LOCUS       NM_022048               8085 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens casein kinase 1 gamma 1 (CSNK1G1), transcript variant
            1, mRNA.
ACCESSION   NM_022048 NM_001011664
VERSION     NM_022048.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8085)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8085)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 8085)
  AUTHORS   Miao,Y., Cui,L., Chen,Z. and Zhang,L.
  TITLE     Gene expression profiling of DMU-212-induced apoptosis and
            anti-angiogenesis in vascular endothelial cells
  JOURNAL   Pharm Biol 54 (4), 660-666 (2016)
   PUBMED   26428916
REFERENCE   4  (bases 1 to 8085)
  AUTHORS   Chia,R., Haddock,S., Beilina,A., Rudenko,I.N., Mamais,A.,
            Kaganovich,A., Li,Y., Kumaran,R., Nalls,M.A. and Cookson,M.R.
  TITLE     Phosphorylation of LRRK2 by casein kinase 1alpha regulates
            trans-Golgi clustering via differential interaction with ARHGEF7
  JOURNAL   Nat Commun 5, 5827 (2014)
   PUBMED   25500533
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8085)
  AUTHORS   Martin,H.C., Kim,G.E., Pagnamenta,A.T., Murakami,Y., Carvill,G.L.,
            Meyer,E., Copley,R.R., Rimmer,A., Barcia,G., Fleming,M.R.,
            Kronengold,J., Brown,M.R., Hudspith,K.A., Broxholme,J., Kanapin,A.,
            Cazier,J.B., Kinoshita,T., Nabbout,R., Bentley,D., McVean,G.,
            Heavin,S., Zaiwalla,Z., McShane,T., Mefford,H.C., Shears,D.,
            Stewart,H., Kurian,M.A., Scheffer,I.E., Blair,E., Donnelly,P.,
            Kaczmarek,L.K. and Taylor,J.C.
  CONSRTM   WGS500 Consortium
  TITLE     Clinical whole-genome sequencing in severe early-onset epilepsy
            reveals new genes and improves molecular diagnosis
  JOURNAL   Hum Mol Genet 23 (12), 3200-3211 (2014)
   PUBMED   24463883
REFERENCE   6  (bases 1 to 8085)
  AUTHORS   Wang,Y., Hu,L., Tong,X. and Ye,X.
  TITLE     Casein kinase 1gamma1 inhibits the RIG-I/TLR signaling pathway
            through phosphorylating p65 and promoting its degradation
  JOURNAL   J Immunol 192 (4), 1855-1861 (2014)
   PUBMED   24442433
  REMARK    GeneRIF: CK1gamma1 phosphorylates p65 and consequently promotes its
            degradation by ubiquitin E3 ligases CUL2 and COMMD1.
REFERENCE   7  (bases 1 to 8085)
  AUTHORS   Meng,Z., Capalbo,L., Glover,D.M. and Dunphy,W.G.
  TITLE     Role for casein kinase 1 in the phosphorylation of Claspin on
            critical residues necessary for the activation of Chk1
  JOURNAL   Mol Biol Cell 22 (16), 2834-2847 (2011)
   PUBMED   21680713
  REMARK    GeneRIF: casein kinase 1 gamma 1 phosphorylates claspin
REFERENCE   8  (bases 1 to 8085)
  AUTHORS   Guo,L., Jiang,M., Ma,Y., Cheng,H., Ni,X., Ma,Y., Ji,C., Xie,Y. and
            Mao,Y.
  TITLE     Molecular cloning, mapping and characterization of a human
            CK1gamma1 gene
  JOURNAL   Int J Mol Med 10 (2), 227-230 (2002)
   PUBMED   12119564
  REMARK    GeneRIF: A 1756 bp cDNA encoded human protein kinase CK1 (438 AA,
            mol wt 50.272 Da, isoelectric point of 9.37) mapping to chromosome
            15q22.
REFERENCE   9  (bases 1 to 8085)
  AUTHORS   Kusuda,J., Hirai,M., Tanuma,R. and Hashimoto,K.
  TITLE     Cloning, expression analysis and chromosome mapping of human casein
            kinase 1 gamma1 (CSNK1G1): identification of two types of cDNA
            encoding the kinase protein associated with heterologous
            carboxy-terminal sequences
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 298-302 (2000)
   PUBMED   11124537
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB094870.1, AL832551.1,
            AC100840.2, BC077731.1 and BE644696.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022048.4.
