LOCUS       NM_030809               4517 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cysteine and serine rich nuclear protein 2 (CSRNP2),
            transcript variant 1, mRNA.
ACCESSION   NM_030809
VERSION     NM_030809.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4517)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4517)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4517)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   4  (bases 1 to 4517)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4517)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4517)
  AUTHORS   Hendrickx,A., Beullens,M., Ceulemans,H., Den Abt,T., Van Eynde,A.,
            Nicolaescu,E., Lesage,B. and Bollen,M.
  TITLE     Docking motif-guided mapping of the interactome of protein
            phosphatase-1
  JOURNAL   Chem Biol 16 (4), 365-371 (2009)
   PUBMED   19389623
REFERENCE   7  (bases 1 to 4517)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4517)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB059091.1, AJ298133.1 and
            BM975428.1.
            
            On May 17, 2019 this sequence version replaced NM_030809.2.
            
            Summary: The protein encoded by this gene belongs to the CSRNP
            family of nuclear proteins that share conserved regions, including
            cysteine- and serine- rich regions, a basic domain, a
            transcriptional activation domain, and bind the sequence 'AGAGTG',
            thus have the hallmark of transcription factors. Studies in mice
            suggest that these genes may have redundant functions.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.189165.1,
                                           SRR1803613.205820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228515.6/ ENSP00000228515.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                DB059091.1         76-121
            47-4515             AJ298133.1         1-4469
            4516-4517           BM975428.1         12-13               c
FEATURES             Location/Qualifiers
     source          1..4517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..4517
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /note="cysteine and serine rich nuclear protein 2"
                     /db_xref="GeneID:81566"
                     /db_xref="HGNC:HGNC:16006"
                     /db_xref="MIM:620404"
     exon            1..258
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            259..495
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1976
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /note="family with sequence similarity 130, member A1;
                     CSRNP-2; TGF-beta-induced apoptosis protein 12; protein
                     phosphatase 1, regulatory subunit 72"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 2"
                     /protein_id="NP_110436.1"
                     /db_xref="CCDS:CCDS8807.1"
                     /db_xref="GeneID:81566"
                     /db_xref="HGNC:HGNC:16006"
                     /db_xref="MIM:620404"
                     /translation="MDAFTGSGLKRKFDDVDVGSSVSNSDDEISSSDSADSCDSLNPP
                     TTASFTPTSILKRQKQLRRKNVRFDQVTVYYFARRQGFTSVPSQGGSSLGMAQRHNSV
                     RSYTLCEFAQEQEVNHREILREHLKEEKLHAKKMKLTKNGTVESVEADGLTLDDVSDE
