LOCUS       NM_001893               3681 bp    mRNA    linear   PRI 19-MAR-2025
DEFINITION  Homo sapiens casein kinase 1 delta (CSNK1D), transcript variant 1,
            mRNA.
ACCESSION   NM_001893 XM_001132734
VERSION     NM_001893.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3681)
  AUTHORS   Wang,J., Hu,B. and Wang,W.
  TITLE     Prognostic value and immunological role of CSNK1D in human cancers
  JOURNAL   Aging (Albany NY) 15 (17), 8948-8975 (2023)
   PUBMED   37688771
  REMARK    GeneRIF: Prognostic value and immunological role of CSNK1D in human
            cancers.
REFERENCE   2  (bases 1 to 3681)
  AUTHORS   Qi,F., Shen,W., Wei,X., Cheng,Y., Xu,F., Zheng,Y., Li,L., Qin,C.
            and Li,X.
  TITLE     CSNK1D-mediated phosphorylation of HNRNPA2B1 induces
            miR-25-3p/miR-93-5p maturation to promote prostate cancer cell
            proliferation and migration through m6A-dependent manner
  JOURNAL   Cell Mol Life Sci 80 (6), 156 (2023)
   PUBMED   37208565
  REMARK    GeneRIF: CSNK1D-mediated phosphorylation of HNRNPA2B1 induces
            miR-25-3p/miR-93-5p maturation to promote prostate cancer cell
            proliferation and migration through m[6]A-dependent manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3681)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 3681)
  AUTHORS   Yang,M., Qi,R., Liu,Y., Shen,X., Zhao,Y., Jin,N., Wu,R., Liu,F. and
            Gu,J.
  TITLE     Casein Kinase 1delta Phosphorylates TDP-43 and Suppresses Its
            Function in Tau mRNA Processing
  JOURNAL   J Alzheimers Dis 91 (4), 1527-1539 (2023)
   PUBMED   36641675
  REMARK    GeneRIF: Casein Kinase 1delta Phosphorylates TDP-43 and Suppresses
            Its Function in Tau mRNA Processing.
REFERENCE   5  (bases 1 to 3681)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 3681)
  AUTHORS   Walter,J., Capell,A., Grunberg,J., Pesold,B., Schindzielorz,A.,
            Prior,R., Podlisny,M.B., Fraser,P., Hyslop,P.S., Selkoe,D.J. and
            Haass,C.
  TITLE     The Alzheimer's disease-associated presenilins are differentially
            phosphorylated proteins located predominantly within the
            endoplasmic reticulum
  JOURNAL   Mol Med 2 (6), 673-691 (1996)
   PUBMED   8972483
REFERENCE   7  (bases 1 to 3681)
  AUTHORS   Kusuda,J., Hidari,N., Hirai,M. and Hashimoto,K.
  TITLE     Sequence analysis of the cDNA for the human casein kinase I delta
            (CSNK1D) gene and its chromosomal localization
  JOURNAL   Genomics 32 (1), 140-143 (1996)
   PUBMED   8786104
REFERENCE   8  (bases 1 to 3681)
  AUTHORS   Graves,P.R. and Roach,P.J.
  TITLE     Role of COOH-terminal phosphorylation in the regulation of casein
            kinase I delta
  JOURNAL   J Biol Chem 270 (37), 21689-21694 (1995)
   PUBMED   7665585
REFERENCE   9  (bases 1 to 3681)
  AUTHORS   Fish,K.J., Cegielska,A., Getman,M.E., Landes,G.M. and Virshup,D.M.
  TITLE     Isolation and characterization of human casein kinase I epsilon
            (CKI), a novel member of the CKI gene family
  JOURNAL   J Biol Chem 270 (25), 14875-14883 (1995)
   PUBMED   7797465
REFERENCE   10 (bases 1 to 3681)
  AUTHORS   Golsteyn,R.M., Mundt,K.E., Fry,A.M. and Nigg,E.A.
  TITLE     Cell cycle regulation of the activity and subcellular localization
            of Plk1, a human protein kinase implicated in mitotic spindle
            function
  JOURNAL   J Cell Biol 129 (6), 1617-1628 (1995)
   PUBMED   7790358
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC334821.1, BC003558.1,
            AC132872.17 and AA825280.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001893.5.
            
            Summary: This gene is a member of the casein kinase I (CKI) gene
            family whose members have been implicated in the control of
            cytoplasmic and nuclear processes, including DNA replication and
            repair. The encoded protein may also be involved in the regulation
            of apoptosis, circadian rhythm, microtubule dynamics, chromosome
            segregation, and p53-mediated effects on growth. The encoded
            protein is highly similar to the mouse and rat CK1 delta homologs.
