LOCUS       NM_003476               1283 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens cysteine and glycine rich protein 3 (CSRP3),
            transcript variant 1, mRNA.
ACCESSION   NM_003476 NM_001127656 XM_005253152
VERSION     NM_003476.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Giri,P., Jain,D., Kumar,A. and Mohapatra,B.
  TITLE     Identification and in silico characterization of CSRP3 synonymous
            variants in dilated cardiomyopathy
  JOURNAL   Mol Biol Rep 50 (5), 4105-4117 (2023)
   PUBMED   36877346
  REMARK    GeneRIF: Identification and in silico characterization of CSRP3
            synonymous variants in dilated cardiomyopathy.
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Chauhan,P.K. and Sowdhamini,R.
  TITLE     LIM domain-wide comprehensive virtual mutagenesis provides
            structural rationale for cardiomyopathy mutations in CSRP3
  JOURNAL   Sci Rep 12 (1), 3562 (2022)
   PUBMED   35241752
  REMARK    GeneRIF: LIM domain-wide comprehensive virtual mutagenesis provides
            structural rationale for cardiomyopathy mutations in CSRP3.
            Erratum:[Sci Rep. 2022 Mar 14;12(1):4363. doi:
            10.1038/s41598-022-08526-0.. PMID: 35288646]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Salazar-Mendiguchia,J., Barriales-Villa,R., Lopes,L.R., Ochoa,J.P.,
            Rodriguez-Vilela,A., Palomino-Doza,J., Larranaga-Moreira,J.M.,
            Cicerchia,M., Cardenas-Reyes,I., Garcia-Giustiniani,D., Brogger,N.,
            Fernandez,G., Garcia,S., Santiago,L., Velez,P., Ortiz-Genga,M.,
            Elliott,P.M. and Monserrat,L.
  TITLE     The p.(Cys150Tyr) variant in CSRP3 is associated with late-onset
            hypertrophic cardiomyopathy in heterozygous individuals
  JOURNAL   Eur J Med Genet 63 (12), 104079 (2020)
   PUBMED   33035702
  REMARK    GeneRIF: The p.(Cys150Tyr) variant in CSRP3 is associated with
            late-onset hypertrophic cardiomyopathy in heterozygous individuals.
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   Kong,Y., Flick,M.J., Kudla,A.J. and Konieczny,S.F.
  TITLE     Muscle LIM protein promotes myogenesis by enhancing the activity of
            MyoD
  JOURNAL   Mol Cell Biol 17 (8), 4750-4760 (1997)
   PUBMED   9234731
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Fung,Y.W., Wang,R. and Liew,C.C.
  TITLE     Characterization of a human cardiac gene which encodes for a LIM
            domain protein and is developmentally expressed in myocardial
            development
  JOURNAL   J Mol Cell Cardiol 28 (6), 1203-1210 (1996)
   PUBMED   8782062
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Weiskirchen,R., Pino,J.D., Macalma,T., Bister,K. and Beckerle,M.C.
  TITLE     The cysteine-rich protein family of highly related LIM domain
            proteins
  JOURNAL   J Biol Chem 270 (48), 28946-28954 (1995)
   PUBMED   7499425
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Fung,Y.W., Wang,R.X., Heng,H.H. and Liew,C.C.
  TITLE     Mapping of a human LIM protein (CLP) to human chromosome 11p15.1 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 28 (3), 602-603 (1995)
   PUBMED   7490106
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Arber,S., Halder,G. and Caroni,P.
  TITLE     Muscle LIM protein, a novel essential regulator of myogenesis,
            promotes myogenic differentiation
  JOURNAL   Cell 79 (2), 221-231 (1994)
   PUBMED   7954791
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Cirino,A.L. and Ho,C.
  TITLE     Hypertrophic Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301725
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009652.14.
            
            On Apr 9, 2019 this sequence version replaced NM_003476.4.
