LOCUS       NM_001364140            4665 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens casein kinase 1 gamma 3 (CSNK1G3), transcript variant
            8, mRNA.
ACCESSION   NM_001364140 XM_005271891
VERSION     NM_001364140.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4665)
  AUTHORS   Qiu,C.J., Hu,L.Y., Yang,J., Cao,J.J., Pei,B.G., Dai,R.R. and
            Pan,S.J.
  TITLE     A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and
            promotes glioma cell growth
  JOURNAL   Int J Biol Macromol 276 (Pt 2), 134025 (2024)
   PUBMED   39033888
  REMARK    GeneRIF: A novel nanoplatform-based circCSNK1G3 affects CBX7
            protein and promotes glioma cell growth.
REFERENCE   2  (bases 1 to 4665)
  AUTHORS   Piras,R., Ko,E.Y., Barrett,C., De Simone,M., Lin,X., Broz,M.T.,
            Tessaro,F.H.G., Castillo-Martin,M., Cordon-Cardo,C.,
            Goodridge,H.S., Di Vizio,D., Batish,M., Lawrenson,K., Chen,Y.G.,
            Chan,K.S. and Guarnerio,J.
  TITLE     circCsnk1g3- and circAnkib1-regulated interferon responses in
            sarcoma promote tumorigenesis by shaping the immune
            microenvironment
  JOURNAL   Nat Commun 13 (1), 7243 (2022)
   PUBMED   36433954
  REMARK    GeneRIF: circCsnk1g3- and circAnkib1-regulated interferon responses
            in sarcoma promote tumorigenesis by shaping the immune
            microenvironment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4665)
  AUTHORS   Agajanian,M.J., Potjewyd,F.M., Bowman,B.M., Solomon,S., LaPak,K.M.,
            Bhatt,D.P., Smith,J.L., Goldfarb,D., Axtman,A.D. and Major,M.B.
  TITLE     Protein proximity networks and functional evaluation of the casein
            kinase 1 gamma family reveal unique roles for CK1gamma3 in WNT
            signaling
  JOURNAL   J Biol Chem 298 (6), 101986 (2022)
   PUBMED   35487243
  REMARK    GeneRIF: Protein proximity networks and functional evaluation of
            the casein kinase 1 gamma family reveal unique roles for CK1gamma3
            in WNT signaling.
REFERENCE   4  (bases 1 to 4665)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 4665)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4665)
  AUTHORS   Kawakami,F., Suzuki,K. and Ohtsuki,K.
  TITLE     A novel consensus phosphorylation motif in sulfatide- and
            cholesterol-3-sulfate-binding protein substrates for CK1 in vitro
  JOURNAL   Biol Pharm Bull 31 (2), 193-200 (2008)
   PUBMED   18239272
REFERENCE   7  (bases 1 to 4665)
  AUTHORS   Morgan-Lappe,S., Woods,K.W., Li,Q., Anderson,M.G., Schurdak,M.E.,
            Luo,Y., Giranda,V.L., Fesik,S.W. and Leverson,J.D.
  TITLE     RNAi-based screening of the human kinome identifies Akt-cooperating
            kinases: a new approach to designing efficacious multitargeted
            kinase inhibitors
  JOURNAL   Oncogene 25 (9), 1340-1348 (2006)
   PUBMED   16247451
REFERENCE   8  (bases 1 to 4665)
  AUTHORS   Knippschild,U., Wolff,S., Giamas,G., Brockschmidt,C., Wittau,M.,
            Wurl,P.U., Eismann,T. and Stoter,M.
  TITLE     The role of the casein kinase 1 (CK1) family in different signaling
            pathways linked to cancer development
  JOURNAL   Onkologie 28 (10), 508-514 (2005)
   PUBMED   16186692
  REMARK    Review article
REFERENCE   9  (bases 1 to 4665)
  AUTHORS   McKay,R.M., Peters,J.M. and Graff,J.M.
  TITLE     The casein kinase I family in Wnt signaling
  JOURNAL   Dev Biol 235 (2), 388-396 (2001)
   PUBMED   11437445
REFERENCE   10 (bases 1 to 4665)
  AUTHORS   Kusuda,J., Hirai,M., Toyoda,A., Tanuma,R. and Hashimoto,K.
