LOCUS       NM_033027               3164 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cysteine and serine rich nuclear protein 1 (CSRNP1),
            transcript variant 2, mRNA.
ACCESSION   NM_033027
VERSION     NM_033027.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3164)
  AUTHORS   Zhu,J., Xu,H.N., Lin,T. and Xia,Z.J.
  TITLE     Silencing of cysteine and serine rich nuclear protein 1 inhibits
            apoptosis, senescence and collagen degradation in human-derived
            vaginal fibroblasts in response to oxidative stress or DNA damage
  JOURNAL   Exp Cell Res 440 (2), 114139 (2024)
   PUBMED   38908423
  REMARK    GeneRIF: Silencing of cysteine and serine rich nuclear protein 1
            inhibits apoptosis, senescence and collagen degradation in
            human-derived vaginal fibroblasts in response to oxidative stress
            or DNA damage.
REFERENCE   2  (bases 1 to 3164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3164)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3164)
  AUTHORS   Macdonald,C.D., Falconer,A.M.D., Chan,C.M., Wilkinson,D.J.,
            Skelton,A., Reynard,L., Litherland,G.J., Europe-Finner,G.N. and
            Rowan,A.D.
  TITLE     Cytokine-induced cysteine- serine-rich nuclear protein-1 (CSRNP1)
            selectively contributes to MMP1 expression in human chondrocytes
  JOURNAL   PLoS One 13 (11), e0207240 (2018)
   PUBMED   30440036
  REMARK    GeneRIF: cFos bound to the AP-1 cis element within the proximal
            MMP1 promoter only when the gene was transcriptionally silent as
            previously observed for MMP13. cFos contributes to MMP1 expression.
            Silencing of ATF3 (a prime MMP13 modulator) did not affect MMP1
            expression whilst silencing CSRNP1 resulted in substantial
            repression of MMP1 but not MMP13.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3164)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3164)
  AUTHORS   St Pourcain,B., Skuse,D.H., Mandy,W.P., Wang,K., Hakonarson,H.,
            Timpson,N.J., Evans,D.M., Kemp,J.P., Ring,S.M., McArdle,W.L.,
            Golding,J. and Smith,G.D.
  TITLE     Variability in the common genetic architecture of
            social-communication spectrum phenotypes during childhood and
            adolescence
  JOURNAL   Mol Autism 5 (1), 18 (2014)
   PUBMED   24564958
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3164)
  AUTHORS   Wang,K., Ling,T., Wu,H. and Zhang,J.
  TITLE     Screening of candidate tumor-suppressor genes in 3p21.3 and
            investigation of the methylation of gene promoters in oral squamous
            cell carcinoma
  JOURNAL   Oncol Rep 29 (3), 1175-1182 (2013)
   PUBMED   23292452
  REMARK    GeneRIF: Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and
            GNAT1 may be involved in oral squamous cell carcinoma.
REFERENCE   8  (bases 1 to 3164)
  AUTHORS   Esteves,S.L., Domingues,S.C., da Cruz e Silva,O.A., Fardilha,M. and
            da Cruz e Silva,E.F.
  TITLE     Protein phosphatase 1alpha interacting proteins in the human brain
  JOURNAL   OMICS 16 (1-2), 3-17 (2012)
   PUBMED   22321011
REFERENCE   9  (bases 1 to 3164)
  AUTHORS   Gingras,S., Pelletier,S., Boyd,K. and Ihle,J.N.
  TITLE     Characterization of a family of novel cysteine- serine-rich nuclear
            proteins (CSRNP)
  JOURNAL   PLoS One 2 (8), e808 (2007)
   PUBMED   17726538
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3164)
  AUTHORS   Ishiguro,H., Tsunoda,T., Tanaka,T., Fujii,Y., Nakamura,Y. and
            Furukawa,Y.
  TITLE     Identification of AXUD1, a novel human gene induced by AXIN1 and
            its reduced expression in human carcinomas of the lung, liver,
            colon and kidney
  JOURNAL   Oncogene 20 (36), 5062-5066 (2001)
   PUBMED   11526492
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092053.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_033027.3.
            
            Summary: This gene encodes a protein that localizes to the nucleus
            and expression of this gene is induced in response to elevated
            levels of axin. The Wnt signalling pathway, which is negatively
            regulated by axin, is important in axis formation in early
            development and impaired regulation of this signalling pathway is
            often involved in tumors. A decreased level of expression of this
            gene in tumors compared to the level of expression in their
            corresponding normal tissues suggests that this gene product has a
            tumor suppressor function. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Feb 2016].
