LOCUS       NM_004078               1820 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cysteine and glycine rich protein 1 (CSRP1),
            transcript variant 1, mRNA.
ACCESSION   NM_004078
VERSION     NM_004078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1820)
  AUTHORS   Yu,S., Zhao,H., Meng,H., Shi,S., Cao,S., Bian,T. and Ruan,C.
  TITLE     CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as an
            Independent Risk Biomarker for Worse Prognosis
  JOURNAL   Genet Res (Camb) 2023, 8586507 (2023)
   PUBMED   37113556
  REMARK    GeneRIF: CSRP1 Promotes Colon Adenocarcinoma Growth and Serves as
            an Independent Risk Biomarker for Worse Prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1820)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1820)
  AUTHORS   Knierim,E., Hirata,H., Wolf,N.I., Morales-Gonzalez,S.,
            Schottmann,G., Tanaka,Y., Rudnik-Schoneborn,S., Orgeur,M.,
            Zerres,K., Vogt,S., van Riesen,A., Gill,E., Seifert,F., Zwirner,A.,
            Kirschner,J., Goebel,H.H., Hubner,C., Stricker,S., Meierhofer,D.,
            Stenzel,W. and Schuelke,M.
  TITLE     Mutations in Subunits of the Activating Signal Cointegrator 1
            Complex Are Associated with Prenatal Spinal Muscular Atrophy and
            Congenital Bone Fractures
  JOURNAL   Am J Hum Genet 98 (3), 473-489 (2016)
   PUBMED   26924529
REFERENCE   4  (bases 1 to 1820)
  AUTHORS   Wang,Q., Williamson,M., Bott,S., Brookman-Amissah,N., Freeman,A.,
            Nariculam,J., Hubank,M.J., Ahmed,A. and Masters,J.R.
  TITLE     Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer
  JOURNAL   Oncogene 26 (45), 6560-6565 (2007)
   PUBMED   17486081
  REMARK    GeneRIF: Hypomethylation of wingless-related MMTV integration site
            5A (WNT5A), S100 calcium-binding protein P (S100P) and
            cysteine-rich protein 1(CRIP1) was confirmed in the cancer cells by
            bisulfite sequencing.
REFERENCE   5  (bases 1 to 1820)
  AUTHORS   Dube,J.Y., Chapdelaine,P., Trahan,P.L., Deperthes,D., Frenette,G.
            and Tremblay,R.R.
  TITLE     Abundant cysteine-rich protein-1 is localized in the stromal
            compartment of the human prostate
  JOURNAL   Arch Androl 40 (2), 109-115 (1998)
   PUBMED   9507743
REFERENCE   6  (bases 1 to 1820)
  AUTHORS   Erdel,M. and Weiskirchen,R.
  TITLE     Assignment1 of CSRP1 encoding the LIM domain protein CRP1, to human
            chromosome 1q32 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 10-11 (1998)
   PUBMED   9925910
REFERENCE   7  (bases 1 to 1820)
  AUTHORS   Feuerstein,R., Wang,X., Song,D., Cooke,N.E. and Liebhaber,S.A.
  TITLE     The LIM/double zinc-finger motif functions as a protein
            dimerization domain
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10655-10659 (1994)
   PUBMED   7938009
REFERENCE   8  (bases 1 to 1820)
  AUTHORS   Wang,X., Ray,K., Szpirer,J., Levan,G., Liebhaber,S.A. and
            Cooke,N.E.
  TITLE     Analysis of the human cysteine-rich protein gene (CSRP), assignment
            to chromosome 1q24-1q32, and identification of an associated MspI
            polymorphism
  JOURNAL   Genomics 14 (2), 391-397 (1992)
   PUBMED   1385304
REFERENCE   9  (bases 1 to 1820)
  AUTHORS   Wang,X., Lee,G., Liebhaber,S.A. and Cooke,N.E.
  TITLE     Human cysteine-rich protein. A member of the LIM/double-finger
            family displaying coordinate serum induction with c-myc
  JOURNAL   J Biol Chem 267 (13), 9176-9184 (1992)
   PUBMED   1374386
REFERENCE   10 (bases 1 to 1820)
  AUTHORS   Liebhaber,S.A., Emery,J.G., Urbanek,M., Wang,X.K. and Cooke,N.E.
  TITLE     Characterization of a human cDNA encoding a widely expressed and
            highly conserved cysteine-rich protein with an unusual zinc-finger
            motif
  JOURNAL   Nucleic Acids Res 18 (13), 3871-3879 (1990)
   PUBMED   2115670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW163500.1, BC032493.1,
            CF453919.1 and CA411857.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004078.2.