            
            Summary: This gene encodes a member of the casein kinase I gene
            family. This family is comprised of serine/threonine kinases that
            phosphorylate acidic proteins such as caseins. The encoded kinase
            plays a role in cell cycle checkpoint arrest in response to stalled
            replication forks by phosphorylating Claspin. A mutation in this
            gene may be associated with non-syndromic early-onset epilepsy
            (NSEOE). [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shortest isoform (1). Both variants 1
            and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.235003.1, AL832551.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303052.13/ ENSP00000305777.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               DB094870.1         71-565
            496-4363            AL832551.1         344-4211
            4364-4600           AC100840.2         7847-8083
            4601-7877           BC077731.1         1-3277
            7878-8085           BE644696.1         11-218              c
FEATURES             Location/Qualifiers
     source          1..8085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..8085
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /note="casein kinase 1 gamma 1"
                     /db_xref="GeneID:53944"
                     /db_xref="HGNC:HGNC:2454"
                     /db_xref="MIM:606274"
     exon            1..186
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..591
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     CDS             411..1679
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="casein kinase I isoform gamma-1 isoform 1"
                     /protein_id="NP_071331.2"
                     /db_xref="CCDS:CCDS10192.2"
                     /db_xref="GeneID:53944"
                     /db_xref="HGNC:HGNC:2454"
                     /db_xref="MIM:606274"
                     /translation="MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNF
                     RVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLP
                     QVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNL
                     IYRDVKPENFLIGRQGNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYM
                     SINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIE
                     ALCENFPEEMATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIP
                     TPVGSVHVDSGASAITRESHTHRDRPSQQQPLRNQVVSSTNGELNVDDPTGAHSNAPI
                     TAHAEVEVVEEAKCCCFFKRKRKKTAQRHK"
     exon            592..632
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..702
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..854
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            855..1089
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1175
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1260
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1409
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1517
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1624
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..8085
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7851..7856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /note="hexamer: AATAAA"
     polyA_site      7877
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /note="major polyA site"
     regulatory      8061..8066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