  TITLE     Cloning and chromosome mapping of the human casein kinase I gamma3
            gene (CSNK1G3)
  JOURNAL   Cytogenet Cell Genet 83 (1-2), 101-103 (1998)
   PUBMED   9925945
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC026422.5 and AC008541.6.
            
            On Jun 2, 2019 this sequence version replaced NM_001364140.1.
            
            Summary: This gene encodes a member of a family of serine/threonine
            protein kinases that phosphorylate caseins and other acidic
            proteins. A related protein in the African clawed frog participates
            in the transmission of Wnt/beta-catenin signaling. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (8) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (8) is
            1 aa longer compared to isoform 1 and is the longest isoform.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.156166.1,
                                           SRR1660805.99082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000696905.1/ ENSP00000512966.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               AC026422.5         33294-33687
            395-819             AC026422.5         66534-66958
            820-860             AC008541.6         128678-128718       c
            861-930             AC008541.6         124261-124330       c
            931-1079            AC008541.6         108284-108432       c
            1080-1314           AC008541.6         105862-106096       c
            1315-1400           AC008541.6         93672-93757         c
            1401-1485           AC008541.6         93314-93398         c
            1486-1634           AC008541.6         91267-91415         c
            1635-1730           AC008541.6         90411-90506         c
            1731-1826           AC008541.6         86691-86786         c
            1827-1933           AC008541.6         76995-77101         c
            1934-1957           AC008541.6         76463-76486         c
            1958-4665           AC008541.6         64776-67483         c
FEATURES             Location/Qualifiers
     source          1..4665
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q23.2"
     gene            1..4665
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="casein kinase 1 gamma 3"
                     /db_xref="GeneID:1456"
                     /db_xref="HGNC:HGNC:2456"
                     /db_xref="MIM:604253"
     exon            1..394
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            395..819
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             642..2012
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /EC_number="2.7.11.1"
                     /note="isoform 8 is encoded by transcript variant 8"
                     /codon_start=1
                     /product="casein kinase I isoform gamma-3 isoform 8"
                     /protein_id="NP_001351069.1"
                     /db_xref="CCDS:CCDS93772.1"
                     /db_xref="GeneID:1456"
                     /db_xref="HGNC:HGNC:2456"
                     /db_xref="MIM:604253"
                     /translation="MENKKKDKDKSDDRMARPSGRSGHNTRGTGSSSSGVLMVGPNFR
                     VGKKIGCGNFGELRLGKNLYTNEYVAIKLEPMKSRAPQLHLEYRFYKQLGSGDGIPQV
                     YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIY
                     RDVKPENFLIGRPGNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSI
                     NTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVL
                     CENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYMFDYEYDWIGKQLPTP
                     VGAVQQDPALSSNREAHQHRDKMQQSKNQSADHRAAWDSQQANPHHLRAHLAADRHGG
                     SVQVVSSTNGELNTDDPTAGRSNAPITAPTEVEVMDETNCQKVLNMWCCCFFKRRKRK