            
            Summary: This gene encodes a member of the CSRP family of LIM
            domain proteins, which may be involved in regulatory processes
            important for development and cellular differentiation. The
            LIM/double zinc-finger motif found in this protein is found in a
            group of proteins with critical functions in gene regulation, cell
            growth, and somatic differentiation. Mutations in this gene are
            thought to cause heritable forms of hypertrophic cardiomyopathy
            (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively
            spliced transcript variants with different 5' UTR, but encoding the
            same protein, have been found for this gene. [provided by RefSeq,
            Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.113477.1,
                                           SRR5189655.88033.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155550, SAMN03267760
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265968.9/ ENSP00000265968.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC009652.14        106376-106405
            31-170              AC009652.14        115883-116022
            171-339             AC009652.14        120055-120223
            340-472             AC009652.14        122011-122143
            473-566             AC009652.14        123314-123407
            567-1283            AC009652.14        125613-126329
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1283
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /note="cysteine and glycine rich protein 3"
                     /db_xref="GeneID:8048"
                     /db_xref="HGNC:HGNC:2472"
                     /db_xref="MIM:600824"
     exon            1..30
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     exon            31..170
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..643
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cardiac LIM domain protein; LIM domain only 4; cysteine
                     and glycine-rich protein 3 (cardiac LIM protein)"
                     /codon_start=1
                     /product="cysteine and glycine-rich protein 3 isoform 1"
                     /protein_id="NP_003467.1"
                     /db_xref="CCDS:CCDS7848.1"
                     /db_xref="GeneID:8048"
                     /db_xref="HGNC:HGNC:2472"
                     /db_xref="MIM:600824"
                     /translation="MPNWGGGAKCGACEKTVYHAEEIQCNGRSFHKTCFHCMACRKAL
                     DSTTVAAHESEIYCKVCYGRRYGPKGIGYGQGAGCLSTDTGEHLGLQFQQSPKPARSV
                     TTSNPSKFTAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFRCAICGKSLESTNVT
                     DKDGELYCKVCYAKNFGPTGIGFGGLTQQVEKKE"
     exon            171..339
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     exon            340..472
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     exon            473..566
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1283
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /note="hexamer: AATAAA"
     polyA_site      900
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /note="major polyA site"
     regulatory      1248..1253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
                     /note="hexamer: AATAAA"
     polyA_site      1283
                     /gene="CSRP3"
                     /gene_synonym="CLP; CMD1M; CMH12; CRP3; LMO4; MLP"
ORIGIN      
        1 agttgagctg aacggagtcc acacaggcag acttgacctt gaccagatag tcttcaagat
       61 gccaaactgg ggcggaggcg caaaatgtgg agcctgtgaa aagaccgtct accatgcaga
      121 agaaatccag tgcaatggaa ggagtttcca caagacgtgt ttccactgca tggcctgcag
      181 gaaggctctt gacagcacga cagtcgcggc tcatgagtcg gagatctact gcaaggtgtg
      241 ctatgggcgc agatatggcc ccaaagggat cgggtatgga caaggcgctg gctgtctcag
      301 cacagacacg ggcgagcatc tcggcctgca gttccaacag tccccaaagc cggcacgctc
      361 agttaccacc agcaaccctt ccaaattcac tgcgaagttt ggagagtccg agaagtgccc
      421 tcgatgtggc aagtcagtct atgctgctga gaaggttatg ggaggtggca agccttggca
      481 caagacctgt ttccgctgtg ccatctgtgg gaagagtctg gagtccacaa atgtcactga
      541 caaagatggg gaactttatt gcaaagtttg ctatgccaaa aattttggcc ccacgggtat
      601 tgggtttgga ggccttacac aacaagtgga aaagaaagaa tgaagaggtg cgccgtttct
      661 cagatttttt gcgagcctaa aacacttgcc aagtaatcct gcacagatcg atacctttcc
      721 ccaaatagcc tctcctttgt agtcgtacat tatgtgtttc tcctcagaag tgatcaggtc
      781 tttactgaat gttagaagag gcctttggaa gaaaattatg taaagtttaa tctataacaa
      841 atgctttatt atttataatg cttggaatgg gagaggcaat aaataaatgt tttagtgcta
      901 tcttgtatgg ctctagatct tttctttgag atagaaattt tcaaaaacat aaagctagtt
      961 caaaaaacga gttgcagagc atataataaa tttggatgtc aactgagaaa ggagtgagaa
     1021 ggaagaaaca atgcgcaaag gaaagcagtc tttcagaatc tgtcagccaa gtgtctttct
     1081 agttactgct aatggagaag aaaacagggg gtctgggaga aaatagagaa catgatagca
     1141 aaatctaaaa ggaaaatcaa aactaataaa attgctgaag agttgatccc tttgtcctat
     1201 cgtggggctt tgtaatgtta cacatctcgt gaaaactcag aaatgacaat aaagcgtggc
     1261 atttgcctct gtattataaa tga
//