                     DIDVENVEVDDYFFLQPLPTKRRRALLRASGVHRIDAEEKQELRAIRLSREECGCDCR
                     LYCDPEACACSQAGIKCQVDRMSFPCGCSRDGCGNMAGRIEFNPIRVRTHYLHTIMKL
                     ELESKRQVSRPAAPDEEPSPTASCSLTGAQGSETQDFQEFIAENETAVMHLQSAEELE
                     RLKAEEDSSGSSASLDSSIESLGVCILEEPLAVPEELCPGLTAPILIQAQLPPGSSVL
                     CFTENSDHPTASTVNSPSYLNSGPLVYYQVEQRPVLGVKGEPGTEEGSASFPKEKDLN
                     VFSLPVTSLVACSSTDPAALCKSEVGKTPTLEALLPEDCNPEEPENEDFHPSWSPSSL
                     PFRTDNEEGCGMVKTSQQNEDRPPEDSSLELPLAV"
     exon            496..755
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            756..1052
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..4517
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4500..4505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /note="hexamer: AAGAAA"
     polyA_site      4517
                     /gene="CSRNP2"
                     /gene_synonym="C12orf2; C12orf22; FAM130A1; PPP1R72;
                     TAIP-12"
                     /note="major polyA site"
ORIGIN      
        1 attgttagcc ggagccgggg cggttctggg cgtctgctgc cgggggcgcc cgagttgccg
       61 gagacgcccg gccctctctg cctgccggct gggctgccca ccgccctccc tccccgccct
      121 gccgccctgg gagctccccg gccgtcgccg cggggcccgg gactcgctcg ctcctccctc
      181 cttcccaccg ggctagggcg gcggcggcag cgggggcggc agagaccatc acgggaggag
      241 gcagctgcgg cggggccgaa tcctaatgta cctggctagc tggtggtgag taggggcttt
      301 ggggccaact tggtgggctc cccaaggaaa cccctttgaa accaatggat gcattcacgg
      361 gctcgggtct caagaggaag tttgatgatg tggatgtggg ctcatcagtt tccaactcag
      421 atgatgagat ctccagcagt gatagtgctg acagctgcga cagcctcaat cctcctacca
      481 ctgccagctt cacacccaca tccatcctga agcggcagaa gcagctgcgg aggaagaatg
      541 tacgctttga ccaggtgact gtatactact ttgcccggcg ccaaggtttt accagtgtgc
      601 ccagccaggg tggtagctct ctgggcatgg cccagcgcca taactctgta cggagctata
      661 cactctgtga gtttgcccag gaacaggagg tgaaccatcg agagattctg cgtgagcacc
      721 tgaaggaaga gaaactccat gccaagaaaa tgaagctgac caagaatggg acagtggagt
      781 cggtggaggc tgatggcctg acgctggatg atgtgtcaga tgaagatatt gatgtggaaa
      841 atgtggaggt ggatgattac ttcttcctgc agcctctgcc caccaaacgg cgacgggccc
      901 tgctgagggc ttctggggtc caccgtattg atgctgaaga gaagcaagaa cttcgagcca
      961 tccgcctgtc acgggaagaa tgtggttgtg actgccgact gtattgtgac ccagaagcgt
     1021 gtgcctgcag ccaggctggg attaaatgcc aggtggatcg catgtccttt ccatgtggct
     1081 gctcccggga tggctgtggg aacatggcag gacgcattga atttaatcca atccgggtcc
     1141 ggactcatta cctccacacc attatgaagc tggagctgga gagcaagcgg caggtgagcc
     1201 gcccagcagc cccagatgag gagccctccc cgactgccag ttgcagcctg acaggagcac
     1261 agggctctga gacccaggac ttccaggagt tcattgctga gaatgagaca gcagtgatgc
     1321 acctgcagag tgcagaggaa ctggagcggc tcaaggcaga agaagattcc agcggctcta
     1381 gtgccagcct ggactcgagc atcgagagcc tgggtgtgtg catcctagag gagcctctgg
     1441 ctgtccccga agagctgtgc ccaggcctta cagcccccat tctcatccag gctcagctgc
     1501 ccccaggctc ctctgtcctg tgttttaccg agaactcaga ccacccaact gcctcaacgg
     1561 tgaacagccc atcctacttg aacagtgggc ccctggtcta ttatcaagtg gagcagaggc
     1621 cagtcttggg agtgaaagga gagcctggta cggaagaagg ctcagcctct ttcccaaagg
     1681 agaaggatct gaatgtcttc tctctccctg ttacctcact cgtggcttgt agctccacag
     1741 acccagctgc cctctgtaaa tcagaggtgg ggaaaacacc caccctagaa gctctattgc
     1801 ccgaagattg taaccctgag gagcctgaaa atgaagactt ccacccttcc tggtccccct
