LOCUS       NM_001896               1887 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens casein kinase 2 alpha 2 (CSNK2A2), mRNA.
ACCESSION   NM_001896
VERSION     NM_001896.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Ruggeri,E., Frezzato,F., Mouawad,N., Pizzi,M., Scarmozzino,F.,
            Capasso,G., Trimarco,V., Quotti Tubi,L., Cellini,A.,
            Cavarretta,C.A., Ruocco,V., Serafin,A., Angotzi,F., Danesin,N.,
            Manni,S., Facco,M., Piazza,F., Trentin,L. and Visentin,A.
  TITLE     Protein kinase CK2alpha is overexpressed in classical hodgkin
            lymphoma, regulates key signaling pathways, PD-L1 and may represent
            a new target for therapy
  JOURNAL   Front Immunol 15, 1393485 (2024)
   PUBMED   38807597
  REMARK    GeneRIF: Protein kinase CK2alpha is overexpressed in classical
            hodgkin lymphoma, regulates key signaling pathways, PD-L1 and may
            represent a new target for therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Montenarh,M. and Gotz,C.
  TITLE     Protein Kinase CK2alpha', More than a Backup of CK2alpha
  JOURNAL   Cells 12 (24), 2834 (2023)
   PUBMED   38132153
  REMARK    GeneRIF: Protein Kinase CK2alpha', More than a Backup of CK2alpha.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Homma,M.K., Nakato,R., Niida,A., Bando,M., Fujiki,K., Yokota,N.,
            Yamamoto,S., Shibata,T., Takagi,M., Yamaki,J., Kozuka-Hata,H.,
            Oyama,M., Shirahige,K. and Homma,Y.
  TITLE     Cell cycle-dependent gene networks for cell proliferation activated
            by nuclear CK2alpha complexes
  JOURNAL   Life Sci Alliance 7 (1), e202302077 (2023)
   PUBMED   37907238
  REMARK    GeneRIF: Cell cycle-dependent gene networks for cell proliferation
            activated by nuclear CK2alpha complexes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Yang,S., Peng,L.R., Yu,A.Q. and Li,J.
  TITLE     CSNK2A2 promotes hepatocellular carcinoma progression through
            activation of NF-kappaB pathway
  JOURNAL   Ann Hepatol 28 (5), 101118 (2023)
   PUBMED   37268061
  REMARK    GeneRIF: CSNK2A2 promotes hepatocellular carcinoma progression
            through activation of NF-kappaB pathway.
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Yun,C.W., Lee,J.H. and Lee,S.H.
  TITLE     Casein Kinase 2alpha Augments Oxaliplatin Resistance in Colorectal
            Cancer Cells by Increasing ABCE1 Expression
  JOURNAL   Anticancer Res 43 (6), 2519-2525 (2023)
   PUBMED   37247928
  REMARK    GeneRIF: Casein Kinase 2alpha Augments Oxaliplatin Resistance in
            Colorectal Cancer Cells by Increasing ABCE1 Expression.
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Hagiwara,T., Nakaya,K., Nakamura,Y., Nakajima,H., Nishimura,S. and
            Taya,Y.
  TITLE     Specific phosphorylation of the acidic central region of the N-myc
            protein by casein kinase II
  JOURNAL   Eur J Biochem 209 (3), 945-950 (1992)
   PUBMED   1425701
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Lin,A., Frost,J., Deng,T., Smeal,T., al-Alawi,N., Kikkawa,U.,
            Hunter,T., Brenner,D. and Karin,M.
  TITLE     Casein kinase II is a negative regulator of c-Jun DNA binding and
            AP-1 activity
  JOURNAL   Cell 70 (5), 777-789 (1992)
   PUBMED   1516134
  REMARK    Erratum:[Cell. 1992 Nov 27;71(5):887.. PMID: 1423636]
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Sacks,D.B., Davis,H.W., Crimmins,D.L. and McDonald,J.M.
  TITLE     Insulin-stimulated phosphorylation of calmodulin
  JOURNAL   Biochem J 286 (Pt 1) (Pt 1), 211-216 (1992)
   PUBMED   1520270
REFERENCE   9  (bases 1 to 1887)
  AUTHORS   Schubert,U., Schneider,T., Henklein,P., Hoffmann,K., Berthold,E.,
            Hauser,H., Pauli,G. and Porstmann,T.
  TITLE     Human-immunodeficiency-virus-type-1-encoded Vpu protein is
            phosphorylated by casein kinase II
  JOURNAL   Eur J Biochem 204 (2), 875-883 (1992)
   PUBMED   1541298
REFERENCE   10 (bases 1 to 1887)
  AUTHORS   Marais,R.M., Hsuan,J.J., McGuigan,C., Wynne,J. and Treisman,R.
  TITLE     Casein kinase II phosphorylation increases the rate of serum
            response factor-binding site exchange
  JOURNAL   EMBO J 11 (1), 97-105 (1992)
   PUBMED   1740119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009107.11.
            
            On Nov 23, 2018 this sequence version replaced NM_001896.3.
            
            Summary: This gene encodes the alpha', or alpha 2, catalytic
            subunit of the protein kinase enzyme, casein kinase 2 (CK2). Casein
            kinase 2 is a serine/threonine protein kinase that phosphorylates
            acidic proteins such as casein. It is involved in various cellular
            processes, including cell cycle control, apoptosis, and circadian
            rhythms. This heterotetrameric kinase includes two catalytic
            subunits, either alpha or alpha', and two regulatory beta subunits.
