LOCUS       NM_001256686            1309 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens casein kinase 2 alpha 3 (CSNK2A3), mRNA.
ACCESSION   NM_001256686
VERSION     NM_001256686.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1309)
  AUTHORS   Hung,M.S., Lin,Y.C., Mao,J.H., Kim,I.J., Xu,Z., Yang,C.T.,
            Jablons,D.M. and You,L.
  TITLE     Functional polymorphism of the CK2alpha intronless gene plays
            oncogenic roles in lung cancer
  JOURNAL   PLoS One 5 (7), e11418 (2010)
   PUBMED   20625391
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1309)
  AUTHORS   Trembley,J.H., Tatsumi,S., Sakashita,E., Loyer,P., Slaughter,C.A.,
            Suzuki,H., Endo,H., Kidd,V.J. and Mayeda,A.
  TITLE     Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2
            phosphorylation
  JOURNAL   Mol Cell Biol 25 (4), 1446-1457 (2005)
   PUBMED   15684395
REFERENCE   3  (bases 1 to 1309)
  AUTHORS   Pechkova,E., Zanotti,G. and Nicolini,C.
  TITLE     Three-dimensional atomic structure of a catalytic subunit mutant of
            human protein kinase CK2
  JOURNAL   Acta Crystallogr D Biol Crystallogr 59 (Pt 12), 2133-2139 (2003)
   PUBMED   14646071
REFERENCE   4  (bases 1 to 1309)
  AUTHORS   Ermakova,I., Boldyreff,B., Issinger,O.G. and Niefind,K.
  TITLE     Crystal structure of a C-terminal deletion mutant of human protein
            kinase CK2 catalytic subunit
  JOURNAL   J Mol Biol 330 (5), 925-934 (2003)
   PUBMED   12860116
REFERENCE   5  (bases 1 to 1309)
  AUTHORS   Keller,D.M. and Lu,H.
  TITLE     p53 serine 392 phosphorylation increases after UV through induction
            of the assembly of the CK2.hSPT16.SSRP1 complex
  JOURNAL   J Biol Chem 277 (51), 50206-50213 (2002)
   PUBMED   12393879
REFERENCE   6  (bases 1 to 1309)
  AUTHORS   Wirkner,U., Voss,H., Lichter,P., Weitz,S., Ansorge,W. and Pyerin,W.
  TITLE     Human casein kinase II subunit alpha: sequence of a processed
            (pseudo)gene and its localization on chromosome 11
  JOURNAL   Biochim Biophys Acta 1131 (2), 220-222 (1992)
   PUBMED   1610905
REFERENCE   7  (bases 1 to 1309)
  AUTHORS   Boldyreff,B., Klett,C., Gottert,E., Geurts van Kessel,A.,
            Hameister,H. and Issinger,O.G.
  TITLE     Assignment of casein kinase 2 alpha sequences to two different
            human chromosomes
  JOURNAL   Hum Genet 89 (1), 79-82 (1992)
   PUBMED   1577469
REFERENCE   8  (bases 1 to 1309)
  AUTHORS   Yang-Feng,T.L., Zheng,K., Kopatz,I., Naiman,T. and Canaani,D.
  TITLE     Mapping of the human casein kinase II catalytic subunit genes: two
            loci carrying the homologous sequences for the alpha subunit
  JOURNAL   Nucleic Acids Res 19 (25), 7125-7129 (1991)
   PUBMED   1766873
REFERENCE   9  (bases 1 to 1309)
  AUTHORS   Lozeman,F.J., Litchfield,D.W., Piening,C., Takio,K., Walsh,K.A. and
            Krebs,E.G.
  TITLE     Isolation and characterization of human cDNA clones encoding the
            alpha and the alpha' subunits of casein kinase II
  JOURNAL   Biochemistry 29 (36), 8436-8447 (1990)
   PUBMED   2174700
REFERENCE   10 (bases 1 to 1309)
  AUTHORS   Meisner,H., Heller-Harrison,R., Buxton,J. and Czech,M.P.
  TITLE     Molecular cloning of the human casein kinase II alpha subunit
  JOURNAL   Biochemistry 28 (9), 4072-4076 (1989)
   PUBMED   2752008
  REMARK    Erratum:[Biochemistry 1989 Aug 22;28(17):7138]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023946.5.