     1861 caagcctccc cttccgcacg gacaatgaag agggctgtgg gatggtgaag acctcccagc
     1921 agaatgagga tcggccccct gaagattctt ccttagaact ccctctggca gtgtgacagg
     1981 cgctagaggt cctgcctctt acccattctc tatttattcc cttattttat ctaacaccat
     2041 ttcaaaacaa aactgtagaa gcagctgctg ctcccatgtt attttattgg ggtctttggg
     2101 gaatgggtgg gaaaggattg tttgagtatt ttttaaaagg gaaacagtac caaggagacc
     2161 agccctacct tgatctgggg atagtcttgg ggcaaagaaa gctgcgtagt gctgaacatt
     2221 aagctttctg ggccactgga acaaagaact aggatctcac aggaaaagct gggtaactca
     2281 agcagctatt ctttctgtag ggaccagaac acgagaattt gaagagcatg gcaaagccct
     2341 ttctctccca agccccaggc agagtacaag ctcatttttc tcggtggtta ttctgatatc
     2401 ccattttggt gtgtcataat acttcaaact ggaaagtcac ctggtcgagt ctagggagga
     2461 gggagtggaa gggtctctgc ttctgtacaa aatctccagg atttacaaaa atgtaacctg
     2521 ccttccttca atcccatatt tggtaaataa gttaatattt gacatgtttg gtgttctctg
     2581 acctgttccc cacactgggg attcctggtc tgtaacttga attgtttctt ccacatgttc
     2641 ttaagtacta gagttaaact tgtctatgtg tcttttttct ctccatcctt tttccttcgg
     2701 agaaagagct ggattggctg gggatatggt ataacgagcc tgagccttct gtacgtgtct
     2761 gacactagca ctgtcaggca gctttcggct ggggctcacc catcccatag gaggcctatg
     2821 tggagcatta actgtggcca aaggaggcag cgggaacagg ctgcttgcta tctggaaaga
     2881 tgacatattt gtgccatgct tgttttttca cccaggtttt tccctctttg tgagatctga
     2941 gctttagtgg aatgtagaat gtggcaatct taaggtcacc aatcagtttt tgttcttttt
     3001 tcctggatct accctcatgg tcgttttcaa catagcgggt tagagttctt atactgttcc
     3061 agttcaattc caagaattgc aaatgtttat tggacccctc catcttgatg atatataaaa
     3121 attggaagcc aaaccagttc ttaaatgcta catgcaactc ccagattcca aaggattcaa
     3181 gttctaatta taacctttga agcgtataga atggaactca ttcagtttga ttcagttctt
     3241 acctctgtca ggaggaatac agttcctgtt catcctgtgt tctaagatct ccattgaaca
     3301 gcactgattt cctttcatta gcaaagtgat ctttgtctct gttctaaaat ggaggcagta
     3361 gggagcaaaa ctattcttct caagcatcct ttacaccata ctttacttct ggtatggttt
     3421 attaaccaca cacacacaca aaagtgaaaa actgtgttgg gggggagaca ctactcctac
     3481 ttatcttgct cataaagcct tttctggtgg gatattaagg ccctggtgtc ttacagaaac
     3541 catcacgtat gtcgcagcag catttcaccc ctgaagtctc taaactctga gcctgaaaag
     3601 atttgtattt aatacacata acatttttta gttcattctg cctttcctat ttgttccagt
     3661 ttttgcttgg ttttagtttg gaggggaact taagtacaca gatccttatc tctccccatc
     3721 ccctagcctc acaaaacaca gttgagagtc ttttaagtac ctgagctctc gaagctaccc
     3781 agaactgaac tagactcccc taccttagac tggtaccctc aaacacagga ctgaagctta
     3841 attgggaatt tggctttatg gagaaaagaa tctttttcaa agtttgtgtc ggaaggggag
     3901 ggtgaggttt gcccactgtc tctgcaggaa ggctccggct taatctagga agtagattcc
     3961 agctgcacga tgaggaacac attagctttt gggatcaaac caggaatatg aatctgtaat
     4021 tattaagctc attgccaacc cacaagatat gtttctgaaa acctgtagtt tcttaattta
     4081 agtccatccc cttcattaac gctacagttg tgactcacac tgatcccaaa cttttaagtg
     4141 ctaaatatta acatttagca ttaactgtct tgtcaagcga aaggccttct ctacaaccta
     4201 gtccatctca cttctggtgc tacctgagtt ggacagaatt ctagctcatg gttgctagga
     4261 aagctaggcc tctgatcata gaagcagata gcttcagtcc cagtctaggc ctagataaat
     4321 gactcttatt accacaaccc ttattatttt ccaatttcct ttctcacata ctgtacacag
     4381 gtagtatttt caatgtgaat ccaaagcttg tctggttctc tgaaaataat tttttcccct
     4441 ttaggttctt tacattgtga taatgctgta tttaaagaga atatttaaat gtaatattaa
     4501 agaaatattc aaaagaa
//
