LOCUS       NM_001892               5360 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens casein kinase 1 alpha 1 (CSNK1A1), transcript variant
            2, mRNA.
ACCESSION   NM_001892 NM_018548
VERSION     NM_001892.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5360)
  AUTHORS   Pham,A.M. and Kwun,H.J.
  TITLE     Casein kinase 1alpha mediates phosphorylation of the Merkel cell
            polyomavirus large T antigen for beta-TrCP destruction complex
            interaction and subsequent degradation
  JOURNAL   mBio 15 (8), e0111724 (2024)
   PUBMED   38940554
  REMARK    GeneRIF: Casein kinase 1alpha mediates phosphorylation of the
            Merkel cell polyomavirus large T antigen for beta-TrCP destruction
            complex interaction and subsequent degradation.
REFERENCE   2  (bases 1 to 5360)
  AUTHORS   Cullati,S.N., Akizuki,K., Chen,J.S., Johnson,J.L.,
            Yaron-Barir,T.M., Cantley,L.C. and Gould,K.L.
  TITLE     Substrate displacement of CK1 C-termini regulates kinase
            specificity
  JOURNAL   Sci Adv 10 (19), eadj5185 (2024)
   PUBMED   38728403
  REMARK    GeneRIF: Substrate displacement of CK1 C-termini regulates kinase
            specificity.
REFERENCE   3  (bases 1 to 5360)
  AUTHORS   Pan,M., Hu,T., Lyu,J., Yin,Y., Sun,J., Wang,Q., Xu,L., Hu,H. and
            Wang,C.
  TITLE     CSNK1A1/CK1alpha suppresses autoimmunity by restraining the
            CGAS-STING1 signaling
  JOURNAL   Autophagy 20 (2), 311-328 (2024)
   PUBMED   37723657
  REMARK    GeneRIF: CSNK1A1/CK1alpha suppresses autoimmunity by restraining
            the CGAS-STING1 signaling.
REFERENCE   4  (bases 1 to 5360)
  AUTHORS   Nishiguchi,G., Mascibroda,L.G., Young,S.M., Caine,E.A.,
            Abdelhamed,S., Kooijman,J.J., Miller,D.J., Das,S., McGowan,K.,
            Mayasundari,A., Shi,Z., Barajas,J.M., Hiltenbrand,R., Aggarwal,A.,
            Chang,Y., Mishra,V., Narina,S., Thomas,M., Loughran,A.J.,
            Kalathur,R., Yu,K., Zhou,S., Wang,X., High,A.A., Peng,J.,
            Pruett-Miller,S.M., Daniels,D.L., Urh,M., Shelat,A.A.,
            Mullighan,C.G., Riching,K.M., Zaman,G.J.R., Fischer,M., Klco,J.M.
            and Rankovic,Z.
  TITLE     Selective CK1alpha degraders exert antiproliferative activity
            against a broad range of human cancer cell lines
  JOURNAL   Nat Commun 15 (1), 482 (2024)
   PUBMED   38228616
  REMARK    GeneRIF: Selective CK1alpha degraders exert antiproliferative
            activity against a broad range of human cancer cell lines.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5360)
  AUTHORS   Al-Attar,R., Jargstorf,J., Romagnuolo,R., Jouni,M., Alibhai,F.J.,
            Lampe,P.D., Solan,J.L. and Laflamme,M.A.
  TITLE     Casein Kinase 1 Phosphomimetic Mutations Negatively Impact
            Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived
            Cardiomyocytes
  JOURNAL   Biomolecules 14 (1), 61 (2024)
   PUBMED   38254663
  REMARK    GeneRIF: Casein Kinase 1 Phosphomimetic Mutations Negatively Impact
            Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived
            Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5360)
  AUTHORS   Beyaert,R., Vanhaesebroeck,B., Declercq,W., Van Lint,J.,
            Vandenabele,P., Agostinis,P., Vandenheede,J.R. and Fiers,W.
  TITLE     Casein kinase-1 phosphorylates the p75 tumor necrosis factor
            receptor and negatively regulates tumor necrosis factor signaling
            for apoptosis
  JOURNAL   J Biol Chem 270 (40), 23293-23299 (1995)
   PUBMED   7559483
REFERENCE   7  (bases 1 to 5360)
  AUTHORS   Gross,S.D., Hoffman,D.P., Fisette,P.L., Baas,P. and Anderson,R.A.
