LOCUS       NM_001319               2895 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens casein kinase 1 gamma 2 (CSNK1G2), mRNA.
ACCESSION   NM_001319
VERSION     NM_001319.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2895)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2895)
  AUTHORS   Nguyen Hoang,A.T., Hoe,K.L. and Lee,S.J.
  TITLE     CSNK1G2 differently sensitizes tamoxifen-induced decrease in
            PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen
            receptor existence in breast cancer cells
  JOURNAL   PLoS One 16 (4), e0246264 (2021)
   PUBMED   33861751
  REMARK    GeneRIF: CSNK1G2 differently sensitizes tamoxifen-induced decrease
            in PI3K/AKT/mTOR/S6K and ERK signaling according to the estrogen
            receptor existence in breast cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2895)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   4  (bases 1 to 2895)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2895)
  AUTHORS   Li,X., Zhong,L., Wang,Z., Chen,H., Liao,D., Zhang,R., Zhang,H. and
            Kang,T.
  TITLE     Phosphorylation of IRS4 by CK1gamma2 promotes its degradation by
            CHIP through the ubiquitin/lysosome pathway
  JOURNAL   Theranostics 8 (13), 3643-3653 (2018)
   PUBMED   30026872
  REMARK    GeneRIF: IRS4, as a new substrate of CHIP, is negatively regulated
            by CK1gamma2 at the posttranslational level.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2895)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   7  (bases 1 to 2895)
  AUTHORS   Zemlickova,E., Johannes,F.J., Aitken,A. and Dubois,T.
  TITLE     Association of CPI-17 with protein kinase C and casein kinase I
  JOURNAL   Biochem Biophys Res Commun 316 (1), 39-47 (2004)
   PUBMED   15003508
REFERENCE   8  (bases 1 to 2895)
  AUTHORS   Dubois,T., Howell,S., Zemlickova,E. and Aitken,A.
  TITLE     Identification of casein kinase Ialpha interacting protein partners
  JOURNAL   FEBS Lett 517 (1-3), 167-171 (2002)
   PUBMED   12062430
REFERENCE   9  (bases 1 to 2895)
  AUTHORS   Kitabayashi,A.N., Kusuda,J., Hirai,M. and Hashimoto,K.
  TITLE     Cloning and chromosomal mapping of human casein kinase I gamma 2
            (CSNK1G2)
  JOURNAL   Genomics 46 (1), 133-137 (1997)
   PUBMED   9403068
REFERENCE   10 (bases 1 to 2895)
  AUTHORS   Lussier,G. and Larose,L.
  TITLE     A casein kinase I activity is constitutively associated with Nck
  JOURNAL   J Biol Chem 272 (5), 2688-2694 (1997)
   PUBMED   9006905
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012615.4 and AC005306.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001319.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.217532.1,
                                           SRR1163658.269787.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255641.13/ ENSP00000255641.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC012615.4         133619-133865
            248-699             AC005306.2         19583-20034
            700-740             AC005306.2         28380-28420
            741-810             AC005306.2         28517-28586
            811-959             AC005306.2         28677-28825
            960-1194            AC005306.2         28934-29168
            1195-1280           AC005306.2         29238-29323
            1281-1365           AC005306.2         29394-29478
            1366-1514           AC005306.2         29570-29718
            1515-1598           AC005306.2         29827-29910
            1599-1705           AC005306.2         29986-30092
            1706-2895           AC005306.2         30224-31413
FEATURES             Location/Qualifiers
     source          1..2895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2895
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /note="casein kinase 1 gamma 2"
                     /db_xref="GeneID:1455"
                     /db_xref="HGNC:HGNC:2455"
                     /db_xref="MIM:602214"
     exon            1..247
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            248..699
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     CDS             513..1760
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /EC_number="2.7.11.1"
                     /note="CKI-gamma 2"
                     /codon_start=1
                     /product="casein kinase I isoform gamma-2"
                     /protein_id="NP_001310.3"
                     /db_xref="CCDS:CCDS12077.1"
                     /db_xref="GeneID:1455"
                     /db_xref="HGNC:HGNC:2455"
                     /db_xref="MIM:602214"
                     /translation="MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGP
                     NFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGV
                     PQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKS
