LOCUS       NM_152221               2817 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens casein kinase 1 epsilon (CSNK1E), transcript variant
            1, mRNA.
ACCESSION   NM_152221
VERSION     NM_152221.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2817)
  AUTHORS   Yu,Z., Jiang,X., Yin,J., Han,L., Xiong,C., Huo,Z., Xu,J., Shang,J.,
            Xi,K., Nong,L., Huang,Y. and Zhou,X.
  TITLE     CK1epsilon drives osteogenic differentiation of bone marrow
            mesenchymal stem cells via activating Wnt/beta-catenin pathway
  JOURNAL   Aging (Albany NY) 15 (19), 10193-10212 (2023)
   PUBMED   37787983
  REMARK    GeneRIF: CK1epsilon drives osteogenic differentiation of bone
            marrow mesenchymal stem cells via activating Wnt/beta-catenin
            pathway.
REFERENCE   2  (bases 1 to 2817)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 2817)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2817)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 2817)
  AUTHORS   Bono,B., Franco,G., Riva,V., Garbelli,A. and Maga,G.
  TITLE     Novel Insights into the Biochemical Mechanism of CK1epsilon and its
            Functional Interplay with DDX3X
  JOURNAL   Int J Mol Sci 21 (17), 6449 (2020)
   PUBMED   32899434
  REMARK    GeneRIF: Novel Insights into the Biochemical Mechanism of
            CK1epsilon and its Functional Interplay with DDX3X.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2817)
  AUTHORS   Rivers,A., Gietzen,K.F., Vielhaber,E. and Virshup,D.M.
  TITLE     Regulation of casein kinase I epsilon and casein kinase I delta by
            an in vivo futile phosphorylation cycle
  JOURNAL   J Biol Chem 273 (26), 15980-15984 (1998)
   PUBMED   9632646
REFERENCE   7  (bases 1 to 2817)
  AUTHORS   Cegielska,A., Gietzen,K.F., Rivers,A. and Virshup,D.M.
  TITLE     Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved
            by protein phosphatases and limited proteolysis
  JOURNAL   J Biol Chem 273 (3), 1357-1364 (1998)
   PUBMED   9430669
REFERENCE   8  (bases 1 to 2817)
  AUTHORS   Knippschild,U., Milne,D.M., Campbell,L.E., DeMaggio,A.J.,
            Christenson,E., Hoekstra,M.F. and Meek,D.W.
  TITLE     p53 is phosphorylated in vitro and in vivo by the delta and epsilon
            isoforms of casein kinase 1 and enhances the level of casein kinase
            1 delta in response to topoisomerase-directed drugs
  JOURNAL   Oncogene 15 (14), 1727-1736 (1997)
   PUBMED   9349507
REFERENCE   9  (bases 1 to 2817)
  AUTHORS   Fish,K.J., Cegielska,A., Getman,M.E., Landes,G.M. and Virshup,D.M.
  TITLE     Isolation and characterization of human casein kinase I epsilon
            (CKI), a novel member of the CKI gene family
  JOURNAL   J Biol Chem 270 (25), 14875-14883 (1995)
   PUBMED   7797465
REFERENCE   10 (bases 1 to 2817)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL020993.1, CF594072.1,
            BQ642398.1, BC006490.2, BU517079.1 and BC013088.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_152221.2.
            
            Summary: The protein encoded by this gene is a serine/threonine
            protein kinase and a member of the casein kinase I protein family,
            whose members have been implicated in the control of cytoplasmic
            and nuclear processes, including DNA replication and repair. The
            encoded protein is found in the cytoplasm as a monomer and can
            phosphorylate a variety of proteins, including itself. This protein
            has been shown to phosphorylate period, a circadian rhythm protein.
            Two transcript variants encoding the same protein have been found
            for this gene. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longer and
            predominant transcript. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.642477.1,
                                           SRR1163658.390201.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396832.6/ ENSP00000380044.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL020993.1         93986-94010         c
            26-83               CF594072.1         28-85
            84-220              BQ642398.1         43-179
            221-1613            BC006490.2         1-1393
            1614-2019           BU517079.1         183-588
            2020-2153           BC013088.1         1-134
            2154-2817           BC013088.1         141-804
FEATURES             Location/Qualifiers
     source          1..2817
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2817
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /note="casein kinase 1 epsilon"
                     /db_xref="GeneID:1454"
                     /db_xref="HGNC:HGNC:2453"
                     /db_xref="MIM:600863"
     exon            1..274
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            275..362
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1537
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /EC_number="2.7.11.1"