                     /note="hexamer: AATAAA"
     polyA_site      8085
                     /gene="CSNK1G1"
                     /gene_synonym="CK1gamma1"
ORIGIN      
        1 agtggttccg gttcggctcc agccgcccct cggctcctcg ccttccccct cccgtccgcc
       61 ttctcccctc cctcccgctc ctgggaaaga gagaaaccac cgctgcgggt gggtagagaa
      121 gcacttggcg cctcggggag gggaccgcgc ccgcctcatt tgcgccttgc agcactgctg
      181 gaccaggtta caagatgttc acctaagatt gagacctagt gactacattt cctacgggaa
      241 caaataaatg gtttttcatc tcccggagat acattacaaa caaatatggt gctaaaagaa
      301 ctccttacct ttctctgact acaatttatt tggacatact tttgtattga agagaggtat
      361 acatactgaa gctacttgct gtactatagg agactctgtc ctgtaggatc atggaccatc
      421 ctagtaggga aaaggatgaa agacaacgga caactaaacc catggcacaa aggagtgcac
      481 actgctctcg accatctggc tcctcatcgt cctctggggt tcttatggtg ggacccaact
      541 tcagggttgg caagaagata ggatgtggga acttcggaga gctcagatta ggtaaaaatc
      601 tctacaccaa tgaatatgta gcaatcaaac tggaaccaat aaaatcacgt gctccacagc
      661 ttcatttaga gtacagattt tataaacagc ttggcagtgc aggtgaaggt ctcccacagg
      721 tgtattactt tggaccatgt gggaaatata atgccatggt gctggagctc cttggcccta
      781 gcttggagga cttgtttgac ctctgtgacc gaacatttac tttgaagacg gtgttaatga
      841 tagccatcca gctgctttct cgaatggaat acgtgcactc aaagaacctc atttaccgag
      901 atgtcaagcc agagaacttc ctgattggtc gacaaggcaa taagaaagag catgttatac
      961 acattataga ctttggactg gccaaggaat acattgaccc cgaaaccaaa aaacacatac
     1021 cttataggga acacaaaagt ttaactggaa ctgcaagata tatgtctatc aacacgcatc
     1081 ttggcaaaga gcaaagccgg agagatgatt tggaagccct aggccatatg ttcatgtatt
     1141 tccttcgagg cagcctcccc tggcaaggac tcaaggctga cacattaaaa gagagatatc
     1201 aaaaaattgg tgacaccaaa aggaatactc ccattgaagc tctctgtgag aactttccag
     1261 aggagatggc aacctacctt cgatatgtca ggcgactgga cttctttgaa aaacctgatt
     1321 atgagtattt acggaccctc ttcacagacc tctttgaaaa gaaaggctac acctttgact
     1381 atgcctatga ttgggttggg agacctattc ctactccagt agggtcagtt cacgtagatt
     1441 ctggtgcatc tgcaataact cgagaaagcc acacacatag ggatcggcca tcacaacagc
     1501 agcctcttcg aaatcaggtg gttagctcaa ccaatggaga gctgaatgtt gatgatccca
     1561 cgggagccca ctccaatgca ccaatcacag ctcatgccga ggtggaggta gtggaggaag
     1621 ctaagtgctg ctgtttcttt aagaggaaaa ggaagaagac tgctcagcgc cacaagtgac
     1681 cagtgcctcc caggagtcct caggccctgg ggactctgac tcaattgtac ctgcagctcc
     1741 tgccatttct cattggaagg gactcctctt tgggggaggg tggatatcca aaccaaaaag
     1801 aagaaaacag atgcccccag aaggggccag tgcgggcagc cagggcctag tgggtcattg
     1861 gccatctccg cctgcctaag gctctgagca ggtcccagag ctgctgttcc tccactgctt
     1921 gcccataggg ctgcctggtt gactctcctt cccattgttt acagtgaagg tgtcattcac
     1981 aaaaactcaa ggactgctat tctccttctt ccccttagtt tactcctggt ttttacccca
     2041 ccctcaaccc tctccagcat aaaacctagt gagctaaagg ctttgtctgc agaaggagat
     2101 caagaggctg ggggtaaggc caagaaggta ggaggaaaat ggcagacctg ggctggagaa
     2161 gaaccttctc cgtatcccag gtgtgcctgg cagtatggtt tcctcttcct ctgtgcctgt
     2221 gcagcattca tcccagctgg ccttggggtt caggttcctt cttccctccc tcctgtgaag
     2281 ttacactgta ggacacaagc tgtgagcaat ctgcagtcta ctgtccctgt gtgttggcgt
     2341 tcttagcttt tttgacaaac tcttttctcc aggtagtagg acaatgaaaa ttgttctaag
     2401 caaaggaaag aaaactgact ttgttgcact tttagttttt ttaaaaaaaa caaaaacaaa
     2461 aacatggcag atgcatattg tgtctggtta tattgggggt tttactttta cctgttttga
     2521 gggggatggg gccggccaag ccattcagag agaacatggg tccagaggac attctcagtg
