LOCUS       NM_006574               2154 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chondroitin sulfate proteoglycan 5 (CSPG5), transcript
            variant 1, mRNA.
ACCESSION   NM_006574
VERSION     NM_006574.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Pinter,A., Hevesi,Z., Zahola,P., Alpar,A. and Hanics,J.
  TITLE     Chondroitin sulfate proteoglycan-5 forms perisynaptic matrix
            assemblies in the adult rat cortex
  JOURNAL   Cell Signal 74, 109710 (2020)
   PUBMED   32653642
  REMARK    GeneRIF: Chondroitin sulfate proteoglycan-5 forms perisynaptic
            matrix assemblies in the adult rat cortex.
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   So,H.C., Fong,P.Y., Chen,R.Y., Hui,T.C., Ng,M.Y., Cherny,S.S.,
            Mak,W.W., Cheung,E.F., Chan,R.C., Chen,E.Y., Li,T. and Sham,P.C.
  TITLE     Identification of neuroglycan C and interacting partners as
            potential susceptibility genes for schizophrenia in a Southern
            Chinese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (1), 103-113 (2010)
   PUBMED   19367581
  REMARK    GeneRIF: results suggest that NGC may be a novel candidate gene,
            and neuregulin signaling pathways may play an important role in
            schizophrenia
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Ichihara-Tanaka,K., Oohira,A., Rumsby,M. and Muramatsu,T.
  TITLE     Neuroglycan C is a novel midkine receptor involved in process
            elongation of oligodendroglial precursor-like cells
  JOURNAL   J Biol Chem 281 (41), 30857-30864 (2006)
   PUBMED   16901907
  REMARK    GeneRIF: neuroglycan C is a novel component of midkine receptors
            involved in process elongation
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Aono,S., Tokita,Y., Yasuda,Y., Hirano,K., Yamauchi,S., Shuo,T.,
            Matsui,F., Keino,H., Kashiwai,A., Kawamura,N., Shimada,A.,
            Kishikawa,M., Asai,M. and Oohira,A.
  TITLE     Expression and identification of a new splice variant of
            neuroglycan C, a transmembrane chondroitin sulfate proteoglycan, in
            the human brain
  JOURNAL   J Neurosci Res 83 (1), 110-118 (2006)
   PUBMED   16299773
  REMARK    GeneRIF: NGC IV, which was first found in the present study, had
            the shortest cytoplasmic domain among the four variants
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Kinugasa,Y., Ishiguro,H., Tokita,Y., Oohira,A., Ohmoto,H. and
            Higashiyama,S.
  TITLE     Neuroglycan C, a novel member of the neuregulin family
  JOURNAL   Biochem Biophys Res Commun 321 (4), 1045-1049 (2004)
   PUBMED   15358134
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Hassel,B., Schreff,M., Stube,E.M., Blaich,U. and Schumacher,S.
  TITLE     CALEB/NGC interacts with the Golgi-associated protein PIST
  JOURNAL   J Biol Chem 278 (41), 40136-40143 (2003)
   PUBMED   12885772
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Yasuda,Y., Tokita,Y., Aono,S., Matsui,F., Ono,T., Sonta,S.,
            Watanabe,E., Nakanishi,Y. and Oohira,A.
  TITLE     Cloning and chromosomal mapping of the human gene of neuroglycan C
            (NGC), a neural transmembrane chondroitin sulfate proteoglycan with
            an EGF module
  JOURNAL   Neurosci Res 32 (4), 313-322 (1998)
   PUBMED   9950058
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB636494.1, AF461087.1,
            AW003890.1 and BM674119.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_006574.3.
            
            Summary: The protein encoded by this gene is a proteoglycan that
            may function as a neural growth and differentiation factor. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, May 2011].