            
            Transcript Variant: This variant (2) contains an alternate 5'
            terminal exon, resulting in a novel 5' UTR and the use of a
            downstream start codon, compared to variant 1. The encoded isoform
            (b) has a shorter N-terminus compared to isoform a. Variants 2 and
            3 encode the same isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB053121.1, SRR1660805.175666.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000273153.10/ ENSP00000273153.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC092053.3         141571-141724
            155-399             AC092053.3         148440-148684
            400-659             AC092053.3         149906-150165
            660-974             AC092053.3         150711-151025
            975-3164            AC092053.3         151118-153307
FEATURES             Location/Qualifiers
     source          1..3164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..3164
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /note="cysteine and serine rich nuclear protein 1"
                     /db_xref="GeneID:64651"
                     /db_xref="HGNC:HGNC:14300"
                     /db_xref="MIM:606458"
     exon            1..154
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..399
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1964
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /note="isoform b is encoded by transcript variant 2; AXIN1
                     up-regulated 1; axin-1 up-regulated gene 1 protein;
                     TGF-beta-induced apoptosis protein 3"
                     /codon_start=1
                     /product="cysteine/serine-rich nuclear protein 1 isoform
                     b"
                     /protein_id="NP_149016.2"
                     /db_xref="CCDS:CCDS2682.1"
                     /db_xref="GeneID:64651"
                     /db_xref="HGNC:HGNC:14300"
                     /db_xref="MIM:606458"
                     /translation="MTGLLKRKFDQLDEDNSSVSSSSSSSGCQSRSCSPSSSVSRAWD
                     SEEEGPWDQMPLPDRDFCGPRSFTPLSILKRARRERPGRVAFDGITVFYFPRCQGFTS
                     VPSRGGCTLGMALRHSACRRFSLAEFAQEQARARHEKLRQRLKEEKLEMLQWKLSAAG
                     VPQAEAGLPPVVDAIDDASVEEDLAVAVAGGRLEEVSFLQPYPARRRRALLRASGVRR
                     IDREEKRELQALRQSREDCGCHCDRICDPETCSCSLAGIKCQMDHTAFPCGCCREGCE
                     NPMGRVEFNQARVQTHFIHTLTRLQLEQEAESFRELEAPAQGSPPSPGEEALVPTFPL
                     AKPPMNNELGDNSCSSDMTDSSTASSSASGTSEAPDCPTHPGLPGPGFQPGVDDDSLA
                     RILSFSDSDFGGEEEEEEEGSVGNLDNLSCFHPADIFGTSDPGGLASWTHSYSGCSFT
                     SGVLDENANLDASCFLNGGLEGSREGSLPGTSVPPSMDAGRSSSVDLSLSSCDSFELL
                     QALPDYSLGPHYTSQKVSDSLDNIEAPHFPLPGLSPPGDASSCFLESLMGFSEPAAEA
                     LDPFIDSQFEDTVPASLMEPVPV"
     exon            400..659
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..974
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..3164
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3144..3149
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /note="hexamer: AATAAA"
     polyA_site      3164
                     /gene="CSRNP1"
                     /gene_synonym="AXUD1; CSRNP-1; FAM130B; TAIP-3; URAX1"
                     /note="major polyA site"
ORIGIN      
        1 agtctcccgc cgccgccgcc gctgccggac gcgcagagcg aggggcggct ggaccgacgg
       61 ctgccgggcc gagcgcacag agtcgcggcg cagggggcgt ccccggccgg gacgcgggtc
      121 gcgtcgttgt cctccgcgag cgtccggatt gcaggctgtc tgtccccaga ccccagagca
      181 cgtccggcac caccatgact gggctgttga agaggaaatt tgaccagctg gatgaggaca
      241 actcctcggt ctcctcctcc tcctcttcct ctgggtgcca gtctcgctcc tgctccccaa
