LOCUS       NM_001898                749 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens cystatin SN (CST1), mRNA.
ACCESSION   NM_001898
VERSION     NM_001898.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 749)
  AUTHORS   Yuan,L., Zhou,D., Li,W., Guan,J., Li,J. and Xu,B.
  TITLE     TFAP2C Activates CST1 Transcription to Facilitate Breast Cancer
            Progression and Suppress Ferroptosis
  JOURNAL   Biochem Genet 62 (5), 3858-3875 (2024)
   PUBMED   38243003
  REMARK    GeneRIF: TFAP2C Activates CST1 Transcription to Facilitate Breast
            Cancer Progression and Suppress Ferroptosis.
REFERENCE   2  (bases 1 to 749)
  AUTHORS   Hoyer,A., Chakraborty,S., Lilienthal,I., Konradsen,J.R.,
            Katayama,S. and Soderhall,C.
  TITLE     The functional role of CST1 and CCL26 in asthma development
  JOURNAL   Immun Inflamm Dis 12 (1), e1162 (2024)
   PUBMED   38270326
  REMARK    GeneRIF: The functional role of CST1 and CCL26 in asthma
            development.
REFERENCE   3  (bases 1 to 749)
  AUTHORS   Zhong,W., Liu,Y., Zhang,L., Zhuang,W., Chen,J., Huang,Z., Zheng,Y.
            and Huang,Y.
  TITLE     Combination of serum CST1 and HE4 for early diagnosis of
            endometrial cancer
  JOURNAL   PeerJ 11, e16424 (2023)
   PUBMED   38077439
  REMARK    GeneRIF: Combination of serum CST1 and HE4 for early diagnosis of
            endometrial cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 749)
  AUTHORS   Muttuvelu,D.V., Cehofski,L.J., Holtz,J., Utheim,T.P., Chen,X.,
            Vorum,H., Heegaard,S., Rasmussen,M.L.R., Khan,A.M., Abduljabar,A.B.
            and Honore,B.
  TITLE     Meibomian Gland Dysfunction Is Associated with Low Levels of
            Immunoglobulin Chains and Cystatin-SN
  JOURNAL   Int J Mol Sci 24 (20), 15115 (2023)
   PUBMED   37894795
  REMARK    GeneRIF: Meibomian Gland Dysfunction Is Associated with Low Levels
            of Immunoglobulin Chains and Cystatin-SN.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 749)
  AUTHORS   Yao,L., Yuan,X., Fu,H., Guo,Q., Wu,Y., Xuan,S., Kermani,N.Z.,
            Adcock,I.M., Zeng,X., Liu,Y., Xie,M. and Yao,X.
  TITLE     Epithelium-derived cystatin SN inhibits house dust mite protease
            activity in allergic asthma
  JOURNAL   Allergy 78 (6), 1507-1523 (2023)
   PUBMED   37026502
  REMARK    GeneRIF: Epithelium-derived cystatin SN inhibits house dust mite
            protease activity in allergic asthma.
REFERENCE   6  (bases 1 to 749)
  AUTHORS   Takahashi,M., Honda,Y., Ogawa,K. and Barka,T.
  TITLE     Immunofluorescence localization of cystatins in human lacrimal
            gland and in the exorbital lacrimal gland of the rat
  JOURNAL   Acta Ophthalmol (Copenh) 70 (5), 625-631 (1992)
   PUBMED   1471486
REFERENCE   7  (bases 1 to 749)
  AUTHORS   Isemura,S., Saitoh,E., Sanada,K. and Minakata,K.
  TITLE     Identification of full-sized forms of salivary (S-type) cystatins
            (cystatin SN, cystatin SA, cystatin S, and two phosphorylated forms
            of cystatin S) in human whole saliva and determination of
            phosphorylation sites of cystatin S
  JOURNAL   J Biochem 110 (4), 648-654 (1991)
   PUBMED   1778989
REFERENCE   8  (bases 1 to 749)
  AUTHORS   Bobek,L.A., Aguirre,A. and Levine,M.J.
  TITLE     Human salivary cystatin S. Cloning, sequence analysis,
            hybridization in situ and immunocytochemistry
  JOURNAL   Biochem J 278 (Pt 3) (Pt 3), 627-635 (1991)
   PUBMED   1898352
REFERENCE   9  (bases 1 to 749)
  AUTHORS   Al-Hashimi,I., Dickinson,D.P. and Levine,M.J.