  TITLE     A phosphatidylinositol 4,5-bisphosphate-sensitive casein kinase I
            alpha associates with synaptic vesicles and phosphorylates a subset
            of vesicle proteins
  JOURNAL   J Cell Biol 130 (3), 711-724 (1995)
   PUBMED   7622570
REFERENCE   8  (bases 1 to 5360)
  AUTHORS   Fish,K.J., Cegielska,A., Getman,M.E., Landes,G.M. and Virshup,D.M.
  TITLE     Isolation and characterization of human casein kinase I epsilon
            (CKI), a novel member of the CKI gene family
  JOURNAL   J Biol Chem 270 (25), 14875-14883 (1995)
   PUBMED   7797465
REFERENCE   9  (bases 1 to 5360)
  AUTHORS   Tapia,C., Featherstone,T., Gomez,C., Taillon-Miller,P.,
            Allende,C.C. and Allende,J.E.
  TITLE     Cloning and chromosomal localization of the gene coding for human
            protein kinase CK1
  JOURNAL   FEBS Lett 349 (2), 307-312 (1994)
   PUBMED   8050587
REFERENCE   10 (bases 1 to 5360)
  AUTHORS   Brockman,J.L., Gross,S.D., Sussman,M.R. and Anderson,R.A.
  TITLE     Cell cycle-dependent localization of casein kinase I to mitotic
            spindles
  JOURNAL   Proc Natl Acad Sci U S A 89 (20), 9454-9458 (1992)
   PUBMED   1409656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA144898.1, BC008717.2, L37042.1, BC009186.2, BU618830.1 and
            AC021078.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001892.5.
            
            Transcript Variant: This variant (2) lacks an in-frame internal
            exon, compared to variant 1. This results in a shorter protein
            (isoform 2), compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.1592500.1,
                                           SRR1803617.77686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467144 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377843.8/ ENSP00000367074.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               DA144898.1         114-458
            346-1165            BC008717.2         1-820
            1166-1651           L37042.1           902-1387
            1652-2275           BC009186.2         32-655
            2276-2358           BC008717.2         1932-2014
            2359-2448           BU618830.1         17-106              c
            2449-5360           AC021078.5         120973-123884
FEATURES             Location/Qualifiers
     source          1..5360
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..5360
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="casein kinase 1 alpha 1"
                     /db_xref="GeneID:1452"
                     /db_xref="HGNC:HGNC:2451"
                     /db_xref="MIM:600505"
     exon            1..598
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     CDS             476..1489
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     down-regulated in lung cancer; epididymis secretory sperm
                     binding protein Li 77p; CKI-alpha; clock regulator kinase"
                     /codon_start=1
                     /product="casein kinase I isoform alpha isoform 2"
                     /protein_id="NP_001883.4"
                     /db_xref="CCDS:CCDS47303.1"
                     /db_xref="GeneID:1452"
                     /db_xref="HGNC:HGNC:2451"
                     /db_xref="MIM:600505"
                     /translation="MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVA
                     VKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFN
                     FCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGL
                     AKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTS
                     LPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMY
                     LRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNM
                     KGF"
     exon            599..705
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            706..832
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            833..931
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1071