            Three transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Feb 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.2167838.1,
                                           SRR11853567.14164.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314028.11/ ENSP00000324464.6
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DC334821.1         19-29
            12-1395             BC003558.1         1-1384
            1396-1396           AC132872.17        97082-97082
            1397-1986           BC003558.1         1386-1975
            1987-3454           AC132872.17        101716-103183
            3455-3681           AA825280.1         16-242              c
FEATURES             Location/Qualifiers
     source          1..3681
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3681
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /note="casein kinase 1 delta"
                     /db_xref="GeneID:1453"
                     /db_xref="HGNC:HGNC:2452"
                     /db_xref="MIM:600864"
     exon            1..395
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..1567
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.26"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tau-protein kinase CSNK1D"
                     /codon_start=1
                     /product="casein kinase I isoform delta isoform 1"
                     /protein_id="NP_001884.2"
                     /db_xref="CCDS:CCDS11805.1"
                     /db_xref="GeneID:1453"
                     /db_xref="HGNC:HGNC:2452"
                     /db_xref="MIM:600864"
                     /translation="MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKT
                     KHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSL
                     KTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDAR
                     THQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKA
                     ATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNL
                     FHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRL
                     RGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDT
                     SRMSTSQIPGRVASSGLQSVVHR"
     exon            396..506
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            507..655
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            656..884
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1055
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1204
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1376
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1516
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..3681
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /note="hexamer: AAGAAA"
     polyA_site      1986
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /note="major polyA site"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /note="hexamer: AATAAA"
     polyA_site      3681
                     /gene="CSNK1D"
                     /gene_synonym="ASPS; CKI-delta; CKId; CKIdelta; FASPS2;
                     HCKID"
                     /note="major polyA site"
ORIGIN      
        1 acagcgcgat ggcggcggct cctttaggca gctgaaaggg gatttaggcc cggaagatcc
       61 gagtccatcc gcggcgggga gagggcaagc gggaccggta ggggccggag cagcggcggc
      121 ggcgctcgga ctgtcccatc cgccccgtat tgaggcgctg ggagcggcgg ggcgacagga
      181 aagcgatggt gaaagcgggg ccgtgagggg ggcggagccg ggagccggac ccgcagtagc
      241 ggcagcagcg gcgccgcctc ccagagttca gacccaggaa gcggccggga gggcaggagc
      301 gaatcgggcc gccgccgcca tggagctgag agtcgggaac aggtaccggc tgggccggaa
      361 gatcggcagc ggctccttcg gagacatcta tctcggtacg gacattgctg caggagaaga
      421 ggttgccatc aagcttgaat gtgtcaaaac caaacaccct cagctccaca ttgagagcaa
      481 aatctacaag atgatgcagg gaggagtggg catccccacc atcagatggt gcggggcaga
      541 gggggactac aacgtcatgg tgatggagct gctggggcca agcctggagg acctcttcaa