                     TIQRHK"
     exon            820..860
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            861..930
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1079
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1314
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1400
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1485
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1634
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1730
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1826
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1933
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..1957
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..4665
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3038..3043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="hexamer: AATAAA"
     polyA_site      3071
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="major polyA site"
     regulatory      4357..4362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="hexamer: AATAAA"
     regulatory      4367..4372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="hexamer: AATAAA"
     polyA_site      4376
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
     polyA_site      4387
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="major polyA site"
     regulatory      4644..4649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
                     /note="hexamer: AATACA"
     polyA_site      4665
                     /gene="CSNK1G3"
                     /gene_synonym="CKI-gamma 3; CSNK1G3L"
ORIGIN      
        1 catgtgttca cttccgggtc cggcgtcgat ccggatgccc gaggcagaag gatgtttgac
       61 ctccggataa gcgaggcgct gctgtgcatt cattccgggc tgcatcggtg gcgacagcag
      121 aggctcgggc ggcgactctc cggccagcgg cggcggtagg aggcaccagc ggcagtgcag
      181 ggaccgaatc cgagcagcgc tgcgttacct ctctctctcg ctccttcccc cctacctcgc
      241 tcgctcgctc gctcgctccc tgcgtggctc gctttcctcc tccggccgcc ggcgggtgtg
      301 atgtgccgcc gccgctgccc ccgccggcgc tgacggactg ggggcgccgc ccgcgcccgg
      361 gaccgacccc tctgctcgcg gccgcgcctt tgagctctct atcaatatca gctcacatca
      421 ttgaaaagat aattttgaag acatgttttg ctgaaaagac actaagaaaa attttacgaa
      481 tgggatgaac atgctccagt taattgacta cctactgcaa tttgaatgtt aacattaccc
      541 atctggtaca gttacctagt gatgtaccta ttttcacaat accctgtttc agtgtgcttg
      601 tcttgattaa agaattcaaa gtggagtacc gcaaacttga tatggaaaat aaaaagaaag
      661 acaaggacaa atcagatgat agaatggcac gacctagtgg tcgatcggga cacaacactc
      721 gaggaactgg gtcttcatcg tctggagttt taatggttgg acctaacttt agagttggaa
      781 aaaaaattgg atgtggcaat tttggagaat tacgattagg gaaaaattta tacacaaatg
      841 aatatgtggc aattaagttg gagcccatga aatcaagagc accacagcta catttggaat
      901 acagattcta taagcagtta ggatctggag atggtatacc tcaagtttac tatttcggcc
      961 cttgtggtaa atacaatgct atggtgctgg aactgctggg acctagtttg gaagacttgt
     1021 ttgacttgtg tgacagaaca ttttctctta aaacagttct catgatagct atacaactga
     1081 tttctcgcat ggaatatgtc cattcaaaga acttgatata cagagatgta aaacctgaga
     1141 acttcttaat aggacgacca ggaaacaaaa cccagcaagt tattcacatt atagattttg
     1201 gtttggcaaa ggaatatatt gatccggaga caaagaaaca cataccatac agagaacaca
     1261 agagccttac aggaacagct agatatatga gcataaacac acatttagga aaagaacaaa
     1321 gtagaagaga cgatttagaa gctttaggtc atatgttcat gtattttctg agaggcagtc
     1381 ttccttggca aggcttaaag gctgacacat taaaggagag gtatcagaaa attggagata
     1441 caaaacgggc tacaccaata gaagtgttat gtgaaaattt tccagaagaa atggcaacat
     1501 atcttcgtta tgtaagaagg ctagattttt ttgaaaaacc agactatgac tacttaagaa
     1561 agctttttac tgacttgttt gatcgaaaag gatatatgtt tgattatgaa tatgactgga
     1621 ttggtaaaca gttgcctact ccagtgggtg cagttcagca agatcctgct ctgtcatcaa