      301 gctcttctgt ctcccgtgcc tgggactcag aggaggaagg cccctgggat cagatgcccc
      361 tgcctgaccg tgacttctgc ggccccagaa gtttcacccc cctgtctatc ctgaagcggg
      421 ctcgccggga gcgcccaggc cgtgtagcct ttgatgggat caccgtcttc tacttccccc
      481 gctgccaggg cttcaccagt gtgcccagcc gtggtggctg tactctgggt atggcccttc
      541 gccacagtgc ttgccgtcgc ttctctttgg ctgagtttgc gcaggagcaa gcccgtgcac
      601 ggcacgagaa gctccgccag cgcttgaaag aggagaagtt ggagatgctg cagtggaagc
      661 tttcggcagc tggggtaccc caggcagagg cagggctgcc acctgtggtg gatgccattg
      721 atgacgcctc tgtggaggag gacttggcag tcgctgtggc aggtggccgg ttggaagaag
      781 tgagcttcct acagccctac ccagcccggc gacgtcgagc tctgctgagg gcttcaggtg
      841 tgcgaaggat cgatcgggag gagaagcggg agctgcaggc actgcgccaa tcccgggagg
      901 attgtggctg tcactgcgat aggatctgcg accctgagac ctgcagctgc agcctggcag
      961 gcatcaagtg ccagatggac cacacagcat tcccctgtgg ctgctgcagg gagggctgtg
     1021 agaaccccat gggccgtgtg gaatttaatc aggcaagagt tcagacccat ttcatccaca
     1081 cactcacccg cctgcagttg gaacaggagg ctgagagctt tagggagctg gaggcccctg
     1141 cccagggcag cccacccagc cctggtgagg aggccctggt ccctactttc ccactggcca
     1201 agccccccat gaacaatgag ctgggagaca acagctgcag cagcgacatg actgattctt
     1261 ctacagcatc ttcatcagca tcgggcacta gtgaggctcc tgactgcccc acccacccag
     1321 gcctgcctgg ccctggcttc cagcctggcg ttgatgatga cagcctggca cgcatcttga
     1381 gtttcagtga ctctgacttc ggtggggagg aggaggaaga ggaggaaggg agcgtgggga
     1441 acctggacaa cctcagctgc ttccatccag ctgacatctt tggtactagt gaccctggtg
     1501 gcctggccag ctggacccac agctattctg gctgtagctt cacatcaggc gtcctggatg
     1561 agaatgccaa cctggatgcc agctgcttcc taaatggtgg ccttgaaggg tcaagggaag
     1621 gcagccttcc tggcacctca gtgccaccca gcatggacgc tggccggagt agctcagtgg
     1681 atctcagctt gtcttcttgt gactcctttg agttactcca ggctctgcca gattatagtc
     1741 tggggcctca ctacacatca cagaaggtgt ctgacagcct ggacaacatc gaggcacctc
     1801 acttccccct gcctggcctg tctccacctg gggatgccag cagttgcttc ctggagtccc
     1861 tcatgggctt ctccgagcca gccgccgaag ccctagatcc ctttattgac agccagtttg
     1921 aggacactgt cccagcatct ctaatggagc ctgtgccggt gtgaggacca ggatgtcttt
     1981 tcccagcccc aagagacctg ttgctgcttt cttgtaatta tggggctccc cagagtctgc
     2041 gtaacagtct cccactggct ggctcaccca caggtgccat gtgcacactc ctggttttca
     2101 aacaattctc tggatttatt tatttgtttt aacttttctg tgctgaagag aggactgggg
     2161 ggagggggct tcccctttca gctgcccggc cccccacacc cacagcttgc tcttctatct
     2221 ccacaacgtg agcctggaag aggagaaaat gtggctcctc tggagcttgg cagaccactt
     2281 ttcggtcttt gcgtgatgtt ccttagccca aagacggtga gacagggctg aaatcaggtg
     2341 gcttctgcca ccctgagccc tagacccatg ggtggctaaa tccactggac tgtgaagact
     2401 ataatttatt tccataattt atttggagat tgaggaggct ttggttgcac ttctttggct
     2461 ggtgggtaat gccaggggtg gggtgggcac aggccctcaa gagccccttt tgccttgtag
     2521 tcctacacct tgccctgcct gggctttggt gcagactagg tgtggatttg agctctgtga
     2581 tctatgtctg ctgcctggct cctagatggc tctgtgggca ggtgctggcc aaggacatca
     2641 tctaggcagg gggagagcct gggctgaaca gctgtgacca aaactccctt ctgccccacc
     2701 ctgccccctc cacttcctgc cctctgttcc atcttccccc ttcccaaagg ccacagcctt
     2761 tattccaggc ccagggatgt aggaggggga aggaggaaac aggaagccca gagagggcaa
     2821 agggcctacc tcggggcgcg aaccatgccc cagactatta tctcagggct ttctgggcac
     2881 tgcacttcag cgtggcccac ctgcccatgc cctgaggcca gttggcgagg ggtggctcct
     2941 gagggttttt ataccctttg tttgctaatg tttaattttg catcataatt tctacattgt
     3001 ccctgagtgt cagaactata atttattcca tttctctctg tgtctgtgcc aagaaacgca
     3061 ggctctgggc ctgccccttg cccaggaggc cttgccagcc tgtgtgcttg tgggaacacc
     3121 ttgtacctga gcttacaggt accaataaag aggctttatt ttta
//