      601 cttctgctcc aggaaattca gcctcaaaac cgtcctgctg cttgctgacc aaatgatcag
      661 tcgcatcgaa tacattcatt caaagaactt catccaccgg gatgtgaagc cagacaactt
      721 cctcatgggc ctggggaaga agggcaacct ggtgtacatc atcgacttcg ggctggccaa
      781 gaagtaccgg gatgcacgca cccaccagca catcccctat cgtgagaaca agaacctcac
      841 ggggacggcg cggtacgcct ccatcaacac gcaccttgga attgaacaat cccgaagaga
      901 tgacttggag tctctgggct acgtgctaat gtacttcaac ctgggctctc tcccctggca
      961 ggggctgaag gctgccacca agagacagaa atacgaaagg attagcgaga agaaaatgtc
     1021 cacccccatc gaagtgttgt gtaaaggcta cccttccgaa tttgccacat acctgaattt
     1081 ctgccgttcc ttgcgttttg acgacaagcc tgactactcg tacctgcggc agcttttccg
     1141 gaatctgttc catcgccagg gcttctccta tgactacgtg ttcgactgga acatgctcaa
     1201 atttggtgcc agccgggccg ccgatgacgc cgagcgggag cgcagggacc gagaggagcg
     1261 gctgagacac tcgcggaacc cggctacccg cggcctccct tccacagcct ccggccgcct
     1321 gcgggggacg caggaagtgg ctccccccac acccctcacc cctacctcac acacggctaa
     1381 cacctccccc cggcccgtct ccggcatgga gagagagcgg aaagtgagta tgcggctgca
     1441 ccgcggggcc cccgtcaaca tctcctcgtc cgacctcaca ggccgacaag atacctctcg
     1501 catgtccacc tcacagattc ctggtcgggt ggcttccagt ggtcttcagt ctgtcgtgca
     1561 ccgatgagaa ctctccttat tgctgtgaag ggcagacaat gcatggctga tctactctgt
     1621 taccaatggc tttactagtg acacgtcccc cggtctagga tcgaaatgtt aacaccggga
     1681 gctctccagg ccactcaccc agcgacgctc gtgggggaaa catactaaac ggacagactc
     1741 caagagctgc caccgctggg gctgcactgc ggccccccac gtgaactcgg ttgtaacggg
     1801 gctgggaaga aaagcagaga gagaattgca gagaatcaga ctccttttcc agggcctcag
     1861 ctccctccag tggtggccgc cctgtactcc ctgacgattc cactgtaact accaatcttc
     1921 tacttggtta agacagtttt gtatcatttt gctaaaaatt attggcttaa atctgtgtaa
     1981 agaaaatctg tctttttatt gtttcttgtc tgtttttgca gtcttacaaa aaaaatgttg
     2041 actaaggaat tctgagacag gctggcttgg agttagtgta tgaggtggag tcgggcaggg
     2101 agaaggtgca ggtggatctc aagggtgtgt gctgtgtttg ttttgcagtg ttttattgtc
     2161 cgctttggag aggagatttc tcatcaaaag tccgtggtgt gtgtgtgtgc ccgtgtgtgg
     2221 tgggacctct tcaacctgat tttggcgtct caccctccct cctcccgtaa ttgacatgcc
     2281 tgctgtcagg aactcttgag gccctcggag agcagttagg gaccgcaggc tgccgcgggg
     2341 caggggtgca gtgggtgtta ccaggcaaag cactgcgcgc ttcttcccca ggaggtgggc
     2401 aggcagctga gagcttggaa gcagaggctt tgagacccta gcaggacaat tgggagtccc
     2461 aggattcaag gtggaagatg cgtttctggt cccttgggag aggactgtga accgagaggt
     2521 ggttactgta gtgtttgttg ccttgctgcc tttgcactca gtccattttc tcagcactca
     2581 atgctcctgt gcggattggc actccgtctg tatgaatgcc tgtgcttaaa accaggagcg
     2641 gggctgtcct tgccacgtgc caagactagc tcagaaaagc cggcaggcca gaaggaccca
     2701 ccctgaggtg ccaaggagca ggtgactctc ccaaccggac ccagaacctt cacggccaga
     2761 aagtagagtc tgcgctgtga ccttctgttg ggcgcgtgtc tgttggtcag aagtgaagca
     2821 gcgtgcgtgg ggccgagtcc caccagaagg caggtggcct ccgtgagctg gtgctgcccc
     2881 aggctccatg ctgctgtgcc ctgaggttcc caggatgcct tctcgcctct cactccgcag
     2941 cacttgggcg gtagccagtg gccatgtgct cccaacccca atgcgcaggg cagtctgtgt
     3001 tcgtgggcac ttcggctgga ccccatcacg atggacgatg ttccctttgg actctagggc
     3061 ttcgaaggtg tgcaccttgg ttctcccttc tcctccccag agttccccgg atgccataac
     3121 tggctggcgt cccagaacac agttgttcac ccccccacca gctggctggc cgtctgcctg
     3181 agcccatgga tgctttctca atcctaggct ggttactgtg taagcgtttt ggagtacggg
     3241 gccttgagcg ggtgggagct gtgtgttgaa gtacagaggg aggttggggt gggtcagagc
     3301 cgagttaaga gattttcttt gttgctggac cccttcttga aggtagacgt cccccacccg
     3361 gagagacgtc gcgctgtggc ctgaagtggc gcaagcttgc tttgtaaata tctgtggtcc
     3421 cgatgtagtg cccagaacgt ttgtgcgagg cagctctgcg cccgggttcc agcccgagcc
     3481 tcgccgggtc gcgtcttcgg agtgcttgtg acagtccttg cccagtatct agtccccgtc
     3541 gccccgtgca ggagacgtag gtaggacgtc gtgtcagctg tgcactgacg gccagtctcc
     3601 gagctgtgcg tttgtatcgc cactgtattt gtgtacttta acaatcgtgt aaataataaa
     3661 ttcataatga cttctacctt t
//