     2581 gaaagagttt gatctgcagc acccagaaga gaagccaaac tcggtgtcat tctgagtgaa
     2641 cactcaggtt ggcaagaaaa catacttgaa ttttcattca tcttctcagc agctgaagaa
     2701 tgtccctacc agagcatctt gacctaatca gcttacagtt tgaaaaccta gctctccaga
     2761 acatgagatg agccagccga gccagactgt gaccaggaaa cagctcatcc cagagaagga
     2821 gatgcttaac aaaaaaaaat tgaaattgtt tcccatgctg ccagggactt ccaactagat
     2881 agccatgtga cgtcctggtg acttggggga aaaattagtg atgaaacagc caccaccata
     2941 ttgccattag tggaaaaaaa gaggacagtg aacctgcctt ccacctgcca gagggacctc
     3001 agggtgtggc attatagggc caggaaaaga aaatcggtgt atcctatctg ccccaatagc
     3061 tgagctgtag catttgggct ggcctgcctt atcagaaacc aagcttatga agatcttctc
     3121 ccagcaggtc catagcagta ggcttaggat gcagtatatg gggccgcatt taaaaggagg
     3181 gaaagattgt ttggtgctgg aacattccag ggaaaaggag actggaatga aaggtctgaa
     3241 attatcttct caattggact ccttccagaa aggtggccgt gcctctaagc atgtttttcc
     3301 cagtatgccc taggcctccc cccatggtgt tttcatatga ggtactactg tgaaggatct
     3361 ggttcctcat tcactgtttg acaagtcttt catgtgtgga gttactcttc tcatgcccaa
     3421 ttttcatttg agtttagtgg cttaaccaaa caatgactcc tcattccagc ggtgacagaa
     3481 gagaaagggt catttacatc aggaaagagg tcttgtatct gggagtagag agctaaccat
     3541 ggagcacagt ggctggtggg tgacttagtc tgatggtttg tggaccatag aagtcttcac
     3601 ctctggtttg aggtgcaggg ctgtcttttg tactggaggg tgtggggata ttttctgata
     3661 gttgccattt cttgaaaaat tcccttgatg taccttacac agagcagaaa taacattaac
     3721 atggatcaga ggtactgggc ttcatctgtt ccattggacc ttggctaggg aatatcattt
     3781 cactggcatc aaacctgctt agcttatgaa aagatggtaa tatgtcattt ctataaatgt
     3841 ttctatatat gaaacataaa gtggcaggga gatacaatat cacacccctt ccccacaagg
     3901 actgtgaata ttgggattta tgtccttgcc attacctagt ggttacagcc ctatcactaa
     3961 aatttacatc gtttctcagt tgggatttgg gcattgctaa cttactgtat agaaagttta
     4021 acttttcctc acccctgtat agaaaatgcc ttgcctctca agagagggca gagggggggc
     4081 caggtgcagt ggctcacgcc tgtaatccca gcagtttggg aggccaaggc aagtggatca
     4141 tgtgaggtca agagttcgag accagcctgg ccaacatggt gaaaccccgt ctctacaaaa
     4201 aatacaaaaa ttagctgggc atggtggcat gctcccgtag tcccagctac tcgggaggct
     4261 gaggcaggag aatcacttga gcctgggagg cagaagttgc agtgagccga gatcgcacca
     4321 ctgcactcca gcctgggcaa cagagtgaga ctctgtctaa aaagaaaaaa aaaaaagggc
     4381 agagggaaat ggtgggaatg cctggagcat cctggcactc tatactctac tgagtgcctc
     4441 tcttcagccc ctcaccctgc ttccacacac acacacacaa aagcaaaggc actgaccagc
     4501 ttggctgcag ggcaagctgc cttgcagctg gatttgcgac tttttttttg tcttaaaatt
     4561 tttactggat cagttgtagg ggactgtact tcctaagaca ctgttctcac cttccaacct
     4621 cacaaatctc ttactagata tttggttttt ataacaaggg taaagaatcc caggtccctt
     4681 tagcatgcag agtaatggtg atccctccag agccattggc acttcaaagt ggtcccagac
     4741 ctgggagatt ctggtgggat cttccttaaa aataagcaaa aaacctgagt accctagatg
     4801 caattggcca tttgtttcag gcccatcagc gaatcagggc tccctcctca accctactgc
     4861 tacagttcct tagctgtatg cctcagccag atccttgggg ttagggcatg cactcgctga
     4921 ctgtccccac ccatccactt gctctgtagt ttctgagctt tctccatttc acaagtatgg
     4981 tgcctaacga tctttttctt taggattgat gcagttgttt ttcctgaaag ctaactcagc
     5041 atctattcat aaaaaccctt aatagtatac attaggagtt ttcccaagct ctacagtccc
     5101 tcagacattg catcctaaac agatttgagg cacacaggcc aagactccac caaggcataa
     5161 atggtccccc ctactccctt ttgaccaggg tatcacttgt gtctctgcag taagagttgg
     5221 tcaagttgct ctacgcacct tggtgctttc cagagatctc actccagact gcccccaagg
     5281 gtggatagag tatcctgaca gccagtgtgc actcatgact gccttaatta acattcttct
