LOCUS       NM_001320                929 bp    mRNA    linear   PRI 30-APR-2025
DEFINITION  Homo sapiens casein kinase 2 beta (CSNK2B), transcript variant 1,
            mRNA.
ACCESSION   NM_001320
VERSION     NM_001320.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 929)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   2  (bases 1 to 929)
  AUTHORS   Azad,P., Zhou,D., Tu,H.C., Villafuerte,F.C., Traver,D., Rana,T.M.
            and Haddad,G.G.
  TITLE     Long noncoding RNA HIKER regulates erythropoiesis in Monge's
            disease via CSNK2B
  JOURNAL   J Clin Invest 133 (11), e165831 (2023)
   PUBMED   37022795
  REMARK    GeneRIF: Long noncoding RNA HIKER regulates erythropoiesis in
            Monge's disease via CSNK2B.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 929)
  AUTHORS   Matsumoto,M., Modliszewski,J.L., Shinozaki,K., Maezawa,R.,
            Perez,V.M., Ishikawa,Y., Suzuki,R., McKnight,K.L., Masaki,T.,
            Hirai-Yuki,A., Kohara,M., Lemon,S.M., Selitsky,S.R. and Yamane,D.
  TITLE     CSNK2B modulates IRF1 binding to functional DNA elements and
            promotes basal and agonist-induced antiviral signaling
  JOURNAL   Nucleic Acids Res 51 (9), 4451-4466 (2023)
   PUBMED   37094077
  REMARK    GeneRIF: CSNK2B modulates IRF1 binding to functional DNA elements
            and promotes basal and agonist-induced antiviral signaling.
REFERENCE   4  (bases 1 to 929)
  AUTHORS   Di Stazio,M., Zanus,C., Faletra,F., Pesaresi,A., Ziccardi,I.,
            Morgan,A., Girotto,G., Costa,P., Carrozzi,M., d'Adamo,A.P. and
            Musante,L.
  TITLE     Haploinsufficiency as a Foreground Pathomechanism of
            Poirer-Bienvenu Syndrome and Novel Insights Underlying the
            Phenotypic Continuum of CSNK2B-Associated Disorders
  JOURNAL   Genes (Basel) 14 (2), 250 (2023)
   PUBMED   36833176
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 929)
  AUTHORS   Li,X., Xie,S., Xia,Q., Yan,J., Chen,S. and Shen,J.
  TITLE     MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell
            Proliferation via a CSNK2B/CDK4 Axis
  JOURNAL   Technol Cancer Res Treat 22, 15330338221150544 (2023)
   PUBMED   36617978
  REMARK    GeneRIF: MicroRNA-1205 Suppresses Hepatocellular Carcinoma Cell
            Proliferation via a CSNK2B/CDK4 Axis.
REFERENCE   6  (bases 1 to 929)
  AUTHORS   Lippa,N., Mulhern,M., Ernst Florido,M., Earley,C. and Sands,T.T.
  TITLE     CSNK2B-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   39236211
REFERENCE   7  (bases 1 to 929)
  AUTHORS   Schubert,U., Schneider,T., Henklein,P., Hoffmann,K., Berthold,E.,
            Hauser,H., Pauli,G. and Porstmann,T.
  TITLE     Human-immunodeficiency-virus-type-1-encoded Vpu protein is
            phosphorylated by casein kinase II
  JOURNAL   Eur J Biochem 204 (2), 875-883 (1992)
   PUBMED   1541298
REFERENCE   8  (bases 1 to 929)
  AUTHORS   Litchfield,D.W., Lozeman,F.J., Cicirelli,M.F., Harrylock,M.,
            Ericsson,L.H., Piening,C.J. and Krebs,E.G.
  TITLE     Phosphorylation of the beta subunit of casein kinase II in human
            A431 cells. Identification of the autophosphorylation site and a
            site phosphorylated by p34cdc2
  JOURNAL   J Biol Chem 266 (30), 20380-20389 (1991)
   PUBMED   1939094
REFERENCE   9  (bases 1 to 929)
  AUTHORS   Voss,H., Wirkner,U., Jakobi,R., Hewitt,N.A., Schwager,C.,
            Zimmermann,J., Ansorge,W. and Pyerin,W.
  TITLE     Structure of the gene encoding human casein kinase II subunit beta
  JOURNAL   J Biol Chem 266 (21), 13706-13711 (1991)
   PUBMED   1856204
REFERENCE   10 (bases 1 to 929)
  AUTHORS   Teitz,T., Eli,D., Penner,M., Bakhanashvili,M., Naiman,T.,
            Timme,T.L., Wood,C.M., Moses,R.E. and Canaani,D.