            The closely related gene paralog encoding the alpha, or alpha 1
            subunit (CSNK2A1, Gene ID: 1457) is found on chromosome 20. An
            intronic variant in this gene (alpha 2) may be associated with
            leukocyte telomere length in a South Asian population. A related
            transcribed pseudogene is found on chromosome 11. [provided by
            RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008812.2, SRR1163655.325568.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262506.8/ ENSP00000262506.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               AC009107.11        69210-69683         c
            475-586             AC009107.11        68310-68421         c
            587-688             AC009107.11        58332-58433         c
            689-739             AC009107.11        55837-55887         c
            740-799             AC009107.11        46028-46087         c
            800-883             AC009107.11        40187-40270         c
            884-994             AC009107.11        39262-39372         c
            995-1096            AC009107.11        38784-38885         c
            1097-1197           AC009107.11        38161-38261         c
            1198-1346           AC009107.11        37137-37285         c
            1347-1440           AC009107.11        35631-35724         c
            1441-1887           AC009107.11        29484-29930         c
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q21"
     gene            1..1887
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /note="casein kinase 2 alpha 2"
                     /db_xref="GeneID:1459"
                     /db_xref="HGNC:HGNC:2459"
                     /db_xref="MIM:115442"
     exon            1..474
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..1423
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /EC_number="2.7.11.1"
                     /note="CK II alpha'; casein kinase 2, alpha prime
                     polypeptide; casein kinase 2 alpha'"
                     /codon_start=1
                     /product="casein kinase II subunit alpha'"
                     /protein_id="NP_001887.1"
                     /db_xref="CCDS:CCDS10794.1"
                     /db_xref="GeneID:1459"
                     /db_xref="HGNC:HGNC:2459"
                     /db_xref="MIM:115442"
                     /translation="MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVR
                     KLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTV
                     KDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKP
                     HNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWS
                     LGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQ
                     HSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ
                     PCADNAVLSSGLTAAR"
     exon            475..586
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..688
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            689..739
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            740..799
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            800..883
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            884..994
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1096
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1197
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1346
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1440
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1887
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1867..1872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /note="hexamer: AATAAA"
     polyA_site      1887
                     /gene="CSNK2A2"
                     /gene_synonym="CK2A2; CK2alpha'; CSNK2A1"
                     /note="major polyA site"
ORIGIN      
        1 ctctcctcct tcttctccgc tgccgccgcc gctgcccctt tcccggccgg tggctgccgc
       61 tgccggtgcc gccgccgccg cctcctgggg gccgcgagcc gagcggagac cgccgcggag
      121 cgcgagcgcc gcccgccccg ccgccccgcc ggccgctcca gggccgggcc ggctcggccg
      181 gcgccccccg cgcccccagc ccgcccgccc ccgcgggccc ggcctggcgc ggccgcccgc
      241 cgccgcgctc ctcctcctcc tcctccagcg cccggcggcc cgctgcctcc tccgcccgac
      301 gccccgcgtc ccccgccgcg ccgccgccgc caccctctgc gccccgcgcc gccccccggt
      361 cccgcccgcc atgcccggcc cggccgcggg cagcagggcc cgggtctacg ccgaggtgaa
      421 cagtctgagg agccgcgagt actgggacta cgaggctcac gtcccgagct ggggtaatca
      481 agatgattac caactggttc gaaaacttgg tcggggaaaa tatagtgaag tatttgaggc
      541 cattaatatc accaacaatg agagagtggt tgtaaaaatc ctgaagccag tgaagaaaaa
      601 gaagataaaa cgagaggtta agattctgga gaaccttcgt ggtggaacaa atatcattaa
      661 gctgattgac actgtaaagg accccgtgtc aaagacacca gctttggtat ttgaatatat
      721 caataataca gattttaagc aactctacca gatcctgaca gactttgata tccggtttta
      781 tatgtatgaa ctacttaaag ctctggatta ctgccacagc aagggaatca tgcacaggga
      841 tgtgaaacct cacaatgtca tgatagatca ccaacagaaa aagctgcgac tgatagattg
      901 gggtctggca gaattctatc atcctgctca ggagtacaat gttcgtgtag cctcaaggta
      961 cttcaaggga ccagagctcc tcgtggacta tcagatgtat gattatagct tggacatgtg
     1021 gagtttgggc tgtatgttag caagcatgat ctttcgaagg gaaccattct tccatggaca
     1081 ggacaactat gaccagcttg ttcgcattgc caaggttctg ggtacagaag aactgtatgg
     1141 gtatctgaag aagtatcaca tagacctaga tccacacttc aacgatatcc tgggacaaca
     1201 ttcacggaaa cgctgggaaa actttatcca tagtgagaac agacaccttg tcagccctga
     1261 ggccctagat cttctggaca aacttctgcg atacgaccat caacagagac tgactgccaa
     1321 agaggccatg gagcacccat acttctaccc tgtggtgaag gagcagtccc agccttgtgc
     1381 agacaatgct gtgctttcca gtggtctcac ggcagcacga tgaagactgg aaagcgacgg
     1441 gtctgttgcg gttctcccac ttttccataa gcagaacaag aaccaaatca aacgtcttaa
     1501 cgcgtataga gagatcacgt tccgtgagca gacacaaaac ggtggcaggt ttggcgagca
     1561 cgaactagac caagcgaagg gcagcccacc accgtatatc aaacctcact tccgaatgta
     1621 aaaggctcac ttgcctttgg cttcctgttg acttcttccc gacccagaaa gcatggggaa
     1681 tgtgaagggt atgcagaatg ttgttggtta ctgttgctcc ccgagcccct cgactcgtcc
     1741 cgtggccgcc tgtttttcca gcaaaccacg ctaactagct gaccacagac tccacagtgg
     1801 ggggacgggc gcagtatgtg gcatggcggc agttacatat tattatttta aaagtatata
     1861 ttattgaata aaaggtttta aaagaaa
//