     5341 gctattatgg agcctgtcca gcaataaaca gggtctagga aggtacaaga ttagcttcca
     5401 gttaaaatcc cattttatat tggaatgcat gagctacaga tgacagcaga gatcctgagg
     5461 tttctagaca tgttgattgt ctcttttttc taaatgaact ccaagtactt agaaaacagt
     5521 ccctgtccat cagccagaaa aggtgaccat cacccctaaa gtaatttcca aacttagttc
     5581 agtgggaaga tatgctggta gtgcatattc agtgttgatt ttcagtgcta gtaaccactt
     5641 ttaatgccag aaatatgtaa caatgataat gtaacgtcaa agtggttact aaagattata
     5701 gccttaactt ttttatgtaa aagataaaat ccattcctcc tcccagtgag caagcatggc
     5761 ttgcatttct caaaaatgag aacttccatg gcagccaaga aaacgtcttc tcagaggaac
     5821 tttcgtttga tgcatctccc aagcccacat gcctcctgtg ttccagccac ctcttccatt
     5881 tcacatttaa accagctctc cattcccatt gagttgccct aacaacattg tctccagtgt
     5941 cagaaccata ttaaggttcg tttctcagat tgggagcctg caacaccata cagccaacat
     6001 tgcctttgcc acgccactgc caccatcccc accattgccc tatggtgggc agatgaattc
     6061 cagaaaccct cagggagcca ggataattag gcaacccatc tgaattggcc acgtaagtga
     6121 caggcactta tctctcgggt tcttgctttt gcagactcca gggaagtcct gtctagaggt
     6181 cgatggcaga gactcctagt ctttcccatg aggggttgat aggaatcaaa ttgggattcc
     6241 tttggctttg ggttttgttt ttttgttgtt gtttttggtt ttcagtttgt tttttggtgt
     6301 atggggggtg attttgtttc tgaataagaa aaagaagagg caaccatggc ccttatgtgg
     6361 gtttatcctt tttgagcaat gttttagcca caagtaagga atcttgaaag tcttttgtcc
     6421 agcaagcagt cttaaaaatg tttttcctaa ctccttttgc aggtgactaa gtacaaaaaa
     6481 atagttttct cattgtattc aaaatagtga gtaggttccc tggataatac acagtggtag
     6541 ttgacatatt ttctcaaaac acaaccagaa aacccacttc cggtatttgt aaatcacctt
     6601 tcaagggaaa aagtgaacac gtattccttg tatttctagt ttgattacca aacctgatgt
     6661 tacaaagaaa cctccgttct gtagacagaa tttcttttat ttttcttctt ttactcctca
     6721 caatcacttt cccagtgcca tcaccatcta taaggtctca gagcagagga ttattcatgg
     6781 taataagtgg gggtgtggtg cagccattcc agtaacaccc acaagaggac agctgttctg
     6841 aatgtcccca cccacccctc tttcagtaca ggtgagacat tttcagttca tgagctccag
     6901 accaaatccc aggccagccc ttgcaccaaa agcctttttt agaaggctta tcagtctatt
     6961 aggaatgtct caggaaagat gagccatttc tttggggaga aatatattta cagatggaag
     7021 tgtgtgactg cgtgtctgtg tgtgtgtgtg gtgtgtgtgc gcacgtgagt gcgtgtgttc
     7081 atctatgtgc atttcacttc cataaagacc cagcccaagc tgctgggaac catgtgttcc
     7141 tgagtattct cagaggttaa acaagtgaca agtgagcttc tgaaattagt gtctcagcaa
     7201 gctggcttta ggaatgagcc ccattttatc aagcagagaa aaaaaataac agcagaaaag
     7261 ataaagataa accaaaaata tatacccccc aatggaaaat aatgttgatt cagcaattcc
     7321 cataggatgt attacatgct ctaatttatt atattattat ttatctgtct ttgatctttg
     7381 cccattgtac tcttaaaaag atgttgggat gttgattgcg atttttaaac aactagataa
     7441 tgtataaatc agcagtggaa atcagtttta atgtgtggat gtgtctgatt attgttaaat
     7501 gcctcttttt ttactttttt tttttttaga tgtataatgt ttcataaacc ctggcactgg
     7561 tcacaaagct cagctgtgaa aatgaaattt gtagtatttt taaacatgaa tgtcaatttc
     7621 aagtgtattt gaaatggttc ctccaggaga gatatttgtg caccattagg aaaatcttct
     7681 ctgcagagga agtagccttc tttggagaaa atggaaaatg ggttctgata tgtgatctca
     7741 gagtagccca tttcctaggg caccatggaa aacacaaatg tgatctttaa gtatacctct
     7801 tccccagttt ggggaggaaa ggactcagtt tgcacccttt ttgtatgtaa aataaaatgt
     7861 cttacctttc ttggctactt ctgcttgttt ggttggttga ttggtttgtc tgtttttaat
     7921 ctccctcggc tcatttgtaa ttaacaatct agctaggact aactttgatg cgattcaaga
     7981 ctcctgtgaa caaaaataat ttggcattct tgtttcattc cttggattaa atattgtctt
     8041 ctcctgtgag tcacttcaaa aataaatact gctgtctctc ttcga
//