            
            On May 17, 2019 this sequence version replaced NM_001256686.1.
            
            Summary: This gene encodes a protein that is highly similar to the
            casein kinase II alpha protein. Casein kinase II is a
            serine/threonine protein kinase complex that phosphorylates
            numerous substrates including casein. The alpha subunit is the
            catalytic component of the complex. Mutations in this gene may be
            associated with a susceptibility to lung cancer. There are
            contradictory views among published reports of this gene as to
            whether or not it is a protein-coding gene or a processed
            pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by
            RefSeq, Feb 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY112721.1, SRR1660809.191092.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000528848.3/ ENSP00000473553.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1309              AC023946.5         150685-151993
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1309
                     /gene="CSNK2A3"
                     /gene_synonym="CSNK2A1P"
                     /note="casein kinase 2 alpha 3"
                     /db_xref="GeneID:283106"
                     /db_xref="HGNC:HGNC:2458"
     exon            1..1309
                     /gene="CSNK2A3"
                     /gene_synonym="CSNK2A1P"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1307
                     /gene="CSNK2A3"
                     /gene_synonym="CSNK2A1P"
                     /EC_number="2.7.11.1"
                     /note="casein kinase 2, alpha 1 polypeptide pseudogene;
                     casein kinase 2, alpha 3 polypeptide; CK II alpha 3;
                     casein kinase II alpha 1 polypeptide pseudogene"
                     /codon_start=1
                     /product="casein kinase II subunit alpha 3"
                     /protein_id="NP_001243615.1"
                     /db_xref="CCDS:CCDS59224.1"
                     /db_xref="GeneID:283106"
                     /db_xref="HGNC:HGNC:2458"
                     /translation="MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRK
                     LGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVK
                     DPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPH
                     NVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRL
                     GCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRH
                     SRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARM
                     GSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ"
ORIGIN      
        1 ccgctgccgc ttccaccaca gtgtgaagaa aacaggtctg aaacaaggtc ttacccccaa
       61 gctgcttctg aacacagtga ctgccagatc tccaaacatc aagtccagct ttgtccgcca
      121 acctgtctga catgtcggga cccgtgccaa gcagggccag agtttacaca gatgttaata
      181 cacacagacc tcgagaatac tgggattacg agtcacatgt ggtggaatgg ggaaatcaag
      241 atgactacca gctggttcga aaattaggcc gaggtaaata cagtgaagta tttgaagcca
      301 tcaacatcac aaataatgaa aaagttgttg ttaaaattct caagccagta aaaaagaaga
      361 aaattaagcg tgaaataaag attttggaga atttgagagg aggtcccaac atcatcacac
      421 tggcagacat tgtaaaagac cctgtgtcac gaacccccgc cttggttttt gaacacgtaa
      481 acaacacaga cttcaagcaa ttgtaccaga cgttaacaga ctatgatatt cgattttaca
      541 tgtatgagat tctgaaggcc ctggattatt gtcacagcat gggaattatg cacagagatg
      601 tcaagcccca taatgtcatg attgatcatg agcacagaaa gctacgacta atagactggg
      661 gtttggctga gttttatcat cctggccaag aatataatgt ccgagttgct tcccgatact
      721 tcaaaggtcc tgagctactt gtagactatc agatgtacga ttatagtttg gatatgtgga
      781 gattgggttg tatgctggca agtatgatct ttcggaagga gccatttttc catggacgtg
      841 acaattatga tcagttggtg aggatagcca agtttctggg gacagaagat ttatatggct
      901 atattgacaa atacaacatt gaattagatc cacgtttcaa tgatatcttg ggcagacact
      961 ctcgaaagcg atgggaacgc tttgtccaca gtgaaaatca gcaccttgtc agccctgagg
     1021 ccttggattt cctggacaaa ctgctgcgat atgaccacca gtcacggctt actgcaagag
     1081 aggccatgga gcacccctat ttctacactg ttgtgaagga ccaggctcga atgggttcat
     1141 ctagcatgcc agggggcagt acgcccgtca gcagcgccaa tgtgatgtca gggatttctt
     1201 cagtgccaac tccttcaccc cttggacctc tggcaggctc accagtgatt gctgctgcca
     1261 acccccttgg gatgcctgtt ccagctgcca ctggcgctca gcagtaacg
//