  TITLE     Expression of the cDNA for the beta subunit of human casein kinase
            II confers partial UV resistance on xeroderma pigmentosum cells
  JOURNAL   Mutat Res 236 (1), 85-97 (1990)
   PUBMED   1694965
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC112017.1 and DB570461.2.
            
            On Nov 30, 2019 this sequence version replaced NM_001320.6.
            
            Summary: This gene encodes the beta subunit of casein kinase II, a
            ubiquitous protein kinase which regulates metabolic pathways,
            signal transduction, transcription, translation, and replication.
            The enzyme is composed of three subunits, alpha, alpha prime and
            beta, which form a tetrameric holoenzyme. The alpha and alpha prime
            subunits are catalytic, while the beta subunit serves regulatory
            functions. The enzyme localizes to the endoplasmic reticulum and
            the Golgi apparatus. Two transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Sep
            2013].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ065124.1, BQ643279.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375882.7/ ENSP00000365042.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-857               BC112017.1         14-870
            858-929             DB570461.2         620-691
FEATURES             Location/Qualifiers
     source          1..929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..929
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /note="casein kinase 2 beta"
                     /db_xref="GeneID:1460"
                     /db_xref="HGNC:HGNC:2460"
                     /db_xref="MIM:115441"
     exon            1..129
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     exon            130..212
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..788
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     phosvitin; casein kinase II subunit beta; alternative
                     name: G5a, phosvitin; Casein kinase II beta subunit; CK II
                     beta; protein G5a; casein kinase 2, beta polypeptide;
                     CSNK2B-LY6G5B-532; CSNK2B-LY6G5B-560; CSNK2B-LY6G5B-562;
                     CSNK2B-LY6G5B-1072; CSNK2B-LY6G5B-1103"
                     /codon_start=1
                     /product="casein kinase II subunit beta isoform 1"
                     /protein_id="NP_001311.3"
                     /db_xref="CCDS:CCDS4712.1"
                     /db_xref="GeneID:1460"
                     /db_xref="HGNC:HGNC:2460"
                     /db_xref="MIM:115441"
                     /translation="MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVP
                     HYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQ
                     QGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFG
                     TGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR"
     exon            213..315
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     exon            316..431
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     exon            508..697
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     exon            698..929
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      908..913
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /note="hexamer: AATAAA"
     polyA_site      929
                     /gene="CSNK2B"
                     /gene_synonym="CK2B; CK2N; Ckb1; Ckb2; CSK2B; G5A;
                     POBINDS"
                     /note="major polyA site"
ORIGIN      
        1 aatttccact ccccccaccc cacttcgcct gccgcggtcg ggtccgcggc ctgcgctgta
       61 gcggtcgccg ccgttccctg gaagtagcaa cttccctacc ccaccccagt cctggtcccc
      121 gtccagccgc tgacgtgaag atgagcagct cagaggaggt gtcctggatt tcctggttct
      181 gtgggctccg tggcaatgaa ttcttctgtg aagtggatga agactacatc caggacaaat
      241 ttaatcttac tggactcaat gagcaggtcc ctcactatcg acaagctcta gacatgatct
      301 tggacctgga gcctgatgaa gaactggaag acaaccccaa ccagagtgac ctgattgagc
      361 aggcagccga gatgctttat ggattgatcc acgcccgcta catccttacc aaccgtggca
      421 tcgcccagat gttggaaaag taccagcaag gagactttgg ttactgtcct cgtgtgtact
      481 gtgagaacca gccaatgctt cccattggcc tttcagacat cccaggtgaa gccatggtga
      541 agctctactg ccccaagtgc atggatgtgt acacacccaa gtcatcaaga caccatcaca
      601 cggatggcgc ctacttcggc actggtttcc ctcacatgct cttcatggtg catcccgagt
      661 accggcccaa gagacctgcc aaccagtttg tgcccaggct ctacggtttc aagatccatc
      721 cgatggccta ccagctgcag ctccaagccg ccagcaactt caagagccca gtcaagacga
      781 ttcgctgatt ccctccccca cctgtcctgc agtctttgac ttttcctttc ttttttgcca
      841 ccctttcagg aaccctgtat ggtttttagt ttaaattaaa ggagtcgtta tcgtggtggg
      901 aatatgaaat aaagtagaag aaaaggcca
//