            
            Summary: This gene encodes a member of the cysteine-rich protein
            (CSRP) family. This gene family includes a group of LIM domain
            proteins, which may be involved in regulatory processes important
            for development and cellular differentiation. The LIM/double
            zinc-finger motif found in this gene product occurs in proteins
            with critical functions in gene regulation, cell growth, and
            somatic differentiation. Alternatively spliced transcript variants
            have been described. [provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1). Variants 1, 4 and 5 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1042749.1,
                                           SRR3476690.112544.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340006.7/ ENSP00000345079.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AW163500.1         137-146
            11-1188             BC032493.1         1-1178
            1189-1560           CF453919.1         391-762
            1561-1820           CA411857.1         15-274              c
FEATURES             Location/Qualifiers
     source          1..1820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1820
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /note="cysteine and glycine rich protein 1"
                     /db_xref="GeneID:1465"
                     /db_xref="HGNC:HGNC:2469"
                     /db_xref="MIM:123876"
     exon            1..54
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     exon            55..167
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..637
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM-domain protein; cysteine-rich protein 1; epididymis
                     luminal protein 141; epididymis secretory protein Li 286;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="cysteine and glycine-rich protein 1 isoform 1"
                     /protein_id="NP_004069.1"
                     /db_xref="CCDS:CCDS1413.1"
                     /db_xref="GeneID:1465"
                     /db_xref="HGNC:HGNC:2469"
                     /db_xref="MIM:123876"
                     /translation="MPNWGGGKKCGVCQKTVYFAEEVQCEGNSFHKSCFLCMVCKKNL
                     DSTTVAVHGEEIYCKSCYGKKYGPKGYGYGQGAGTLSTDKGESLGIKHEEAPGHRPTT
                     NPNASKFAQKIGGSERCPRCSQAVYAAEKVIGAGKSWHKACFRCAKCGKGLESTTLAD
                     KDGEIYCKGCYAKNFGPKGFGFGQGAGALVHSE"
     exon            168..336
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     exon            337..466
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     exon            467..560
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     exon            561..1820
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /note="hexamer: AATAAA"
     polyA_site      1820
                     /gene="CSRP1"
                     /gene_synonym="CRP; CRP1; CSRP; CYRP; D1S181E; HEL-141;
                     HEL-S-286"
                     /note="major polyA site"
ORIGIN      
        1 agccgccact tccgagagcg cctgccgccc ctgcgccgcc gagccagctg ccagaatgcc
       61 gaactgggga ggaggcaaga aatgtggggt gtgtcagaag acggtttact ttgccgaaga
      121 ggttcagtgc gaaggcaaca gcttccataa atcctgcttc ctgtgcatgg tctgcaagaa
      181 gaatctggac agtaccactg tggccgtgca tggtgaggag atttactgca agtcctgcta
      241 cggcaagaag tatgggccca aaggctatgg ctacgggcag ggcgcaggca ccctcagcac
      301 tgacaagggg gagtcgctgg gtatcaagca cgaggaagcc cctggccaca ggcccaccac
      361 caaccccaat gcatccaaat ttgcccagaa gattggtggc tccgagcgct gcccccgatg
      421 cagccaggca gtctatgctg cggagaaggt gattggtgct gggaagtcct ggcataaggc
      481 ctgctttcga tgtgccaagt gtggcaaagg ccttgagtca accaccctgg cagacaagga
      541 tggcgagatt tactgcaaag gatgttatgc taaaaacttc gggcccaagg gctttggttt
      601 tgggcaagga gctggggcct tggtccactc tgagtgaggc caccatcacc caccacaccc
      661 tgcccactcc tgcgcttttc atcgccattc cattcccagc agctttggag acctccagga
      721 ttatttctct gtcagccctg ccacatatca ctaatgactt gaacttgggc atctggctcc
      781 ctttggtttg ggggtctgcc tgaggtccca ccccactaaa gggctcccca ggcctgggat
      841 ctgacaccat caccagtagg agacctcagt gttttgggtc taggtgagag caggcccctc
      901 tccccacacc tcgccccaca gagctctgtt cttagcctcc tgtgctgcgt gtccatcatc
      961 agctgaccaa gacacctgag gacacatctt ggcacccaga ggagcagcag caacaggctg
     1021 gagggagagg gaagcaagac caagatgagg aggggggaag gctgggtttt ttggatctca
     1081 gagattctcc tctgtgggaa agaggttgag cttcctggtg tccctcagag taagcctgag
     1141 gagtcccagc ttagggagtc actattggag gcagagaggc atgcaggcag ggtcctagga
     1201 gcccctgctt ctccaggcct cttgcctttg agtctttgtg gaatggatag cctcccacta
     1261 ggactgggag gagaataacc caggtcttaa ggaccccaaa gtcaggatgt tgtttgatct
     1321 tctcaaacat ctagttccct gcttgatggg aggatcctaa tgaaatacct gaaacatata
     1381 ttggcattta tcaatggctc aaatcttcat ttatctctgg ccttaaccct ggctcctgag
     1441 gctgcggcca gcagagccca ggccagggct ctgttcttgc cacacctgct tgatcctcag
     1501 atgtggaggg aggtaggcac tgcctcagtc ttcatccaaa cacctttccc tttgccctga
     1561 gacctcagaa tcttcccttt aacccaagac cctgcctctt ccactccacc cttctccagg
     1621 gacccttaga tcacatcact ccacccctgc caggccccag gttaggaata gtggtgggag
     1681 gaaggggaaa gggctgggcc tcaccgctcc cagcaactga aaggacaaca ctatctggag
     1741 ccacccactg aaagggctgc aggcatgggc tgtacccaag ctgatttctc atctggtcaa
     1801 taaagctgtt tagaccagaa
//
