /gene_synonym="CLM; CTES7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..533
                     /gene="CST9"
                     /gene_synonym="CLM; CTES7A"
                     /note="cystatin-like molecule; testatin"
                     /codon_start=1
                     /product="cystatin-9 precursor"
                     /protein_id="NP_001008693.2"
                     /db_xref="CCDS:CCDS33450.1"
                     /db_xref="GeneID:128822"
                     /db_xref="HGNC:HGNC:13261"
                     /db_xref="MIM:616543"
                     /translation="MSSPQRRKAMPWALSLLLMGFQLLVTYAWCSEEEMGGNNKIVQD
                     PMFLATVEFALNTFNVQSKEEHAYRLLRVLSSWREDSMDRKWRGKMVFSMNLQLRQTV
                     CRKFEDDIDNCPFQESLELNNVRQGISFPQVHSCGCCMGCGVGTGAADKAIPRDKGK"
     exon            309..1633
                     /gene="CST9"
                     /gene_synonym="CLM; CTES7A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtggacgcc agggatctga agggcaaagg caagggctgc tggagcctgc atcatgtcga
       61 gtccgcagag gaggaaggct atgccctggg cactgtcact gcttctcatg ggcttccagc
      121 tcctggtgac ttatgcctgg tgttctgaag aggaaatggg tggtaataat aaaatagtcc
      181 aggatcctat gttcctcgcc acagtggagt ttgccttgaa cactttcaac gtgcagagca
      241 aggaggagca tgcctacagg ctgttgcgcg tcctgagttc atggagggag gatagcatgg
      301 acagaaagtg gcgaggtaag atggtgttct ccatgaatct gcaactgcgc caaaccgtat
      361 gtaggaaatt tgaagatgac attgacaact gcccttttca agaaagcctg gagctgaaca
      421 acgtaagaca gggcatcagc tttcctcagg tccacagctg tggatgctgc atggggtgtg
      481 gtgtgggcac aggagcagct gacaaagcca ttccgaggga caaagggaag tgagcccaca
      541 gcaggctgta ccaggctgcc ctgcttgtgc cttagtggga agcccagtga ggcattaagc
      601 ccaggggttc actttcaggc ccctggccaa tctgagtttc ctgattctgc cctctgacac
      661 cattgcagct gcctgcacct gggccacatg gccttcagaa ccttctctct ggtcttcctc
      721 cccacttctt ccctgccttc tagagaaaga gcctggagac aatggtgaca atgtctgtgg
      781 gtacttttct cagggtttcc ctaccctgcc ctagacccaa aagtggtgga ggctgagaag
      841 aagccccact gccctcgctc ctaggccctg ctgagctgca gcacctgctc taggggacga
      901 gctccaagca aagcctggct ctgggaaaac ttcccattct tagtcaaccc ccttattgta
      961 agattaacaa ataggtaact aattgcctaa gtctgggaac tgcttccact gggacaaaac
     1021 attctcctgc tgctcttgga tgcagggatc acaccaggac agcctggggt tcccctgagg
     1081 ggcacgggct ggaggaggag gcatggcaca agtgaccctg gctaaggagg gagggagcct
     1141 caaatcacgt tgtagttcag gattggcctc aggctcaggc tagacctgaa ggccagagcc
     1201 acgtggcaca attgctggcc ccaggaatgg gcaaggtgga gatggaacct gtgttgaggg
     1261 cagatgccac aagattcccg aacctcccca aaccccgccc tactgtctct tcctgtttgt
     1321 tccctcggac cttcagctgc ttcttcactg ttgaaaccat gccctggaag acatattttg
     1381 aactcctgaa caagacctgc tcagaggggc tctcctgagt ggaagccact cacatgcctg
     1441 gccacatgct gccccctccc ccgtggacac cagctgttcc caggagttga catatcagtg
     1501 gctgagcagc tccgtgcata tttgttctct tattttgcaa gtgtctgagg ttttatgact
     1561 tggcatttta gaaaatcctc actgtccagg ttcctcaagt agaataggtc attaaacatc
     1621 agcatttgca gaa
//