     1681 acagagaagc acatcaacac agagataaga tgcaacaatc caaaaaccag tcggcagacc
     1741 acagggcagc ttgggactcc cagcaggcaa atccccacca tttgagagct caccttgcag
     1801 cagacagaca tggtggctcg gtacaggttg taagttctac aaatggagag ttaaacacag
     1861 atgaccccac cgcaggacgt tcaaatgcac ccatcacagc ccctactgaa gtagaagtga
     1921 tggatgaaac caactgccag aaagtgttga acatgtggtg ctgctgtttt ttcaaacgaa
     1981 ggaaaaggaa aaccatacag cgccacaaat gactctggac acagacagat cctggggagt
     2041 tacttacatg ttcatctgct gtcttgtgat taaaatcatc tctgtagtga ccacgtatat
     2101 tttcaaggac tcactcttag aaacaaaaat gtcatacttt catacttcat tttgtggttg
     2161 tcttacattc tttttctttt tttttttttc tctaatttaa cctttatgga agctttaaag
     2221 ttttgtcaaa acatgagtgc tttgcccatc agtgaatgga atggaccaat gaggtggtat
     2281 caatgaatat agttccatag aacattttcc agaagttctt ctgttgtaga aagcagtaca
     2341 gtatcttaag tgtcaaccag ttatatacct aatctggttt tttataactt ctgtaagagc
     2401 ataatcaaac aggaattttc ttttctcagt ggataataca acagagaaaa cagagttgcc
     2461 caaatattta aaagaagtta ttccttgaga agttcatatt ttgtgacatc tgcattgatt
     2521 tcagtattac tgatggtact gttattcata agtcatatta acattctctc cgtgaaatca
     2581 tggtacagtc actgcccaga ggtactgagg aaaaagcaat atgggttcgg cagatggtgg
     2641 tggtaaaatg aatcttaagg agtgtggtaa atatgtgctc cgcttttgtt gcatcactat
     2701 gtgaagtact gtgttgcaga agtggcaaaa gcgcttattt ttaaaaatgc aaaatatttg
     2761 tacaatgtaa ctttatgctt ccaaataata atgtatgtta gacagcaaga aatgaatact
     2821 ttaaaaagtg atgtatgttg gagttataaa gaaatacact aaggagaggt agtaaatgtg
     2881 aaccttgttg cagtgtataa ggtggaagcc taaagaaatc tcaccgaaac ttactgctga
     2941 atgattacat tctcccttaa gcagaaaact ttggatgtgc catgcaatgg tgtctgtgta
     3001 attattttgc tctttgatta aaaaaaagac ccccagcaat aaaaagtggg tcactctatg
     3061 ccctctgtgc acattagtct cttgtattca actttgctga ttctctggaa ttttcctact
     3121 ctttagcata attttgatga ttgaaaaata ttttggaaag gatgggtcag gtgctttgcc
     3181 tccatagtct tttgaagtgc ctgcatatga acaacaacaa caacaacaaa aaattctgta
     3241 aaaaaggaag cccattccac ttttcaagta tgctttgttt taagccataa agacacacat
     3301 gtagttttgt cacattctac tagccaaaat tttcaagaag ggttaaaaca aagactggct
     3361 agaaagataa ttattttgaa taaatctcat attcatcttt catttatata attgttactt
     3421 attcctccca tgcagtctct tcgttgtctt taagtgtgtg cctccaggca tgcttattta
     3481 tttttattgt ctcaaggtaa catttaagat gtatattaaa gtaaagctac atttttttac
     3541 ttcattattg catttacagg gatttaattg tactttgtaa tttatttttc ttattagcca
     3601 aaagtttaat gcattttttt ttgatgaatt aggcacccac atgaacacca caaatcagga
     3661 cattgtttat cattgttgct atgaatccta tgaatgatct tttttttatt ttaaagacct
     3721 acacttaacc tacaaaacat ttgctgtata atttggtcaa cagtttctat ctatctgtat
     3781 actgtcatga tgtcttaaac tgcaggagtt acatactgag tttatatttt tatttgcttt
     3841 gagcaaggta gataaacatt ttggccatta taatgtgaaa ccacttcttc tttctttaca
     3901 gtatttgacc aaacttgtgt gtctatgata tttgtaaata catgcgaata tctgtatttc
     3961 ttatcataag cctatttagt tttattctca gtagggtttt ttggattgta cagtgtttat
     4021 atgatctgaa ctccttatac ataagaaggt gtgtatatta atccaattat ggacttaaaa
     4081 tattttaaaa gtataaatac ccttatttgc tgcaaagacc agtgtgtagg catttgcttt
     4141 ttagcaatat ttttaagtgc tccattttaa tgccgaggaa taagtctttt ggcaacacaa
     4201 actggtcaat aataggtaat gcaggtatgt tcaggttaag ccaacaatgt tttgcatttt
     4261 tatgcttatt ttctgtcaac actaatgaag tcaacattgc ctgaatgtct gaataatgaa
     4321 acacatccct gtttaaaagt atgtaactga aaaagaaata aaaaaaaata aaagtagttt
     4381 ttttaaactt gctctttccc atttcctcta aagatgggta aaataatgtc actccctaat
     4441 ttaagatagg aattataaaa atttggttta tttagtctgt tatatatgag aagcagagct
     4501 aaaggaatat gcttttgtta ttttatgttt tgttttgctt tcttgaaatc cagtggtaaa
     4561 aagcacacac taggaaggat ctaagctttc tttaatataa aaaaaattat acttctctga
     4621 actgtttaat agagcaataa ttaaatacat cttctgataa attaa
//