                     /codon_start=1
                     /product="casein kinase I isoform epsilon"
                     /protein_id="NP_689407.1"
                     /db_xref="GeneID:1454"
                     /db_xref="HGNC:HGNC:2453"
                     /db_xref="MIM:600863"
                     /translation="MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKT
                     KHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPT
                     GATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSD
                     LTGRQEVSRIPASQTSVPFDHLGK"
     exon            363..473
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            474..622
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            623..851
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1022
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1171
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1364
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1504
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1569
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..2817
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2794..2799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /note="hexamer: AATAAA"
     polyA_site      2817
                     /gene="CSNK1E"
                     /gene_synonym="CKIe; CKIepsilon; HCKIE"
                     /note="major polyA site"
ORIGIN      
        1 gagagcgcgc gagccggcgg cgggggcggg cgggcgggca ggaggccggg aggagggagg
       61 cggcggcggc ggcggcggcg gcggcgagag cccagagcca gagcccggcc ggggccgagc
      121 ggagcgcggc ggcggcggcg gcggcggcgg ctgggccggg agaggctggc gcgccgggcg
      181 gctccgcgaa tcctccggca tccgccccgg cgggccgccc ccgcccgcgg cagccccccg
      241 agcagtggcc cggcatcggc gccttcccgg cgggcaagag tgagccatgg agctacgtgt
      301 ggggaacaag taccgcctgg gacggaagat cgggagcggg tccttcggag atatctacct
      361 gggtgccaac atcgcctctg gtgaggaagt cgccatcaag ctggagtgtg tgaagacaaa
      421 gcacccccag ctgcacatcg agagcaagtt ctacaagatg atgcagggtg gcgtggggat
      481 cccgtccatc aagtggtgcg gagctgaggg cgactacaac gtgatggtca tggagctgct
      541 ggggcctagc ctcgaggacc tgttcaactt ctgttcccgc aaattcagcc tcaagacggt
      601 gctgctcttg gccgaccaga tgatcagccg catcgagtat atccactcca agaacttcat
      661 ccaccgggac gtcaagcccg acaacttcct catggggctg gggaagaagg gcaacctggt
      721 ctacatcatc gacttcggcc tggccaagaa gtaccgggac gcccgcaccc accagcacat
      781 tccctaccgg gaaaacaaga acctgaccgg cacggcccgc tacgcttcca tcaacacgca
      841 cctgggcatt gagcaaagcc gtcgagatga cctggagagc ctgggctacg tgctcatgta
      901 cttcaacctg ggctccctgc cctggcaggg gctcaaagca gccaccaagc gccagaagta
      961 tgaacggatc agcgagaaga agatgtcaac gcccatcgag gtcctctgca aaggctatcc
     1021 ctccgaattc tcaacatacc tcaacttctg ccgctccctg cggtttgacg acaagcccga
     1081 ctactcttac ctacgtcagc tcttccgcaa cctcttccac cggcagggct tctcctatga
     1141 ctacgtcttt gactggaaca tgctgaaatt cggtgcagcc cggaatcccg aggatgtgga
     1201 ccgggagcgg cgagaacacg aacgcgagga gaggatgggg cagctacggg ggtccgcgac
     1261 ccgagccctg ccccctggcc cacccacggg ggccactgcc aaccggctcc gcagtgccgc
     1321 cgagcccgtg gcttccacgc cagcctcccg catccagccg gctggcaata cttctcccag
     1381 agcgatctcg cgggtcgacc gggagaggaa ggtgagtatg aggctgcaca ggggtgcgcc
     1441 cgccaacgtc tcctcctcag acctcactgg gcggcaagag gtctcccgga tcccagcctc
     1501 acagacaagt gtgccatttg accatctcgg gaagtgagga gagcccccat tggaccagtg
     1561 tttgcttagt gtcttcactg tattttcttt aaaaaaaaaa aaaaaaaaaa aaaggcaaaa
     1621 ataaaccact caaaagaaca acaaaaaaac ccagcacaaa accgacgatg gagtttgttt
     1681 ctttgatttc tttgccaatg gcaagaagat gagatgccct cagcactgag gattcttgcc
     1741 cccttgtggt gcccgctgcc cccaaccttc aggctgccag atgctcccct gacaacacca
     1801 ggctacagga gccagacgcc agggcctgcc cggcctcctg ttcctgcccc cacccaccac
     1861 ctgcctggag aggaacgggt cgggtccgtg tcggagaagt gacaggtccc agagccaaag
     1921 ccggccctca agcatcatca gggagtggtg tagtcagttg aaggcagttc ccaccgagtt
     1981 ttccgagcct cagaatccag gagatacgca cagccccacc cactctgaga tgacagtggc
     2041 tgacttcccg tgctgggctt ttccattgtc cccctggcct ccaggctcct cctctgcctc
     2101 tccatggagt gggtggggag gtggtggggg ccggcgtccc ctgcgtgtgt gtgtgtgtgt
     2161 gtgtgtgtgg atgtattgac ctgtgtttcc caagacagca ggtgccacgg cccgccccgc
     2221 ctgccagccc gaattcccgt tctcctgtgt ctactaacaa ggacatgggg gtgggcggtg
     2281 acctccgcat ccctcagagc tcagagggtc ctcgctgcca ccggtccccc cctagcccgt
     2341 catcagccgg tggcagctcc atcttccatt cctggtttta gggcagaatc catggagact
     2401 gcttccagaa ggcatctggc tctgagttat aaattacttc cctggtcctg acagtcacct
     2461 ggggtccccc ctctccctgg ttccaccttt ctgaggagga gcctggagtc agggctgggt
     2521 tttggattaa cccatccttc ctagttaaca cctttttgtt tttattttat tttatttttg
     2581 tttgttttct ccgtgtgtgt gttttcctaa tttatttacc tctgtttccc ctttttcctt
     2641 ttttttttta attaaagagc aaagcttttt attactttgt aatttaaaaa actgaaaaaa
     2701 aaaaaactga agaactttgg ggggaatttt gtactttttt cctgtgtaaa tattggactt
     2761 ttttgagctt tatcgtggtt gttaatttga agtaataaag tagaaaagat aaagtga
//