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1150
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1225
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1332
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1481
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..5360
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2332..2337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: ATTAAA"
     polyA_site      2349
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="major polyA site"
     regulatory      3982..3987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATAAA"
     regulatory      3992..3997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATATA"
     polyA_site      4003
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="major polyA site"
     polyA_site      4028
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
     regulatory      5340..5345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
                     /note="hexamer: AATAAA"
     polyA_site      5360
                     /gene="CSNK1A1"
                     /gene_synonym="CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1;
                     PRO2975"
ORIGIN      
        1 cccagagtgc tctgcgccgt gaagaagcgg ctcccgggga ctgggggcat tttgtgttgg
       61 ctggagctgg agtaacaaga tggcgtcgtc cgcggagtga caggggtccc tctgggccgg
      121 agccggcggc agtggtggca gcggtatcgc cgccctagct caccgcgccc cttttccagc
      181 ccgcgacgtc gccgcgcaag cgaggcagcg gcggccgccg agaaacaagt ggcccagcct
      241 ggtaaccgcc gagaagccct tcacaaactg cggcctggca aaaagaaacc tgactgagcg
      301 gcggtgatca ggttcccctc tgctgattct gggccccgaa ccccggtaaa ggcctccgtg
      361 ttccgtttcc tgccgccctc ctccgtagcc ttgcctagtg taggagcccc gaggcctccg
      421 tcctcttccc agaggtgtcg gggcttggcc ccagcctcca tcttcgtctc tcaggatggc
      481 gagtagcagc ggctccaagg ctgaattcat tgtcggaggg aaatataaac tggtacggaa
      541 gatcgggtct ggctccttcg gggacatcta tttggcgatc aacatcacca acggcgagga
      601 agtggcagtg aagctagaat ctcagaaggc caggcatccc cagttgctgt acgagagcaa
      661 gctctataag attcttcaag gtggggttgg catcccccac atacggtggt atggtcagga
      721 aaaagactac aatgtactag tcatggatct tctgggacct agcctcgaag acctcttcaa
      781 tttctgttca agaaggttca caatgaaaac tgtacttatg ttagctgacc agatgatcag
      841 tagaattgaa tatgtgcata caaagaattt tatacacaga gacattaaac cagataactt
      901 cctaatgggt attgggcgtc actgtaataa gttattcctt attgattttg gtttggccaa
      961 aaagtacaga gacaacagga caaggcaaca cataccatac agagaagata aaaacctcac
     1021 tggcactgcc cgatatgcta gcatcaatgc acatcttggt attgagcaga gtcgccgaga
     1081 tgacatggaa tcattaggat atgttttgat gtattttaat agaaccagcc tgccatggca
     1141 agggctaaag gctgcaacaa agaaacaaaa atatgaaaag attagtgaaa agaagatgtc
     1201 cacgcctgtt gaagttttat gtaaggggtt tcctgcagaa tttgcgatgt acttaaacta
     1261 ttgtcgtggg ctacgctttg aggaagcccc agattacatg tatctgaggc agctattccg
     1321 cattcttttc aggaccctga accatcaata tgactacaca tttgattgga caatgttaaa
     1381 gcagaaagca gcacagcagg cagcctcttc cagtgggcag ggtcagcagg cccaaacccc
     1441 cacaggcaag caaactgaca aaaccaagag taacatgaaa ggtttctaag catgaattga
     1501 ggaacagaag aagcagagca gatgatcgga gcagcatttg tttctcccca aatctagaaa
     1561 ttttagttca tatgtacact agccagtggt tgtggacaac catttacttg gtgtaaagaa
     1621 cttaatttca gtataaactg actctgggca gcattggtga tgctgtatcc tgagttgtag
     1681 cctctgtaat tgtgaatatt aactgagata gtgaaacatg gtgtccggtt ttctattgca
     1741 ttttttcaag tggaaaagtt aactaaatgg ttgacacaca aaaattggtg gagaaattgt
     1801 gcatatgcca attttttgtt aaaacctttt gttttgaact atactgcttt gagatctcat
     1861 ttcagaagaa cggcatgaac agtcttcagc cacagttgtg atggttgtta aatgctcaca
     1921 attgtgcatt cttagggttt ttccatccct ggggtttgca agttgttcac ttaaaacatt
     1981 cttaaaatgg ttggcttctt gtctgcaagc cagctgatat ggtagcaacc aaagattcca
     2041 gtgtttgagc atatgaaaga ctctgcctgc ttaattgtgc tagaaataac agcatctaaa
     2101 gtgaagactt aagaaaaact tagtgactac tagattatcc ttaggactct gcattaactc
     2161 tataatgttc ttggtattaa aaaaaaagca tatttgtcac agaaatttag ttaacatctt