                     LIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARY
                     MSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPI
                     EVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPL
                     PTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVE
                     VADETKCCCFFKRRKRKSLQRHK"
     exon            700..740
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..810
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            811..959
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1194
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1280
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1365
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1514
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1598
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1705
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..2895
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /note="hexamer: AAGAAA"
     polyA_site      2895
                     /gene="CSNK1G2"
                     /gene_synonym="CK1g2"
                     /note="major polyA site"
ORIGIN      
        1 agacgctggc ggcgtaaggc gcgcgggccc cggagcgggc gcggcggagc gcggcgagcc
       61 cggcgcctcc cgtcccgaac atgcggaggc cggcccaggc ggcgcgggag ccggagcggg
      121 ggcccaagcg gcaccggagc cggagcgcga gggggcgcgg ggcccggagc gggggtccgc
      181 gctgcgctgc tgaggccggg ccggccgccc agacgctgcc cgcgggcccg gccacggcgg
      241 agccaagctg tgagccgtga gctttgaggc ggtgggatgt gtcagcagaa tgtctcctgc
      301 ccccgagagc gaccccgagg ccactgagaa gagcagcgcg gcctggccgg cccgaacgcc
      361 tgcgtctcag tagctgggag ccacgggccc acgcccgccc accggccgca gtgatgttct
      421 agccacagag gagccaagac ctcaggtttc cagagacttg ggatttgcac ggcagcagag
      481 tcaccgtgga gaggccaggg tatcacaaac ttatggattt tgacaagaaa ggagggaaag
      541 gggagacgga ggagggccgg agaatgtcca aggccggcgg gggccggagc agccacggca
      601 tccggagctc ggggaccagc tcgggggtcc tgatggtggg ccccaacttc cgcgtcggca
      661 agaagatcgg ctgcggcaac ttcggggagc tccgcctagg aaagaatctc tatacaaatg
      721 aatacgtggc tatcaaattg gagccgatca agtcccgggc cccgcagctg cacctggagt
      781 accggttcta caagcagctc agcgccacag agggcgtccc tcaggtctac tacttcggtc
      841 cgtgcgggaa gtacaacgcc atggtgctgg agctgctggg gcccagcctg gaggacctgt
      901 tcgacctgtg cgaccggacc ttcacgctca agacggtgct gatgatcgcc atccagctga
      961 tcacgcgcat ggagtatgtg cacaccaaga gcctaatcta ccgggacgtg aagcccgaga
     1021 acttcctggt gggccgcccg gggaccaagc ggcagcatgc catccacatc atcgacttcg
     1081 ggctggccaa ggagtacatc gaccccgaga ccaagaagca catcccgtac cgcgagcaca
     1141 agagcctgac gggcacggcg cgctacatga gcatcaacac gcacctgggc aaggagcaga
     1201 gccgccgcga cgacctggag gcgctgggcc acatgttcat gtacttcctg cgcggcagcc
     1261 tcccctggca ggggctcaag gccgacacgc tcaaggagcg gtaccagaag atcggggaca
     1321 ccaaacgcgc cacgcccatc gaggtgctct gcgagaactt cccagaggag atggccacgt
     1381 acctgcgcta tgtgcggcgc ctggacttct tcgagaagcc cgactatgac tacctgcgga
     1441 agctcttcac cgacctcttc gaccgcagtg gcttcgtgtt cgactatgag tacgactggg
     1501 ccgggaagcc cctgccgacc cccatcggca ccgtccacac cgacctgccc tcccagcctc
     1561 agctccggga caaaacccag ccgcacagca aaaaccaggc gttgaactcc accaacgggg
     1621 agctgaatgc ggacgacccc acggccggcc actccaacgc cccgatcaca gcgcctgcag
     1681 aggtggaggt ggccgatgaa accaaatgct gctgtttctt caagaggaga aagagaaaat
     1741 cgctgcagcg acacaagtga ccctgggcgc gtgcagcccc ctgaatcttc tccgtgcagc
     1801 cccttggggc gcgaccttgt gcgaggccct cggggcccac ccacagcggc ccagggccag
     1861 accctggctg gaagccagaa cgcagactgc aggggccgcg cctggctcag gcggccccac
     1921 ccccgggacg tggggtcact tccttcatgt aagactttgg ccgaaatttc tacacctgtg
     1981 tctagtcctc ccctccaaga gcattaacta tttaaaacaa ggaaaagagg aaaaaaaaaa
     2041 cagaggcccg ccctacccca ctcctgcccc tccgtttctt tgctgaagtg agtagtgtga
     2101 tcctggaggc cccccggcct ggccccgccc cgccagccgc ccccgttagc gtcataaagt
     2161 ccagcttgtc tccctcgatc caaaggccgt tttctcgagg ggagggcagg cccggcctgg
     2221 aggggtgctg tggagctgtc ttgcccaggc cctcctggga gggggacagg cattgttgcc
     2281 aggggtgagg ccgtgcccca ggcctccccg aaaccaaagg ggaaggcagg ggtggggccg
     2341 tggctgaagc cggctcccca accaaaatgc tgcaccaaag ctcgggcgcc gcgggcacgg
     2401 ctgctgcagt ctcttcccag cctggccctg gcaaggggcg ggtgggcgct gccaggcggg
     2461 tgcttctcga cgcacttgct cccggaggct gcgccccggc gcctggaacc cgaggtggga
     2521 ggaccggttg gtgtcaccct gctcggccct cagccctgcc gcgtggggcg cgtgggcacg
     2581 gagcttcctg cctctctgct ccgacacccg gcaagcagcc ggagacaaaa cgccttaaag
     2641 cccccggccc agccctgcag gtatattgca ggggcctggg ggcggccctg gactggcggg
     2701 cggttcccca gtggggtgcc ctggaggctg ccgggcagag tggagcagct tggggccgtg
     2761 cccagggcgg tggctgtgag tctagttttt gctttaccaa gtgtacagaa atggcattta
     2821 cgtttctctg atgctccctt gaagccatag aatttagggg cttttttaaa aaaataaaag
     2881 aaaaatgaaa ccaaa
//