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            segment compared to variant 3. The resulting isoform (1) has the
            same N- and C-termini but is shorter compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461087.1, SRR3476690.355884.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264723.9/ ENSP00000264723.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                DB636494.1         5-74
            71-734              AF461087.1         1998-2661
            735-735             AW003890.1         644-644
            736-1509            AF461087.1         2663-3436
            1510-2154           BM674119.1         18-662              c
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2154
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /note="chondroitin sulfate proteoglycan 5"
                     /db_xref="GeneID:10675"
                     /db_xref="HGNC:HGNC:2467"
                     /db_xref="MIM:606775"
     exon            1..269
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1792
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; acidic leucine-rich EGF-like domain-containing
                     brain protein; chondroitin sulfate proteoglycan 5
                     (neuroglycan C)"
                     /codon_start=1
                     /product="chondroitin sulfate proteoglycan 5 isoform 1
                     precursor"
                     /protein_id="NP_006565.2"
                     /db_xref="CCDS:CCDS2757.1"
                     /db_xref="GeneID:10675"
                     /db_xref="HGNC:HGNC:2467"
                     /db_xref="MIM:606775"
                     /translation="MGRAGGGGPGRGPPPLLLFLGAALVLASGAVPAREAGSAVEAEE
                     LVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLE
                     ADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDK
                     LSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDG
                     EGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLD
                     EEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPG
                     SSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVEN
                     IGAFCRCNTQDYIWHKGMRCESIITDFQVMCVAVGSAALVLLLLFMMTVFFAKKLYLL
                     KTENTKLRRTNKFRTPSELHNDNFSLSTIAEGSHPNDDPSAPHKIQEVLKSCLKEEES
                     FNIQNSMSPKLEGGKGDQADLDVNCLQNNLT"
     exon            270..1365
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1554
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..1630
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..2154
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2133..2138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /note="hexamer: AATAAA"
     polyA_site      2154
                     /gene="CSPG5"
                     /gene_synonym="NGC"
                     /note="major polyA site"
ORIGIN      
        1 aggcgcggcg cgccggggac agcggcggac ggcggcggcg gcggcatgcg gctcctcgcg
       61 ctgcccatcg tgggctgagg cggccgcaga accggcggga ggcgcggcgg ccgggcgagc
      121 cgagggcgca gccagccggg cggaccgcgg acagcggtcg gggcgccgcg ccatggggcg
      181 agccgggggc gggggcccgg gccgggggcc gccgccactg ctgctgtttc tgggggccgc
      241 gctggtcctg gcctctgggg ccgtgccggc gcgtgaggcg ggcagcgcgg ttgaggccga
      301 agagctggtg aagggcagcc cggcgtggga gccgcctgcc aacgacacgc gggaagaagc
      361 cggcccacca gcggctgggg aagatgaggc gtcgtggacg gcgcccggtg gcgagctggc
      421 cgggccagaa gaggtgctgc aggagtcggc tgcggtgacc ggcaccgcct ggctggaagc
      481 tgacagccca ggcctgggag gagtgaccgc agaggcgggc agcggcgatg cccaggccct
      541 tccagctacg ctccaggctc cccacgaggt cctcgggcag tcaatcatgc cccctgccat
      601 tcctgaggct acagaggcca gcgggccacc ctcccccacc cccggcgaca agctgagccc
      661 agcttctgaa ctccccaagg agagcccctt ggaggtttgg ctgaacctgg ggggcagcac
      721 acccgaccct caagggccag agctgactta cccatttcag ggcaccctgg agccccaacc
      781 ggcatcagat atcattgaca tcgactactt cgaaggactg gatggtgagg gtcgtggcgc
      841 agatctgggg agcttcccag ggtcaccagg aacctcagag aaccaccctg atactgaggg
      901 agagacccct tcctggagcc tgcttgactt atacgatgat ttcaccccct tcgatgaatc
      961 tgatttctac cccaccacat ccttttatga tgacttggat gaagaggagg aggaagagga
     1021 ggatgacaaa gatgcagtag gaggtggaga cctagaagat gaaaatgagc ttctagtgcc
     1081 cactgggaag cctggtctgg ggcccgggac aggccagccc accagtcggt ggcatgctgt
     1141 ccctccacag cacactctgg ggtcggtccc cggcagcagc atcgccctca ggccccgccc
     1201 aggagagcca ggcagggact tggcctccag tgaaaatggc actgagtgcc gcagtggctt
     1261 tgtgcggcat aacggctcct gccggtcagt gtgcgacctc ttcccaagtt actgtcacaa
     1321 tggcggccag tgctacctgg tggagaacat aggggccttc tgcaggtgca acacgcagga
     1381 ctacatctgg cacaagggga tgcgctgcga gtccatcatc accgacttcc aggtgatgtg
     1441 cgtggccgtg ggctcggctg ccctcgtcct gctcctgctc ttcatgatga cggtgttctt
     1501 tgccaagaag ctctacctgc tcaagacgga gaataccaag ctgcgtagga ccaacaaatt
     1561 ccggacccca tctgagctcc acaatgataa cttctccctc tccaccattg ccgagggctc
     1621 tcacccaaat gatgatccta gtgctcccca caaaatccag gaggttctca agtcctgcct
     1681 gaaagaggag gagtcattta acatccagaa ctccatgtcg cccaaacttg agggtggcaa
     1741 aggtgaccag gctgacttgg atgtgaactg tcttcagaat aatttaacct aaagcagagc
     1801 aagaagagag gaagcggggg tagtgggtgg ggggtagggg aagaaacatt atctcctctt
     1861 gtacagagtc tatttcttgt aaccatttgt taaactcttt tctttttctg atctcatggc
     1921 atgcttttat gtattttgta caggaggcaa aaaaatactt aaaataagca aagaaactga
     1981 acagaattgc atacattggg ttgttttttc tgtgctgtct gtacattgct tctgctgctg
     2041 tgatttctaa acctgtgctg ttattcaact gacttttttt tgtactttga cccacgtttt
     2101 tttgaaatac cagtaaaaaa caaagttctt gaaataaaac tttttaaaaa gtta
//