     2221 acaactgaac atgtatgtat gttgcttaga taaatgtaat cactgtaaac atctatatga
     2281 tctgggattt tgtttttatt ttgaaatggg agcttttttg tttacaagtt cattaaaaac
     2341 taaaaactgt ttctgtaagg aaatgagatt ttttttaaac aacaaaaaat gccttgctga
     2401 ctcactatta aataaaaatc tccccaattt tttgatagac tacttcaagc catttgttac
     2461 atggtattcc tttgcaagtc aatttaggtt tcgtgttata acttttcctc tttttttaag
     2521 aaaaatgaaa aaagtaattc ttttgtctga aggggaaagg cattctttca tttttttctt
     2581 tttttttttt tttttttatg acttgcaggc acaatatcta gtactgcaac tgccagaact
     2641 tggtattgta gctgctgccc gctgactagc agctggactg attttgaata aaaatgaaag
     2701 cattaaaggg tttccctaca aaacattttt ctttaaaata cttttgaaat ggctataagc
     2761 agttgacttt cacccttgga gagcatcaca ctgtgtgagg ttcagtgatt gttgaccctc
     2821 cccagcccct cctgcttctt taagttatct gtgtgcgtgc gcttcctctc aatcttcttt
     2881 gcacgctcat ttctttttct ctgacccatg agaaaggaaa acttactgat gataattttt
     2941 aaatagtgta atttattcat ttatagcatg tcaggataaa ttaaaagaac atttgtctgg
     3001 aaatgctgcc gggagcctat tgtgtaaatg taggtatttt gtaaaataac cttgaaattg
     3061 taaattgaca cgtgtttggt cagattgtgt caagtttaat ttgttttgtt ttcttttttc
     3121 ttttttttat ttgaaaacta ctttagcaat aattaattcc atgattatca cattctgcca
     3181 ttaagggata ttagtaccgt aatactgaag aaattttatt aagtctgaac ttctggggta
     3241 ggcagcttct ttgtttcttt tctatccacc cttgtcggtt gaggtatttg tttcttgact
     3301 aataaaccct ttgatacttt tagccagaaa tcagtctcat aaagctattt ttgagtatag
     3361 tttgtgtaaa ataaaaatgt ttagctttgg taataacttc caagctgaac tccctctagc
     3421 aagatatttt tcagtgcttt tatttactat gcacttagac tatgcacttt ttctgaaata
     3481 tttttgtaac acttttttgt atttttgcca tttgaaaagg ttgtggtgta gttggtctgt
     3541 aattaagttg cagatttaaa actgctgtta gctttgtaaa tcaaaatata ggtgtttttt
     3601 gtcctggtat atcgtcattc catctgcagc tggagctgga atcccattga tcttctagct
     3661 accattcatt ttcttcactg ttcacaaaag aagagtgtga aattcagtga atgctgttac
     3721 taatcctgtt acgagatgaa tctcatttca ccaaaattaa attatgtttt tccgctaaaa
     3781 tgatgataca agttgaagac acatcactct gaaattggaa gacctcacca cttaaggctc
     3841 cacagtggct tactcagctg aactctaggt tactactctt tactttgttc acccattggg
     3901 gggtgcagtt tttttaaaat gttgggagat ggccattcta actactgttg aatgtctctg
     3961 ttttgggaag gtataacaag aaataaaaaa gaatatatat gaagggagag actggttatc
     4021 tcctcccata tggttgtgct tatcctctta tggcttacaa atgaatattt ggaggtttgc
     4081 tttcacaatg atttcccatc aacaaatatt tttagtagga tttttcctgt ttctgttagt
     4141 ccttgcagta ctcataaatg ttttaagctg agcatactgt aatagtcata agtttaattt
     4201 cattataata aaaataatca aacaaaagga ctttagaacc caagacaatg agctagtttt
     4261 ccctaaagtt tgctgaacta ttaaggaata tgttcttata gcttttgact agaatgagtc
     4321 atgggaattc taagaaggga tggcctagac atttttagct cagttaaatt cagcatttaa
     4381 tgcaggtgag ttcctgggtc gttttccaac tagtctggaa cagtctggtt ctgactcaaa
     4441 ctggtataaa gcattatttt aggttttctc tttgccagtt tttaagcagt tataaccatg
     4501 taaatcaaga tgtgaggaca tctatatgaa gtatagtaaa gaagtggtgt cagcagatca
     4561 atatgtgtgt cctgggtgtg ctgctctctt aagtgagact ttgtgagact atactttaaa
     4621 tgcattatta ccattgctta cattttgggg gattttcttc ctcctcaaaa cttccatttc
     4681 tattgtaata ttcttaatga caatcttttt ttttttttag cagtgtatgt ttgaaacagc
     4741 caaagatggc gatgaaccaa gtgtaaattg atctaagcag cccatgcagt ttgtgttgaa
     4801 tcaacaaaca gtgtattgtt gaagtgaaat tattttctga aatgacttgt tagaccagtt
     4861 ttgaggacat actcaaaagt agagtaataa tggctcctgg gatggagaaa tatgagatga
     4921 acctggaaca ttctattatg gtgccacaaa ggaaatctaa aaaaaaaaaa aaaaaaaaaa
     4981 gtggttggct aggagcagtg gcacacgcct gtgattccag cactttggga ggccgaagtg
     5041 ggcaggagtt caagaccagc ctggccaaca tagtgaaacc ctgtctctac taaaaataca
     5101 aaaattagcc gggtgtggtg gcgggcgcct gtaatcccag cttttcaaga ggctgaggca
     5161 gaagaatcgc ttgaacccgg gagatggagg ttgcagtgag ctgagatcgt gccactgcac
     5221 tccagcctgg gcgttgcagt gagactccgt ctcaacaaca acaaaaaggt ggatacatgt
     5281 caaaagggca caggagccac ttgaaggatt atacttgcta aatctgtgtc aattatcaaa
     5341 ataaactggt agcaacgtta
//