  TITLE     Purification, molecular cloning, and sequencing of salivary
            cystatin SA-1
  JOURNAL   J Biol Chem 263 (19), 9381-9387 (1988)
   PUBMED   2837486
REFERENCE   10 (bases 1 to 749)
  AUTHORS   Saitoh,E., Isemura,S., Sanada,K., Kim,H.S., Smithies,O. and
            Maeda,N.
  TITLE     Cystatin superfamily. Evidence that family II cystatin genes are
            evolutionarily related to family III cystatin genes
  JOURNAL   Biol Chem Hoppe Seyler 369 Suppl, 191-197 (1988)
   PUBMED   3202964
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021225.2 and AL591074.10.
            
            On Jul 2, 2020 this sequence version replaced NM_001898.2.
            
            Summary: The cystatin superfamily encompasses proteins that contain
            multiple cystatin-like sequences. Some of the members are active
            cysteine protease inhibitors, while others have lost or perhaps
            never acquired this inhibitory activity. There are three inhibitory
            families in the superfamily, including the type 1 cystatins
            (stefins), type 2 cystatins and the kininogens. The type 2 cystatin
            proteins are a class of cysteine proteinase inhibitors found in a
            variety of human fluids and secretions, where they appear to
            provide protective functions. The cystatin locus on chromosome 20
            contains the majority of the type 2 cystatin genes and pseudogenes.
            This gene is located in the cystatin locus and encodes a cysteine
            proteinase inhibitor found in saliva, tears, urine, and seminal
            fluid. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021225.2, CB957799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2151887
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304749.7/ ENSP00000305731.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               BC021225.2         1-341
            342-342             AL591074.10        39352-39352         c
            343-749             BC021225.2         343-749
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..749
                     /gene="CST1"
                     /note="cystatin SN"
                     /db_xref="GeneID:1469"
                     /db_xref="HGNC:HGNC:2473"
                     /db_xref="MIM:123855"
     exon            1..297
                     /gene="CST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..495
                     /gene="CST1"
                     /note="cystatin 1; cystatin SA-I; cysteine proteinase
                     inhibitor, type 2 family; cystain-SA-I; salivary
                     cystatin-SA-1"
                     /codon_start=1
                     /product="cystatin-SN precursor"
                     /protein_id="NP_001889.2"
                     /db_xref="CCDS:CCDS13160.1"
                     /db_xref="GeneID:1469"
                     /db_xref="HGNC:HGNC:2473"
                     /db_xref="MIM:123855"
                     /translation="MAQYLSTLLLLLATLAVALAWSPKEEDRIIPGGIYNADLNDEWV
                     QRALHFAISEYNKATKDDYYRRPLRVLRARQQTVGGVNYFFDVEVGRTICTKSQPNLD
                     TCAFHEQPELQKKQLCSFEIYEVPWENRRSLVKSRCQES"
     exon            298..411
                     /gene="CST1"
                     /inference="alignment:Splign:2.1.0"
     exon            412..749
                     /gene="CST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      731..736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CST1"
                     /note="hexamer: ATTAAA"
     polyA_site      749
                     /gene="CST1"
                     /note="major polyA site"
ORIGIN      
        1 gctccctgcc tcgggctctc accctcctct cctgcagctc cagctttgtg ctctgcctct
       61 gaggagacca tggcccagta tctgagtacc ctgctgctcc tgctggccac cctagctgtg
      121 gccctggcct ggagccccaa ggaggaggat aggataatcc cgggtggcat ctataacgca
      181 gacctcaatg atgagtgggt acagcgtgcc cttcacttcg ccatcagcga gtataacaag
      241 gccaccaaag atgactacta cagacgtccg ctgcgggtac taagagccag gcaacagacc
      301 gttggggggg tgaattactt cttcgacgta gaggtgggcc gcaccatatg taccaagtcc
      361 cagcccaact tggacacctg tgccttccat gaacagccag aactgcagaa gaaacagttg
      421 tgctctttcg agatctacga agttccctgg gagaacagaa ggtccctggt gaaatccagg
      481 tgtcaagaat cctagggatc tgtgccaggc cattcgcacc agccaccacc cactcccacc
      541 ccctgtagtg ctcccacccc tggactggtg gcccccaccc tgcgggaggc ctccccatgt
      601 gcctgcgcca agagacagac agagaaggct gcaggagtcc tttgttgctc agcagggcgc
      661 tctgccctcc ctccttcctt cttgcttcta atagccctgg tacatggtac acaccccccc
      721 acctcctgca attaaacagt agcatcgcc
//
